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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q16620	NTRK2	T84703	Successful Target	Non-small-cell lung cancer Solid tumour/cancer	[ICD-11: 2C25] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
2	Q96RP8	KCNA7	T84737	Literature-reported Target
3	Q13490	BIRC2	T84780	Clinical trial target	Metastatic lymph node neoplasm	[ICD-11: 2D60]	Neoplasms
4	Q8TCW9	PROKR1	T85115	Patented-recorded Target
5	P35575	G6PC	T85221	Clinical trial target	Inborn carbohydrate metabolism error	[ICD-11: 5C51]	Endocrine, nutritional or metabolic diseases
6	Q09470	KCNA1	T85272	Literature-reported Target
7	P53779	MAPK10	T85421	Clinical trial target	Dissociative neurological symptom disorder	[ICD-11: 6B60]	Mental, behavioural or neurodevelopmental disorders
8	P06213	INSR	T85435	Successful Target	Acute diabete complication Type 2 diabetes mellitus	[ICD-11: 5A2Y] [ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
9	P43115	PTGER3	T85467	Clinical trial target	Glaucoma Solid tumour/cancer Transplanted organ/tissue	[ICD-11: 9C61] [ICD-11: 2A00-2F9Z] [ICD-11: QB63]	Diseases of the visual system Neoplasms Factors influencing health status or contact with health services
10	P41229	KDM5C	T85540	Literature-reported Target
11	Q9NZQ8	TRPM5	T85545	Literature-reported Target
12	P55011	SLC12A2	T85581	Clinical trial target	Heart failure	[ICD-11: BD10-BD1Z]	Diseases of the circulatory system
13	P10599	TXN	T85616	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
14	P01138	NGF	T85670	Clinical trial target	Chronic pain General pain disorder Osteoarthritis Pain	[ICD-11: MG30] [ICD-11: 8E43] [ICD-11: FA00-FA05] [ICD-11: MG30-MG3Z]	Symptoms, signs or clinical findings, not elsewhere classified Diseases of the nervous system Diseases of the musculoskeletal system or connective tissue Symptoms, signs or clinical findings, not elsewhere classified
15	Q02880	TOP2B	T85733	Successful Target	Breast cancer Chemoprotection	[ICD-11: 2C60-2C6Y] [ICD-11: N.A.]	Neoplasms N.A
16	P11802	CDK4	T85799	Successful Target	Breast cancer Lung cancer Psoriasis	[ICD-11: 2C60-2C6Y] [ICD-11: 2C25] [ICD-11: EA90]	Neoplasms Neoplasms Diseases of the skin
17	P12931	SRC	T85943	Successful Target	Breast cancer Ischemia Myeloproliferative neoplasm Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 8B10-8B11] [ICD-11: 2A20] [ICD-11: 2A00-2F9Z]	Neoplasms Diseases of the nervous system Neoplasms Neoplasms
18	Q9NYA1	SPHK1	T86014	Clinical trial target	Ovarian cancer Psychoactive substances use disorder	[ICD-11: 2C73] [ICD-11: 6C4G]	Neoplasms Mental, behavioural or neurodevelopmental disorders
19	O14746	TERT	T86052	Clinical trial target	Human immunodeficiency virus disease Myelodysplastic syndrome Pancreatic cancer	[ICD-11: 1C60-1C62] [ICD-11: 2A37] [ICD-11: 2C10]	Certain infectious or parasitic diseases Neoplasms Neoplasms
20	Q96S37	SLC22A12	T86057	Successful Target	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Endocrine, nutritional or metabolic diseases
21	P48147	PREP	T86161	Clinical trial target	Coeliac disease Influenza Lung cancer Mild neurocognitive disorder	[ICD-11: DA95] [ICD-11: 1E30-1E32] [ICD-11: 2C25] [ICD-11: 6D71]	Diseases of the digestive system Certain infectious or parasitic diseases Neoplasms Mental, behavioural or neurodevelopmental disorders
22	Q9NP59	MSTP079	T86264	Clinical trial target	Acute disease anaemia Anemia Myelodysplastic syndrome Myeloproliferative neoplasm Thalassaemia	[ICD-11: 3A90] [ICD-11: 3A00-3A9Z] [ICD-11: 2A37] [ICD-11: 2A20] [ICD-11: 3A50]	Diseases of the blood or blood-forming organs Diseases of the blood or blood-forming organs Neoplasms Neoplasms Diseases of the blood or blood-forming organs
23	Q9H2S1	KCNN2	T86271	Clinical trial target	Myelopathy	[ICD-11: 8B42]	Diseases of the nervous system
24	Q8TDU6	GPBAR1	T86273	Clinical trial target	Type 2 diabetes mellitus	[ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases
25	P21860	ERBB3	T86350	Clinical trial target	Breast cancer Colorectal cancer Head and neck cancer Lung cancer Malignant mesenchymal neoplasm Metastatic lymph node neoplasm Pancreatic cancer Psoriasis Solid tumour/cancer Squamous cell carcinoma	[ICD-11: 2C60-2C6Y] [ICD-11: 2B91] [ICD-11: 2D42] [ICD-11: 2C25] [ICD-11: 2B5D-2B5Y] [ICD-11: 2D60] [ICD-11: 2C10] [ICD-11: EA90] [ICD-11: 2A00-2F9Z] [ICD-11: 2B60-2D01]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Diseases of the skin Neoplasms Neoplasms