List of therapeutic targets associated diseases



                                                                                                                                                        Sr. No. Uniprot ID Gene name TTD ID Target type Disease name ICD-11 Disease class
                                                                                                                                                        1P33032MC5RT95302Clinical trial target
                                                                                                                                                      • Acne vulgaris
                                                                                                                                                      • Sebaceous gland disorder
                                                                                                                                                      • [ICD-11: ED80]
                                                                                                                                                      • [ICD-11: ED91]
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • 2P17181IFNAR1T95371Clinical trial target
                                                                                                                                                      • Hepatitis virus infection
                                                                                                                                                      • Ovarian cancer
                                                                                                                                                      • [ICD-11: 1E50-1E51]
                                                                                                                                                      • [ICD-11: 2C73]
                                                                                                                                                      • Certain infectious or parasitic diseases
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 3P43004SLC1A2T95438Literature-reported Target
                                                                                                                                                        4Q96PD7DGAT2T95558Successful Target
                                                                                                                                                      • Inborn lipid metabolism error
                                                                                                                                                      • [ICD-11: 5C52]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • 5O95665NTSR2T95605Literature-reported Target
                                                                                                                                                        6Q9UIF9BAZ2AT95682Literature-reported Target
                                                                                                                                                        7Q99558MAP3K14T95736Literature-reported Target
                                                                                                                                                        8P78325ADAM8T95761Literature-reported Target
                                                                                                                                                        9P53985SLC16A1T95842Literature-reported Target
                                                                                                                                                        10Q9UK32RPS6KA6T95878Patented-recorded Target
                                                                                                                                                      • Mature B-cell leukaemia
                                                                                                                                                      • [ICD-11: 2A82]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 11P48736PIK3CGT95913Successful Target
                                                                                                                                                      • Follicular lymphoma
                                                                                                                                                      • Malignant haematopoietic neoplasm
                                                                                                                                                      • Mature B-cell leukaemia
                                                                                                                                                      • [ICD-11: 2A80]
                                                                                                                                                      • [ICD-11: 2B33]
                                                                                                                                                      • [ICD-11: 2A82]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 12Q9UBY5LPAR3T95923Clinical trial target
                                                                                                                                                      • Fibrosis
                                                                                                                                                      • Systemic sclerosis
                                                                                                                                                      • [ICD-11: GA14-GC01]
                                                                                                                                                      • [ICD-11: 4A42]
                                                                                                                                                      • Diseases of the genitourinary system
                                                                                                                                                      • Diseases of the immune system
                                                                                                                                                      • 13Q9UHC3ASIC3T95947Literature-reported Target
                                                                                                                                                      • Chronic pain
                                                                                                                                                      • Pain
                                                                                                                                                      • [ICD-11: MG30]
                                                                                                                                                      • [ICD-11: MG30-MG3Z]
                                                                                                                                                      • Symptoms, signs or clinical findings, not elsewhere classified
                                                                                                                                                      • Symptoms, signs or clinical findings, not elsewhere classified
                                                                                                                                                      • 14Q14376GALET96014Literature-reported Target
                                                                                                                                                        15P61073CXCR4T96079Successful Target
                                                                                                                                                      • Malignant haematopoietic neoplasm
                                                                                                                                                      • Multiple myeloma
                                                                                                                                                      • [ICD-11: 2B33]
                                                                                                                                                      • [ICD-11: 2A83]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 16P48058GRIA4T96235Successful Target
                                                                                                                                                      • Neuropathy
                                                                                                                                                      • [ICD-11: 8C0Z]
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                      • 17Q8TBC4UBA3T96311Literature-reported Target
                                                                                                                                                        18P08236GUSBT96413Successful Target
                                                                                                                                                      • Lysosomal disease
                                                                                                                                                      • [ICD-11: 5C56]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • 19Q9P0U3SENP1T96435Literature-reported Target
                                                                                                                                                        20P08238HSP90AB1T96623Clinical trial target
                                                                                                                                                      • Breast cancer
                                                                                                                                                      • Lung cancer
                                                                                                                                                      • Malignant haematopoietic neoplasm
                                                                                                                                                      • Mature B-cell leukaemia
                                                                                                                                                      • Myeloproliferative neoplasm
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • Stomach cancer
                                                                                                                                                      • [ICD-11: 2C60-2C6Y]
                                                                                                                                                      • [ICD-11: 2C25]
                                                                                                                                                      • [ICD-11: 2B33]
                                                                                                                                                      • [ICD-11: 2A82]
                                                                                                                                                      • [ICD-11: 2A20]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • [ICD-11: 2B72]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 21P52789HK2T96685Clinical trial target
                                                                                                                                                      • Epidermal dysplasias
                                                                                                                                                      • [ICD-11: EK90]
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • 22Q15393SF3B3T96723Clinical trial target
                                                                                                                                                      • Acute myeloid leukaemia
                                                                                                                                                      • Chronic myelomonocytic leukaemia
                                                                                                                                                      • Myelodysplastic syndrome
                                                                                                                                                      • [ICD-11: 2A60]
                                                                                                                                                      • [ICD-11: 2A40]
                                                                                                                                                      • [ICD-11: 2A37]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 23P53602MVDT96862Literature-reported Target
                                                                                                                                                        24Q14680MELKT96892Clinical trial target
                                                                                                                                                      • Acute myeloid leukaemia
                                                                                                                                                      • Breast cancer
                                                                                                                                                      • Mature B-cell leukaemia
                                                                                                                                                      • Mature B-cell lymphoma
                                                                                                                                                      • Myelodysplastic syndrome
                                                                                                                                                      • Myeloproliferative neoplasm
                                                                                                                                                      • [ICD-11: 2A60]
                                                                                                                                                      • [ICD-11: 2C60-2C6Y]
                                                                                                                                                      • [ICD-11: 2A82]
                                                                                                                                                      • [ICD-11: 2A85]
                                                                                                                                                      • [ICD-11: 2A37]
                                                                                                                                                      • [ICD-11: 2A20]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 25Q7L7X3TAOK1T97016Literature-reported Target