List of therapeutic targets associated diseases



                                                                                                                                                        Sr. No. Uniprot ID Gene name TTD ID Target type Disease name ICD-11 Disease class
                                                                                                                                                        1P62508ESRRGT59875Literature-reported Target
                                                                                                                                                        2P47901AVPR1BT59881Successful Target
                                                                                                                                                      • Acute diabete complication
                                                                                                                                                      • Autism spectrum disorder
                                                                                                                                                      • Hypo-osmolality/hyponatraemia
                                                                                                                                                      • [ICD-11: 5A2Y]
                                                                                                                                                      • [ICD-11: 6A02]
                                                                                                                                                      • [ICD-11: 5C72]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Mental, behavioural or neurodevelopmental disorders
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • 3P19971TYMPT59929Successful Target
                                                                                                                                                      • Depression
                                                                                                                                                      • [ICD-11: 6A70-6A7Z]
                                                                                                                                                      • Mental, behavioural or neurodevelopmental disorders
                                                                                                                                                      • 4Q16512PKN1T60003Literature-reported Target
                                                                                                                                                        5P28702RXRBT60077Successful Target
                                                                                                                                                      • Kaposi sarcoma
                                                                                                                                                      • [ICD-11: 2B57]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 6P47871GCGRT60182Successful Target
                                                                                                                                                      • Hypo-glycaemia
                                                                                                                                                      • [ICD-11: 5A41]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • 7Q13873BMPR2T60213Literature-reported Target
                                                                                                                                                      • Joint derangement
                                                                                                                                                      • Prostate cancer
                                                                                                                                                      • Urinary system disease
                                                                                                                                                      • Urinary/pelvic organs injury
                                                                                                                                                      • [ICD-11: FA34]
                                                                                                                                                      • [ICD-11: 2C82]
                                                                                                                                                      • [ICD-11: GC2Z]
                                                                                                                                                      • [ICD-11: NB92]
                                                                                                                                                      • Diseases of the musculoskeletal system or connective tissue
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Diseases of the genitourinary system
                                                                                                                                                      • Injury, poisoning or certain other consequences of external causes
                                                                                                                                                      • 8Q99571P2RX4T60330Clinical trial target
                                                                                                                                                        9O14804TAAR5T60362Literature-reported Target
                                                                                                                                                        10P11926ODC1T60366Successful Target
                                                                                                                                                      • African trypanosomiasis
                                                                                                                                                      • [ICD-11: 1F51]
                                                                                                                                                      • Certain infectious or parasitic diseases
                                                                                                                                                      • 11Q9HCN6GP6T60514Clinical trial target
                                                                                                                                                      • Arterial occlusive disease
                                                                                                                                                      • Cerebral ischaemic stroke
                                                                                                                                                      • [ICD-11: BD40]
                                                                                                                                                      • [ICD-11: 8B11]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                      • 12P14151SELLT60526Clinical trial target
                                                                                                                                                      • Asthma
                                                                                                                                                      • Circulatory system disease
                                                                                                                                                      • [ICD-11: CA23]
                                                                                                                                                      • [ICD-11: BE2Z]
                                                                                                                                                      • Diseases of the respiratory system
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • 13Q5T7T8COX1T60529Successful Target
                                                                                                                                                      • Eye anterior segment structural developmental anomaly
                                                                                                                                                      • Female pelvic pain
                                                                                                                                                      • Hyper-lipoproteinaemia
                                                                                                                                                      • Indeterminate colitis
                                                                                                                                                      • Nutritional deficiency
                                                                                                                                                      • Osteoarthritis
                                                                                                                                                      • Pain
                                                                                                                                                      • Postoperative inflammation
                                                                                                                                                      • Rheumatoid arthritis
                                                                                                                                                      • Seborrhoeic dermatitis
                                                                                                                                                      • Tuberculosis
                                                                                                                                                      • Ulcerative colitis
                                                                                                                                                      • [ICD-11: LA11]
                                                                                                                                                      • [ICD-11: GA34]
