List of therapeutic targets associated diseases


                                                                                                                                                        Sr. No. Uniprot ID Gene name TTD ID Target type Disease name ICD-11 Disease class
                                                                                                                                                        1P25101EDNRAT23499Successful Target
                                                                                                                                                      • Cardiovascular disease
                                                                                                                                                      • Pulmonary hypertension
                                                                                                                                                      • Urinary system clinical symptom
                                                                                                                                                      • [ICD-11: BA00-BE2Z]
                                                                                                                                                      • [ICD-11: BB01]
                                                                                                                                                      • [ICD-11: MF8Y]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Symptoms, signs or clinical findings, not elsewhere classified
                                                                                                                                                        • 2Q13237PRKG2T23606Literature-reported Target
                                                                                                                                                        3P35869AHRT23666Successful Target
                                                                                                                                                      • Psoriasis
                                                                                                                                                      • Thrombocytopenia
                                                                                                                                                      • [ICD-11: EA90]
                                                                                                                                                      • [ICD-11: 3B64]
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Diseases of the blood or blood-forming organs
                                                                                                                                                        • 4P30411BDKRB2T23714Successful Target
                                                                                                                                                      • Innate/adaptive immunodeficiency
                                                                                                                                                      • [ICD-11: 4A00]
                                                                                                                                                      • Diseases of the immune system
                                                                                                                                                        • 5Q96S53TESK2T23785Literature-reported Target
                                                                                                                                                        6Q16875PFKFB3T23787Clinical trial target
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 7Q9NPI1BRD7T23984Literature-reported Target
                                                                                                                                                        8Q04759PRKCQT23995Clinical trial target
                                                                                                                                                      • Transplant rejection
                                                                                                                                                      • [ICD-11: NE84]
                                                                                                                                                      • Injury, poisoning or certain other consequences of external causes
                                                                                                                                                        • 9P38571LIPAT24373Successful Target
                                                                                                                                                      • Enzyme deficiency
                                                                                                                                                      • [ICD-11: 5C51-5C57]
                                                                                                                                                      • Endocrine, nutritional or metabolic diseases
                                                                                                                                                        • 10P27708CADT24548Literature-reported Target
                                                                                                                                                        11P16455MGMTT24587Clinical trial target
                                                                                                                                                      • Sarcoma
                                                                                                                                                      • [ICD-11: 2A60-2C35]
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 12P10323ACRT24595Literature-reported Target
                                                                                                                                                        13Q01668CACNA1DT24793Clinical trial target
                                                                                                                                                      • Alzheimer disease
                                                                                                                                                      • [ICD-11: 8A20]
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                        • 14Q8NB78KDM1BT24823Patented-recorded Target
                                                                                                                                                        15P04070PROCT24836Successful Target
                                                                                                                                                      • Chronic lower extremities peripheral venous insufficiency
                                                                                                                                                      • Hemangioma
                                                                                                                                                      • [ICD-11: BD74]
                                                                                                                                                      • [ICD-11: 2E81-2F2Y]
                                                                                                                                                      • Diseases of the circulatory system
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 16Q13698CACNA1ST24965Literature-reported Target
                                                                                                                                                        17Q12908SLC10A2T24982Successful Target
                                                                                                                                                      • Pruritus
                                                                                                                                                      • [ICD-11: EC90]
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                        • 18P21917DRD4T24983Successful Target
                                                                                                                                                      • Allergic/hypersensitivity disorder
                                                                                                                                                      • Schizophrenia
                                                                                                                                                      • [ICD-11: 4A80-4A8Z]
                                                                                                                                                      • [ICD-11: 6A20]
                                                                                                                                                      • Diseases of the immune system
                                                                                                                                                      • Mental, behavioural or neurodevelopmental disorders
                                                                                                                                                        • 19Q05823RNASELT25200Literature-reported Target
                                                                                                                                                        20P08183ABCB1T25258Clinical trial target
                                                                                                                                                      • Lung cancer
                                                                                                                                                      • [ICD-11: 2C25]
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 21Q15910EZH2T25265Successful Target
                                                                                                                                                      • Follicular lymphoma
                                                                                                                                                      • [ICD-11: 2A80]
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 22P51449RORCT25307Clinical trial target
                                                                                                                                                      • Autoimmune disease
                                                                                                                                                      • Crohn disease
                                                                                                                                                      • Lung cancer
                                                                                                                                                      • Multiple sclerosis
                                                                                                                                                      • Psoriasis
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • [ICD-11: 4A40-4A45]
                                                                                                                                                      • [ICD-11: DD70]
                                                                                                                                                      • [ICD-11: 2C25]
                                                                                                                                                      • [ICD-11: 8A40]
                                                                                                                                                      • [ICD-11: EA90]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • Diseases of the immune system
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                      • Neoplasms
                                                                                                                                                      • Diseases of the nervous system
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 23P49682CXCR3T25315Preclinical target
                                                                                                                                                      • Hepatic fibrosis/cirrhosis
                                                                                                                                                      • Postoperative inflammation
                                                                                                                                                      • Psoriasis
                                                                                                                                                      • Solid tumour/cancer
                                                                                                                                                      • [ICD-11: DB93]
                                                                                                                                                      • [ICD-11: 1A00-CA43]
                                                                                                                                                      • [ICD-11: EA90]
                                                                                                                                                      • [ICD-11: 2A00-2F9Z]
                                                                                                                                                      • Diseases of the digestive system
                                                                                                                                                      • Postoperative inflammation
                                                                                                                                                      • Diseases of the skin
                                                                                                                                                      • Neoplasms
                                                                                                                                                        • 24Q15125EBPT25317Clinical trial target
                                                                                                                                                      • Rheumatoid arthritis
                                                                                                                                                      • [ICD-11: FA20]
                                                                                                                                                      • Diseases of the musculoskeletal system or connective tissue
                                                                                                                                                        • 25Q9Y4C1KDM3AT25362Literature-reported Target