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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	O15399	GRIN2D	T56588	Literature-reported Target	Neurodegenerative disorder	[ICD-11: 8A20-8A23]	Diseases of the nervous system
2	Q9UGL1	KDM5B	T56871	Literature-reported Target
3	P25025	CXCR2	T56923	Successful Target	Fungal infection Pain	[ICD-11: 1F29-1F2F] [ICD-11: MG30-MG3Z]	Certain infectious or parasitic diseases Symptoms, signs or clinical findings, not elsewhere classified
4	Q15375	EPHA7	T57006	Literature-reported Target
5	P23467	PTPRB	T57034	Clinical trial target	Chronic arterial occlusive disease Retinopathy	[ICD-11: BD4Z] [ICD-11: 9B71]	Diseases of the circulatory system Diseases of the visual system
6	P35626	GRK3	T57174	Literature-reported Target
7	Q96LB2	MRGPRX1	T57253	Literature-reported Target
8	P29317	EPHA2	T57278	Clinical trial target	Brain cancer Solid tumour/cancer	[ICD-11: 2A00] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
9	Q15172	PPP2R5A	T57291	Literature-reported Target
10	Q9H2G2	SLK	T57307	Literature-reported Target
11	O60906	SMPD2	T57316	Literature-reported Target
12	P10635	CYP2D6	T57392	Successful Target	Insomnia	[ICD-11: 7A00-7A0Z]	Sleep-wake disorders
13	Q9NPC2	KCNK9	T57613	Literature-reported Target
14	P10721	KIT	T57700	Successful Target	Bone/articular cartilage neoplasm Colorectal cancer Gastrointestinal stromal tumour Mature B-cell lymphoma Myeloproliferative neoplasm Renal cell carcinoma Thrombocytopenia	[ICD-11: 2F7B] [ICD-11: 2B91] [ICD-11: 2B5B] [ICD-11: 2A85] [ICD-11: 2A20] [ICD-11: 2C90] [ICD-11: 3B64]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Diseases of the blood or blood-forming organs
15	Q9H4A4	RNPEP	T57818	Literature-reported Target
16	P42574	CASP3	T57943	Clinical trial target	Brain cancer	[ICD-11: 2A00]	Neoplasms
17	Q99677	LPAR4	T58130	Literature-reported Target
18	Q13002	GRIK2	T58178	Literature-reported Target
19	P29322	EPHA8	T58266	Literature-reported Target
20	Q9Y570	PPME1	T58307	Patented-recorded Target
21	P35498	SCN1A	T58440	Patented-recorded Target
22	P50613	CDK7	T58449	Clinical trial target	Breast cancer Lung cancer Malignant haematopoietic neoplasm Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 2C25] [ICD-11: 2B33] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms
23	P21802	FGFR2	T58454	Successful Target	Hepatitis virus infection Liver cancer Oral mucositis	[ICD-11: 1E50-1E51] [ICD-11: 2C12] [ICD-11: DA01]	Certain infectious or parasitic diseases Neoplasms Diseases of the digestive system
24	P20248	CCNA2	T58470	Literature-reported Target	Retina cancer	[ICD-11: 2D02]	Neoplasms
25	Q8NET8	TRPV3	T58496	Clinical trial target	Pain	[ICD-11: MG30-MG3Z]	Symptoms, signs or clinical findings, not elsewhere classified