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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q96BR1	SGK3	T64102	Literature-reported Target
2	P42224	STAT1	T64205	Patented-recorded Target	Skin and skin-structure infection	[ICD-11: 1F28-1G0Z]	Certain infectious or parasitic diseases
3	Q9HBA0	TRPV4	T64213	Clinical trial target	Acute myeloid leukaemia Heart failure Hodgkin lymphoma	[ICD-11: 2A60] [ICD-11: BD10-BD1Z] [ICD-11: 2B30]	Neoplasms Diseases of the circulatory system Neoplasms
4	P18065	IGFBP2	T64268	Literature-reported Target
5	P43403	ZAP70	T64553	Patented-recorded Target
6	Q16790	CA9	T64567	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
7	P46098	HTR3A	T64591	Successful Target	Chronic pain Corneal disease Epilepsy/seizure Irritable bowel syndrome Nausea/vomiting	[ICD-11: MG30] [ICD-11: 9A76-9A78] [ICD-11: 8A61-8A6Z] [ICD-11: DD91] [ICD-11: MD90]	Symptoms, signs or clinical findings, not elsewhere classified Diseases of the visual system Diseases of the nervous system Diseases of the digestive system Symptoms, signs or clinical findings, not elsewhere classified
8	P26012	ITGB8	T64597	Clinical trial target	Chronic kidney disease	[ICD-11: GB61]	Diseases of the genitourinary system
9	O00141	SGK1	T64682	Clinical trial target	Prostate cancer	[ICD-11: 2C82]	Neoplasms
10	Q9Y5N1	HRH3	T64765	Successful Target	Somnolence	[ICD-11: MG42]	Symptoms, signs or clinical findings, not elsewhere classified
11	O43497	CACNA1G	T64795	Successful Target	Epilepsy/seizure Hypertension Multiple structural anomalies syndrome Pancreatic cancer Schizophrenia	[ICD-11: 8A61-8A6Z] [ICD-11: BA00-BA04] [ICD-11: LD2F] [ICD-11: 2C10] [ICD-11: 6A20]	Diseases of the nervous system Diseases of the circulatory system Developmental anomalies Neoplasms Mental, behavioural or neurodevelopmental disorders
12	P35346	SSTR5	T64830	Successful Target	Cushing syndrome	[ICD-11: 5A70]	Endocrine, nutritional or metabolic diseases
13	Q9UL51	HCN2	T65005	Literature-reported Target
14	P50281	MMP14	T65019	Clinical trial target	Hepatic fibrosis/cirrhosis	[ICD-11: DB93]	Diseases of the digestive system
15	P21589	NT5E	T65116	Clinical trial target	Ovarian cancer Pancreatic cancer Solid tumour/cancer	[ICD-11: 2C73] [ICD-11: 2C10] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms
16	P28845	HSD11B1	T65200	Clinical trial target	Influenza Lupus erythematosus Type 2 diabetes mellitus	[ICD-11: 1E30-1E32] [ICD-11: 4A40] [ICD-11: 5A11]	Certain infectious or parasitic diseases Diseases of the immune system Endocrine, nutritional or metabolic diseases
17	Q99527	GPER1	T65236	Successful Target	Contraceptive management	[ICD-11: QA21]	Factors influencing health status or contact with health services
18	P14384	CPM	T65483	Literature-reported Target
19	Q9UBC3	DNMT3B	T65501	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
20	P07327	ADH1A	T65570	Successful Target	Exposure to noxious substances harmful effect	[ICD-11: NE61]	Injury, poisoning or certain other consequences of external causes
21	Q9Y2I1	NISCH	T65689	Literature-reported Target
22	P35414	APLNR	T65783	Clinical trial target	Heart failure	[ICD-11: BD10-BD1Z]	Diseases of the circulatory system
23	Q6P179	ERAP2	T65818	Literature-reported Target
24	Q16539	MAPK14	T65864	Clinical trial target	Coronary atherosclerosis Myocardial infarction Rheumatoid arthritis Vitamin deficiency	[ICD-11: BA52] [ICD-11: BA41-BA43] [ICD-11: FA20] [ICD-11: 5B55-5B5F]	Diseases of the circulatory system Diseases of the circulatory system Diseases of the musculoskeletal system or connective tissue Endocrine, nutritional or metabolic diseases
25	P14618	PKM	T65889	Clinical trial target	Renal cell carcinoma	[ICD-11: 2C90]	Neoplasms