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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P49137	MAPKAPK2	T21307	Clinical trial target	Acute laryngitis/tracheitis Hidradenitis suppurativa Monogenic autoinflammatory syndrome Peritoneal cancer Psoriatic arthritis Rheumatoid arthritis Solid tumour/cancer	[ICD-11: CA05] [ICD-11: ED92] [ICD-11: 4A60] [ICD-11: 2C51] [ICD-11: FA21] [ICD-11: FA20] [ICD-11: 2A00-2F9Z]	Diseases of the respiratory system Diseases of the skin Diseases of the immune system Neoplasms Diseases of the musculoskeletal system or connective tissue Diseases of the musculoskeletal system or connective tissue Neoplasms
2	Q13370	PDE3B	T21357	Patented-recorded Target
3	Q01469	FABP5	T21507	Patented-recorded Target
4	P49761	CLK3	T21585	Literature-reported Target
5	O60285	NUAK1	T21653	Literature-reported Target
6	Q99707	MTR	T21661	Literature-reported Target
7	P09211	GSTP1	T21669	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
8	P12004	PCNA	T21782	Clinical trial target	Obesity	[ICD-11: 5B80-5B81]	Endocrine, nutritional or metabolic diseases
9	P23975	SLC6A2	T21945	Successful Target	Acute pain Attention deficit hyperactivity disorder Chronic pain Corneal disease Depression Glaucoma Migraine Nicotine use disorder Obesity Pain Stomach cancer	[ICD-11: MG31] [ICD-11: 6A05] [ICD-11: MG30] [ICD-11: 9A76-9A78] [ICD-11: 6A70-6A7Z] [ICD-11: 9C61] [ICD-11: 8A80] [ICD-11: 6C4A] [ICD-11: 5B80-5B81] [ICD-11: MG30-MG3Z] [ICD-11: 2B72]	Symptoms, signs or clinical findings, not elsewhere classified Mental, behavioural or neurodevelopmental disorders Symptoms, signs or clinical findings, not elsewhere classified Diseases of the visual system Mental, behavioural or neurodevelopmental disorders Diseases of the visual system Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Endocrine, nutritional or metabolic diseases Symptoms, signs or clinical findings, not elsewhere classified Neoplasms
10	P21728	DRD1	T22118	Successful Target	Abortion Allergic/hypersensitivity disorder Hypertension Parkinsonism	[ICD-11: JA00] [ICD-11: 4A80-4A8Z] [ICD-11: BA00-BA04] [ICD-11: 8A00]	Pregnancy, childbirth or the puerperium Diseases of the immune system Diseases of the circulatory system Diseases of the nervous system
11	Q9UBN7	HDAC6	T22274	Clinical trial target	Multiple myeloma Solid tumour/cancer	[ICD-11: 2A83] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms
12	Q12879	GRIN2A	T22285	Successful Target	Nutritional deficiency	[ICD-11: 5B50-5B71]	Endocrine, nutritional or metabolic diseases
13	P42858	HTT	T22496	Clinical trial target	Choreiform disorder	[ICD-11: 8A01]	Diseases of the nervous system
14	Q9NY91	SLC5A4	T22583	Clinical trial target	Acute diabete complication Type 2 diabetes mellitus	[ICD-11: 5A2Y] [ICD-11: 5A11]	Endocrine, nutritional or metabolic diseases Endocrine, nutritional or metabolic diseases
15	P10145	CXCL8	T22658	Successful Target	Pain	[ICD-11: MG30-MG3Z]	Symptoms, signs or clinical findings, not elsewhere classified
16	P49281	SLC11A2	T22717	Literature-reported Target
17	Q9UNI1	CELA1	T22839	Successful Target	Alpha-1-antitrypsin deficiency Bronchitis	[ICD-11: 5C5A] [ICD-11: CA20]	Endocrine, nutritional or metabolic diseases Diseases of the respiratory system
18	P06401	PGR	T22939	Successful Target	Breast cancer Contraceptive management Menstrual cycle bleeding disorder Preterm labour/delivery Solid tumour/cancer	[ICD-11: 2C60-2C6Y] [ICD-11: QA21] [ICD-11: GA20] [ICD-11: JB00] [ICD-11: 2A00-2F9Z]	Neoplasms Factors influencing health status or contact with health services Diseases of the genitourinary system Pregnancy, childbirth or the puerperium Neoplasms
19	Q00526	CDK3	T22956	Clinical trial target	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	Neoplasms
20	O00142	TK2	T22976	Clinical trial target	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Endocrine, nutritional or metabolic diseases
21	P52333	JAK3	T23172	Successful Target	Alopecia Atopic eczema Myeloproliferative neoplasm Rheumatoid arthritis	[ICD-11: ED70] [ICD-11: EA80] [ICD-11: 2A20] [ICD-11: FA20]	Diseases of the skin Diseases of the skin Neoplasms Diseases of the musculoskeletal system or connective tissue
22	P18564	ITGB6	T23178	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
23	P51843	NR0B1	T23191	Literature-reported Target
24	P11137	MAP2	T23276	Clinical trial target	Arteries/arterioles disorder Melanoma Pancreatic cancer Solid tumour/cancer	[ICD-11: BD52] [ICD-11: 2C30] [ICD-11: 2C10] [ICD-11: 2A00-2F9Z]	Diseases of the circulatory system Neoplasms Neoplasms Neoplasms
25	P05164	MPO	T23471	Clinical trial target	Left ventricular failure Postoperative inflammation	[ICD-11: BD11] [ICD-11: 1A00-CA43]	Diseases of the circulatory system Postoperative inflammation