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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P53778	MAPK12	T79798	Successful Target	Thrombocytopenia	[ICD-11: 3B64]	Diseases of the blood or blood-forming organs
2	P08912	CHRM5	T79961	Successful Target	Abnormal micturition Anterior uveitis Appearance/behaviour symptom Asthma Brain disease Central and peripheral nervous disease Chronic obstructive pulmonary disease Cognition symptoms/signs/clinical symptom Cough Digestive system disease Female pelvic pain Functional bladder disorder Gastritis General examination Glaucoma Hypertension Infectious gastroenteritis/colitis Irritable bowel syndrome Nystagmus Oesophagus motility disorder Pain Pancreatitis Parkinsonism Peptic ulcer Polyuria Tonus and reflex abnormality Unspecific substance harmful effect Urgency	[ICD-11: MF50] [ICD-11: 9A96] [ICD-11: MB23] [ICD-11: CA23] [ICD-11: 8C70-8E61] [ICD-11: 8A04-8E7Z] [ICD-11: CA22] [ICD-11: MB21] [ICD-11: MD12] [ICD-11: DE2Z] [ICD-11: GA34] [ICD-11: GC50] [ICD-11: DA42] [ICD-11: QA00] [ICD-11: 9C61] [ICD-11: BA00-BA04] [ICD-11: 1A40] [ICD-11: DD91] [ICD-11: 9C84] [ICD-11: DA21] [ICD-11: MG30-MG3Z] [ICD-11: DC31-DC34] [ICD-11: 8A00] [ICD-11: DA61] [ICD-11: MF55] [ICD-11: MB47] [ICD-11: NE6Z] [ICD-11: N.A.]	Symptoms, signs or clinical findings, not elsewhere classified Diseases of the visual system Symptoms, signs or clinical findings, not elsewhere classified Diseases of the respiratory system Diseases of the nervous system Diseases of the nervous system Diseases of the respiratory system Symptoms, signs or clinical findings, not elsewhere classified Symptoms, signs or clinical findings, not elsewhere classified Diseases of the digestive system Diseases of the genitourinary system Diseases of the genitourinary system Diseases of the digestive system Factors influencing health status or contact with health services Diseases of the visual system Diseases of the circulatory system Certain infectious or parasitic diseases Diseases of the digestive system Diseases of the visual system Diseases of the digestive system Symptoms, signs or clinical findings, not elsewhere classified Diseases of the digestive system Diseases of the nervous system Diseases of the digestive system Symptoms, signs or clinical findings, not elsewhere classified Symptoms, signs or clinical findings, not elsewhere classified Injury, poisoning or certain other consequences of external causes N.A
3	Q9Y210	TRPC6	T80165	Literature-reported Target
4	P42336	PIK3CA	T80276	Successful Target	Breast cancer Follicular lymphoma Malignant haematopoietic neoplasm	[ICD-11: 2C60-2C6Y] [ICD-11: 2A80] [ICD-11: 2B33]	Neoplasms Neoplasms Neoplasms
5	Q13705	ACVR2B	T80338	Literature-reported Target	Nervous system paraneoplastic/autoimmune disorder	[ICD-11: 8E4A]	Diseases of the nervous system
6	P47870	GABRB2	T80387	Successful Target	Depression Insomnia Mental/behavioural/neurodevelopmental disorder Tonus and reflex abnormality	[ICD-11: 6A70-6A7Z] [ICD-11: 7A00-7A0Z] [ICD-11: 6E20-6E8Z] [ICD-11: MB47]	Mental, behavioural or neurodevelopmental disorders Sleep-wake disorders Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified
7	P40337	VHL	T80423	Patented-recorded Target
8	Q9UJW3	DNMT3L	T80487	Patented-recorded Target
9	P19784	CSNK2A2	T80526	Patented-recorded Target
10	Q92731	ESR2	T80896	Successful Target	Breast cancer Cushing syndrome Menopausal disorder Vasomotor/allergic rhinitis	[ICD-11: 2C60-2C6Y] [ICD-11: 5A70] [ICD-11: GA30] [ICD-11: CA08]	Neoplasms Endocrine, nutritional or metabolic diseases Diseases of the genitourinary system Diseases of the respiratory system
11	P35968	KDR	T80975	Successful Target	Breast cancer Colorectal cancer Gastrointestinal stromal tumour Malignant digestive organ neoplasm Renal cell carcinoma Solid tumour/cancer Stomach cancer Thrombocytopenia Thyroid cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 2B91] [ICD-11: 2B5B] [ICD-11: 2C11] [ICD-11: 2C90] [ICD-11: 2A00-2F9Z] [ICD-11: 2B72] [ICD-11: 3B64] [ICD-11: 2D10]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Diseases of the blood or blood-forming organs Neoplasms
12	P14625	HSP90B1	T81311	Clinical trial target	Lung cancer	[ICD-11: 2C25]	Neoplasms
13	O00311	CDC7	T81358	Clinical trial target	Malignant haematopoietic neoplasm Solid tumour/cancer	[ICD-11: 2B33] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
14	O00206	TLR4	T81443	Clinical trial target	Allergic/hypersensitivity disorder Prostate cancer Sepsis	[ICD-11: 4A80-4A8Z] [ICD-11: 2C82] [ICD-11: 1G40-1G41]	Diseases of the immune system Neoplasms Certain infectious or parasitic diseases
15	Q9BV23	ABHD6	T81452	Patented-recorded Target
16	Q86YT5	SLC13A5	T81547	Literature-reported Target
17	O43293	DAPK3	T81623	Literature-reported Target
18	P54750	PDE1A	T81637	Literature-reported Target
19	P51511	MMP15	T81658	Literature-reported Target
20	P78527	PRKDC	T81735	Clinical trial target	Rectum cancer Solid tumour/cancer	[ICD-11: 2B92] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
21	P22314	UBA1	T81780	Patented-recorded Target	Leukaemia	[ICD-11: 2A60-2B33]	Neoplasms
22	Q9Y2K2	SIK3	T81830	Clinical trial target	Ovarian cancer	[ICD-11: 2C73]	Neoplasms
23	P14735	IDE	T81900	Successful Target	Skin and skin-structure infection	[ICD-11: 1F28-1G0Z]	Certain infectious or parasitic diseases
24	P19634	SLC9A1	T82028	Clinical trial target	Angina pectoris	[ICD-11: BA40]	Diseases of the circulatory system
25	O60603	TLR2	T82078	Clinical trial target	Prostate cancer	[ICD-11: 2C82]	Neoplasms