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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q15078	CDK5R1	T09513	Literature-reported Target
2	P05186	ALPL	T09538	Successful Target	Genetic prion disease Parasitic infection	[ICD-11: 8E02] [ICD-11: 1D0Y-1G2Z]	Diseases of the nervous system Certain infectious or parasitic diseases
3	P09382	LGALS1	T09544	Patented-recorded Target
4	Q99705	MCHR1	T09572	Clinical trial target	Obesity	[ICD-11: 5B80-5B81]	Endocrine, nutritional or metabolic diseases
5	Q9NYN9	PTPN13	T09672	Patented-recorded Target
6	P40394	ADH7	T09770	Literature-reported Target
7	P11387	TOP1	T09826	Successful Target	Bacterial infection Colorectal cancer Lung cancer Ovarian cancer Solid tumour/cancer	[ICD-11: 1A00-1C4Z] [ICD-11: 2B91] [ICD-11: 2C25] [ICD-11: 2C73] [ICD-11: 2A00-2F9Z]	Certain infectious or parasitic diseases Neoplasms Neoplasms Neoplasms Neoplasms
8	P50052	AGTR2	T09909	Successful Target	Hypertension Secondary hypertension	[ICD-11: BA00-BA04] [ICD-11: BA04]	Diseases of the circulatory system Diseases of the circulatory system
9	P51681	CCR5	T09960	Successful Target	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	Certain infectious or parasitic diseases
10	P24864	CCNE1	T10052	Literature-reported Target
11	Q99895	CTRC	T10118	Patented-recorded Target
12	Q13332	PTPRS	T10147	Successful Target	Bone paget disease	[ICD-11: FB85]	Diseases of the musculoskeletal system or connective tissue
13	P01730	CD4	T10191	Successful Target	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	Certain infectious or parasitic diseases
14	Q07343	PDE4B	T10265	Clinical trial target	Asthma Idiopathic interstitial pneumonitis Mild neurocognitive disorder	[ICD-11: CA23] [ICD-11: CB03] [ICD-11: 6D71]	Diseases of the respiratory system Diseases of the respiratory system Mental, behavioural or neurodevelopmental disorders
15	Q8IWQ3	BRSK2	T10375	Literature-reported Target
16	O14939	PLD2	T10383	Clinical trial target	Coagulation defect	[ICD-11: 3B10]	Diseases of the blood or blood-forming organs
17	P25106	ACKR3	T10491	Preclinical target	Asthma Solid tumour/cancer	[ICD-11: CA23] [ICD-11: 2A00-2F9Z]	Diseases of the respiratory system Neoplasms
18	P05107	ITGB2	T10513	Clinical trial target	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	Diseases of the immune system
19	P49146	NPY2R	T10670	Clinical trial target	Acute diabete complication Metabolic disorder Obesity	[ICD-11: 5A2Y] [ICD-11: 5C50-5D2Z] [ICD-11: 5B80-5B81]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
20	Q9Y256	RCE1	T10756	Literature-reported Target
21	P49336	CDK8	T10822	Clinical trial target	Acute myeloid leukaemia Myelodysplastic syndrome	[ICD-11: 2A60] [ICD-11: 2A37]	Neoplasms Neoplasms
22	O00767	SCD	T10897	Successful Target	Bacterial infection	[ICD-11: 1A00-1C4Z]	Certain infectious or parasitic diseases
23	P16109	SELP	T10965	Successful Target	Circulatory system disease Sickle-cell disorder	[ICD-11: BE2Z] [ICD-11: 3A51]	Diseases of the circulatory system Diseases of the blood or blood-forming organs
24	P28221	HTR1D	T11072	Successful Target	Migraine Pituitary gland disorder	[ICD-11: 8A80] [ICD-11: 5A60-5A61]	Diseases of the nervous system Endocrine, nutritional or metabolic diseases
25	Q9BZ11	ADAM33	T11192	Patented-recorded Target