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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P15169	CPN1	T34471	Literature-reported Target
2	P27169	PON1	T34562	Literature-reported Target
3	P45880	VDAC2	T35158	Literature-reported Target
4	Q13489	BIRC3	T35173	Clinical trial target	Metastatic lymph node neoplasm	[ICD-11: 2D60]	Neoplasms
5	P28562	DUSP1	T35194	Clinical trial target	Lung cancer	[ICD-11: 2C25]	Neoplasms
6	P26447	S100A4	T35265	Literature-reported Target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
7	O95382	MAP3K6	T35283	Literature-reported Target
8	O35273	SMAD3	T35445	Preclinical target	Kidney fibrosis	[ICD-11: GC01]	Diseases of the genitourinary system
9	P01111	NRAS	T35486	Clinical trial target	Colorectal cancer Head and neck cancer Lung cancer Pancreatic cancer Solid tumour/cancer	[ICD-11: 2B91] [ICD-11: 2D42] [ICD-11: 2C25] [ICD-11: 2C10] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
10	P18054	ALOX12	T35527	Literature-reported Target
11	P10696	ALPG	T35565	Literature-reported Target
12	P20701	ITGAL	T35640	Successful Target	Psoriasis Visual system disease	[ICD-11: EA90] [ICD-11: 9E1Z]	Diseases of the skin Diseases of the visual system
13	P34913	EPHX2	T35734	Clinical trial target	Chronic obstructive pulmonary disease Hypertension	[ICD-11: CA22] [ICD-11: BA00-BA04]	Diseases of the respiratory system Diseases of the circulatory system
14	Q9H7B4	SMYD3	T35792	Preclinical target	Colon cancer Solid tumour/cancer	[ICD-11: 2B90] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
15	O95696	BRD1	T35809	Literature-reported Target
16	P51512	MMP16	T35824	Literature-reported Target
17	Q01726	MC1R	T35842	Successful Target	Hypoactive sexual desire dysfunction Inborn porphyrin/heme metabolism error	[ICD-11: HA00] [ICD-11: 5C58]	Conditions related to sexual health Endocrine, nutritional or metabolic diseases
18	Q6ZQN7	SLCO4C1	T36053	Successful Target	Cardiac arrhythmia Heart failure	[ICD-11: BC9Z] [ICD-11: BD10-BD1Z]	Diseases of the circulatory system Diseases of the circulatory system
19	P0DMS8	ADORA3	T36059	Clinical trial target	Psoriasis Solid tumour/cancer	[ICD-11: EA90] [ICD-11: 2A00-2F9Z]	Diseases of the skin Neoplasms
20	P43220	GLP1R	T36075	Successful Target	Type 2 diabetes mellitus Type-1/2 diabete	[ICD-11: 5A11] [ICD-11: 5A10-5A11]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
21	P01106	MYC	T36121	Literature-reported Target
22	P29120	PCSK1	T36445	Literature-reported Target
23	P25116	F2R	T36483	Successful Target	Myocardial infarction	[ICD-11: BA41-BA43]	Diseases of the circulatory system
24	Q03181	PPARD	T36557	Clinical trial target	Non-alcoholic fatty liver disease Obesity	[ICD-11: DB92] [ICD-11: 5B80-5B81]	Diseases of the digestive system Endocrine, nutritional or metabolic diseases
25	Q16644	MAPKAPK3	T36581	Literature-reported Target