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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P13674	P4HA1	T61729	Clinical trial target	Hepatic fibrosis/cirrhosis Transplant rejection	[ICD-11: DB93] [ICD-11: NE84]	Diseases of the digestive system Injury, poisoning or certain other consequences of external causes
2	P27815	PDE4A	T61744	Successful Target	Asthma	[ICD-11: CA23]	Diseases of the respiratory system
3	P07858	CTSB	T61746	Preclinical target	Alopecia Alzheimer disease Asthma Bone cancer Brain cancer Cardiac arrest Cerebral ischaemic stroke Chronic obstructive pulmonary disease Chronic pain Cystic fibrosis Digestive system disease Hepatic fibrosis/cirrhosis Idiopathic interstitial pneumonitis Meningioma Metastatic tumour Multiple sclerosis Neurodegenerative disorder Osteoarthritis Psoriasis Rheumatoid arthritis	[ICD-11: ED70] [ICD-11: 8A20] [ICD-11: CA23] [ICD-11: 2B5Z] [ICD-11: 2A00] [ICD-11: MC82] [ICD-11: 8B11] [ICD-11: CA22] [ICD-11: MG30] [ICD-11: CA25] [ICD-11: DE2Z] [ICD-11: DB93] [ICD-11: CB03] [ICD-11: 2A01] [ICD-11: 2D50-2E2Z] [ICD-11: 8A40] [ICD-11: 8A20-8A23] [ICD-11: FA00-FA05] [ICD-11: EA90] [ICD-11: FA20]	Diseases of the skin Diseases of the nervous system Diseases of the respiratory system Neoplasms Neoplasms Symptoms, signs or clinical findings, not elsewhere classified Diseases of the nervous system Diseases of the respiratory system Symptoms, signs or clinical findings, not elsewhere classified Diseases of the respiratory system Diseases of the digestive system Diseases of the digestive system Diseases of the respiratory system Neoplasms Neoplasms Diseases of the nervous system Diseases of the nervous system Diseases of the musculoskeletal system or connective tissue Diseases of the skin Diseases of the musculoskeletal system or connective tissue
4	Q92887	CMOAT	T61792	Literature-reported Target
5	P24592	IGFBP6	T61800	Literature-reported Target
6	P25786	PSMA1	T61997	Successful Target
7	P04181	OAT	T62073	Literature-reported Target
8	P30531	SLC6A1	T62184	Successful Target	Epilepsy/seizure Multiple myeloma	[ICD-11: 8A61-8A6Z] [ICD-11: 2A83]	Diseases of the nervous system Neoplasms
9	Q6ZQW0	INDOL1	T62266	Patented-recorded Target
10	Q05586	GRIN1	T62276	Successful Target	Bacterial infection HIV-infected patients with tuberculosis	[ICD-11: 1A00-1C4Z] [ICD-11: 1B10-1B14]	Certain infectious or parasitic diseases Certain infectious or parasitic diseases
11	P34903	GABRA3	T62292	Successful Target	Intentional self-harm	[ICD-11: PC91]	External causes of morbidity or mortality
12	O43193	MLNR	T62306	Clinical trial target	Digestive system disease Gastroduodenal motor/secretory disorder Gastro-oesophageal reflux disease Irritable bowel syndrome Pain	[ICD-11: DE2Z] [ICD-11: DA41] [ICD-11: DA22] [ICD-11: DD91] [ICD-11: MG30-MG3Z]	Diseases of the digestive system Diseases of the digestive system Diseases of the digestive system Diseases of the digestive system Symptoms, signs or clinical findings, not elsewhere classified
13	P07101	TH	T62390	Successful Target	Adrenomedullary hyperfunction Nutritional deficiency	[ICD-11: 5A75] [ICD-11: 5B50-5B71]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
14	P42263	GRIA3	T62391	Successful Target	Neuropathy	[ICD-11: 8C0Z]	Diseases of the nervous system
15	P43405	SYK	T62431	Successful Target	Thrombocytopenia	[ICD-11: 3B64]	Diseases of the blood or blood-forming organs
16	O14757	CHEK1	T62449	Clinical trial target	Anal cancer Head and neck cancer Hodgkin lymphoma Lung cancer Lymphoma Ovarian cancer Pancreatic cancer Solid tumour/cancer	[ICD-11: 2C00] [ICD-11: 2D42] [ICD-11: 2B30] [ICD-11: 2C25] [ICD-11: 2A80-2A86] [ICD-11: 2C73] [ICD-11: 2C10] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
17	P23458	JAK1	T62460	Successful Target	Atopic eczema Myeloproliferative neoplasm Rheumatoid arthritis Thrombocytosis	[ICD-11: EA80] [ICD-11: 2A20] [ICD-11: FA20] [ICD-11: 3B63]	Diseases of the skin Neoplasms Diseases of the musculoskeletal system or connective tissue Diseases of the blood or blood-forming organs
18	P25098	GRK2	T62548	Patented-recorded Target
19	Q9ULD8	KCNH3	T62643	Literature-reported Target
20	P16662	UGT2B7	T62815	Literature-reported Target
21	Q14416	GRM2	T62820	Clinical trial target	Alzheimer disease Bipolar disorder Dengue fever Depression Epilepsy/seizure Mental/behavioural/neurodevelopmental disorder Obesity Psychotic disorder Schizophrenia	[ICD-11: 8A20] [ICD-11: 6A60] [ICD-11: 1D2Z] [ICD-11: 6A70-6A7Z] [ICD-11: 8A61-8A6Z] [ICD-11: 6E20-6E8Z] [ICD-11: 5B80-5B81] [ICD-11: 6A20-6A25] [ICD-11: 6A20]	Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Certain infectious or parasitic diseases Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Endocrine, nutritional or metabolic diseases Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders
22	P55085	F2RL1	T62841	Clinical trial target	Chronic pain	[ICD-11: MG30]	Symptoms, signs or clinical findings, not elsewhere classified
23	P31391	SSTR4	T62974	Clinical trial target	Chronic pain Hepatitis virus infection	[ICD-11: MG30] [ICD-11: 1E50-1E51]	Symptoms, signs or clinical findings, not elsewhere classified Certain infectious or parasitic diseases
24	Q8WTV0	SCARB1	T62998	Literature-reported Target
25	Q9UHD2	TBK1	T63024	Patented-recorded Target