Intrapetacin A



Compound IDCDAMM02992
Common nameIntrapetacin A
IUPAC name[1-acetyloxy-10-hydroxy-3-methoxy-7,8-dimethyl-7-(3-methylidenepent-4-enyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 4-hydroxybenzoate
Molecular formulaC30H38O8

Experimental data

Retention time0.58
Adduct[M+H]+
Actual mz527.266
Theoretical mz527.264
Error2.7
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.6733

Identifiers and class information

Inchi keyNXJIENULLHZFNA-OYJJAWTRNA-N
SmilesO=C(OC1C=C2C(OC)OC(OC(=O)C)C23C(O)CC(C)C(C)(CCC(=C)C=C)C3C1)C4=CC=C(O)C=C4
SuperclassLipids and lipid-like molecules
ClassPrenol lipids

Plant source

  • Clitoria ternatea L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)1
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)10
    Number of reactive functional groups (#rtvFG)4
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)526.625
    Computed dipole moment(dipole)5.818
    Total solvent accessible surface area (SASA)866.242
    Hydrophobic component of SASA (FOSA)449.939
    Hydrophilic component of SASA (FISA)163.177
    Pie component of the SASA (PISA)253.125
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1629.83
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)9.85
    Free energy of solvation of dipole (dip^2/V)0.0207683
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.016081
    Globularity descriptor (glob)0.773192
    Predicted polarizability in cubic angstroms (QPpolrz)55.068
    Predicted hexadecane/gas partition coefficient (QPlogPC16)16.904
    Predicted octanol/gas partition coefficient (QPlogPoct)26.88
    Predicted water/gas partition coefficient (QPlogPw)15.061
    Predicted octanol/water partition coefficient (QPlogPo/w)4.412
    Predicted aqueous solubility (QPlogS)-6.651
    Conformation-independent predicted aqueous solubility (CIQPlogS)-6.416
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-6.409
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)280.86
    Predicted brain/blood partition coefficient (QPlogBB)-1.859
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)125.381
    Predicted skin permeability, log Kp (QPlogKp)-2.675
    PM3 calculated ionization potential (IP(ev))9.501
    PM3 calculated electron affinity (EA(eV))0.511
    Number of likely metabolic reactions (#metab)4
    Prediction of binding to human serum albumin (QPlogKhsa)0.618
    Predicted qualitative human oral absorption (HumanOralAbsorption)1
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)83.642
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)124.097
    Number of nitrogen and oxygen atoms (#NandO)8
    Number of violations of Lipinski’s rule of five (RuleOfFive)1
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    Q12809KCNH2HERGT20251SwissTargetPrediction
    P12821ACEAngiotensin-converting enzymeT98311SwissTargetPrediction
    O15379HDAC3Histone deacetylase 3T05090SwissTargetPrediction
    P41594GRM5Metabotropic glutamate receptor 5T99347SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P13866SLC5A1Sodium/glucose cotransporter 1T54771SwissTargetPrediction
    P08473MMENeprilysinT05409SwissTargetPrediction
    P42785PRCPLysosomal Pro-X carboxypeptidaseT20371SwissTargetPrediction
    Q9UQL6HDAC5Histone deacetylase 5T07930SwissTargetPrediction
    Q8WUI4HDAC7Histone deacetylase 7T98698SwissTargetPrediction
    P56524HDAC4Histone deacetylase 4T63816SwissTargetPrediction
    Q9UKV0HDAC9Histone deacetylase 9T03687SwissTargetPrediction
    P43235CTSKCathepsin KT11388SwissTargetPrediction
    Q9UBN7HDAC6Histone deacetylase 6T22274SwissTargetPrediction
    Q92769HDAC2Histone deacetylase 2T51191SwissTargetPrediction
    P04183TK1Thymidine kinase, cytosolicT30081SwissTargetPrediction
    O00519FAAHAnandamide amidohydrolaseT11754SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P06401PGRProgesterone receptorT22939SwissTargetPrediction
    P07339CTSDCathepsin DT67102SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    Q13547HDAC1Histone deacetylase 1T68547SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    Q9BY41HDAC8Histone deacetylase 8T28887SwissTargetPrediction
    P08183ABCB1P-glycoprotein 1T25258SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    P00519ABL1Tyrosine-protein kinase ABLT63505SwissTargetPrediction
    O60674JAK2Tyrosine-protein kinase JAK2T08391SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    P09237MMP7Matrix metalloproteinase 7T73475SwissTargetPrediction
    P07711CTSLCathepsin LT98691SwissTargetPrediction
    P32245MC4RMelanocortin receptor 4T72458SwissTargetPrediction
    P07858CTSBCathepsin (B and K)T61746SwissTargetPrediction
    Q01726MC1RMelanocortin receptor 1T35842SwissTargetPrediction
    P41968MC3RMelanocortin receptor 3T76846SwissTargetPrediction
