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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	O75899	GABBR2	T42446	Successful Target	Depression Epilepsy/seizure Multiple sclerosis Narcolepsy	[ICD-11: 6A70-6A7Z] [ICD-11: 8A61-8A6Z] [ICD-11: 8A40] [ICD-11: 7A20]	Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Diseases of the nervous system Sleep-wake disorders
2	O15075	DCLK1	T42447	Literature-reported Target
3	Q93009	USP7	T42658	Preclinical target	Postoperative inflammation Solid tumour/cancer	[ICD-11: 1A00-CA43] [ICD-11: 2A00-2F9Z]	Postoperative inflammation Neoplasms
4	O15554	KCNN4	T42724	Clinical trial target	Alzheimer disease Chronic pain	[ICD-11: 8A20] [ICD-11: MG30]	Diseases of the nervous system Symptoms, signs or clinical findings, not elsewhere classified
5	Q9UBS0	RPS6KB2	T42760	Clinical trial target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
6	Q96PY6	NEK1	T43031	Literature-reported Target
7	P08575	PTPRC	T43115	Clinical trial target	Acute myeloid leukaemia Transplanted organ/tissue	[ICD-11: 2A60] [ICD-11: QB63]	Neoplasms Factors influencing health status or contact with health services
8	P35398	RORA	T43206	Preclinical target	Liver cancer Type 2 diabetes mellitus	[ICD-11: 2C12] [ICD-11: 5A11]	Neoplasms Endocrine, nutritional or metabolic diseases
9	O60259	KLK8	T43289	Literature-reported Target
10	P08709	F7	T43332	Successful Target	Coagulation defect	[ICD-11: 3B10]	Diseases of the blood or blood-forming organs
11	P80365	HSD11B2	T43721	Clinical trial target	Type 2 diabetes mellitus	[ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases
12	Q9Y5Y9	SCN10A	T43739	Successful Target	Corneal disease Human immunodeficiency virus disease Sensation disturbance Substance abuse	[ICD-11: 9A76-9A78] [ICD-11: 1C60-1C62] [ICD-11: MB40] [ICD-11: 6C40]	Diseases of the visual system Certain infectious or parasitic diseases Symptoms, signs or clinical findings, not elsewhere classified Mental, behavioural or neurodevelopmental disorders
13	P14061	HSD17B1	T44011	Clinical trial target
14	P08588	ADRB1	T44068	Successful Target	Allergic/hypersensitivity disorder Asthma Cardiac arrhythmia Central and peripheral nervous disease Circulatory system disease Conduction disorder Coronary atherosclerosis Essential hypertension Glaucoma Heart failure Hypertension Migraine Sepsis Supraventricular tachyarrhythmia Ventricular tachyarrhythmia	[ICD-11: 4A80-4A8Z] [ICD-11: CA23] [ICD-11: BC9Z] [ICD-11: 8A04-8E7Z] [ICD-11: BE2Z] [ICD-11: BC63] [ICD-11: BA52] [ICD-11: BA00] [ICD-11: 9C61] [ICD-11: BD10-BD1Z] [ICD-11: BA00-BA04] [ICD-11: 8A80] [ICD-11: 1G40-1G41] [ICD-11: BC81] [ICD-11: BC71]	Diseases of the immune system Diseases of the respiratory system Diseases of the circulatory system Diseases of the nervous system Diseases of the circulatory system Diseases of the circulatory system Diseases of the circulatory system Diseases of the circulatory system Diseases of the visual system Diseases of the circulatory system Diseases of the circulatory system Diseases of the nervous system Certain infectious or parasitic diseases Diseases of the circulatory system Diseases of the circulatory system
15	Q92772	CDKL2	T44341	Literature-reported Target
16	O15146	MUSK	T44387	Literature-reported Target
17	P50750	CDK9	T44458	Clinical trial target	Acute myeloid leukaemia Lymphoma Malignant haematopoietic neoplasm Mature B-cell leukaemia Mature B-cell lymphoma Non-alcoholic fatty liver disease Solid tumour/cancer	[ICD-11: 2A60] [ICD-11: 2A80-2A86] [ICD-11: 2B33] [ICD-11: 2A82] [ICD-11: 2A85] [ICD-11: DB92] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Diseases of the digestive system Neoplasms
18	Q14721	KCNB1	T44516	Literature-reported Target
19	P48775	TDO2	T44818	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
20	Q05655	PRKCD	T44861	Clinical trial target	Myocardial infarction	[ICD-11: BA41-BA43]	Diseases of the circulatory system
21	P01275	GCG	T44919	Clinical trial target	Acute diabete complication Diabetes mellitus Obesity Parkinsonism Type 2 diabetes mellitus	[ICD-11: 5A2Y] [ICD-11: 5A10] [ICD-11: 5B80-5B81] [ICD-11: 8A00] [ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Diseases of the nervous system Endocrine, nutritional or metabolic diseases
22	P19320	VCAM1	T44991	Literature-reported Target
23	Q96T53	FKSG89	T45228	Patented-recorded Target	Obesity Type 2 diabetes mellitus	[ICD-11: 5B80-5B81] [ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
24	P34998	CRHR1	T45262	Successful Target	Staphylococcal/streptococcal disease	[ICD-11: 1B5Y]	Certain infectious or parasitic diseases
25	Q9ULA0	DNPEP	T45287	Clinical trial target	Hypertension	[ICD-11: BA00-BA04]	Diseases of the circulatory system