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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q16853	AOC3	T69619	Successful Target	Hypertension	[ICD-11: BA00-BA04]	Diseases of the circulatory system
2	P48067	SLC6A9	T69685	Clinical trial target	Schizophrenia	[ICD-11: 6A20]	Mental, behavioural or neurodevelopmental disorders
3	Q13093	PLA2G7	T69912	Clinical trial target	Alzheimer disease Arterial occlusive disease Cardiovascular disease	[ICD-11: 8A20] [ICD-11: BD40] [ICD-11: BA00-BE2Z]	Diseases of the nervous system Diseases of the circulatory system Diseases of the circulatory system
4	P30291	WEE1	T69991	Clinical trial target	Ovarian cancer Solid tumour/cancer Uterine ligament/parametrium/uterine adnexa neoplasm	[ICD-11: 2C73] [ICD-11: 2A00-2F9Z] [ICD-11: 2C72]	Neoplasms Neoplasms Neoplasms
5	Q9Y3Q0	NAALAD2	T70036	Literature-reported Target
6	P24941	CDK2	T70176	Clinical trial target	Brain cancer Breast cancer Lung cancer Lymphoma Malignant haematopoietic neoplasm Non-small-cell lung cancer Solid tumour/cancer Thymoma	[ICD-11: 2A00] [ICD-11: 2C60-2C6Y] [ICD-11: 2C25] [ICD-11: 2A80-2A86] [ICD-11: 2B33] [ICD-11: 2C25] [ICD-11: 2A00-2F9Z] [ICD-11: 2C27]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
7	P54764	EPHA4	T70234	Literature-reported Target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
8	P18405	SRD5A1	T70309	Clinical trial target	Prostate disease	[ICD-11: GA91]	Diseases of the genitourinary system
9	Q02643	GHRHR	T70449	Successful Target	Bone growth disorder Human immunodeficiency virus disease	[ICD-11: FB86] [ICD-11: 1C60-1C62]	Diseases of the musculoskeletal system or connective tissue Certain infectious or parasitic diseases
10	P53634	CTSC	T70490	Clinical trial target	Bronchiectasis	[ICD-11: CA24]	Diseases of the respiratory system
11	P16152	CBR1	T70518	Clinical trial target	Asthma	[ICD-11: CA23]	Diseases of the respiratory system
12	Q969V1	MCHR2	T70539	Literature-reported Target
13	Q9BXA5	SUCNR1	T70633	Literature-reported Target
14	Q4U2R8	SLC22A6	T70680	Successful Target	Gout Inborn purine/pyrimidine/nucleotide metabolism error Ocular disease	[ICD-11: FA25] [ICD-11: 5C55] [ICD-11: N.A.]	Diseases of the musculoskeletal system or connective tissue Endocrine, nutritional or metabolic diseases N.A
15	P49763	PGF	T70792	Successful Target	Colorectal cancer	[ICD-11: 2B91]	Neoplasms
16	P53667	LIMK1	T70840	Literature-reported Target
17	Q13164	MAPK7	T70851	Patented-recorded Target
18	P43681	CHRNA4	T70967	Successful Target	Aneurysm/dissection Hypertensive crisis Hypotension	[ICD-11: BD50] [ICD-11: BA03] [ICD-11: BA20-BA21]	Diseases of the circulatory system Diseases of the circulatory system Diseases of the circulatory system
19	P49841	GSK3B	T70977	Clinical trial target	Myotonic disorder	[ICD-11: 8C71]	Diseases of the nervous system
20	P01112	HRAS	T71081	Literature-reported Target
21	Q9Y271	CYSLTR1	T71192	Successful Target	Asthma	[ICD-11: CA23]	Diseases of the respiratory system
22	P16066	NPR1	T71230	Successful Target	Heart failure	[ICD-11: BD10-BD1Z]	Diseases of the circulatory system
23	Q9Y243	AKT3	T71266	Successful Target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
24	O95819	MAP4K4	T71367	Patented-recorded Target
25	O00444	PLK4	T71374	Literature-reported Target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms