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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q9HAZ1	CLK4	T98225	Literature-reported Target
2	P29350	PTPN6	T98264	Patented-recorded Target
3	P29466	CASP1	T98269	Clinical trial target	Epilepsy/seizure Fibrosis Rheumatoid arthritis Type 2 diabetes mellitus	[ICD-11: 8A61-8A6Z] [ICD-11: GA14-GC01] [ICD-11: FA20] [ICD-11: 5A11]	Diseases of the nervous system Diseases of the genitourinary system Diseases of the musculoskeletal system or connective tissue Endocrine, nutritional or metabolic diseases
4	O96013	PAK4	T98293	Clinical trial target	Malignant haematopoietic neoplasm Solid tumour/cancer	[ICD-11: 2B33] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
5	P12821	ACE	T98311	Target	Heart failure Hypertension	[ICD-11: BD10-BD1Z] [ICD-11: BA00-BA04]	Diseases of the circulatory system Diseases of the circulatory system
6	Q13451	FKBP5	T98337	Literature-reported Target
7	P04818	TYMS	T98397	Clinical trial target	Solid tumour/cancer Stomach cancer	[ICD-11: 2A00-2F9Z] [ICD-11: 2B72]	Neoplasms Neoplasms
8	P14635	CCNB1	T98459	Patented-recorded Target
9	O60755	GALR3	T98494	Clinical trial target	Mild neurocognitive disorder	[ICD-11: 6D71]	Mental, behavioural or neurodevelopmental disorders
10	P35590	TIE1	T98539	Literature-reported Target
11	Q96KB5	PBK	T98642	Literature-reported Target	Nasopharyngeal cancer	[ICD-11: 2B6B]	Neoplasms
12	P07711	CTSL	T98691	Target	Middle East Respiratory Syndrome Severe acute respiratory syndrome	[ICD-11: 1D64] [ICD-11: 1D65]	Certain infectious or parasitic diseases Certain infectious or parasitic diseases
13	Q8WUI4	HDAC7	T98698	Patented-recorded Target
14	Q9UNA0	ADAMTS5	T98896	Clinical trial target	Osteoarthritis	[ICD-11: FA00-FA05]	Diseases of the musculoskeletal system or connective tissue
15	P10828	THRB	T98933	Successful Target	Hyper-lipoproteinaemia	[ICD-11: 5C80]	Endocrine, nutritional or metabolic diseases
16	P09958	FUR	T98945	Target	Middle East Respiratory Syndrome	[ICD-11: 1D64]	Certain infectious or parasitic diseases
17	Q15120	PDK3	T99029	Literature-reported Target
18	Q02750	MAP2K1	T99057	Target	Metastatic tumour Phakomatoses/hamartoneoplastic syndrome	[ICD-11: 2D50-2E2Z] [ICD-11: LD2D]	Neoplasms Developmental anomalies
19	P15056	BRAF	T99089	Successful Target	Melanoma	[ICD-11: 2C30]	Neoplasms
20	Q9HBH9	MKNK2	T99160	Clinical trial target	Breast cancer Colorectal cancer Liver cancer Lymphoma Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 2B91] [ICD-11: 2C12] [ICD-11: 2A80-2A86] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
21	Q14973	SLC10A1	T99189	Successful Target	Hepatitis virus infection	[ICD-11: 1E50-1E51]	Certain infectious or parasitic diseases
22	P49810	PSEN2	T99204	Clinical trial target	Osteoarthritis Shoulder lesion Soft tissue disorder	[ICD-11: FA00-FA05] [ICD-11: FB53] [ICD-11: FB56]	Diseases of the musculoskeletal system or connective tissue Diseases of the musculoskeletal system or connective tissue Diseases of the musculoskeletal system or connective tissue
23	Q13546	RIPK1	T99340	Clinical trial target	Alzheimer disease Cutaneous lupus erythematosus Motor neuron disease Nervous system paraneoplastic/autoimmune disorder Pancreatic cancer Psoriasis Rheumatoid arthritis Ulcerative colitis	[ICD-11: 8A20] [ICD-11: EB50-EB5Z] [ICD-11: 8B60] [ICD-11: 8E4A] [ICD-11: 2C10] [ICD-11: EA90] [ICD-11: FA20] [ICD-11: DD71]	Diseases of the nervous system Diseases of the skin Diseases of the nervous system Diseases of the nervous system Neoplasms Diseases of the skin Diseases of the musculoskeletal system or connective tissue Diseases of the digestive system
24	P41594	GRM5	T99347	Clinical trial target	Fragile X chromosome Parkinsonism	[ICD-11: LD55] [ICD-11: 8A00]	Developmental anomalies Diseases of the nervous system
25	Q14833	GRM4	T99402	Literature-reported Target	Parkinsonism	[ICD-11: 8A00]	Diseases of the nervous system