Cavipetin D



Compound IDCDAMM03025
Common nameCavipetin D
IUPAC name4-(16-hydroxy-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenoxy)-3-methyl-4-oxobut-2-enoic acid
Molecular formulaC25H38O5

Experimental data

Retention time1.35
Adduct[M+H]+
Actual mz419.274
Theoretical mz419.279
Error11.63
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.1827

Identifiers and class information

Inchi keyOYLSINCAGYDFBO-SDWHTVMGSA-N
SmilesO=C(O)C=C(C(=O)OCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CO)C
SuperclassLipids and lipid-like molecules
ClassPrenol lipids

Plant source

  • Clitoria ternatea L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)5
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)1
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)16
    Number of reactive functional groups (#rtvFG)2
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)418.572
    Computed dipole moment(dipole)1.604
    Total solvent accessible surface area (SASA)922.822
    Hydrophobic component of SASA (FOSA)660.255
    Hydrophilic component of SASA (FISA)208.126
    Pie component of the SASA (PISA)54.442
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1607.08
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)5.7
    Free energy of solvation of dipole (dip^2/V)0.0016016
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0087352
    Globularity descriptor (glob)0.719017
    Predicted polarizability in cubic angstroms (QPpolrz)48.408
    Predicted hexadecane/gas partition coefficient (QPlogPC16)16.17
    Predicted octanol/gas partition coefficient (QPlogPoct)21.415
    Predicted water/gas partition coefficient (QPlogPw)8.74
    Predicted octanol/water partition coefficient (QPlogPo/w)5.931
    Predicted aqueous solubility (QPlogS)-8.185
    Conformation-independent predicted aqueous solubility (CIQPlogS)-5.379
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.531
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)26.659
    Predicted brain/blood partition coefficient (QPlogBB)-3.085
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)12.512
    Predicted skin permeability, log Kp (QPlogKp)-3.627
    PM3 calculated ionization potential (IP(ev))9.415
    PM3 calculated electron affinity (EA(eV))0.903
    Number of likely metabolic reactions (#metab)13
    Prediction of binding to human serum albumin (QPlogKhsa)0.927
    Predicted qualitative human oral absorption (HumanOralAbsorption)1
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)74.231
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)106.5
    Number of nitrogen and oxygen atoms (#NandO)5
    Number of violations of Lipinski’s rule of five (RuleOfFive)1
    Number of violations of Jorgensen’s rule of three (RuleOfThree)2

