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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P47869	GABRA2	T51452	Successful Target	Intentional self-harm	[ICD-11: PC91]	External causes of morbidity or mortality
2	P14867	GABRA1	T51487	Successful Target	Acute respiratory distress syndrome Anxiety disorder Chronic insomnia Chronic pain Corneal disease Cystitis Depression Epilepsy/seizure Headache Insomnia Malaria Mental/behavioural/neurodevelopmental disorder Tonus and reflex abnormality	[ICD-11: CB00] [ICD-11: 6B00-6B0Z] [ICD-11: 7A00] [ICD-11: MG30] [ICD-11: 9A76-9A78] [ICD-11: GC00] [ICD-11: 6A70-6A7Z] [ICD-11: 8A61-8A6Z] [ICD-11: 8A80-8A84] [ICD-11: 7A00-7A0Z] [ICD-11: 1F40-1F45] [ICD-11: 6E20-6E8Z] [ICD-11: MB47]	Diseases of the respiratory system Mental, behavioural or neurodevelopmental disorders Sleep-wake disorders Symptoms, signs or clinical findings, not elsewhere classified Diseases of the visual system Diseases of the genitourinary system Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Diseases of the nervous system Sleep-wake disorders Certain infectious or parasitic diseases Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified
3	P68400	CSNK2A1	T51565	Clinical trial target	Coronavirus infection Liver cancer Solid tumour/cancer	[ICD-11: 1D92] [ICD-11: 2C12] [ICD-11: 2A00-2F9Z]	Certain infectious or parasitic diseases Neoplasms Neoplasms
4	Q8IWU9	TPH2	T51593	Successful Target	Carcinoid syndrome Small intestine developmental anomaly	[ICD-11: 5B10] [ICD-11: DA90]	Endocrine, nutritional or metabolic diseases Diseases of the digestive system
5	Q9BZP6	CHIA	T51597	Literature-reported Target
6	P25963	NFKBIA	T51672	Clinical trial target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
7	P04049	RAF1	T51883	Clinical trial target	Melanoma Non-small-cell lung cancer Ovarian cancer Solid tumour/cancer	[ICD-11: 2C30] [ICD-11: 2C25] [ICD-11: 2C73] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms
8	Q16348	PEPT2	T52067	Literature-reported Target
9	P00480	OTC	T52098	Clinical trial target	Metabolism inborn error	[ICD-11: 5C50]	Endocrine, nutritional or metabolic diseases
10	P37088	SCNN1A	T52173	Successful Target	Heart failure Hypertension Oedema	[ICD-11: BD10-BD1Z] [ICD-11: BA00-BA04] [ICD-11: MG29]	Diseases of the circulatory system Diseases of the circulatory system Symptoms, signs or clinical findings, not elsewhere classified
11	P53396	ACLY	T52189	Successful Target	Hyper-lipoproteinaemia	[ICD-11: 5C80]	Endocrine, nutritional or metabolic diseases
12	Q13133	NR1H3	T52297	Patented-recorded Target	Depression	[ICD-11: 6A70-6A7Z]	Mental, behavioural or neurodevelopmental disorders
13	P15559	NQO1	T52389	Clinical trial target	Choreiform disorder CNS anomalies syndrome Inborn energy metabolism error Intellectual development disorder Pancreatic cancer Solid tumour/cancer	[ICD-11: 8A01] [ICD-11: LD20] [ICD-11: 5C53] [ICD-11: LD90] [ICD-11: 2C10] [ICD-11: 2A00-2F9Z]	Diseases of the nervous system Developmental anomalies Endocrine, nutritional or metabolic diseases Developmental anomalies Neoplasms Neoplasms
14	Q08752	PPID	T52447	Patented-recorded Target
15	P03956	MMP1	T52450	Successful Target	Lung cancer	[ICD-11: 2C25]	Neoplasms
16	O95398	RAPGEF3	T52489	Clinical trial target	Epidermal dysplasias	[ICD-11: EK90]	Diseases of the skin
17	P07550	ADRB2	T52522	Successful Target	Asthma Chronic obstructive pulmonary disease Conduction disorder Preterm labour/delivery Sleep-related breathing disorder	[ICD-11: CA23] [ICD-11: CA22] [ICD-11: BC63] [ICD-11: JB00] [ICD-11: 7A4Z]	Diseases of the respiratory system Diseases of the respiratory system Diseases of the circulatory system Pregnancy, childbirth or the puerperium Sleep-wake disorders
18	Q9H4A3	WNK1	T52638	Literature-reported Target
19	P21452	TACR2	T52790	Clinical trial target	Irritable bowel syndrome	[ICD-11: DD91]	Diseases of the digestive system
20	P41146	OPRL1	T52921	Clinical trial target	Atopic eczema Depression Headache Heart failure	[ICD-11: EA80] [ICD-11: 6A70-6A7Z] [ICD-11: 8A80-8A84] [ICD-11: BD10-BD1Z]	Diseases of the skin Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Diseases of the circulatory system
21	P30874	SSTR2	T53024	Successful Target	Cushing syndrome Diagnostic imaging Pituitary gland disorder	[ICD-11: 5A70] [ICD-11: N.A.] [ICD-11: 5A60-5A61]	Endocrine, nutritional or metabolic diseases N.A Endocrine, nutritional or metabolic diseases
22	O14733	MAP2K7	T53159	Literature-reported Target
23	Q96KQ7	EHMT2	T53251	Preclinical target	Breast cancer Postoperative inflammation Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 1A00-CA43] [ICD-11: 2A00-2F9Z]	Neoplasms Postoperative inflammation Neoplasms
24	P13497	BMP1	T53350	Literature-reported Target
25	P22748	CA4	T53378	Successful Target	Bacterial infection Glaucoma Seborrhoeic dermatitis	[ICD-11: 1A00-1C4Z] [ICD-11: 9C61] [ICD-11: EA81]	Certain infectious or parasitic diseases Diseases of the visual system Diseases of the skin