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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q14534	SQLE	T93344	Successful Target	Dermatophytosis Skin fungal infection disorder	[ICD-11: 1F28] [ICD-11: EA60]	Certain infectious or parasitic diseases Diseases of the skin
2	P40189	IL6ST	T93440	Successful Target	Rheumatoid arthritis	[ICD-11: FA20]	Diseases of the musculoskeletal system or connective tissue
3	P06881	CALCA	T93509	Clinical trial target	General pain disorder	[ICD-11: 8E43]	Diseases of the nervous system
4	P41231	P2RY2	T93515	Clinical trial target	Visual system disease	[ICD-11: 9E1Z]	Diseases of the visual system
5	P49798	RGS4	T93580	Literature-reported Target
6	P57078	RIPK4	T93594	Literature-reported Target
7	O60911	CTSV	T93653	Patented-recorded Target	Bone cancer Chronic pain	[ICD-11: 2B5Z] [ICD-11: MG30]	Neoplasms Symptoms, signs or clinical findings, not elsewhere classified
8	Q8TDV5	GPR119	T93788	Successful Target	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	Mental, behavioural or neurodevelopmental disorders
9	P55211	CASP9	T93903	Clinical trial target	Cystic fibrosis	[ICD-11: CA25]	Diseases of the respiratory system
10	P16885	PLCG2	T93922	Literature-reported Target
11	P00734	F2	T94033	Successful Target	Bleeding disorder Coagulation defect Ischaemic/haemorrhagic stroke Multiple sclerosis Myocardial infarction Nutritional deficiency Thrombocytopenia Thrombosis	[ICD-11: GA20-GA21] [ICD-11: 3B10] [ICD-11: 8B20] [ICD-11: 8A40] [ICD-11: BA41-BA43] [ICD-11: 5B50-5B71] [ICD-11: 3B64] [ICD-11: DB61-GB90]	Diseases of the genitourinary system Diseases of the blood or blood-forming organs Diseases of the nervous system Diseases of the nervous system Diseases of the circulatory system Endocrine, nutritional or metabolic diseases Diseases of the blood or blood-forming organs Diseases of the digestive system
12	P10276	RARA	T94085	Clinical trial target	Alzheimer disease Mature T-cell lymphoma	[ICD-11: 8A20] [ICD-11: 2A90]	Diseases of the nervous system Neoplasms
13	Q16513	PKN2	T94197	Literature-reported Target
14	Q96SB4	SRPK1	T94201	Preclinical target	Retinopathy	[ICD-11: 9B71]	Diseases of the visual system
15	P16233	PNLIP	T94309	Successful Target	Bacterial infection Obesity	[ICD-11: 1A00-1C4Z] [ICD-11: 5B80-5B81]	Certain infectious or parasitic diseases Endocrine, nutritional or metabolic diseases
16	Q969S8	HDAC10	T94324	Patented-recorded Target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
17	P23919	DTYMK	T94400	Literature-reported Target
18	P23443	RPS6KB1	T94479	Clinical trial target	Alzheimer disease Solid tumour/cancer Ulcerative colitis	[ICD-11: 8A20] [ICD-11: 2A00-2F9Z] [ICD-11: DD71]	Diseases of the nervous system Neoplasms Diseases of the digestive system
19	P31751	AKT2	T94621	Literature-reported Target
20	O43868	SLC28A2	T94627	Literature-reported Target
21	P01130	LDLR	T94692	Successful Target	Lung cancer	[ICD-11: 2C25]	Neoplasms
22	O15382	BCAT2	T94788	Literature-reported Target
23	P12955	PEPD	T94823	Literature-reported Target
24	Q06418	TYRO3	T94880	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
25	P20916	MAG	T95286	Clinical trial target	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	Diseases of the nervous system