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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P26010	ITGB7	T07403	Successful Target	Crohn disease	[ICD-11: DD70]	Diseases of the digestive system
2	P04114	APOB	T07533	Clinical trial target	Hyper-lipoproteinaemia	[ICD-11: 5C80]	Endocrine, nutritional or metabolic diseases
3	Q92995	USP13	T07584	Preclinical target	Postoperative inflammation	[ICD-11: 1A00-CA43]	Postoperative inflammation
4	O76074	PDE5A	T07663	Successful Target	Hypertension Innate/adaptive immunodeficiency Sexual dysfunction Tonus and reflex abnormality	[ICD-11: BA00-BA04] [ICD-11: 4A00] [ICD-11: HA00-HA01] [ICD-11: MB47]	Diseases of the circulatory system Diseases of the immune system Conditions related to sexual health Symptoms, signs or clinical findings, not elsewhere classified
5	Q13177	PAK2	T07766	Literature-reported Target
6	P32418	SLC8A1	T07775	Literature-reported Target
7	P28222	HTR1B	T07806	Successful Target	Migraine Pituitary gland disorder Psychotic disorder Schizophrenia	[ICD-11: 8A80] [ICD-11: 5A60-5A61] [ICD-11: 6A20-6A25] [ICD-11: 6A20]	Diseases of the nervous system Endocrine, nutritional or metabolic diseases Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders
8	Q9UQL6	HDAC5	T07930	Patented-recorded Target
9	Q5S007	LRRK2	T08123	Clinical trial target	Parkinsonism	[ICD-11: 8A00]	Diseases of the nervous system
10	O95747	OXSR1	T08198	Literature-reported Target
11	P10144	GZMB	T08298	Literature-reported Target	Aneurysm/dissection	[ICD-11: BD50]	Diseases of the circulatory system
12	O60674	JAK2	T08391	Successful Target	Atopic eczema Myeloproliferative neoplasm Rheumatoid arthritis Thrombocytosis	[ICD-11: EA80] [ICD-11: 2A20] [ICD-11: FA20] [ICD-11: 3B63]	Diseases of the skin Neoplasms Diseases of the musculoskeletal system or connective tissue Diseases of the blood or blood-forming organs
13	P48065	SLC6A12	T08446	Literature-reported Target
14	Q9UJ67	APAF1	T08499	Clinical trial target	Chronic pain Gout Postoperative inflammation Solid tumour/cancer	[ICD-11: MG30] [ICD-11: FA25] [ICD-11: 1A00-CA43] [ICD-11: 2A00-2F9Z]	Symptoms, signs or clinical findings, not elsewhere classified Diseases of the musculoskeletal system or connective tissue Postoperative inflammation Neoplasms
15	Q9UF33	EPHA6	T08647	Literature-reported Target
16	P04156	PRNP	T08722	Literature-reported Target
17	P41240	CSK	T08741	Patented-recorded Target
18	P22894	MMP8	T08856	Clinical trial target	Rheumatoid arthritis	[ICD-11: FA20]	Diseases of the musculoskeletal system or connective tissue
19	P18507	GABRG2	T08910	Successful Target	Depression Mental/behavioural/neurodevelopmental disorder Tonus and reflex abnormality	[ICD-11: 6A70-6A7Z] [ICD-11: 6E20-6E8Z] [ICD-11: MB47]	Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified
20	O00763	ACACB	T08922	Successful Target	Type 2 diabetes mellitus	[ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases
21	P04439	HLA-A	T08985	Literature-reported Target
22	P40306	PSMB10	T09022	Patented-recorded Target
23	P42575	CASP2	T09128	Patented-recorded Target
24	P53671	LIMK2	T09133	Literature-reported Target
25	Q08345	DDR1	T09185	Patented-recorded Target