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    Q12809KCNH2HERGT20251SwissTargetPrediction
    Q07820MCL1Induced myeloid leukemia cell differentiation protein Mcl-1T14912SwissTargetPrediction
    P04818TYMSThymidylate synthase (by homology)T98397SwissTargetPrediction
    P12821ACEAngiotensin-converting enzymeT98311SwissTargetPrediction
    O15379HDAC3Histone deacetylase 3T05090SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P08514ITGA2BIntegrin alpha-IIb/beta-3T50688SwissTargetPrediction
    Q96RI1NR1H4Bile acid receptor FXRT51426SwissTargetPrediction
    P08473MMENeprilysinT05409SwissTargetPrediction
    Q9UBN7HDAC6Histone deacetylase 6T22274SwissTargetPrediction
    Q92769HDAC2Histone deacetylase 2T51191SwissTargetPrediction
    P42330AKR1C3Aldo-keto-reductase family 1 member C3T60857SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P15090FABP4Fatty acid binding protein adipocyteT07217SwissTargetPrediction
    Q01469FABP5Fatty acid binding protein epidermalT21507SwissTargetPrediction
    Q8TDU6GPBAR1G-protein coupled bile acid receptor 1T86273SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    Q14534SQLESqualene monooxygenase (by homology)T93344SEA
    P00338LDHAL-lactate dehydrogenase A chainT15053SwissTargetPrediction
    P07195LDHBL-lactate dehydrogenase B chainT88057SwissTargetPrediction
    P21731TBXA2RThromboxane A2 receptorT76198SwissTargetPrediction
    P35372OPRM1Mu opioid receptorT47768SwissTargetPrediction
    P10827THRAThyroid hormone receptor alphaT79591SwissTargetPrediction
    P10828THRBThyroid hormone receptor beta-1T98933SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P13497BMP1Bone morphogenetic protein 1T53350SwissTargetPrediction
    P43116PTGER2Prostanoid EP2 receptorT38529SwissTargetPrediction
    Q9Y5Y4PTGDR2G protein-coupled receptor 44T61722SwissTargetPrediction
    P49356FNTBFarnesyl protein transferaseT13127SEA
    Q15722LTB4RLeukotriene B4 receptor 1T59626SwissTargetPrediction
    P31749AKT1Serine/threonine-protein kinase AKTT67619SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P10276RARARetinoic acid receptor alphaT94085SwissTargetPrediction
    P01375TNFTNF-alphaT20178SwissTargetPrediction
    P47871GCGRGlucagon receptorT60182SwissTargetPrediction
    P30556AGTR1Type-1 angiotensin II receptorT74456SwissTargetPrediction
    O00329PIK3CDPI3-kinase p110-delta subunitT67849SwissTargetPrediction
    P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P47712PLA2G4ACytosolic phospholipase A2T14834SwissTargetPrediction
    P35408PTGER4Prostanoid EP4 receptorT18876SwissTargetPrediction
    P06756ITGAVVitronectin receptor alphaT67103SwissTargetPrediction
    P05556ITGB1Integrin alpha2/beta1T01851SwissTargetPrediction
    P11362FGFR1Fibroblast growth factor receptor 1T47101SwissTargetPrediction
    P34995PTGER1Prostanoid EP1 receptorT15497SwissTargetPrediction
    Q12908SLC10A2Ileal bile acid transporterT24982SwissTargetPrediction
    Q13258PTGDRProstanoid DP receptorT68782SwissTargetPrediction
    P24557TBXAS1Thromboxane-A synthaseT78356SwissTargetPrediction
    P32239CCKBRCholecystokinin B receptor (by homology)T05849SwissTargetPrediction
    P43088PTGFRProstanoid FP receptorT75797SwissTargetPrediction
    P19793RXRARetinoid X receptor alpha (by homology)T13726SwissTargetPrediction
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    O76074PDE5APhosphodiesterase 5AT07663SwissTargetPrediction
    P31751AKT2Serine/threonine-protein kinase AKT2T94621SwissTargetPrediction
    P43119PTGIRProstanoid IP receptorT99954SwissTargetPrediction
    P29317EPHA2Ephrin type-A receptor 2T57278SwissTargetPrediction
    O00408PDE2APhosphodiesterase 2AT77400SwissTargetPrediction
    P10415BCL2Apoptosis regulator Bcl-2T31309SwissTargetPrediction
    P42224STAT1Signal transducer and activator of transcription 1-alpha/betaT64205SwissTargetPrediction
    P03951F11Coagulation factor XIT46040SwissTargetPrediction
    P28702RXRBRetinoid X receptor betaT60077SwissTargetPrediction
    P13631RARGRetinoic acid receptor gammaT82146SwissTargetPrediction
    P48443RXRGRetinoid X receptor gammaT46456SwissTargetPrediction
    P10826RARBRetinoic acid receptor betaT61657SwissTargetPrediction
    Q96DB2HDAC11Histone deacetylase 11T97903SwissTargetPrediction
    Q969S8HDAC10Histone deacetylase 10T94324SwissTargetPrediction
    O95136S1PR2Sphingosine 1-phosphate receptor Edg-5T47888SwissTargetPrediction
    Q14973SLC10A1Bile acid transporterT99189SwissTargetPrediction
    P42229STAT5ASignal transducer and activator of transcription 5AT20027SwissTargetPrediction
    P49356FNTBFarnesyl protein transferaseT13127SEA
