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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P46663	BDKRB1	T58589	Clinical trial target	Osteoarthritis Retinopathy Rheumatoid arthritis	[ICD-11: FA00-FA05] [ICD-11: 9B71] [ICD-11: FA20]	Diseases of the musculoskeletal system or connective tissue Diseases of the visual system Diseases of the musculoskeletal system or connective tissue
2	P11940	PABPC1	T58679	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
3	Q9UQD0	SCN8A	T58741	Clinical trial target	Epilepsy/seizure Epileptic encephalopathy	[ICD-11: 8A61-8A6Z] [ICD-11: 8A62]	Diseases of the nervous system Diseases of the nervous system
4	P37231	PPARG	T58921	Successful Target	Acute diabete complication Alzheimer disease Type 2 diabetes mellitus	[ICD-11: 5A2Y] [ICD-11: 8A20] [ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases Diseases of the nervous system Endocrine, nutritional or metabolic diseases
5	P78362	SRPK2	T58924	Literature-reported Target
6	Q9Y345	SLC6A5	T58937	Literature-reported Target
7	P28482	MAPK1	T58970	Clinical trial target	Arteries/arterioles disorder Melanoma Pancreatic cancer Solid tumour/cancer	[ICD-11: BD52] [ICD-11: 2C30] [ICD-11: 2C10] [ICD-11: 2A00-2F9Z]	Diseases of the circulatory system Neoplasms Neoplasms Neoplasms
8	P41143	OPRD1	T58992	Successful Target	Bowel habit change Irritable bowel syndrome Pain	[ICD-11: ME05] [ICD-11: DD91] [ICD-11: MG30-MG3Z]	Symptoms, signs or clinical findings, not elsewhere classified Diseases of the digestive system Symptoms, signs or clinical findings, not elsewhere classified
9	P80404	ABAT	T59045	Successful Target	Brain cancer Epilepsy/seizure Epileptic encephalopathy Mineral deficiency Nutritional deficiency	[ICD-11: 2A00] [ICD-11: 8A61-8A6Z] [ICD-11: 8A62] [ICD-11: 5B5K] [ICD-11: 5B50-5B71]	Neoplasms Diseases of the nervous system Diseases of the nervous system Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
10	P19099	CYP11B2	T59056	Clinical trial target	Hypertension	[ICD-11: BA00-BA04]	Diseases of the circulatory system
11	P09619	PDGFRB	T59102	Successful Target	Acute diabete complication Renal cell carcinoma Thrombocytopenia	[ICD-11: 5A2Y] [ICD-11: 2C90] [ICD-11: 3B64]	Endocrine, nutritional or metabolic diseases Neoplasms Diseases of the blood or blood-forming organs
12	Q05513	PRKCZ	T59190	Patented-recorded Target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
13	P00533	EGFR	T59328	Successful Target	Angina pectoris Breast cancer Colorectal cancer Diabetic foot ulcer Ischemia Lung cancer Non-small-cell lung cancer Renal cell carcinoma Solid tumour/cancer Unspecific body region injury	[ICD-11: BA40] [ICD-11: 2C60-2C6Y] [ICD-11: 2B91] [ICD-11: BD54] [ICD-11: 8B10-8B11] [ICD-11: 2C25] [ICD-11: 2C25] [ICD-11: 2C90] [ICD-11: 2A00-2F9Z] [ICD-11: ND56]	Diseases of the circulatory system Neoplasms Neoplasms Diseases of the circulatory system Diseases of the nervous system Neoplasms Neoplasms Neoplasms Neoplasms Injury, poisoning or certain other consequences of external causes
14	Q00796	SORD	T59445	Literature-reported Target
15	Q9BWQ3	ASCT2	T59493	Literature-reported Target
16	Q99640	PKMYT1	T59537	Literature-reported Target
17	P11717	IGF2R	T59550	Clinical trial target	Fibrosis Sarcoidosis	[ICD-11: GA14-GC01] [ICD-11: 4B20]	Diseases of the genitourinary system Diseases of the immune system
18	P32249	EBI2	T59577	Literature-reported Target
19	Q92847	GHSR	T59604	Successful Target	Chronic pain Pituitary gland disorder	[ICD-11: MG30] [ICD-11: 5A60-5A61]	Symptoms, signs or clinical findings, not elsewhere classified Endocrine, nutritional or metabolic diseases
20	Q15722	LTB4R	T59626	Clinical trial target	Human immunodeficiency virus disease Pulmonary disease Renal cell carcinoma	[ICD-11: 1C60-1C62] [ICD-11: 1B10-1F85] [ICD-11: 2C90]	Certain infectious or parasitic diseases Certain infectious or parasitic diseases Neoplasms
21	Q9NYY3	PLK2	T59654	Patented-recorded Target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
22	Q13639	HTR4	T59679	Successful Target	Gastro-oesophageal reflux disease Irritable bowel syndrome	[ICD-11: DA22] [ICD-11: DD91]	Diseases of the digestive system Diseases of the digestive system
23	P51608	MECP2	T59686	Clinical trial target	Intellectual development disorder	[ICD-11: LD90]	Developmental anomalies
24	P49789	FHIT	T59720	Successful Target	Nausea/vomiting	[ICD-11: MD90]	Symptoms, signs or clinical findings, not elsewhere classified
25	P62136	PPP1CA	T59845	Successful Target	Molluscum contagiosum	[ICD-11: 1E76]	Certain infectious or parasitic diseases