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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	O00329	PIK3CD	T67849	Successful Target	Follicular lymphoma Malignant haematopoietic neoplasm Mature B-cell leukaemia Mature B-cell lymphoma Stomach cancer	[ICD-11: 2A80] [ICD-11: 2B33] [ICD-11: 2A82] [ICD-11: 2A85] [ICD-11: 2B72]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
2	O15455	TLR3	T67894	Clinical trial target	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	Certain infectious or parasitic diseases
3	P07948	LYN	T68163	Clinical trial target	Musculoskeletal disorder Solid tumour/cancer	[ICD-11: FA00-FC0Z] [ICD-11: 2A00-2F9Z]	Diseases of the musculoskeletal system or connective tissue Neoplasms
4	P08253	MMP2	T68251	Successful Target	Lung cancer	[ICD-11: 2C25]	Neoplasms
5	P25774	CTSS	T68290	Clinical trial target	Autoimmune disease Coeliac disease Crohn disease Diabetes mellitus General pain disorder Pain Sjogren syndrome	[ICD-11: 4A40-4A45] [ICD-11: DA95] [ICD-11: DD70] [ICD-11: 5A10] [ICD-11: 8E43] [ICD-11: MG30-MG3Z] [ICD-11: 4A43]	Diseases of the immune system Diseases of the digestive system Diseases of the digestive system Endocrine, nutritional or metabolic diseases Diseases of the nervous system Symptoms, signs or clinical findings, not elsewhere classified Diseases of the immune system
6	O43895	XPNPEP2	T68320	Literature-reported Target
7	Q4ZFZ2	FSHR	T68334	Successful Target	Female infertility	[ICD-11: GA31]	Diseases of the genitourinary system
8	O94782	USP1	T68470	Literature-reported Target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
9	Q86Y97	KMT5C	T68490	Preclinical target
10	Q13547	HDAC1	T68547	Successful Target	Multiple myeloma Mycosis fungoides	[ICD-11: 2A83] [ICD-11: 2B01]	Neoplasms Neoplasms
11	P23526	AHCY	T68698	Literature-reported Target
12	Q09013	DMPK	T68766	Clinical trial target	Myotonic disorder	[ICD-11: 8C71]	Diseases of the nervous system
13	Q13258	PTGDR	T68782	Clinical trial target	Coronary atherosclerosis	[ICD-11: BA52]	Diseases of the circulatory system
14	Q8TDS5	OXER1	T68834	Literature-reported Target
15	Q13003	GRIK3	T68876	Literature-reported Target
16	P28336	NMBR	T68887	Clinical trial target	Breast cancer Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
17	Q86VZ5	SGMS1	T68967	Clinical trial target	Hypertension	[ICD-11: BA00-BA04]	Diseases of the circulatory system
18	P51575	P2RX1	T69091	Literature-reported Target
19	P08922	ROS1	T69128	Successful Target	Lung cancer Non-small-cell lung cancer	[ICD-11: 2C25] [ICD-11: 2C25]	Neoplasms Neoplasms
20	P51532	SMARCA4	T69200	Literature-reported Target
21	P15735	PHKG2	T69208	Literature-reported Target
22	O43614	HCRTR2	T69485	Successful Target	Insomnia	[ICD-11: 7A00-7A0Z]	Sleep-wake disorders
23	Q14994	NR1I3	T69506	Successful Target	Dizziness and giddiness	[ICD-11: MB48]	Symptoms, signs or clinical findings, not elsewhere classified
24	O75874	IDH1	T69563	Successful Target	Acute myeloid leukaemia	[ICD-11: 2A60]	Neoplasms
25	P34947	GRK5	T69612	Patented-recorded Target