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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q9BX92	CFB	T66011	Successful Target	Haemolytic anemia	[ICD-11: 3A20-3A2Z]	Diseases of the blood or blood-forming organs
2	P30518	AVPR2	T66237	Successful Target	Acute diabete complication Autism spectrum disorder Enuresis Hypo-osmolality/hyponatraemia Pituitary gland disorder Polyuria	[ICD-11: 5A2Y] [ICD-11: 6A02] [ICD-11: 6C00] [ICD-11: 5C72] [ICD-11: 5A60-5A61] [ICD-11: MF55]	Endocrine, nutritional or metabolic diseases Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Symptoms, signs or clinical findings, not elsewhere classified
3	Q86TI2	DPP9	T66252	Clinical trial target	Neutropenia	[ICD-11: 4B00]	Diseases of the immune system
4	P00746	CFD	T66383	Clinical trial target	Haemolytic anemia Retinopathy	[ICD-11: 3A20-3A2Z] [ICD-11: 9B71]	Diseases of the blood or blood-forming organs Diseases of the visual system
5	Q99835	SMO	T66505	Successful Target	Basal cell carcinoma Chronic myelomonocytic leukaemia Solid tumour/cancer	[ICD-11: 2C32] [ICD-11: 2A40] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms
6	Q12791	KCNMA1	T66538	Clinical trial target	Asthma Functional bladder disorder	[ICD-11: CA23] [ICD-11: GC50]	Diseases of the respiratory system Diseases of the genitourinary system
7	P35354	PTGS2	T66665	Successful Target	Chronic pain Female pelvic pain Hyper-lipoproteinaemia Indeterminate colitis Knee osteoarthritis Osteoarthritis Pain Rheumatoid arthritis Tuberculosis	[ICD-11: MG30] [ICD-11: GA34] [ICD-11: 5C80] [ICD-11: DD72] [ICD-11: FA01] [ICD-11: FA00-FA05] [ICD-11: MG30-MG3Z] [ICD-11: FA20] [ICD-11: 1B10-1B12]	Symptoms, signs or clinical findings, not elsewhere classified Diseases of the genitourinary system Endocrine, nutritional or metabolic diseases Diseases of the digestive system Diseases of the musculoskeletal system or connective tissue Diseases of the musculoskeletal system or connective tissue Symptoms, signs or clinical findings, not elsewhere classified Diseases of the musculoskeletal system or connective tissue Certain infectious or parasitic diseases
8	P00488	F13A1	T66925	Patented-recorded Target
9	Q9Y4W7	PARG	T66935	Literature-reported Target
10	P07339	CTSD	T67102	Clinical trial target	Multiple sclerosis	[ICD-11: 8A40]	Diseases of the nervous system
11	P06756	ITGAV	T67103	Clinical trial target	Colorectal cancer Solid tumour/cancer	[ICD-11: 2B91] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
12	P14416	DRD2	T67162	Successful Target	Allergic/hypersensitivity disorder Alzheimer disease Asthma Attention deficit hyperactivity disorder Bipolar disorder Breathing abnormality Cardiovascular disease Cerebral ischaemia Depression Digestive system disease Essential hypertension Faecal incontinence Gangrene Glaucoma Heart failure Hyperaemia Hypertension Hypotension Inborn porphyrin/heme metabolism error Insomnia Itching Migraine Nausea/vomiting Pain Parkinsonism Pituitary gland disorder Postpartum haemorrhage Psychotic disorder Pulmonary hypertension Schizophrenia Substance abuse Thyrotoxicosis Type 2 diabetes mellitus	[ICD-11: 4A80-4A8Z] [ICD-11: 8A20] [ICD-11: CA23] [ICD-11: 6A05] [ICD-11: 6A60] [ICD-11: MD11] [ICD-11: BA00-BE2Z] [ICD-11: 8B1Z] [ICD-11: 6A70-6A7Z] [ICD-11: DE2Z] [ICD-11: BA00] [ICD-11: ME07] [ICD-11: MC85] [ICD-11: 9C61] [ICD-11: BD10-BD1Z] [ICD-11: 9A61-9B7Y] [ICD-11: BA00-BA04] [ICD-11: BA20-BA21] [ICD-11: 5C58] [ICD-11: 7A00-7A0Z] [ICD-11: 1F28-1G07] [ICD-11: 8A80] [ICD-11: MD90] [ICD-11: MG30-MG3Z] [ICD-11: 8A00] [ICD-11: 5A60-5A61] [ICD-11: JA43] [ICD-11: 6A20-6A25] [ICD-11: BB01] [ICD-11: 6A20] [ICD-11: 6C40] [ICD-11: 5A02] [ICD-11: 5A11]	Diseases of the immune system Diseases of the nervous system Diseases of the respiratory system Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified Diseases of the circulatory system Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Diseases of the digestive system Diseases of the circulatory system Symptoms, signs or clinical findings, not elsewhere classified Symptoms, signs or clinical findings, not elsewhere classified Diseases of the visual system Diseases of the circulatory system Diseases of the visual system Diseases of the circulatory system Diseases of the circulatory system Endocrine, nutritional or metabolic diseases Sleep-wake disorders Certain infectious or parasitic diseases Diseases of the nervous system Symptoms, signs or clinical findings, not elsewhere classified Symptoms, signs or clinical findings, not elsewhere classified Diseases of the nervous system Endocrine, nutritional or metabolic diseases Pregnancy, childbirth or the puerperium Mental, behavioural or neurodevelopmental disorders Diseases of the circulatory system Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
13	P43354	NR4A2	T67163	Literature-reported Target
14	P06734	FCER2	T67207	Clinical trial target	Leukaemia	[ICD-11: 2A60-2B33]	Neoplasms
15	Q14703	MBTPS1	T67231	Literature-reported Target
16	P15144	ANPEP	T67272	Clinical trial target	Psoriasis	[ICD-11: EA90]	Diseases of the skin
17	Q16651	PRSS8	T67339	Literature-reported Target
18	P47897	QARS	T67416	Clinical trial target	Muscular dystrophy	[ICD-11: 8C70]	Diseases of the nervous system
19	P31749	AKT1	T67619	Successful Target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
20	P14672	GLUT4	T67658	Clinical trial target	Type 2 diabetes mellitus	[ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases
21	P20309	CHRM3	T67684	Successful Target	Asthma Chronic obstructive pulmonary disease Functional bladder disorder Glaucoma Nausea/vomiting Peptic ulcer Respiratory system disease Sebaceous gland disorder Sjogren syndrome Tonus and reflex abnormality	[ICD-11: CA23] [ICD-11: CA22] [ICD-11: GC50] [ICD-11: 9C61] [ICD-11: MD90] [ICD-11: DA61] [ICD-11: CB40-CB7Z] [ICD-11: ED91] [ICD-11: 4A43] [ICD-11: MB47]	Diseases of the respiratory system Diseases of the respiratory system Diseases of the genitourinary system Diseases of the visual system Symptoms, signs or clinical findings, not elsewhere classified Diseases of the digestive system Diseases of the respiratory system Diseases of the skin Diseases of the immune system Symptoms, signs or clinical findings, not elsewhere classified
22	P29401	TKT	T67754	Literature-reported Target
23	Q10469	MGAT2	T67812	Patented-recorded Target
24	P47900	P2RY1	T67818	Literature-reported Target
25	Q9UEW8	STK39	T67837	Literature-reported Target