                                                                                                                                                      • [ICD-11: 5C80]
                                                                                                                                                      • [ICD-11: DD72]
                                                                                                                                                      • [ICD-11: 5B50-5B71]
                                                                                                                                                      • [ICD-11: FA00-FA05]
                                                                                                                                                      • [ICD-11: MG30-MG3Z]
                                                                                                                                                      • [ICD-11: 1A00-CA43]
                                                                                                                                                      • [ICD-11: FA20]
                                                                                                                                                      • [ICD-11: EA81]
                                                                                                                                                      • [ICD-11: 1B10-1B12]
                                                                                                                                                      • [ICD-11: DD71]
                                                                                                                                                      • Developmental anomalies
                                                                                                                                                      • Diseases of the genitourinary system
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Diseases of the musculoskeletal system or connective tissue
                                                                                                                                                      • Symptoms, signs or clinical findings, not elsewhere classified
                                                                                                                                                      • Postoperative inflammation
                                                                                                                                                      • Diseases of the musculoskeletal system or connective tissue
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Certain infectious or parasitic diseases
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                      • 14P16473TSHRT60606Successful Target
                                                                                                                                                      • Hypo-thyroidism
                                                                                                                                                      • Thyroid cancer
                                                                                                                                                      • [ICD-11: 5A00]
                                                                                                                                                      • [ICD-11: 2D10]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 15P07949RETT60631Successful Target
                                                                                                                                                      • Colorectal cancer
                                                                                                                                                      • Lung cancer
                                                                                                                                                      • Mature B-cell lymphoma
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • Thrombocytopenia
                                                                                                                                                      • Thyroid cancer
                                                                                                                                                      • [ICD-11: 2B91]
                                                                                                                                                      • [ICD-11: 2C25]
                                                                                                                                                      • [ICD-11: 2A85]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • [ICD-11: 3B64]
                                                                                                                                                      • [ICD-11: 2D10]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Diseases of the blood or blood-forming organs
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 16P41145OPRK1T60693Successful Target
                                                                                                                                                      • Non-specific cutaneous vascular symptom
                                                                                                                                                      • Pain
                                                                                                                                                      • Pruritus
                                                                                                                                                      • [ICD-11: ME64]
                                                                                                                                                      • [ICD-11: MG30-MG3Z]
                                                                                                                                                      • [ICD-11: EC90]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Symptoms, signs or clinical findings, not elsewhere classified
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • 17P42330AKR1C3T60857Successful Target
                                                                                                                                                      • Female pelvic pain
                                                                                                                                                      • [ICD-11: GA34]
                                                                                                                                                      • Diseases of the genitourinary system
                                                                                                                                                      • 18Q9BX84TRPM6T61029Literature-reported Target
                                                                                                                                                        19Q14831GRM7T61243Literature-reported Target
                                                                                                                                                        20P06280GLAT61339Successful Target
                                                                                                                                                      • Inborn carbohydrate metabolism error
                                                                                                                                                      • [ICD-11: 5C51]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • 21Q02127DHODHT61400Successful Target
                                                                                                                                                      • Hyper-lipoproteinaemia
                                                                                                                                                      • Multiple sclerosis
                                                                                                                                                      • [ICD-11: 5C80]
                                                                                                                                                      • [ICD-11: 8A40]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                      • 22P00797RENT61622Successful Target
                                                                                                                                                      • Hypertension
                                                                                                                                                      • [ICD-11: BA00-BA04]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • 23P10826RARBT61657Successful Target
                                                                                                                                                      • Kaposi sarcoma
                                                                                                                                                      • [ICD-11: 2B57]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 24P60568IL2T61698Successful Target
                                                                                                                                                      • Multiple sclerosis
                                                                                                                                                      • Renal cell carcinoma
                                                                                                                                                      • [ICD-11: 8A40]
                                                                                                                                                      • [ICD-11: 2C90]
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • 25Q9Y5Y4PTGDR2T61722Clinical trial target
                                                                                                                                                      • Coronary atherosclerosis
                                                                                                                                                      • [ICD-11: BA52]
                                                                                                                                                      • Diseases of the circulatory system