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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	O75581	LRP6	T49755	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
2	P06493	CDK1	T49898	Clinical trial target	Breast cancer Lung cancer Malignant haematopoietic neoplasm Mature B-cell lymphoma Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 2C25] [ICD-11: 2B33] [ICD-11: 2A85] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
3	P09769	FGR	T49925	Literature-reported Target
4	P37173	TGFBR2	T49989	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
5	P21757	MSR1	T50007	Literature-reported Target
6	Q9H228	S1PR5	T50089	Clinical trial target	Multiple sclerosis	[ICD-11: 8A40]	Diseases of the nervous system
7	O75582	RPS6KA5	T50224	Patented-recorded Target
8	P23415	GLRA1	T50269	Successful Target	Tonus and reflex abnormality	[ICD-11: MB47]	Symptoms, signs or clinical findings, not elsewhere classified
9	Q9UM07	PADI4	T50429	Literature-reported Target
10	P11309	PIM1	T50594	Clinical trial target	Acute myeloid leukaemia Solid tumour/cancer	[ICD-11: 2A60] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
11	P08514	ITGA2B	T50688	Successful Target	Acquired hypermelanosis Angina pectoris Myocardial infarction	[ICD-11: ED60] [ICD-11: BA40] [ICD-11: BA41-BA43]	Diseases of the skin Diseases of the circulatory system Diseases of the circulatory system
12	Q9UHL4	DPP7	T50773	Patented-recorded Target
13	P08138	NGFR	T50942	Successful Target	Neurotrophic keratitis	[ICD-11: 9A74]	Diseases of the visual system
14	P42892	ECE1	T50970	Literature-reported Target
15	O15229	KMO	T50973	Clinical trial target
16	Q16288	NTRK3	T51076	Successful Target	Non-small-cell lung cancer Solid tumour/cancer	[ICD-11: 2C25] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
17	Q13936	CACNA1C	T51115	Successful Target	Alzheimer disease	[ICD-11: 8A20]	Diseases of the nervous system
18	P07202	TPO	T51120	Successful Target	Thyrotoxicosis	[ICD-11: 5A02]	Endocrine, nutritional or metabolic diseases
19	P22083	FUT4	T51146	Successful Target	Appendicitis	[ICD-11: DB10]	Diseases of the digestive system
20	Q92769	HDAC2	T51191	Clinical trial target	Lymphoma Solid tumour/cancer	[ICD-11: 2A80-2A86] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
21	Q13464	ROCK1	T51282	Successful Target	Glaucoma	[ICD-11: 9C61]	Diseases of the visual system
22	Q5NUL3	FFAR4	T51385	Literature-reported Target
23	O14980	XPO1	T51407	Clinical trial target	Liposarcoma Multiple myeloma Stomach cancer	[ICD-11: 2B59] [ICD-11: 2A83] [ICD-11: 2B72]	Neoplasms Neoplasms Neoplasms
24	P13945	ADRB3	T51408	Successful Target	Angina pectoris Asthma Chronic obstructive pulmonary disease Dystonic disorder Functional bladder disorder Hypertension Parkinsonism	[ICD-11: BA40] [ICD-11: CA23] [ICD-11: CA22] [ICD-11: 8A02] [ICD-11: GC50] [ICD-11: BA00-BA04] [ICD-11: 8A00]	Diseases of the circulatory system Diseases of the respiratory system Diseases of the respiratory system Diseases of the nervous system Diseases of the genitourinary system Diseases of the circulatory system Diseases of the nervous system
25	Q96RI1	NR1H4	T51426	Successful Target	Autoimmune liver disease Cholelithiasis Osteoarthritis	[ICD-11: DB96] [ICD-11: DC11] [ICD-11: FA00-FA05]	Diseases of the digestive system Diseases of the digestive system Diseases of the musculoskeletal system or connective tissue