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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P09237	MMP7	T73475	Successful Target	Lung cancer	[ICD-11: 2C25]	Neoplasms
2	P01008	SERPINC1	T73476	Successful Target	Coagulation defect Coronary thrombosis Deep vein thrombosis Tinnitus	[ICD-11: 3B10] [ICD-11: BA43] [ICD-11: BD71] [ICD-11: MC41]	Diseases of the blood or blood-forming organs Diseases of the circulatory system Diseases of the circulatory system Symptoms, signs or clinical findings, not elsewhere classified
3	O43613	HCRTR1	T73482	Clinical trial target	Depression Insomnia Opioid use disorder	[ICD-11: 6A70-6A7Z] [ICD-11: 7A00-7A0Z] [ICD-11: 6C43]	Mental, behavioural or neurodevelopmental disorders Sleep-wake disorders Mental, behavioural or neurodevelopmental disorders
4	P39086	GRIK1	T73495	Successful Target	Epilepsy/seizure Substance abuse	[ICD-11: 8A61-8A6Z] [ICD-11: 6C40]	Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders
5	Q9BYW2	SETD2	T73551	Literature-reported Target
6	Q13882	PTK6	T73694	Clinical trial target	Cardiovascular disease Postoperative inflammation	[ICD-11: BA00-BE2Z] [ICD-11: 1A00-CA43]	Diseases of the circulatory system Postoperative inflammation
7	P07148	FABP1	T73712	Successful Target	Cardiovascular disease	[ICD-11: BA00-BE2Z]	Diseases of the circulatory system
8	P30926	CHRNB4	T73724	Clinical trial target	Nicotine use disorder	[ICD-11: 6C4A]	Mental, behavioural or neurodevelopmental disorders
9	P49760	CLK2	T73725	Patented-recorded Target
10	P29323	EPHB2	T73756	Clinical trial target	Kaposi sarcoma Melanoma Pancreatic cancer Solid tumour/cancer	[ICD-11: 2B57] [ICD-11: 2C30] [ICD-11: 2C10] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms
11	Q9UPC5	GPR34	T73859	Literature-reported Target
12	Q9H3R0	KDM4C	T73863	Patented-recorded Target
13	P32297	CHRNA3	T74166	Successful Target	Cough	[ICD-11: MD12]	Symptoms, signs or clinical findings, not elsewhere classified
14	Q9NS75	CYSLTR2	T74238	Clinical trial target	Asthma	[ICD-11: CA23]	Diseases of the respiratory system
15	P51451	BLK	T74307	Patented-recorded Target
16	P36888	FLT3	T74312	Successful Target	Acute myeloid leukaemia Bone/articular cartilage neoplasm Colorectal cancer Human immunodeficiency virus disease Idiopathic interstitial pneumonitis Mastocytosis Mature B-cell lymphoma Myeloproliferative neoplasm	[ICD-11: 2A60] [ICD-11: 2F7B] [ICD-11: 2B91] [ICD-11: 1C60-1C62] [ICD-11: CB03] [ICD-11: 2A21] [ICD-11: 2A85] [ICD-11: 2A20]	Neoplasms Neoplasms Neoplasms Certain infectious or parasitic diseases Diseases of the respiratory system Neoplasms Neoplasms Neoplasms
17	Q03405	PLAUR	T74363	Successful Target	Myeloproliferative neoplasm Thrombocytosis	[ICD-11: 2A20] [ICD-11: 3B63]	Neoplasms Diseases of the blood or blood-forming organs
18	P30556	AGTR1	T74456	Successful Target	Essential hypertension Hypertension Secondary hypertension Urinary system clinical symptom	[ICD-11: BA00] [ICD-11: BA00-BA04] [ICD-11: BA04] [ICD-11: MF8Y]	Diseases of the circulatory system Diseases of the circulatory system Diseases of the circulatory system Symptoms, signs or clinical findings, not elsewhere classified
19	O43526	KCNQ2	T74483	Literature-reported Target	Pain	[ICD-11: MG30-MG3Z]	Symptoms, signs or clinical findings, not elsewhere classified
20	Q9UK17	KCND3	T74500	Successful Target	Acidosis	[ICD-11: 5C73]	Endocrine, nutritional or metabolic diseases
21	Q8WZA2	RAPGEF4	T74607	Literature-reported Target
22	Q14004	CDK13	T74839	Literature-reported Target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
23	P09172	DBH	T74937	Clinical trial target	Heart failure Post-traumatic stress disorder	[ICD-11: BD10-BD1Z] [ICD-11: 6B40]	Diseases of the circulatory system Mental, behavioural or neurodevelopmental disorders
24	P33981	TTK	T74977	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
25	P28300	LOX	T75152	Literature-reported Target