Heitziamide B



Compound IDCDAMM02991
Common nameHeitziamide B
IUPAC name3-(7-hydroxy-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide
Molecular formulaC14H17NO4

Experimental data

Retention time0.51
Adduct[M+H]+
Actual mz264.124
Theoretical mz264.123
Error4.26
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.1066

Identifiers and class information

Inchi keyDHMCGPVUHSTCIP-ONEGZZNKSA-N
SmilesO=C(C=CC1=CC(O)=C2OCOC2=C1)NCC(C)C
SuperclassPhenylpropanoids and polyketides
ClassCinnamic acids and derivatives

Plant source

  • Clitoria ternatea L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)6
    Number of reactive functional groups (#rtvFG)2
    Predicted central nervous system activity (CNS)-1
    Molecular weight (mol_MW)263.293
    Computed dipole moment(dipole)5.497
    Total solvent accessible surface area (SASA)521.094
    Hydrophobic component of SASA (FOSA)299.244
    Hydrophilic component of SASA (FISA)105.866
    Pie component of the SASA (PISA)115.984
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)879.296
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)4.75
    Free energy of solvation of dipole (dip^2/V)0.0343614
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0128912
    Globularity descriptor (glob)0.851803
    Predicted polarizability in cubic angstroms (QPpolrz)26.29
    Predicted hexadecane/gas partition coefficient (QPlogPC16)8.343
    Predicted octanol/gas partition coefficient (QPlogPoct)13.959
    Predicted water/gas partition coefficient (QPlogPw)8.767
    Predicted octanol/water partition coefficient (QPlogPo/w)2.094
    Predicted aqueous solubility (QPlogS)-3.113
    Conformation-independent predicted aqueous solubility (CIQPlogS)-3.15
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.483
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)981.694
    Predicted brain/blood partition coefficient (QPlogBB)-0.771
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)484.928
    Predicted skin permeability, log Kp (QPlogKp)-2.486
    PM3 calculated ionization potential (IP(ev))9.043
    PM3 calculated electron affinity (EA(eV))0.792
    Number of likely metabolic reactions (#metab)1
    Prediction of binding to human serum albumin (QPlogKhsa)-0.165
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)92.755
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)78.735
    Number of nitrogen and oxygen atoms (#NandO)5
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    P09960LTA4HLeukotriene A4 hydrolaseT03691SwissTargetPrediction
    Q14833GRM4Metabotropic glutamate receptor 4T99402SwissTargetPrediction
    P42338PIK3CBPI3-kinase p110-beta subunitT05031SwissTargetPrediction
    P14416DRD2Dopamine D2 receptorT67162SwissTargetPrediction
    P27338MAOBMonoamine oxidase BT83011SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SwissTargetPrediction
    P35354PTGS2Cyclooxygenase-2T66665SwissTargetPrediction
    P14920DAOD-amino-acid oxidaseT33124SwissTargetPrediction
    P10275ARAndrogen ReceptorT11211SwissTargetPrediction
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction
    Q8NER1TRPV1Vanilloid receptorT83193SwissTargetPrediction
    Q9H3N8HRH4Histamine H4 receptorT26500SwissTargetPrediction
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    P14174MIFMacrophage migration inhibitory factorT39977SwissTargetPrediction
    P09917ALOX5Arachidonate 5-lipoxygenaseT00140SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    P35462DRD3Dopamine D3 receptorT02551SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    P30291WEE1Serine/threonine-protein kinase WEE1T69991SwissTargetPrediction
