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List of therapeutic targets associated diseases

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Sr. No.	Uniprot ID	Gene name	TTD ID	Target type	Disease name	ICD-11	Disease class
1	P50406	HTR6	T16691	Clinical trial target	Alzheimer disease Schizophrenia	[ICD-11: 8A20] [ICD-11: 6A20]	Diseases of the nervous system Mental, behavioural or neurodevelopmental disorders
2	P80370	DLK1	T16738	Clinical trial target	Motor neuron disease	[ICD-11: 8B60]	Diseases of the nervous system
3	O60341	KDM1A	T16739	Clinical trial target	Acute myeloid leukaemia Alzheimer disease Ewing sarcoma Lung cancer Lymphoma Malignant haematopoietic neoplasm Myelodysplastic syndrome Myeloproliferative neoplasm Solid tumour/cancer	[ICD-11: 2A60] [ICD-11: 8A20] [ICD-11: 2B52] [ICD-11: 2C25] [ICD-11: 2A80-2A86] [ICD-11: 2B33] [ICD-11: 2A37] [ICD-11: 2A20] [ICD-11: 2A00-2F9Z]	Neoplasms Diseases of the nervous system Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms Neoplasms
4	P98170	XIAP	T16769	Clinical trial target	Metastatic lymph node neoplasm	[ICD-11: 2D60]	Neoplasms
5	O60344	ECE2	T16799	Literature-reported Target
6	Q99873	PRMT1	T16808	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
7	P19022	CDH2	T16868	Clinical trial target	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Neoplasms
8	P14091	CTSE	T16891	Literature-reported Target
9	Q92831	KAT2B	T16902	Literature-reported Target
10	O43570	CA12	T16987	Successful Target	Bacterial infection Seborrhoeic dermatitis	[ICD-11: 1A00-1C4Z] [ICD-11: EA81]	Certain infectious or parasitic diseases Diseases of the skin
11	P16591	FER	T16993	Literature-reported Target
12	P24593	IGFBP5	T17008	Literature-reported Target
13	Q6B0I6	KDM4D	T17036	Patented-recorded Target
14	P11388	TOP2A	T17048	Clinical trial target	Acute myeloid leukaemia Kaposi sarcoma Solid tumour/cancer	[ICD-11: 2A60] [ICD-11: 2B57] [ICD-11: 2A00-2F9Z]	Neoplasms Neoplasms Neoplasms
15	P45974	USP5	T17067	Preclinical target	Postoperative inflammation Solid tumour/cancer	[ICD-11: 1A00-CA43] [ICD-11: 2A00-2F9Z]	Postoperative inflammation Neoplasms
16	P56373	P2RX3	T17140	Clinical trial target	Cough	[ICD-11: MD12]	Symptoms, signs or clinical findings, not elsewhere classified
17	Q13163	MAP2K5	T17143	Literature-reported Target
18	P08263	GSTA1	T17221	Literature-reported Target
19	Q9Y6F1	PARP3	T17228	Patented-recorded Target
20	Q9Y6W6	DUSP10	T17339	Literature-reported Target
21	P00374	DHFR	T17345	Successful Target	Indeterminate colitis Solid tumour/cancer Tuberculosis Urinary tract infection	[ICD-11: DD72] [ICD-11: 2A00-2F9Z] [ICD-11: 1B10-1B12] [ICD-11: GC08]	Diseases of the digestive system Neoplasms Certain infectious or parasitic diseases Diseases of the genitourinary system
22	P50135	HNMT	T17448	Successful Target	Episodic vestibular syndrome Malaria	[ICD-11: AB31] [ICD-11: 1F40-1F45]	Diseases of the ear or mastoid process Certain infectious or parasitic diseases
23	O00255	MEN1	T17485	Clinical trial target	Acute myeloid leukaemia Malignant haematopoietic neoplasm	[ICD-11: 2A60] [ICD-11: 2B33]	Neoplasms Neoplasms
24	O95977	S1PR4	T17523	Literature-reported Target
25	Q9BYT3	STK33	T17552	Literature-reported Target