    O75116ROCK2Rho-associated protein kinase 2T06093SwissTargetPrediction
    P23458JAK1Tyrosine-protein kinase JAK1T62460SwissTargetPrediction
    Q99685MGLLMonoglyceride lipaseT18664SwissTargetPrediction
    P08238HSP90AB1Heat shock protein HSP 90-betaT96623SwissTargetPrediction
    P32246CCR1C-C chemokine receptor type 1T16016SwissTargetPrediction
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    P25774CTSSCathepsin ST68290SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P29597TYK2Tyrosine-protein kinase TYK2T78932SwissTargetPrediction
    Q9HBH1PDFPeptide deformylase mitochondrialT89515SwissTargetPrediction
    P42892ECE1Endothelin-converting enzyme 1T50970SwissTargetPrediction
    Q9Y5Z0BACE2Beta secretase 2T01280SwissTargetPrediction
    P32745SSTR3Somatostatin receptor 3T13644SwissTargetPrediction
    P32239CCKBRCholecystokinin B receptor (by homology)T05849SwissTargetPrediction
    Q00987MDM2p53-binding protein Mdm-2T00176SwissTargetPrediction
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    Q9BV23ABHD6Monoacylglycerol lipase ABHD6T81452SwissTargetPrediction
    P56373P2RX3P2X purinoceptor 3T17140SwissTargetPrediction
    P09601HMOX1Heme oxygenase 1 (by homology)T25703SwissTargetPrediction
    P00746CFDComplement factor DT66383SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    P10415BCL2Apoptosis regulator Bcl-2T31309SwissTargetPrediction
    Q06418TYRO3Tyrosine-protein kinase receptor TYRO3T94880SwissTargetPrediction
    Q5VT25CDC42BPASerine or threonine-protein kinase MRCK-AT00075SwissTargetPrediction
    Q96DB2HDAC11Histone deacetylase 11T97903SwissTargetPrediction
    P33032MC5RMelanocortin receptor 5T95302SwissTargetPrediction
    P33316DUTdUTP pyrophosphataseT39054SwissTargetPrediction
    Q969S8HDAC10Histone deacetylase 10T94324SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T20251DI0175Heart failure[ICD-11: BD10-BD1Z]Q12809KCNH2
    T98311DI0175Heart failure[ICD-11: BD10-BD1Z]P12821ACE
    T98311DI0190Hypertension[ICD-11: BA00-BA04]P12821ACE
    T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
    T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
    T99347DI0152Fragile X chromosome[ICD-11: LD55]P41594GRM5
    T99347DI0331Parkinsonism[ICD-11: 8A00]P41594GRM5
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T54771DI0120Diabetes mellitus[ICD-11: 5A10]P13866SLC5A1
    T54771DI0175Heart failure[ICD-11: BD10-BD1Z]P13866SLC5A1
    T54771DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P13866SLC5A1
    T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
    T63816DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P56524HDAC4
    T11388DI0237Low bone mass disorder[ICD-11: FB83]P43235CTSK
    T22274DI0274Multiple myeloma[ICD-11: 2A83]Q9UBN7HDAC6
    T22274DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UBN7HDAC6
    T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
    T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
    T30081DI0012Acute myeloid leukaemia[ICD-11: 2A60]P04183TK1
    T30081DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P04183TK1
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T22939DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06401PGR
    T22939DI0100Contraceptive management[ICD-11: QA21]P06401PGR
    T22939DI0255Menstrual cycle bleeding disorder[ICD-11: GA20]P06401PGR
    T22939DI0344Preterm labour/delivery[ICD-11: JB00]P06401PGR
    T22939DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06401PGR
    T67102DI0275Multiple sclerosis[ICD-11: 8A40]P07339CTSD
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T68547DI0274Multiple myeloma[ICD-11: 2A83]Q13547HDAC1
    T68547DI0283Mycosis fungoides[ICD-11: 2B01]Q13547HDAC1
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T63505DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00519ABL1
    T63505DI0220Ischemia[ICD-11: 8B10-8B11]P00519ABL1
    T63505DI0250Mature B-cell lymphoma[ICD-11: 2A85]P00519ABL1
    T63505DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00519ABL1
    T08391DI0039Atopic eczema[ICD-11: EA80]O60674JAK2
    T08391DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60674JAK2
    T08391DI0366Rheumatoid arthritis[ICD-11: FA20]O60674JAK2
    T08391DI0404Thrombocytosis[ICD-11: 3B63]O60674JAK2
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
    T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
    T72458DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]P32245MC4R
    T72458DI0228Large intestine motility disorder[ICD-11: DB32]P32245MC4R
    T72458DI0308Obesity[ICD-11: 5B80-5B81]P32245MC4R
    T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
    T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
    T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
