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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P16389	KCNA2	T19492	Literature-reported Target
2	O95622	ADCY5	T19531	Literature-reported Target
3	O60502	OGA	T19567	Clinical trial target	Alzheimer disease Parkinsonism	[ICD-11: 8A20] [ICD-11: 8A00]	Diseases of the nervous system Diseases of the nervous system
4	P80192	MAP3K9	T19760	Clinical trial target	Asthma	[ICD-11: CA23]	Diseases of the respiratory system
5	P42229	STAT5A	T20027	Patented-recorded Target
6	Q8TDC3	BRSK1	T20053	Literature-reported Target
7	P01375	TNF	T20178	Successful Target	Arterial occlusive disease Multiple myeloma Psoriasis Rheumatoid arthritis	[ICD-11: BD40] [ICD-11: 2A83] [ICD-11: EA90] [ICD-11: FA20]	Diseases of the circulatory system Neoplasms Diseases of the skin Diseases of the musculoskeletal system or connective tissue
8	P19429	TNNI3	T20186	Literature-reported Target
9	Q12809	KCNH2	T20251	Successful Target	Heart failure	[ICD-11: BD10-BD1Z]	Diseases of the circulatory system
10	P07333	CSF1R	T20333	Successful Target	Bone/articular cartilage neoplasm	[ICD-11: 2F7B]	Neoplasms
11	P42785	PRCP	T20371	Patented-recorded Target
12	P00918	CA2	T20401	Successful Target	Bacterial infection Essential hypertension Glaucoma Heart failure Insomnia Seborrhoeic dermatitis	[ICD-11: 1A00-1C4Z] [ICD-11: BA00] [ICD-11: 9C61] [ICD-11: BD10-BD1Z] [ICD-11: 7A00-7A0Z] [ICD-11: EA81]	Certain infectious or parasitic diseases Diseases of the circulatory system Diseases of the visual system Diseases of the circulatory system Sleep-wake disorders Diseases of the skin
13	Q9NR20	DYRK4	T20542	Literature-reported Target
14	P51685	CCR8	T20575	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
15	P42226	STAT6	T20585	Literature-reported Target
16	P55212	CASP6	T20600	Patented-recorded Target
17	P08173	CHRM4	T20709	Successful Target	Asthma Eye anterior segment structural developmental anomaly Glaucoma Nausea/vomiting Respiratory system disease	[ICD-11: CA23] [ICD-11: LA11] [ICD-11: 9C61] [ICD-11: MD90] [ICD-11: CB40-CB7Z]	Diseases of the respiratory system Developmental anomalies Diseases of the visual system Symptoms, signs or clinical findings, not elsewhere classified Diseases of the respiratory system
18	P15692	VEGFA	T20761	Successful Target	Colorectal cancer Retinopathy Vascular system developmental anomaly	[ICD-11: 2B91] [ICD-11: 9B71] [ICD-11: LA90]	Neoplasms Diseases of the visual system Developmental anomalies
19	O60825	PFKFB2	T20776	Literature-reported Target
20	Q15118	PDK1	T20891	Clinical trial target	Lymphoma	[ICD-11: 2A80-2A86]	Neoplasms
21	O43683	BUB1	T20953	Patented-recorded Target
22	Q6W5P4	NPSR1	T20958	Patented-recorded Target
23	Q00535	CDK5	T20973	Patented-recorded Target	Obesity	[ICD-11: 5B80-5B81]	Endocrine, nutritional or metabolic diseases
24	Q9Y239	NOD1	T21038	Literature-reported Target
25	Q99814	EPAS1	T21123	Successful Target	Adrenomedullary hyperfunction	[ICD-11: 5A75]	Endocrine, nutritional or metabolic diseases