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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P27037	ACVR2A	T47366	Clinical trial target	Acute myeloid leukaemia Idiopathic inflammatory myopathy	[ICD-11: 2A60] [ICD-11: 4A41]	Neoplasms Diseases of the immune system
2	Q14191	WRN	T47583	Literature-reported Target	Mature T-cell lymphoma	[ICD-11: 2A90]	Neoplasms
3	P36896	ACVR1B	T47594	Patented-recorded Target
4	Q9Y251	HPSE	T47623	Successful Target	African trypanosomiasis Ocular disease	[ICD-11: 1F51] [ICD-11: N.A.]	Certain infectious or parasitic diseases N.A
5	P29376	LTK	T47657	Literature-reported Target
6	P35372	OPRM1	T47768	Successful Target	Acute pain Bowel habit change Chronic pain Corneal disease Cough Depression Digestive system disease Irritable bowel syndrome Large intestine motility disorder Opioid use disorder Pain Pruritus Sensation disturbance	[ICD-11: MG31] [ICD-11: ME05] [ICD-11: MG30] [ICD-11: 9A76-9A78] [ICD-11: MD12] [ICD-11: 6A70-6A7Z] [ICD-11: DE2Z] [ICD-11: DD91] [ICD-11: DB32] [ICD-11: 6C43] [ICD-11: MG30-MG3Z] [ICD-11: EC90] [ICD-11: MB40]	Symptoms, signs or clinical findings, not elsewhere classified Symptoms, signs or clinical findings, not elsewhere classified Symptoms, signs or clinical findings, not elsewhere classified Diseases of the visual system Symptoms, signs or clinical findings, not elsewhere classified Mental, behavioural or neurodevelopmental disorders Diseases of the digestive system Diseases of the digestive system Diseases of the digestive system Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified Diseases of the skin Symptoms, signs or clinical findings, not elsewhere classified
7	Q15139	PRKD1	T47885	Literature-reported Target	Solid tumour/cancer Urinary system disease	[ICD-11: 2A00-2F9Z] [ICD-11: GC2Z]	Neoplasms Diseases of the genitourinary system
8	O95136	S1PR2	T47888	Clinical trial target	Ulcerative colitis	[ICD-11: DD71]	Diseases of the digestive system
9	P08069	IGF1R	T48069	Successful Target	Multiple structural anomalies syndrome Pituitary gland disorder Thyrotoxicosis	[ICD-11: LD2F] [ICD-11: 5A60-5A61] [ICD-11: 5A02]	Developmental anomalies Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
10	P49286	MTNR1B	T48268	Successful Target	Insomnia	[ICD-11: 7A00-7A0Z]	Sleep-wake disorders
11	Q01650	SLC7A5	T48330	Literature-reported Target
12	P01116	KRAS	T48598	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
13	Q9NR97	TLR8	T48703	Clinical trial target	Epidermal dysplasias Hepatitis virus infection Herpes simplex infection Lupus erythematosus Melanoma Mycosis fungoides Solid tumour/cancer Squamous cell carcinoma Vasomotor/allergic rhinitis	[ICD-11: EK90] [ICD-11: 1E50-1E51] [ICD-11: 1F00] [ICD-11: 4A40] [ICD-11: 2C30] [ICD-11: 2B01] [ICD-11: 2A00-2F9Z] [ICD-11: 2B60-2D01] [ICD-11: CA08]	Diseases of the skin Certain infectious or parasitic diseases Certain infectious or parasitic diseases Diseases of the immune system Neoplasms Neoplasms Neoplasms Neoplasms Diseases of the respiratory system
14	Q07108	CD69	T48780	Literature-reported Target
15	Q92753	RORB	T48812	Patented-recorded Target
16	Q05940	SLC18A2	T48873	Successful Target	Choreiform disorder Dissociative neurological symptom disorder Dystonic disorder Essential hypertension Hypertension	[ICD-11: 8A01] [ICD-11: 6B60] [ICD-11: 8A02] [ICD-11: BA00] [ICD-11: BA00-BA04]	Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Diseases of the circulatory system Diseases of the circulatory system
17	P28074	PSMB5	T49031	Patented-recorded Target
18	Q9UKP6	UTS2R	T49072	Clinical trial target	Asthma	[ICD-11: CA23]	Diseases of the respiratory system
19	P51955	NEK2	T49102	Literature-reported Target
20	P79483	HLA-DRB3	T49146	Clinical trial target	Influenza Leukaemia Malignant haematopoietic neoplasm Solid tumour/cancer	[ICD-11: 1E30-1E32] [ICD-11: 2A60-2B33] [ICD-11: 2B33] [ICD-11: 2A00-2F9Z]	Certain infectious or parasitic diseases Neoplasms Neoplasms Neoplasms
21	P17706	PTPN2	T49156	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
22	P54760	EPHB4	T49507	Clinical trial target	Brain cancer Cystic/dysplastic kidney disease Lung cancer Metastatic meninges neoplasm Metastatic tumour	[ICD-11: 2A00] [ICD-11: GB8Y] [ICD-11: 2C25] [ICD-11: 2D51] [ICD-11: 2D50-2E2Z]	Neoplasms Diseases of the genitourinary system Neoplasms Neoplasms Neoplasms
23	P51787	KCNQ1	T49526	Successful Target	Hypertension	[ICD-11: BA00-BA04]	Diseases of the circulatory system
24	Q15569	TESK1	T49542	Literature-reported Target
25	P0DMV8	HSPA1A	T49639	Clinical trial target	Diabetic foot ulcer Herpes simplex infection Leukaemia Malignant digestive organ neoplasm Metastatic malignant neoplasm Neuropathy Solid tumour/cancer Stomach cancer	[ICD-11: BD54] [ICD-11: 1F00] [ICD-11: 2A60-2B33] [ICD-11: 2C11] [ICD-11: 2D50-2E09] [ICD-11: 8C0Z] [ICD-11: 2A00-2F9Z] [ICD-11: 2B72]	Diseases of the circulatory system Certain infectious or parasitic diseases Neoplasms Neoplasms Neoplasms Diseases of the nervous system Neoplasms Neoplasms