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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P01589	IL2RA	T03313	Successful Target	Transplant rejection	[ICD-11: NE84]	Injury, poisoning or certain other consequences of external causes
2	Q12772	SREBF2	T03385	Literature-reported Target
3	P39900	MMP12	T03500	Clinical trial target	Asthma Lung cancer Renal cell carcinoma	[ICD-11: CA23] [ICD-11: 2C25] [ICD-11: 2C90]	Diseases of the respiratory system Neoplasms Neoplasms
4	Q15208	STK38	T03581	Literature-reported Target
5	Q92793	CREBBP	T03634	Clinical trial target	Acute myeloid leukaemia Prostate cancer Solid tumour/cancer Systemic sclerosis	[ICD-11: 2A60] [ICD-11: 2C82] [ICD-11: 2A00-2F9Z] [ICD-11: 4A42]	Neoplasms Neoplasms Neoplasms Diseases of the immune system
6	P37840	SNCA	T03644	Clinical trial target	Alzheimer disease Autonomic nervous system disorder Parkinsonism	[ICD-11: 8A20] [ICD-11: 8D87] [ICD-11: 8A00]	Diseases of the nervous system Diseases of the nervous system Diseases of the nervous system
7	P00813	ADA	T03661	Successful Target	Adaptive immunity immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia	[ICD-11: 4A01] [ICD-11: 2B33] [ICD-11: 2A82]	Diseases of the immune system Neoplasms Neoplasms
8	Q13443	ADAM9	T03672	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
9	Q9UKV0	HDAC9	T03687	Patented-recorded Target
10	P09960	LTA4H	T03691	Successful Target	Acute myeloid leukaemia	[ICD-11: 2A60]	Neoplasms
11	Q92843	BCL2L2	T03755	Clinical trial target	Myeloproliferative neoplasm	[ICD-11: 2A20]	Neoplasms
12	Q9BPW0	PPP5C	T04123	Patented-recorded Target
13	Q9GZQ4	NMUR2	T04210	Literature-reported Target
14	O75716	STK16	T04303	Literature-reported Target
15	Q9NZ70	TAK1	T04361	Literature-reported Target	Mature B-cell lymphoma	[ICD-11: 2A85]	Neoplasms
16	Q9UGI6	KCNN3	T04388	Clinical trial target	Myelopathy	[ICD-11: 8B42]	Diseases of the nervous system
17	Q96PF2	TSSK2	T04413	Literature-reported Target
18	Q8NFJ6	PROKR2	T04497	Literature-reported Target
19	P78352	DLG4	T04507	Clinical trial target	Cerebral ischaemia Ischaemic/haemorrhagic stroke	[ICD-11: 8B1Z] [ICD-11: 8B20]	Diseases of the nervous system Diseases of the nervous system
20	P02708	CHRNA1	T04689	Successful Target	Tonus and reflex abnormality	[ICD-11: MB47]	Symptoms, signs or clinical findings, not elsewhere classified
21	O95551	TDP2	T04696	Literature-reported Target
22	P19525	EIF2AK2	T04831	Patented-recorded Target
23	P42338	PIK3CB	T05031	Clinical trial target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
24	Q5XXA6	DOG1	T05089	Successful Target	Gout Viral intestinal infection	[ICD-11: FA25] [ICD-11: 1A2Z]	Diseases of the musculoskeletal system or connective tissue Certain infectious or parasitic diseases
25	O15379	HDAC3	T05090	Clinical trial target	Lymphoma Solid tumour/cancer	[ICD-11: 2A80-2A86] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms