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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	O14842	FFAR1	T25608	Clinical trial target	Type 2 diabetes mellitus	[ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases
2	Q9Y4K0	LOXL2	T25637	Clinical trial target	Colorectal cancer	[ICD-11: 2B91]	Neoplasms
3	P09601	HMOX1	T25703	Clinical trial target	Neonatal hyperbilirubinaemia	[ICD-11: KA87]	Certain conditions originating in the perinatal period
4	Q6L5J4	FPRL2	T25705	Literature-reported Target	Alzheimer disease	[ICD-11: 8A20]	Diseases of the nervous system
5	P23284	PPIB	T25847	Successful Target	Nutritional deficiency	[ICD-11: 5B50-5B71]	Endocrine, nutritional or metabolic diseases
6	Q13507	TRPC3	T25861	Literature-reported Target
7	Q09472	EP300	T25956	Clinical trial target	Prostate cancer Solid tumour/cancer	[ICD-11: 2C82] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
8	P05362	ICAM1	T26203	Successful Target	Visual system disease	[ICD-11: 9E1Z]	Diseases of the visual system
9	Q9UHJ5	PRLR	T26226	Clinical trial target	Fallopian tube cancer Ovarian cancer Peritoneal cancer Solid tumour/cancer	[ICD-11: 2C74] [ICD-11: 2C73] [ICD-11: 2C51] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Neoplasms
10	P31644	GABRA5	T26368	Successful Target	Intentional self-harm	[ICD-11: PC91]	External causes of morbidity or mortality
11	P05106	ITGB3	T26457	Literature-reported Target
12	Q9H3N8	HRH4	T26500	Clinical trial target	Asthma Atopic eczema Psoriasis Rheumatoid arthritis Vasomotor/allergic rhinitis	[ICD-11: CA23] [ICD-11: EA80] [ICD-11: EA90] [ICD-11: FA20] [ICD-11: CA08]	Diseases of the respiratory system Diseases of the skin Diseases of the skin Diseases of the musculoskeletal system or connective tissue Diseases of the respiratory system
13	P09848	LCT	T26617	Literature-reported Target
14	P15121	AKR1B1	T26623	Successful Target	Neuropathy Rheumatoid arthritis	[ICD-11: 8C0Z] [ICD-11: FA20]	Diseases of the nervous system Diseases of the musculoskeletal system or connective tissue
15	Q9Y6Q9	NCOA3	T26774	Literature-reported Target
16	O14764	GABRD	T27376	Successful Target	Depression Insomnia Mental/behavioural/neurodevelopmental disorder	[ICD-11: 6A70-6A7Z] [ICD-11: 7A00-7A0Z] [ICD-11: 6E20-6E8Z]	Mental, behavioural or neurodevelopmental disorders Sleep-wake disorders Mental, behavioural or neurodevelopmental disorders
17	Q9ULD4	KIAA1286	T27466	Literature-reported Target
18	Q07002	CDK18	T27577	Literature-reported Target
19	Q9HAN5	TRP1	T27602	Successful Target	Mature B-cell lymphoma Multiple myeloma	[ICD-11: 2A85] [ICD-11: 2A83]	Neoplasms Neoplasms
20	P31645	SLC6A4	T27812	Successful Target	Anxiety disorder Attention deficit hyperactivity disorder Chronic pain concerning food/fluid intake symptom Corneal disease Cough Depression Migraine Nicotine use disorder Obesity Pain	[ICD-11: 6B00-6B0Z] [ICD-11: 6A05] [ICD-11: MG30] [ICD-11: MG43] [ICD-11: 9A76-9A78] [ICD-11: MD12] [ICD-11: 6A70-6A7Z] [ICD-11: 8A80] [ICD-11: 6C4A] [ICD-11: 5B80-5B81] [ICD-11: MG30-MG3Z]	Mental, behavioural or neurodevelopmental disorders Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified Symptoms, signs or clinical findings, not elsewhere classified Diseases of the visual system Symptoms, signs or clinical findings, not elsewhere classified Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Endocrine, nutritional or metabolic diseases Symptoms, signs or clinical findings, not elsewhere classified
21	Q96SW2	CRBN	T27861	Clinical trial target	Brain cancer Diffuse large B-cell lymphoma Liver cancer Lupus erythematosus Lymphoma Mature B-cell leukaemia Multiple myeloma Sarcoidosis Solid tumour/cancer	[ICD-11: 2A00] [ICD-11: 2A81] [ICD-11: 2C12] [ICD-11: 4A40] [ICD-11: 2A80-2A86] [ICD-11: 2A82] [ICD-11: 2A83] [ICD-11: 4B20] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms Diseases of the immune system Neoplasms Neoplasms Neoplasms Diseases of the immune system Neoplasms
22	Q9BYF1	ACE2	T27889	Clinical trial target	Acute diabete complication Intrathoracic organs injury Pulmonary hypertension	[ICD-11: 5A2Y] [ICD-11: NB32] [ICD-11: BB01]	Endocrine, nutritional or metabolic diseases Injury, poisoning or certain other consequences of external causes Diseases of the circulatory system
23	P50391	NPY4R	T27944	Clinical trial target	Acute diabete complication Obesity Schizophrenia	[ICD-11: 5A2Y] [ICD-11: 5B80-5B81] [ICD-11: 6A20]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases Mental, behavioural or neurodevelopmental disorders
24	P01100	FOS	T28025	Literature-reported Target
25	Q15349	RPS6KA2	T28043	Literature-reported Target	Mature B-cell leukaemia	[ICD-11: 2A82]	Neoplasms