List of therapeutic targets associated diseases



                                                                                                                                                        Sr. No. Uniprot ID Gene name TTD ID Target type Disease name ICD-11 Disease class
                                                                                                                                                        1P41180CASRT92076Successful Target
                                                                                                                                                      • Hyper-parathyroidism
                                                                                                                                                      • [ICD-11: 5A51]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • 2P16220CREB1T92098Literature-reported Target
                                                                                                                                                        3Q02763TEKT92144Clinical trial target
                                                                                                                                                      • Breast cancer
                                                                                                                                                      • Chronic arterial occlusive disease
                                                                                                                                                      • Mature B-cell lymphoma
                                                                                                                                                      • Myeloproliferative neoplasm
                                                                                                                                                      • Retinopathy
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • [ICD-11: 2C60-2C6Y]
                                                                                                                                                      • [ICD-11: BD4Z]
                                                                                                                                                      • [ICD-11: 2A85]
                                                                                                                                                      • [ICD-11: 2A20]
                                                                                                                                                      • [ICD-11: 9B71]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Diseases of the visual system
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 4P41586ADCYAP1R1T92185Clinical trial target
                                                                                                                                                      • Migraine
                                                                                                                                                      • [ICD-11: 8A80]
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                      • 5Q14123PDE1CT92439Literature-reported Target
                                                                                                                                                        6Q07973CYP24A1T92458Clinical trial target
                                                                                                                                                      • Psoriasis
                                                                                                                                                      • [ICD-11: EA90]
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • 7Q9Y2T3GDAT92460Literature-reported Target
                                                                                                                                                        8O43353RIPK2T92463Clinical trial target
                                                                                                                                                      • Cardiovascular disease
                                                                                                                                                      • Postoperative inflammation
                                                                                                                                                      • [ICD-11: BA00-BE2Z]
                                                                                                                                                      • [ICD-11: 1A00-CA43]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Postoperative inflammation
                                                                                                                                                      • 9O00418EEF2KT92494Successful Target
                                                                                                                                                      • Breast cancer
                                                                                                                                                      • [ICD-11: 2C60-2C6Y]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 10P07384CAPN1T92517Patented-recorded Target
                                                                                                                                                        11Q16678CYP1B1T92521Clinical trial target
                                                                                                                                                        12P54687BCAT1T92557Literature-reported Target
                                                                                                                                                        13P35348ADRA1AT92609Successful Target
                                                                                                                                                      • Hypertension
                                                                                                                                                      • Prostate hyperplasia
                                                                                                                                                      • [ICD-11: BA00-BA04]
                                                                                                                                                      • [ICD-11: GA90]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Diseases of the genitourinary system
                                                                                                                                                      • 14Q92560BAP1T92628Literature-reported Target
                                                                                                                                                        15Q92633LPAR1T92640Clinical trial target
                                                                                                                                                      • Fibrosis
                                                                                                                                                      • Idiopathic interstitial pneumonitis
                                                                                                                                                      • Psoriasis
                                                                                                                                                      • Systemic sclerosis
                                                                                                                                                      • [ICD-11: GA14-GC01]
                                                                                                                                                      • [ICD-11: CB03]
                                                                                                                                                      • [ICD-11: EA90]
                                                                                                                                                      • [ICD-11: 4A42]
                                                                                                                                                      • Diseases of the genitourinary system
                                                                                                                                                      • Diseases of the respiratory system
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Diseases of the immune system
                                                                                                                                                      • 16Q9UDY8MALT1T92678Clinical trial target
                                                                                                                                                      • Malignant haematopoietic neoplasm
                                                                                                                                                      • Mature B-cell leukaemia
                                                                                                                                                      • [ICD-11: 2B33]
                                                                                                                                                      • [ICD-11: 2A82]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 17P51164ATP4BT92687Successful Target
                                                                                                                                                      • Gastro-oesophageal reflux disease
                                                                                                                                                      • Helicobacter infection
                                                                                                                                                      • Oesophageal ulcer
                                                                                                                                                      • Peptic ulcer
                                                                                                                                                      • [ICD-11: DA22]
                                                                                                                                                      • [ICD-11: DA42-DA63]
                                                                                                                                                      • [ICD-11: DA25]
                                                                                                                                                      • [ICD-11: DA61]
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                      • 18O43451MGAMT92777Successful Target
                                                                                                                                                      • Acute diabete complication
                                                                                                                                                      • Inborn carbohydrate metabolism error
                                                                                                                                                      • [ICD-11: 5A2Y]
                                                                                                                                                      • [ICD-11: 5C51]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • 19Q13627DYRK1AT92803Patented-recorded Target
                                                                                                                                                      • Cytomegaloviral disease
                                                                                                                                                      • [ICD-11: 1D82]
                                                                                                                                                      • Certain infectious or parasitic diseases
                                                                                                                                                      • 20P24530EDNRBT92828Successful Target
                                                                                                                                                      • Cardiovascular disease
                                                                                                                                                      • Pulmonary hypertension
                                                                                                                                                      • [ICD-11: BA00-BE2Z]
                                                                                                                                                      • [ICD-11: BB01]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • 21Q9H6Q9KIF20BT92865Literature-reported Target
                                                                                                                                                        22P17342NPR3T92963Clinical trial target
                                                                                                                                                      • Heart failure
                                                                                                                                                      • [ICD-11: BD10-BD1Z]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • 23P49768PSEN1T93105Clinical trial target
                                                                                                                                                      • Osteoarthritis
                                                                                                                                                      • Shoulder lesion
                                                                                                                                                      • Soft tissue disorder
                                                                                                                                                      • [ICD-11: FA00-FA05]
                                                                                                                                                      • [ICD-11: FB53]
                                                                                                                                                      • [ICD-11: FB56]
                                                                                                                                                      • Diseases of the musculoskeletal system or connective tissue
                                                                                                                                                      • Diseases of the musculoskeletal system or connective tissue
                                                                                                                                                      • Diseases of the musculoskeletal system or connective tissue
                                                                                                                                                      • 24O60741HCN1T93266Literature-reported Target
                                                                                                                                                        25P15309ACPPT93283Clinical trial target
                                                                                                                                                      • Prostate cancer
                                                                                                                                                      • [ICD-11: 2C82]
                                                                                                                                                      • Neoplasms