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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P00750	PLAT	T45299	Successful Target	Bleeding disorder Procedure injury	[ICD-11: GA20-GA21] [ICD-11: NE81]	Diseases of the genitourinary system Injury, poisoning or certain other consequences of external causes
2	P06748	NPM1	T45591	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
3	P10636	MAPT	T45593	Clinical trial target	Acute myeloid leukaemia Alzheimer disease Mild neurocognitive disorder	[ICD-11: 2A60] [ICD-11: 8A20] [ICD-11: 6D71]	Neoplasms Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders
4	P20142	PGC	T45601	Literature-reported Target
5	P03951	F11	T46040	Clinical trial target	Cerebral ischaemic stroke Clotting disorder	[ICD-11: 8B11] [ICD-11: 3B4Z]	Diseases of the nervous system Diseases of the blood or blood-forming organs
6	P08172	CHRM2	T46185	Successful Target	Asthma Glaucoma Muscle disorder Peptic ulcer Respiratory system disease Sebaceous gland disorder	[ICD-11: CA23] [ICD-11: 9C61] [ICD-11: FB32-FB3Z] [ICD-11: DA61] [ICD-11: CB40-CB7Z] [ICD-11: ED91]	Diseases of the respiratory system Diseases of the visual system Diseases of the musculoskeletal system or connective tissue Diseases of the digestive system Diseases of the respiratory system Diseases of the skin
7	Q9H8M2	BRD9	T46216	Literature-reported Target	Acute myeloid leukaemia	[ICD-11: 2A60]	Neoplasms
8	Q16769	QPCT	T46245	Clinical trial target	Dementia	[ICD-11: 6D80-6D8Z]	Mental, behavioural or neurodevelopmental disorders
9	Q99720	SIGMAR1	T46360	Successful Target	Cough	[ICD-11: MD12]	Symptoms, signs or clinical findings, not elsewhere classified
10	P48443	RXRG	T46456	Successful Target	Kaposi sarcoma Light sensitivity impairment	[ICD-11: 2B57] [ICD-11: 9D45]	Neoplasms Diseases of the visual system
11	Q9NYK1	TLR7	T46482	Successful Target	Malaria Skin disease	[ICD-11: 1F40-1F45] [ICD-11: EA00-EM0Z]	Certain infectious or parasitic diseases Neoplasms
12	P41252	IARS	T46515	Literature-reported Target
13	P46952	HAAO	T46527	Literature-reported Target
14	P55157	MTTP	T46628	Successful Target	Hyper-lipoproteinaemia	[ICD-11: 5C80]	Endocrine, nutritional or metabolic diseases
15	P49759	CLK1	T46685	Patented-recorded Target
16	Q96GD4	AURKB	T46781	Clinical trial target	Acute diabete complication Solid tumour/cancer	[ICD-11: 5A2Y] [ICD-11: 2A00-2F9Z]	Endocrine, nutritional or metabolic diseases Neoplasms
17	Q9Y6L6	SLCO1B1	T46814	Literature-reported Target
18	P21918	DRD5	T46828	Successful Target	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	Diseases of the immune system
19	Q9H244	P2RY12	T46937	Successful Target	Myocardial infarction Thrombosis	[ICD-11: BA41-BA43] [ICD-11: DB61-GB90]	Diseases of the circulatory system Diseases of the digestive system
20	P62937	PPIA	T47081	Successful Target	Nutritional deficiency	[ICD-11: 5B50-5B71]	Endocrine, nutritional or metabolic diseases
21	P35270	SPR	T47094	Successful Target	Depression Nausea/vomiting	[ICD-11: 6A70-6A7Z] [ICD-11: MD90]	Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified
22	P11362	FGFR1	T47101	Successful Target	Colorectal cancer Idiopathic interstitial pneumonitis Liver cancer Thrombocytopenia	[ICD-11: 2B91] [ICD-11: CB03] [ICD-11: 2C12] [ICD-11: 3B64]	Neoplasms Diseases of the respiratory system Neoplasms Diseases of the blood or blood-forming organs
23	P05129	PRKCG	T47107	Successful Target	Acute myeloid leukaemia Mastocytosis	[ICD-11: 2A60] [ICD-11: 2A21]	Neoplasms Neoplasms
24	P26927	MST1	T47164	Literature-reported Target	Ischemic heart disease	[ICD-11: BA40-BA6Z]	Diseases of the circulatory system
25	O43826	SLC37A4	T47306	Literature-reported Target