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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P10275	AR	T11211	Successful Target	Acne vulgaris Acute myeloid leukaemia Alcoholic liver disease Breast cancer Chronic obstructive pulmonary disease Female pelvic pain Hypo-osmolality/hyponatraemia Low bone mass disorder Mammary tumour Prostate cancer Testicular dysfunction	[ICD-11: ED80] [ICD-11: 2A60] [ICD-11: DB94] [ICD-11: 2C60-2C6Y] [ICD-11: CA22] [ICD-11: GA34] [ICD-11: 5C72] [ICD-11: FB83] [ICD-11: 2C60-2C6Z] [ICD-11: 2C82] [ICD-11: 5A81]	Diseases of the skin Neoplasms Diseases of the digestive system Neoplasms Diseases of the respiratory system Diseases of the genitourinary system Endocrine, nutritional or metabolic diseases Diseases of the musculoskeletal system or connective tissue Neoplasms Neoplasms Endocrine, nutritional or metabolic diseases
2	Q99500	S1PR3	T11241	Patented-recorded Target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
3	P10809	HSPD1	T11283	Clinical trial target	Diabetes mellitus	[ICD-11: 5A10]	Endocrine, nutritional or metabolic diseases
4	P33527	ABCC1	T11288	Successful Target	Gout	[ICD-11: FA25]	Diseases of the musculoskeletal system or connective tissue
5	P57059	SIK1	T11317	Literature-reported Target
6	P43235	CTSK	T11388	Clinical trial target	Low bone mass disorder	[ICD-11: FB83]	Diseases of the musculoskeletal system or connective tissue
7	P08913	ADRA2A	T11448	Successful Target	Attention deficit hyperactivity disorder Opioid use disorder Substance abuse	[ICD-11: 6A05] [ICD-11: 6C43] [ICD-11: 6C40]	Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders
8	Q9NR96	TLR9	T11451	Clinical trial target	Colorectal cancer Hepatitis virus infection Melanoma Prostate cancer	[ICD-11: 2B91] [ICD-11: 1E50-1E51] [ICD-11: 2C30] [ICD-11: 2C82]	Neoplasms Certain infectious or parasitic diseases Neoplasms Neoplasms
9	Q9UPY5	SLC7A11	T11615	Clinical trial target	Body-focused behaviour disorder	[ICD-11: 6B25]	Mental, behavioural or neurodevelopmental disorders
10	O00519	FAAH	T11754	Successful Target	Corneal disease	[ICD-11: 9A76-9A78]	Diseases of the visual system
11	Q16832	DDR2	T11764	Patented-recorded Target
12	O00400	SLC33A1	T11791	Patented-recorded Target
13	P20813	CYP2B6	T11793	Literature-reported Target
14	Q9Y337	KLK5	T11808	Patented-recorded Target
15	Q92952	KCNN1	T11911	Clinical trial target	Myelopathy	[ICD-11: 8B42]	Diseases of the nervous system
16	P09651	HNRNPA1	T12052	Literature-reported Target
17	Q15465	SHH	T12075	Literature-reported Target
18	Q08493	PDE4C	T12081	Patented-recorded Target
19	O75884	RBBP9	T12084	Literature-reported Target
20	Q04771	ACVR1	T12091	Clinical trial target	Anemia Multiple myeloma Myelodysplastic syndrome Solid tumour/cancer	[ICD-11: 3A00-3A9Z] [ICD-11: 2A83] [ICD-11: 2A37] [ICD-11: 2A00-2F9Z]	Diseases of the blood or blood-forming organs Neoplasms Neoplasms Neoplasms
21	Q15858	SCN9A	T12119	Clinical trial target	Bipolar disorder Chronic pain Extremities vasodilatation General pain disorder Osteoarthritis Pain Radiculopathy Trigeminal nerve disorder	[ICD-11: 6A60] [ICD-11: MG30] [ICD-11: EG00] [ICD-11: 8E43] [ICD-11: FA00-FA05] [ICD-11: MG30-MG3Z] [ICD-11: 8B93] [ICD-11: 8B82]	Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified Diseases of the skin Diseases of the nervous system Diseases of the musculoskeletal system or connective tissue Symptoms, signs or clinical findings, not elsewhere classified Diseases of the nervous system Diseases of the nervous system
22	Q16584	MAP3K11	T12126	Literature-reported Target
23	P24385	CCND1	T12355	Clinical trial target	Myeloproliferative neoplasm	[ICD-11: 2A20]	Neoplasms
24	P30968	GNRHR	T12475	Successful Target	Endometriosis Ovarian developmental anomaly Ovarian dysfunction Pituitary gland disorder Prostate cancer Solid tumour/cancer	[ICD-11: GA10] [ICD-11: LB45] [ICD-11: 5A80] [ICD-11: 5A60-5A61] [ICD-11: 2C82] [ICD-11: 2A00-2F9Z]	Diseases of the genitourinary system Developmental anomalies Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Neoplasms Neoplasms
25	P06239	LCK	T12499	Successful Target	Myeloproliferative neoplasm	[ICD-11: 2A20]	Neoplasms