    O95749GGPS1GeranyltranstransferaseT86528SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T20251DI0175Heart failure[ICD-11: BD10-BD1Z]Q12809KCNH2
    T14912DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q07820MCL1
    T14912DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]Q07820MCL1
    T14912DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q07820MCL1
    T14912DI0252Melanoma[ICD-11: 2C30]Q07820MCL1
    T14912DI0274Multiple myeloma[ICD-11: 2A83]Q07820MCL1
    T14912DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q07820MCL1
    T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
    T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
    T98311DI0175Heart failure[ICD-11: BD10-BD1Z]P12821ACE
    T98311DI0190Hypertension[ICD-11: BA00-BA04]P12821ACE
    T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
    T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T50688DI0007Acquired hypermelanosis[ICD-11: ED60]P08514ITGA2B
    T50688DI0030Angina pectoris[ICD-11: BA40]P08514ITGA2B
    T50688DI0287Myocardial infarction[ICD-11: BA41-BA43]P08514ITGA2B
    T51426DI0043Autoimmune liver disease[ICD-11: DB96]Q96RI1NR1H4
    T51426DI0077Cholelithiasis[ICD-11: DC11]Q96RI1NR1H4
    T51426DI0320Osteoarthritis[ICD-11: FA00-FA05]Q96RI1NR1H4
    T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
    T22274DI0274Multiple myeloma[ICD-11: 2A83]Q9UBN7HDAC6
    T22274DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UBN7HDAC6
    T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
    T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
    T60857DI0145Female pelvic pain[ICD-11: GA34]P42330AKR1C3
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T86273DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q8TDU6GPBAR1
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T93344DI0118Dermatophytosis[ICD-11: 1F28]Q14534SQLE
    T93344DI0385Skin fungal infection disorder[ICD-11: EA60]Q14534SQLE
    T76198DI0102Coronary atherosclerosis[ICD-11: BA52]P21731TBXA2R
    T76198DI0121Diabetic foot ulcer[ICD-11: BD54]P21731TBXA2R
    T76198DI0287Myocardial infarction[ICD-11: BA41-BA43]P21731TBXA2R
    T76198DI0378Sexual dysfunction[ICD-11: HA00-HA01]P21731TBXA2R
    T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
    T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
    T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
    T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
    T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
    T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
    T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
    T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
    T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
    T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
    T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
    T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
    T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
    T79591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10827THRA
    T79591DI0197Hypo-thyroidism[ICD-11: 5A00]P10827THRA
    T98933DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10828THRB
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T38529DI0003Abortion[ICD-11: JA00]P43116PTGER2
    T38529DI0102Coronary atherosclerosis[ICD-11: BA52]P43116PTGER2
    T38529DI0121Diabetic foot ulcer[ICD-11: BD54]P43116PTGER2
    T38529DI0166Glaucoma[ICD-11: 9C61]P43116PTGER2
    T38529DI0356Pulmonary hypertension[ICD-11: BB01]P43116PTGER2
    T38529DI0378Sexual dysfunction[ICD-11: HA00-HA01]P43116PTGER2
    T38529DI0413Transplant rejection[ICD-11: NE84]P43116PTGER2
    T61722DI0102Coronary atherosclerosis[ICD-11: BA52]Q9Y5Y4PTGDR2
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T59626DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]Q15722LTB4R
    T59626DI0355Pulmonary disease[ICD-11: 1B10-1F85]Q15722LTB4R
    T59626DI0361Renal cell carcinoma[ICD-11: 2C90]Q15722LTB4R
    T67619DI0062Breast cancer[ICD-11: 2C60-2C6Y]P31749AKT1
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T94085DI0025Alzheimer disease[ICD-11: 8A20]P10276RARA
    T94085DI0251Mature T-cell lymphoma[ICD-11: 2A90]P10276RARA
    T20178DI0035Arterial occlusive disease[ICD-11: BD40]P01375TNF
    T20178DI0274Multiple myeloma[ICD-11: 2A83]P01375TNF
    T20178DI0351Psoriasis[ICD-11: EA90]P01375TNF
    T20178DI0366Rheumatoid arthritis[ICD-11: FA20]P01375TNF
    T60182DI0193Hypo-glycaemia[ICD-11: 5A41]P47871GCGR
    T74456DI0137Essential hypertension[ICD-11: BA00]P30556AGTR1
    T74456DI0190Hypertension[ICD-11: BA00-BA04]P30556AGTR1
    T74456DI0373Secondary hypertension[ICD-11: BA04]P30556AGTR1
