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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q14145	KEAP1	T83198	Clinical trial target	Pulmonary hypertension Urinary system clinical symptom	[ICD-11: BB01] [ICD-11: MF8Y]	Diseases of the circulatory system Symptoms, signs or clinical findings, not elsewhere classified
2	Q15418	RPS6KA1	T83202	Patented-recorded Target	Mature B-cell leukaemia	[ICD-11: 2A82]	Neoplasms
3	P00740	F9	T83369	Successful Target	Bleeding disorder Coagulation defect	[ICD-11: GA20-GA21] [ICD-11: 3B10]	Diseases of the genitourinary system Diseases of the blood or blood-forming organs
4	Q9HB89	NMUR1	T83382	Literature-reported Target
5	P15328	FOLR1	T83386	Successful Target	Malaria Ovarian cancer	[ICD-11: 1F40-1F45] [ICD-11: 2C73]	Certain infectious or parasitic diseases Neoplasms
6	P09467	FBP1	T83391	Clinical trial target	Type 2 diabetes mellitus	[ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases
7	P04229	HLA-DRB1	T83611	Successful Target	Multiple sclerosis	[ICD-11: 8A40]	Diseases of the nervous system
8	Q9UDU6	HGF	T83797	Clinical trial target	Angina pectoris Chronic arterial occlusive disease Diabetic foot ulcer Graft-versus-host disease Neuropathy	[ICD-11: BA40] [ICD-11: BD4Z] [ICD-11: BD54] [ICD-11: 4B24] [ICD-11: 8C0Z]	Diseases of the circulatory system Diseases of the circulatory system Diseases of the circulatory system Diseases of the immune system Diseases of the nervous system
9	P28335	HTR2C	T83813	Successful Target	Depression Migraine Obesity Pain Pituitary gland disorder	[ICD-11: 6A70-6A7Z] [ICD-11: 8A80] [ICD-11: 5B80-5B81] [ICD-11: MG30-MG3Z] [ICD-11: 5A60-5A61]	Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Endocrine, nutritional or metabolic diseases Symptoms, signs or clinical findings, not elsewhere classified Endocrine, nutritional or metabolic diseases
10	P21397	MAOA	T83875	Successful Target	Depression Parkinsonism	[ICD-11: 6A70-6A7Z] [ICD-11: 8A00]	Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system
11	Q8IXJ6	SIRT2	T83904	Patented-recorded Target	Retinopathy	[ICD-11: 9B71]	Diseases of the visual system
12	Q16647	PTGIS	T83979	Literature-reported Target
13	O75762	TRPA1	T84040	Successful Target	Upper respiratory tract disorder	[ICD-11: CA0Z]	Diseases of the respiratory system
14	P28566	HTR1E	T84117	Successful Target	Pituitary gland disorder	[ICD-11: 5A60-5A61]	Endocrine, nutritional or metabolic diseases
15	Q9Y233	PDE10A	T84133	Clinical trial target	Choreiform disorder Inborn purine/pyrimidine/nucleotide metabolism error Irritable bowel syndrome Schizophrenia Solid tumour/cancer	[ICD-11: 8A01] [ICD-11: 5C55] [ICD-11: DD91] [ICD-11: 6A20] [ICD-11: 2A00-2F9Z]	Diseases of the nervous system Endocrine, nutritional or metabolic diseases Diseases of the digestive system Mental, behavioural or neurodevelopmental disorders Neoplasms
16	P04062	GBA	T84173	Successful Target	Metabolic disorder	[ICD-11: 5C50-5D2Z]	Endocrine, nutritional or metabolic diseases
17	P54289	CACNA2D1	T84316	Successful Target	Chronic obstructive pulmonary disease Hypertension	[ICD-11: CA22] [ICD-11: BA00-BA04]	Diseases of the respiratory system Diseases of the circulatory system
18	Q9H4B7	TUBB1	T84397	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
19	Q6DWJ6	GPR139	T84439	Clinical trial target	Sex development malformative disorder	[ICD-11: LD2A]	Developmental anomalies
20	P30559	OXTR	T84486	Successful Target	Acute diabete complication Autism spectrum disorder Postpartum haemorrhage	[ICD-11: 5A2Y] [ICD-11: 6A02] [ICD-11: JA43]	Endocrine, nutritional or metabolic diseases Mental, behavioural or neurodevelopmental disorders Pregnancy, childbirth or the puerperium
21	P23109	AMPD1	T84553	Literature-reported Target
22	Q16881	TXNRD1	T84581	Successful Target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
23	P15538	CYP11B1	T84621	Successful Target	Breast cancer Cushing syndrome	[ICD-11: 2C60-2C6Y] [ICD-11: 5A70]	Neoplasms Endocrine, nutritional or metabolic diseases
24	P00742	F10	T84631	Successful Target	Blood-forming organ disease Christmas disease Coagulation defect Coronary thrombosis Deep vein thrombosis Supraventricular tachyarrhythmia Thrombosis Venous thromboembolism	[ICD-11: 3C0Z] [ICD-11: 3B11] [ICD-11: 3B10] [ICD-11: BA43] [ICD-11: BD71] [ICD-11: BC81] [ICD-11: DB61-GB90] [ICD-11: BD72]	Diseases of the blood or blood-forming organs Diseases of the blood or blood-forming organs Diseases of the blood or blood-forming organs Diseases of the circulatory system Diseases of the circulatory system Diseases of the circulatory system Diseases of the digestive system Diseases of the circulatory system
25	O43174	CYP26A1	T84634	Clinical trial target	Oesophagitis	[ICD-11: DA24]	Diseases of the digestive system