    T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
    T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
    T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
    T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
    T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
    T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
    T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
    T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
    T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
    T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
    T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
    T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
    T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
    T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
    T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
    T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
    T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
    T35842DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]Q01726MC1R
    T35842DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]Q01726MC1R
    T76846DI0308Obesity[ICD-11: 5B80-5B81]P41968MC3R
    T76846DI0378Sexual dysfunction[ICD-11: HA00-HA01]P41968MC3R
    T76846DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P41968MC3R
    T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
    T62460DI0039Atopic eczema[ICD-11: EA80]P23458JAK1
    T62460DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P23458JAK1
    T62460DI0366Rheumatoid arthritis[ICD-11: FA20]P23458JAK1
    T62460DI0404Thrombocytosis[ICD-11: 3B63]P23458JAK1
    T18664DI0163General pain disorder[ICD-11: 8E43]Q99685MGLL
    T18664DI0409Tic disorder[ICD-11: 8A05]Q99685MGLL
    T96623DI0062Breast cancer[ICD-11: 2C60-2C6Y]P08238HSP90AB1
    T96623DI0238Lung cancer[ICD-11: 2C25]P08238HSP90AB1
    T96623DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P08238HSP90AB1
    T96623DI0249Mature B-cell leukaemia[ICD-11: 2A82]P08238HSP90AB1
    T96623DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P08238HSP90AB1
    T96623DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P08238HSP90AB1
    T96623DI0395Stomach cancer[ICD-11: 2B72]P08238HSP90AB1
    T16016DI0120Diabetes mellitus[ICD-11: 5A10]P32246CCR1
    T16016DI0366Rheumatoid arthritis[ICD-11: FA20]P32246CCR1
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T68290DI0042Autoimmune disease[ICD-11: 4A40-4A45]P25774CTSS
    T68290DI0092Coeliac disease[ICD-11: DA95]P25774CTSS
    T68290DI0107Crohn disease[ICD-11: DD70]P25774CTSS
    T68290DI0120Diabetes mellitus[ICD-11: 5A10]P25774CTSS
    T68290DI0163General pain disorder[ICD-11: 8E43]P25774CTSS
    T68290DI0324Pain[ICD-11: MG30-MG3Z]P25774CTSS
    T68290DI0382Sjogren syndrome[ICD-11: 4A43]P25774CTSS
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T78932DI0351Psoriasis[ICD-11: EA90]P29597TYK2
    T89515DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]Q9HBH1PDF
    T89515DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9HBH1PDF
    T89515DI0243Malaria[ICD-11: 1F40-1F45]Q9HBH1PDF
    T89515DI0251Mature T-cell lymphoma[ICD-11: 2A90]Q9HBH1PDF
    T89515DI0351Psoriasis[ICD-11: EA90]Q9HBH1PDF
    T89515DI0412Toxoplasmosis[ICD-11: 1F57]Q9HBH1PDF
    T01280DI0425Urinary system clinical symptom[ICD-11: MF8Y]Q9Y5Z0BACE2
    T13644DI0108Cushing syndrome[ICD-11: 5A70]P32745SSTR3
    T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
    T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
    T00176DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q00987MDM2
    T00176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q00987MDM2
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T17140DI0105Cough[ICD-11: MD12]P56373P2RX3
    T25703DI0294Neonatal hyperbilirubinaemia[ICD-11: KA87]P09601HMOX1
    T66383DI0170Haemolytic anemia[ICD-11: 3A20-3A2Z]P00746CFD
    T66383DI0365Retinopathy[ICD-11: 9B71]P00746CFD
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T31309DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10415BCL2
    T31309DI0249Mature B-cell leukaemia[ICD-11: 2A82]P10415BCL2
    T31309DI0273Motor neuron disease[ICD-11: 8B60]P10415BCL2
    T31309DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P10415BCL2
    T94880DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06418TYRO3
    T95302DI0005Acne vulgaris[ICD-11: ED80]P33032MC5R
    T95302DI0371Sebaceous gland disorder[ICD-11: ED91]P33032MC5R
    T39054DI0238Lung cancer[ICD-11: 2C25]P33316DUT
    T39054DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P33316DUT
    T94324DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q969S8HDAC10

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