    P55072VCPTransitional endoplasmic reticulum ATPaseT12646SwissTargetPrediction
    P11802CDK4Cyclin-dependent kinase 4T85799SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P78536ADAM17ADAM17T82393SwissTargetPrediction
    P09237MMP7Matrix metalloproteinase 7T73475SwissTargetPrediction
    P51449RORCNuclear receptor ROR-gammaT25307SwissTargetPrediction
    O75460ERN1Serine/threonine-protein kinase/endoribonuclease IRE1T01003SwissTargetPrediction
    P07900HSP90AA1Heat shock protein HSP 90-alphaT18477SwissTargetPrediction
    O00329PIK3CDPI3-kinase p110-delta subunitT67849SwissTargetPrediction
    P05186ALPLAlkaline phosphatase, tissue-nonspecific isozymeT09538SwissTargetPrediction
    P09211GSTP1Glutathione S-transferase PiT21669SwissTargetPrediction
    P39900MMP12Matrix metalloproteinase 12T03500SwissTargetPrediction
    P23526AHCYAdenosylhomocysteinaseT68698SwissTargetPrediction
    P50281MMP14Matrix metalloproteinase 14T65019SwissTargetPrediction
    P78527PRKDCDNA-dependent protein kinaseT81735SwissTargetPrediction
    P00749PLAUUrokinase-type plasminogen activatorT17758SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    Q9UHD2TBK1Serine/threonine-protein kinase TBK1T63024SwissTargetPrediction
    P51164ATP4BPotassium-transporting ATPaseT92687SwissTargetPrediction
    P08236GUSBBeta-glucuronidaseT96413SwissTargetPrediction
    P47989XDHXanthine dehydrogenaseT40954SwissTargetPrediction
    P22001KCNA3Voltage-gated potassium channel subunit Kv1.3T76914SwissTargetPrediction
    P08631HCKTyrosine-protein kinase HCKT31406SwissTargetPrediction
    Q9UBF8PI4KBPI4-kinase beta subunitT12541SwissTargetPrediction
    P10636MAPTMicrotubule-associated protein tauT45593SEA
    O75173ADAMTS4ADAMTS4T79570SwissTargetPrediction
    P51679CCR4C-C chemokine receptor type 4T06955SwissTargetPrediction
    P10696ALPGAlkaline phosphatase placental-likeT35565SwissTargetPrediction
    P62937PPIACyclophilin AT47081SwissTargetPrediction
    Q9UQB9AURKCSerine/threonine-protein kinase Aurora-CT97592SwissTargetPrediction
    P27169PON1Serum paraoxonase/arylesterase 1T34562SwissTargetPrediction
    P19634SLC9A1Sodium/hydrogen exchanger 1T82028SwissTargetPrediction
    Q9NQS5GPR84G-protein coupled receptor 84T98091SwissTargetPrediction
    O43526KCNQ2Voltage-gated potassium channel Kv7.2T74483SEA
    Q7RTX1TAS1R1Taste receptorT41263SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
    T99402DI0331Parkinsonism[ICD-11: 8A00]Q14833GRM4
    T05031DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42338PIK3CB
    T67162DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P14416DRD2
    T67162DI0025Alzheimer disease[ICD-11: 8A20]P14416DRD2
    T67162DI0037Asthma[ICD-11: CA23]P14416DRD2
    T67162DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P14416DRD2
    T67162DI0051Bipolar disorder[ICD-11: 6A60]P14416DRD2
    T67162DI0063Breathing abnormality[ICD-11: MD11]P14416DRD2
    T67162DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P14416DRD2
    T67162DI0073Cerebral ischaemia[ICD-11: 8B1Z]P14416DRD2
    T67162DI0117Depression[ICD-11: 6A70-6A7Z]P14416DRD2
    T67162DI0124Digestive system disease[ICD-11: DE2Z]P14416DRD2
    T67162DI0137Essential hypertension[ICD-11: BA00]P14416DRD2
    T67162DI0142Faecal incontinence[ICD-11: ME07]P14416DRD2
    T67162DI0156Gangrene[ICD-11: MC85]P14416DRD2
    T67162DI0166Glaucoma[ICD-11: 9C61]P14416DRD2
