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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q9Y6R4	MAP3K4	T78492	Literature-reported Target
2	Q13976	PRKG1	T78543	Literature-reported Target
3	P47211	GALR1	T78581	Literature-reported Target	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	Diseases of the nervous system
4	P30939	HTR1F	T78656	Successful Target	Migraine Pituitary gland disorder	[ICD-11: 8A80] [ICD-11: 5A60-5A61]	Diseases of the nervous system Endocrine, nutritional or metabolic diseases
5	P48544	KCNJ5	T78692	Clinical trial target	Acute myeloid leukaemia Hodgkin lymphoma	[ICD-11: 2A60] [ICD-11: 2B30]	Neoplasms Neoplasms
6	P08908	HTR1A	T78709	Successful Target	Anxiety disorder Depression Hypertension Migraine Mood disorder	[ICD-11: 6B00-6B0Z] [ICD-11: 6A70-6A7Z] [ICD-11: BA00-BA04] [ICD-11: 8A80] [ICD-11: 6A60-6E23]	Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Diseases of the circulatory system Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders
7	P48048	KCNJ1	T78710	Patented-recorded Target
8	P29597	TYK2	T78932	Successful Target	Psoriasis	[ICD-11: EA90]	Diseases of the skin
9	Q9HC98	NEK6	T78992	Literature-reported Target
10	P32320	CDA	T79027	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
11	P56817	BACE1	T79031	Clinical trial target	Alzheimer disease	[ICD-11: 8A20]	Diseases of the nervous system
12	Q16198	EWS-Fli1	T79051	Clinical trial target	Ewing sarcoma	[ICD-11: 2B52]	Neoplasms
13	P34969	HTR7	T79062	Clinical trial target	Alzheimer disease Attention deficit hyperactivity disorder Bipolar disorder Depression Mild neurocognitive disorder Parkinsonism Schizophrenia	[ICD-11: 8A20] [ICD-11: 6A05] [ICD-11: 6A60] [ICD-11: 6A70-6A7Z] [ICD-11: 6D71] [ICD-11: 8A00] [ICD-11: 6A20]	Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders
14	P49862	KLK7	T79155	Patented-recorded Target
15	P37288	AVPR1A	T79232	Successful Target	Acute diabete complication Autism spectrum disorder Hypertension Hypo-osmolality/hyponatraemia Localisation	[ICD-11: 5A2Y] [ICD-11: 6A02] [ICD-11: BA00-BA04] [ICD-11: 5C72] [ICD-11: N.A.]	Endocrine, nutritional or metabolic diseases Mental, behavioural or neurodevelopmental disorders Diseases of the circulatory system Endocrine, nutritional or metabolic diseases N.A
16	O75385	KIAA0722	T79307	Literature-reported Target
17	P50053	KHK	T79326	Literature-reported Target
18	Q9Y5K2	KLK4	T79400	Patented-recorded Target
19	P22888	LHCGR	T79473	Successful Target	Female infertility Pituitary gland disorder	[ICD-11: GA31] [ICD-11: 5A60-5A61]	Diseases of the genitourinary system Endocrine, nutritional or metabolic diseases
20	Q9NVM4	PRMT7	T79501	Literature-reported Target
21	O75173	ADAMTS4	T79570	Patented-recorded Target
22	P10827	THRA	T79591	Successful Target	Hyper-lipoproteinaemia Hypo-thyroidism	[ICD-11: 5C80] [ICD-11: 5A00]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
23	Q9P0X4	CACNA1I	T79694	Literature-reported Target
24	Q9H237	PORCN	T79747	Clinical trial target	Idiopathic interstitial pneumonitis Solid tumour/cancer	[ICD-11: CB03] [ICD-11: 2A00-2F9Z]	Diseases of the respiratory system Neoplasms
25	Q9GZQ6	NPFFR1	T79780	Literature-reported Target