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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q8TEK3	DOT1L	T87686	Clinical trial target	Acute myeloid leukaemia Malignant haematopoietic neoplasm Mature B-cell lymphoma	[ICD-11: 2A60] [ICD-11: 2B33] [ICD-11: 2A85]	Neoplasms Neoplasms Neoplasms
2	P21462	FPR1	T87831	Clinical trial target	Peptic ulcer	[ICD-11: DA61]	Diseases of the digestive system
3	Q16478	GRIK5	T87930	Literature-reported Target
4	Q9Y616	IRAK3	T87981	Literature-reported Target
5	P07195	LDHB	T88057	Literature-reported Target
6	Q8TDS4	HCAR2	T88185	Successful Target	Inborn lipid metabolism error	[ICD-11: 5C52]	Endocrine, nutritional or metabolic diseases
7	Q04760	GLO1	T88285	Clinical trial target	Influenza	[ICD-11: 1E30-1E32]	Certain infectious or parasitic diseases
8	P26358	DNMT1	T88304	Clinical trial target	Acute myeloid leukaemia Myelodysplastic syndrome Myeloproliferative neoplasm	[ICD-11: 2A60] [ICD-11: 2A37] [ICD-11: 2A20]	Neoplasms Neoplasms Neoplasms
9	P08185	SERPINA6	T88452	Successful Target	Asthma Postoperative inflammation Respiratory system disease	[ICD-11: CA23] [ICD-11: 1A00-CA43] [ICD-11: CB40-CB7Z]	Diseases of the respiratory system Postoperative inflammation Diseases of the respiratory system
10	Q16236	NFE2L2	T88505	Successful Target	Ataxic disorder	[ICD-11: 8A03]	Diseases of the nervous system
11	O43194	GPR39	T88531	Literature-reported Target	Acute diabete complication	[ICD-11: 5A2Y]	Endocrine, nutritional or metabolic diseases
12	Q6QHF9	PAOX	T88699	Literature-reported Target
13	P63000	RAC1	T88752	Literature-reported Target	Alzheimer disease	[ICD-11: 8A20]	Diseases of the nervous system
14	Q14432	PDE3A	T88975	Successful Target	Arterial occlusive disease Asthma Heart failure Thrombocytosis	[ICD-11: BD40] [ICD-11: CA23] [ICD-11: BD10-BD1Z] [ICD-11: 3B63]	Diseases of the circulatory system Diseases of the respiratory system Diseases of the circulatory system Diseases of the blood or blood-forming organs
15	P00747	PLG	T89034	Successful Target	Angina pectoris Bleeding disorder Menopausal disorder Myocardial infarction Procedure injury Pulmonary thromboembolism	[ICD-11: BA40] [ICD-11: GA20-GA21] [ICD-11: GA30] [ICD-11: BA41-BA43] [ICD-11: NE81] [ICD-11: BB00]	Diseases of the circulatory system Diseases of the genitourinary system Diseases of the genitourinary system Diseases of the circulatory system Injury, poisoning or certain other consequences of external causes Diseases of the circulatory system
16	P05093	CYP17A1	T89041	Successful Target	Prostate cancer	[ICD-11: 2C82]	Neoplasms
17	P36507	MAP2K2	T89055	Clinical trial target	Melanoma Thyroid cancer	[ICD-11: 2C30] [ICD-11: 2D10]	Neoplasms Neoplasms
18	P25929	NPY1R	T89213	Clinical trial target	Binge eating disorder Cardiovascular disease Heart disease Hypertension Obesity	[ICD-11: 6B82] [ICD-11: BA00-BE2Z] [ICD-11: BA41-BA42] [ICD-11: BA00-BA04] [ICD-11: 5B80-5B81]	Mental, behavioural or neurodevelopmental disorders Diseases of the circulatory system Diseases of the circulatory system Diseases of the circulatory system Endocrine, nutritional or metabolic diseases
19	Q07812	BAX	T89251	Clinical trial target	Ovarian dysfunction	[ICD-11: 5A80]	Endocrine, nutritional or metabolic diseases
20	Q02779	MAP3K10	T89323	Literature-reported Target
21	P12268	IMPDH2	T89360	Successful Target	Transplant rejection	[ICD-11: NE84]	Injury, poisoning or certain other consequences of external causes
22	Q00534	CDK6	T89361	Successful Target	Breast cancer Lung cancer Psoriasis	[ICD-11: 2C60-2C6Y] [ICD-11: 2C25] [ICD-11: EA90]	Neoplasms Neoplasms Diseases of the skin
23	P11166	SLC2A1	T89458	Preclinical target	Skin disease	[ICD-11: EA00-EM0Z]	Diseases of the skin
24	Q9HBH1	PDF	T89515	Successful Target	Anxiety disorder Breast cancer Malaria Mature T-cell lymphoma Psoriasis Toxoplasmosis	[ICD-11: 6B00-6B0Z] [ICD-11: 2C60-2C6Y] [ICD-11: 1F40-1F45] [ICD-11: 2A90] [ICD-11: EA90] [ICD-11: 1F57]	Mental, behavioural or neurodevelopmental disorders Neoplasms Certain infectious or parasitic diseases Neoplasms Diseases of the skin Certain infectious or parasitic diseases
25	O95602	POLR1A	T89530	Literature-reported Target