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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P22460	KCNA5	T17569	Successful Target	Angina pectoris	[ICD-11: BA40]	Diseases of the circulatory system
2	P48051	KCNJ6	T17721	Literature-reported Target
3	P00749	PLAU	T17758	Successful Target	Inherited coagulation factor deficiency Myocardial infarction	[ICD-11: 3B14] [ICD-11: BA41-BA43]	Diseases of the blood or blood-forming organs Diseases of the circulatory system
4	O76083	PDE9A	T17852	Clinical trial target	Alzheimer disease Dementia Genitourinary disease Heart failure Mental/behavioural/neurodevelopmental disorder Parkinsonism Schizophrenia Sickle-cell disorder	[ICD-11: 8A20] [ICD-11: 6D80-6D8Z] [ICD-11: GA0Z-GC8Z] [ICD-11: BD10-BD1Z] [ICD-11: 6E20-6E8Z] [ICD-11: 8A00] [ICD-11: 6A20] [ICD-11: 3A51]	Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Diseases of the genitourinary system Diseases of the circulatory system Mental, behavioural or neurodevelopmental disorders Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders Diseases of the blood or blood-forming organs
5	P0DJD9	PGA5	T17863	Literature-reported Target
6	Q15119	PDK2	T17967	Literature-reported Target	Acute diabete complication	[ICD-11: 5A2Y]	Endocrine, nutritional or metabolic diseases
7	P06241	FYN	T17980	Successful Target	Myeloproliferative neoplasm	[ICD-11: 2A20]	Neoplasms
8	Q92800	EZH1	T17986	Clinical trial target	Acute myeloid leukaemia Lung cancer Malignant haematopoietic neoplasm Mature B-cell lymphoma Mature T-cell lymphoma Renal cell carcinoma Solid tumour/cancer Ureteral cancer	[ICD-11: 2A60] [ICD-11: 2C25] [ICD-11: 2B33] [ICD-11: 2A85] [ICD-11: 2A90] [ICD-11: 2C90] [ICD-11: 2A00-2F9Z] [ICD-11: 2C92]	Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
9	Q9UQM7	CAMK2A	T18299	Clinical trial target	Rheumatoid arthritis	[ICD-11: FA20]	Diseases of the musculoskeletal system or connective tissue
10	Q9NRM7	LATS2	T18390	Literature-reported Target
11	P54756	EPHA5	T18474	Literature-reported Target
12	P07900	HSP90AA1	T18477	Successful Target	Acute upper respiratory infection Asthma	[ICD-11: CA07] [ICD-11: CA23]	Diseases of the respiratory system Diseases of the respiratory system
13	Q9H1C0	LPAR5	T18616	Literature-reported Target
14	P05230	FGF1	T18639	Clinical trial target	Chronic arterial occlusive disease Coronary atherosclerosis	[ICD-11: BD4Z] [ICD-11: BA52]	Diseases of the circulatory system Diseases of the circulatory system
15	Q99685	MGLL	T18664	Clinical trial target	General pain disorder Tic disorder	[ICD-11: 8E43] [ICD-11: 8A05]	Diseases of the nervous system Diseases of the nervous system
16	Q6ZMT4	KDM7A	T18784	Literature-reported Target
17	P35408	PTGER4	T18876	Clinical trial target	Asthma Heart failure Migraine Non-small-cell lung cancer Pain Rectum cancer Solid tumour/cancer Transplanted organ/tissue	[ICD-11: CA23] [ICD-11: BD10-BD1Z] [ICD-11: 8A80] [ICD-11: 2C25] [ICD-11: MG30-MG3Z] [ICD-11: 2B92] [ICD-11: 2A00-2F9Z] [ICD-11: QB63]	Diseases of the respiratory system Diseases of the circulatory system Diseases of the nervous system Neoplasms Symptoms, signs or clinical findings, not elsewhere classified Neoplasms Neoplasms Factors influencing health status or contact with health services
18	O75164	KDM4A	T18904	Patented-recorded Target
19	P14555	PLA2G2A	T19160	Clinical trial target	Breast cancer	[ICD-11: 2C60-2C6Y]	Neoplasms
20	P06737	PYGL	T19184	Patented-recorded Target
21	Q96NT5	SLC46A1	T19229	Successful Target	Folate deficiency anaemia Leukaemia Nutritional deficiency	[ICD-11: 3A02] [ICD-11: 2A60-2B33] [ICD-11: 5B50-5B71]	Diseases of the blood or blood-forming organs Neoplasms Endocrine, nutritional or metabolic diseases
22	P11712	CYP2C9	T19244	Successful Target	Bacterial infection	[ICD-11: 1A00-1C4Z]	Certain infectious or parasitic diseases
23	Q9Y5X9	LIPG	T19368	Clinical trial target	Chronic arterial occlusive disease Coagulation defect Coronary atherosclerosis	[ICD-11: BD4Z] [ICD-11: 3B10] [ICD-11: BA52]	Diseases of the circulatory system Diseases of the blood or blood-forming organs Diseases of the circulatory system
24	P02675	FGB	T19414	Successful Target	Bleeding disorder Skin postprocedural disorder	[ICD-11: GA20-GA21] N.A	Diseases of the genitourinary system Diseases of the skin
25	O60760	HPGDS	T19433	Successful Target	Flatworm infection	[ICD-11: 1F70-1F86]	Certain infectious or parasitic diseases