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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	Q9Y3Q4	HCN4	T30286	Literature-reported Target
2	Q96RI0	F2RL3	T30414	Literature-reported Target
3	Q9NQR1	KMT5A	T30420	Preclinical target	Liver cancer Solid tumour/cancer	[ICD-11: 2C12] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
4	Q9H0K1	SIK2	T30495	Clinical trial target	Ovarian cancer	[ICD-11: 2C73]	Neoplasms
5	Q9NPC1	LTB4R2	T30563	Clinical trial target	Human immunodeficiency virus disease Renal cell carcinoma	[ICD-11: 1C60-1C62] [ICD-11: 2C90]	Certain infectious or parasitic diseases Neoplasms
6	P02778	CXCL10	T30635	Clinical trial target	Crohn disease Diabetes mellitus Immune system disease Indeterminate colitis Solid tumour/cancer Ulcerative colitis	[ICD-11: DD70] [ICD-11: 5A10] [ICD-11: 4A01-4B41] [ICD-11: DD72] [ICD-11: 2A00-2F9Z] [ICD-11: DD71]	Diseases of the digestive system Endocrine, nutritional or metabolic diseases Diseases of the immune system Diseases of the digestive system Neoplasms Diseases of the digestive system
7	P01042	KNG1	T30731	Clinical trial target	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	Diseases of the immune system
8	P00390	GSR	T30803	Patented-recorded Target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
9	O15269	SPTLC1	T30817	Literature-reported Target	Hepatitis virus infection	[ICD-11: 1E50-1E51]	Certain infectious or parasitic diseases
10	P21673	SAT1	T30844	Literature-reported Target
11	P62993	GRB2	T30926	Clinical trial target	Acute myeloid leukaemia Malignant haematopoietic neoplasm Mature B-cell lymphoma Myelodysplastic syndrome Myeloproliferative neoplasm	[ICD-11: 2A60] [ICD-11: 2B33] [ICD-11: 2A85] [ICD-11: 2A37] [ICD-11: 2A20]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
12	P25021	HRH2	T30985	Successful Target	Gastro-oesophageal reflux disease Oesophageal/gastroduodenal disorder Peptic ulcer	[ICD-11: DA22] [ICD-11: DD90] [ICD-11: DA61]	Diseases of the digestive system Diseases of the digestive system Diseases of the digestive system
13	P06730	EIF4E	T31186	Literature-reported Target
14	P41595	HTR2B	T31204	Successful Target	Attention deficit hyperactivity disorder Depression Pituitary gland disorder Psychotic disorder	[ICD-11: 6A05] [ICD-11: 6A70-6A7Z] [ICD-11: 5A60-5A61] [ICD-11: 6A20-6A25]	Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Endocrine, nutritional or metabolic diseases Mental, behavioural or neurodevelopmental disorders
15	P10415	BCL2	T31309	Successful Target	Breast cancer Mature B-cell leukaemia Motor neuron disease Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: 2A82] [ICD-11: 8B60] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Diseases of the nervous system Neoplasms
16	P27487	DPP4	T31391	Successful Target	Acute diabete complication Type 2 diabetes mellitus	[ICD-11: 5A2Y] [ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
17	P08631	HCK	T31406	Patented-recorded Target	Indeterminate colitis	[ICD-11: DD72]	Diseases of the digestive system
18	P04054	PLA2G1B	T31479	Successful Target	Leishmaniasis Peroxisomal disease Rosacea Synthesis disorder	[ICD-11: 1F54] [ICD-11: 5C57] [ICD-11: ED90] [ICD-11: 5C52-5C59]	Certain infectious or parasitic diseases Endocrine, nutritional or metabolic diseases Diseases of the skin Endocrine, nutritional or metabolic diseases
19	P10253	GAA	T31514	Successful Target	Inborn carbohydrate metabolism error	[ICD-11: 5C51]	Endocrine, nutritional or metabolic diseases
20	Q9Y5Y6	ST14	T31543	Patented-recorded Target
21	Q99519	NEU1	T31595	Successful Target	Influenza	[ICD-11: 1E30-1E32]	Certain infectious or parasitic diseases
22	P09038	FGF2	T31621	Successful Target	Acne vulgaris	[ICD-11: ED80]	Diseases of the skin
23	P43005	SLC1A1	T31721	Literature-reported Target
24	O15427	SLC16A3	T31788	Literature-reported Target
25	O14672	ADAM10	T31902	Clinical trial target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms