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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P13569	CFTR	T55654	Successful Target	Cystic fibrosis Intrathoracic organs injury Viral intestinal infection	[ICD-11: CA25] [ICD-11: NB32] [ICD-11: 1A2Z]	Diseases of the respiratory system Injury, poisoning or certain other consequences of external causes Certain infectious or parasitic diseases
2	Q05469	LIPE	T55689	Successful Target	Pediculosis	[ICD-11: 1G00]	Certain infectious or parasitic diseases
3	P02753	RBP4	T55703	Clinical trial target	Inherited retinal dystrophy	[ICD-11: 9B70]	Diseases of the visual system
4	P35790	CHKA	T55709	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
5	Q15759	MAPK11	T55729	Clinical trial target	Alzheimer disease Rheumatoid arthritis	[ICD-11: 8A20] [ICD-11: FA20]	Diseases of the nervous system Diseases of the musculoskeletal system or connective tissue
6	Q12866	MERTK	T55781	Clinical trial target	Acute myeloid leukaemia Alzheimer disease Myelodysplastic syndrome Solid tumour/cancer	[ICD-11: 2A60] [ICD-11: 8A20] [ICD-11: 2A37] [ICD-11: 2A00-2F9Z]	Neoplasms Diseases of the nervous system Neoplasms Neoplasms
7	Q15822	CHRNA2	T55815	Successful Target	Corneal disease Depression Glaucoma Nicotine use disorder Tonus and reflex abnormality	[ICD-11: 9A76-9A78] [ICD-11: 6A70-6A7Z] [ICD-11: 9C61] [ICD-11: 6C4A] [ICD-11: MB47]	Diseases of the visual system Mental, behavioural or neurodevelopmental disorders Diseases of the visual system Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified
8	P56696	KCNQ4	T55916	Literature-reported Target
9	P17707	AMD1	T55922	Successful Target	Acidosis	[ICD-11: 5C73]	Endocrine, nutritional or metabolic diseases
10	O75751	EMTH	T55948	Literature-reported Target
11	O15303	GRM6	T55956	Literature-reported Target
12	Q01959	SLC6A3	T55959	Successful Target	Attention deficit hyperactivity disorder Bipolar disorder Corneal disease Narcolepsy Obesity Parkinsonism	[ICD-11: 6A05] [ICD-11: 6A60] [ICD-11: 9A76-9A78] [ICD-11: 7A20] [ICD-11: 5B80-5B81] [ICD-11: 8A00]	Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Diseases of the visual system Sleep-wake disorders Endocrine, nutritional or metabolic diseases Diseases of the nervous system
13	Q99436	PSMB7	T55986	Patented-recorded Target
14	P09936	UCHL1	T56051	Preclinical target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
15	O15054	KDM6B	T56057	Literature-reported Target
16	P50454	SERPINH1	T56104	Literature-reported Target
17	O15164	TRIM24	T56108	Literature-reported Target
18	P54753	EPHB3	T56121	Literature-reported Target
19	Q9HC97	GPR35	T56143	Literature-reported Target
20	P48449	LSS	T56175	Literature-reported Target	Arterial occlusive disease	[ICD-11: BD40]	Diseases of the circulatory system
21	Q9BXC0	HCAR1	T56272	Literature-reported Target
22	Q9UM73	ALK	T56418	Successful Target	Lung cancer Mature T-cell lymphoma Non-small-cell lung cancer	[ICD-11: 2C25] [ICD-11: 2A90] [ICD-11: 2C25]	Neoplasms Neoplasms Neoplasms
23	P11086	PNMT	T56496	Literature-reported Target
24	Q07817	BCL2L1	T56510	Clinical trial target	Myeloproliferative neoplasm	[ICD-11: 2A20]	Neoplasms
25	Q9UNQ0	ABCG2	T56556	Successful Target	Irritable bowel syndrome Rheumatoid arthritis	[ICD-11: DD91] [ICD-11: FA20]	Diseases of the digestive system Diseases of the musculoskeletal system or connective tissue