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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P08311	CTSG	T86385	Clinical trial target	Chronic obstructive pulmonary disease	[ICD-11: CA22]	Diseases of the respiratory system
2	P02766	TTR	T86462	Successful Target	Amyloidosis	[ICD-11: 5D00]	Endocrine, nutritional or metabolic diseases
3	Q9Y4G9	PCSK6	T86503	Literature-reported Target
4	O95749	GGPS1	T86528	Successful Target	Bone paget disease Low bone mass disorder Mineral excesses Musculoskeletal disorder	[ICD-11: FB85] [ICD-11: FB83] [ICD-11: 5B91] [ICD-11: FA00-FC0Z]	Diseases of the musculoskeletal system or connective tissue Diseases of the musculoskeletal system or connective tissue Endocrine, nutritional or metabolic diseases Diseases of the musculoskeletal system or connective tissue
5	P19438	TNFRSF1A	T86552	Clinical trial target	Brain cancer Ovarian cancer	[ICD-11: 2A00] [ICD-11: 2C73]	Neoplasms Neoplasms
6	P43003	SLC1A3	T86582	Literature-reported Target
7	Q07869	PPARA	T86591	Successful Target	Hyperlipidemia Hyper-lipoproteinaemia Type 2 diabetes mellitus	[ICD-11: 5C80] [ICD-11: 5C80] [ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
8	P25440	BRD2	T86597	Target	COVID-19	[ICD-11: 1D6Y]	Certain infectious or parasitic diseases
9	P29275	ADORA2B	T86679	Successful Target	Herpes simplex infection Supraventricular tachyarrhythmia	[ICD-11: 1F00] [ICD-11: BC81]	Certain infectious or parasitic diseases Diseases of the circulatory system
10	P08254	MMP3	T86702	Patented-recorded Target	Corneal disease Hepatitis virus infection Idiopathic interstitial pneumonitis Multiple sclerosis Myocardial infarction Osteoarthritis Rheumatoid arthritis	[ICD-11: 9A76-9A78] [ICD-11: 1E50-1E51] [ICD-11: CB03] [ICD-11: 8A40] [ICD-11: BA41-BA43] [ICD-11: FA00-FA05] [ICD-11: FA20]	Diseases of the visual system Certain infectious or parasitic diseases Diseases of the respiratory system Diseases of the nervous system Diseases of the circulatory system Diseases of the musculoskeletal system or connective tissue Diseases of the musculoskeletal system or connective tissue
11	O94925	GLS	T86734	Clinical trial target	Breast cancer Leukaemia Renal cell carcinoma Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 2A60-2B33] [ICD-11: 2C90] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms
12	P60842	EIF4A1	T86805	Target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
13	P17655	CAPN2	T86837	Target	COVID-19	[ICD-11: 1D6Y]	Certain infectious or parasitic diseases
14	Q9C000	NLRP1	T86910	Literature-reported Target
15	P04746	AMY2A	T86918	Clinical trial target	Cystic fibrosis Pancreatic malfunction	[ICD-11: CA25] [ICD-11: DC30-DC3Z]	Diseases of the respiratory system Diseases of the digestive system
16	Q02790	FKBP4	T87020	Literature-reported Target
17	P25105	PTAFR	T87023	Successful Target	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	Diseases of the nervous system
18	P05067	APP	T87024	Successful Target	Alzheimer disease Diagnostic imaging	[ICD-11: 8A20] [ICD-11: N.A.]	Diseases of the nervous system N.A
19	P48730	CSNK1D	T87109	Preclinical target	Mature B-cell leukaemia Pancreatic cancer	[ICD-11: 2A82] [ICD-11: 2C10]	Neoplasms Neoplasms
20	P35557	GCK	T87166	Clinical trial target	Acute diabete complication Diabetes mellitus Obesity Type 2 diabetes mellitus	[ICD-11: 5A2Y] [ICD-11: 5A10] [ICD-11: 5B80-5B81] [ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
21	P04271	S100B	T87206	Clinical trial target	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	Diseases of the nervous system
22	P01127	PDGFB	T87350	Clinical trial target	Diabetic foot ulcer	[ICD-11: BD54]	Diseases of the circulatory system
23	Q9BXC1	GPR174	T87661	Literature-reported Target
24	Q9Y2T6	GPR55	T87670	Successful Target	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	Mental, behavioural or neurodevelopmental disorders
25	O14965	AURKA	T87675	Clinical trial target	Acute diabete complication Solid tumour/cancer	[ICD-11: 5A2Y] [ICD-11: 2A00-2F9Z]	Endocrine, nutritional or metabolic diseases Neoplasms