List of therapeutic targets associated diseases


                                                                                                                                                        Sr. No. Uniprot ID Gene name TTD ID Target type Disease name ICD-11 Disease class
                                                                                                                                                        1P25100ADRA1DT53381Successful Target
                                                                                                                                                      • Glaucoma
                                                                                                                                                      • Heart failure
                                                                                                                                                      • Hypertension
                                                                                                                                                      • Prostate hyperplasia
                                                                                                                                                      • Sexual dysfunction
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • [ICD-11: 9C61]
                                                                                                                                                      • [ICD-11: BD10-BD1Z]
                                                                                                                                                      • [ICD-11: BA00-BA04]
                                                                                                                                                      • [ICD-11: GA90]
                                                                                                                                                      • [ICD-11: HA00-HA01]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • Diseases of the visual system
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Diseases of the genitourinary system
                                                                                                                                                      • Conditions related to sexual health
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 2P36897TGFBR1T53389Clinical trial target
                                                                                                                                                      • Arterial occlusive disease
                                                                                                                                                      • Lung cancer
                                                                                                                                                      • [ICD-11: BD40]
                                                                                                                                                      • [ICD-11: 2C25]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 3Q9BYP7WNK3T53468Literature-reported Target
                                                                                                                                                        4Q9UG96ICH2T53469Patented-recorded Target
                                                                                                                                                        5P09210GSTA2T53510Literature-reported Target
                                                                                                                                                        6P16234PDGFRAT53524Successful Target
                                                                                                                                                      • Gastrointestinal stromal tumour
                                                                                                                                                      • Kaposi sarcoma
                                                                                                                                                      • Thrombocytopenia
                                                                                                                                                      • [ICD-11: 2B5B]
                                                                                                                                                      • [ICD-11: 2B57]
                                                                                                                                                      • [ICD-11: 3B64]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Diseases of the blood or blood-forming organs
                                                                                                                                                        • 7P04035HMGCRT53585Successful Target
                                                                                                                                                      • Cardiovascular disease
                                                                                                                                                      • Coronary atherosclerosis
                                                                                                                                                      • Dyslipidemia
                                                                                                                                                      • Hyper-lipoproteinaemia
                                                                                                                                                      • Multiple sclerosis
                                                                                                                                                      • Myocardial infarction
                                                                                                                                                      • Pain
                                                                                                                                                      • [ICD-11: BA00-BE2Z]
                                                                                                                                                      • [ICD-11: BA52]
                                                                                                                                                      • [ICD-11: 5C80-5C81]
                                                                                                                                                      • [ICD-11: 5C80]
                                                                                                                                                      • [ICD-11: 8A40]
                                                                                                                                                      • [ICD-11: BA41-BA43]
                                                                                                                                                      • [ICD-11: MG30-MG3Z]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Symptoms, signs or clinical findings, not elsewhere classified
                                                                                                                                                        • 8Q12884FAPT53764Clinical trial target
                                                                                                                                                      • Neutropenia
                                                                                                                                                      • [ICD-11: 4B00]
                                                                                                                                                      • Diseases of the immune system
                                                                                                                                                        • 9Q96KS0EIT6T53904Successful Target
                                                                                                                                                      • Acute disease anaemia
                                                                                                                                                      • [ICD-11: 3A90]
                                                                                                                                                      • Diseases of the blood or blood-forming organs
                                                                                                                                                        • 10Q9H2X6HIPK2T53952Literature-reported Target
                                                                                                                                                        11O43525KCNQ3T54132Clinical trial target
                                                                                                                                                      • Behcet disease
                                                                                                                                                      • [ICD-11: 4A62]
                                                                                                                                                      • Diseases of the immune system
                                                                                                                                                        • 12P14780MMP9T54156Clinical trial target
                                                                                                                                                      • Ischaemic/haemorrhagic stroke
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • Stomach cancer
                                                                                                                                                      • Ulcerative colitis
                                                                                                                                                      • [ICD-11: 8B20]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • [ICD-11: 2B72]
                                                                                                                                                      • [ICD-11: DD71]
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                        • 13P43490NAMPTT54582Clinical trial target
                                                                                                                                                      • Leukaemia
                                                                                                                                                      • Lymphoma
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • [ICD-11: 2A60-2B33]
                                                                                                                                                      • [ICD-11: 2A80-2A86]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 14O95180CACNA1HT54644Successful Target
                                                                                                                                                      • Acidosis
                                                                                                                                                      • Migraine
                                                                                                                                                      • [ICD-11: 5C73]
                                                                                                                                                      • [ICD-11: 8A80]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                        • 15H3BPQ1TCF4T54646Literature-reported Target
                                                                                                                                                        16P13866SLC5A1T54771Clinical trial target
                                                                                                                                                      • Diabetes mellitus
                                                                                                                                                      • Heart failure
                                                                                                                                                      • Type 2 diabetes mellitus
                                                                                                                                                      • [ICD-11: 5A10]
                                                                                                                                                      • [ICD-11: BD10-BD1Z]
                                                                                                                                                      • [ICD-11: 5A11]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                        • 17P28072PSMB6T54973Patented-recorded Target
                                                                                                                                                        18Q99884SLC6A7T54982Literature-reported Target
                                                                                                                                                        19Q9H093NUAK2T55005Literature-reported Target
                                                                                                                                                        20P35813PPM1AT55260Clinical trial target
                                                                                                                                                      • Molluscum contagiosum
                                                                                                                                                      • [ICD-11: 1E76]
                                                                                                                                                      • Certain infectious or parasitic diseases
                                                                                                                                                        • 21P48167GLRBT55285Successful Target
                                                                                                                                                      • Tonus and reflex abnormality
                                                                                                                                                      • [ICD-11: MB47]
                                                                                                                                                      • Symptoms, signs or clinical findings, not elsewhere classified
                                                                                                                                                        • 22P17301ITGA2T55293Clinical trial target
                                                                                                                                                      • Colorectal cancer
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • [ICD-11: 2B91]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 23Q9NWZ3IRAK4T55398Clinical trial target
                                                                                                                                                      • Atopic eczema
                                                                                                                                                      • Cutaneous lupus erythematosus
                                                                                                                                                      • Lymphoma
                                                                                                                                                      • Postoperative inflammation
                                                                                                                                                      • Psoriasis
                                                                                                                                                      • Rheumatoid arthritis
                                                                                                                                                      • [ICD-11: EA80]
                                                                                                                                                      • [ICD-11: EB50-EB5Z]
                                                                                                                                                      • [ICD-11: 2A80-2A86]
                                                                                                                                                      • [ICD-11: 1A00-CA43]
                                                                                                                                                      • [ICD-11: EA90]
                                                                                                                                                      • [ICD-11: FA20]
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Postoperative inflammation
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Diseases of the musculoskeletal system or connective tissue
                                                                                                                                                        • 24Q16665HIF1AT55610Clinical trial target
                                                                                                                                                      • Lymphoma
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • [ICD-11: 2A80-2A86]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 25Q9ULZ9MMP17T55616Literature-reported Target