    T74456DI0425Urinary system clinical symptom[ICD-11: MF8Y]P30556AGTR1
    T67849DI0151Follicular lymphoma[ICD-11: 2A80]O00329PIK3CD
    T67849DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00329PIK3CD
    T67849DI0249Mature B-cell leukaemia[ICD-11: 2A82]O00329PIK3CD
    T67849DI0250Mature B-cell lymphoma[ICD-11: 2A85]O00329PIK3CD
    T67849DI0395Stomach cancer[ICD-11: 2B72]O00329PIK3CD
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T14834DI0039Atopic eczema[ICD-11: EA80]P47712PLA2G4A
    T18876DI0037Asthma[ICD-11: CA23]P35408PTGER4
    T18876DI0175Heart failure[ICD-11: BD10-BD1Z]P35408PTGER4
    T18876DI0264Migraine[ICD-11: 8A80]P35408PTGER4
    T18876DI0303Non-small-cell lung cancer[ICD-11: 2C25]P35408PTGER4
    T18876DI0324Pain[ICD-11: MG30-MG3Z]P35408PTGER4
    T18876DI0360Rectum cancer[ICD-11: 2B92]P35408PTGER4
    T18876DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35408PTGER4
    T18876DI0414Transplanted organ/tissue[ICD-11: QB63]P35408PTGER4
    T67103DI0095Colorectal cancer[ICD-11: 2B91]P06756ITGAV
    T67103DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06756ITGAV
    T01851DI0060Brain cancer[ICD-11: 2A00]P05556ITGB1
    T01851DI0238Lung cancer[ICD-11: 2C25]P05556ITGB1
    T01851DI0365Retinopathy[ICD-11: 9B71]P05556ITGB1
    T47101DI0095Colorectal cancer[ICD-11: 2B91]P11362FGFR1
    T47101DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P11362FGFR1
    T47101DI0235Liver cancer[ICD-11: 2C12]P11362FGFR1
    T47101DI0403Thrombocytopenia[ICD-11: 3B64]P11362FGFR1
    T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
    T24982DI0349Pruritus[ICD-11: EC90]Q12908SLC10A2
    T68782DI0102Coronary atherosclerosis[ICD-11: BA52]Q13258PTGDR
    T78356DI0030Angina pectoris[ICD-11: BA40]P24557TBXAS1
    T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
    T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
    T75797DI0003Abortion[ICD-11: JA00]P43088PTGFR
    T75797DI0102Coronary atherosclerosis[ICD-11: BA52]P43088PTGFR
    T75797DI0166Glaucoma[ICD-11: 9C61]P43088PTGFR
    T13726DI0225Kaposi sarcoma[ICD-11: 2B57]P19793RXRA
    T13726DI0283Mycosis fungoides[ICD-11: 2B01]P19793RXRA
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T07663DI0190Hypertension[ICD-11: BA00-BA04]O76074PDE5A
    T07663DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]O76074PDE5A
    T07663DI0378Sexual dysfunction[ICD-11: HA00-HA01]O76074PDE5A
    T07663DI0411Tonus and reflex abnormality[ICD-11: MB47]O76074PDE5A
    T99954DI0003Abortion[ICD-11: JA00]P43119PTGIR
    T99954DI0102Coronary atherosclerosis[ICD-11: BA52]P43119PTGIR
    T99954DI0356Pulmonary hypertension[ICD-11: BB01]P43119PTGIR
    T57278DI0060Brain cancer[ICD-11: 2A00]P29317EPHA2
    T57278DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29317EPHA2
    T77400DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]O00408PDE2A
    T77400DI0207Indeterminate colitis[ICD-11: DD72]O00408PDE2A
    T77400DI0218Irritable bowel syndrome[ICD-11: DD91]O00408PDE2A
    T77400DI0270Mood disorder[ICD-11: 6A60-6E23]O00408PDE2A
    T31309DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10415BCL2
    T31309DI0249Mature B-cell leukaemia[ICD-11: 2A82]P10415BCL2
    T31309DI0273Motor neuron disease[ICD-11: 8B60]P10415BCL2
    T31309DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P10415BCL2
    T64205DI0383Skin and skin-structure infection[ICD-11: 1F28-1G0Z]P42224STAT1
    T46040DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P03951F11
    T46040DI0089Clotting disorder[ICD-11: 3B4Z]P03951F11
    T60077DI0225Kaposi sarcoma[ICD-11: 2B57]P28702RXRB
    T82146DI0005Acne vulgaris[ICD-11: ED80]P13631RARG
    T82146DI0012Acute myeloid leukaemia[ICD-11: 2A60]P13631RARG
    T82146DI0225Kaposi sarcoma[ICD-11: 2B57]P13631RARG
    T82146DI0277Muscle calcification/ossification[ICD-11: FB31]P13631RARG
    T82146DI0351Psoriasis[ICD-11: EA90]P13631RARG
    T46456DI0225Kaposi sarcoma[ICD-11: 2B57]P48443RXRG
    T46456DI0232Light sensitivity impairment[ICD-11: 9D45]P48443RXRG
    T61657DI0225Kaposi sarcoma[ICD-11: 2B57]P10826RARB
    T94324DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q969S8HDAC10
    T47888DI0419Ulcerative colitis[ICD-11: DD71]O95136S1PR2
    T99189DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]Q14973SLC10A1
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T86528DI0057Bone paget disease[ICD-11: FB85]O95749GGPS1
    T86528DI0237Low bone mass disorder[ICD-11: FB83]O95749GGPS1
    T86528DI0267Mineral excesses[ICD-11: 5B91]O95749GGPS1
    T86528DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]O95749GGPS1

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