    T67162DI0175Heart failure[ICD-11: BD10-BD1Z]P14416DRD2
    T67162DI0185Hyperaemia[ICD-11: 9A61-9B7Y]P14416DRD2
    T67162DI0190Hypertension[ICD-11: BA00-BA04]P14416DRD2
    T67162DI0196Hypotension[ICD-11: BA20-BA21]P14416DRD2
    T67162DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]P14416DRD2
    T67162DI0214Insomnia[ICD-11: 7A00-7A0Z]P14416DRD2
    T67162DI0222Itching[ICD-11: 1F28-1G07]P14416DRD2
    T67162DI0264Migraine[ICD-11: 8A80]P14416DRD2
    T67162DI0293Nausea/vomiting[ICD-11: MD90]P14416DRD2
    T67162DI0324Pain[ICD-11: MG30-MG3Z]P14416DRD2
    T67162DI0331Parkinsonism[ICD-11: 8A00]P14416DRD2
    T67162DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P14416DRD2
    T67162DI0340Postpartum haemorrhage[ICD-11: JA43]P14416DRD2
    T67162DI0354Psychotic disorder[ICD-11: 6A20-6A25]P14416DRD2
    T67162DI0356Pulmonary hypertension[ICD-11: BB01]P14416DRD2
    T67162DI0370Schizophrenia[ICD-11: 6A20]P14416DRD2
    T67162DI0396Substance abuse[ICD-11: 6C40]P14416DRD2
    T67162DI0408Thyrotoxicosis[ICD-11: 5A02]P14416DRD2
    T67162DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14416DRD2
    T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
    T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
    T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
    T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
    T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
    T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T66665DI0087Chronic pain[ICD-11: MG30]P35354PTGS2
    T66665DI0145Female pelvic pain[ICD-11: GA34]P35354PTGS2
    T66665DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P35354PTGS2
    T66665DI0207Indeterminate colitis[ICD-11: DD72]P35354PTGS2
    T66665DI0227Knee osteoarthritis[ICD-11: FA01]P35354PTGS2
    T66665DI0320Osteoarthritis[ICD-11: FA00-FA05]P35354PTGS2
    T66665DI0324Pain[ICD-11: MG30-MG3Z]P35354PTGS2
    T66665DI0366Rheumatoid arthritis[ICD-11: FA20]P35354PTGS2
    T66665DI0416Tuberculosis[ICD-11: 1B10-1B12]P35354PTGS2
    T33124DI0038Ataxic disorder[ICD-11: 8A03]P14920DAO
    T33124DI0370Schizophrenia[ICD-11: 6A20]P14920DAO
    T11211DI0005Acne vulgaris[ICD-11: ED80]P10275AR
    T11211DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10275AR
    T11211DI0021Alcoholic liver disease[ICD-11: DB94]P10275AR
    T11211DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10275AR
    T11211DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P10275AR
    T11211DI0145Female pelvic pain[ICD-11: GA34]P10275AR
    T11211DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P10275AR
    T11211DI0237Low bone mass disorder[ICD-11: FB83]P10275AR
    T11211DI0247Mammary tumour[ICD-11: 2C60-2C6Z]P10275AR
    T11211DI0346Prostate cancer[ICD-11: 2C82]P10275AR
    T11211DI0401Testicular dysfunction[ICD-11: 5A81]P10275AR
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T26500DI0037Asthma[ICD-11: CA23]Q9H3N8HRH4
    T26500DI0039Atopic eczema[ICD-11: EA80]Q9H3N8HRH4
    T26500DI0351Psoriasis[ICD-11: EA90]Q9H3N8HRH4
    T26500DI0366Rheumatoid arthritis[ICD-11: FA20]Q9H3N8HRH4
    T26500DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q9H3N8HRH4
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T39977DI0403Thrombocytopenia[ICD-11: 3B64]P14174MIF
    T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
    T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
    T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T02551DI0051Bipolar disorder[ICD-11: 6A60]P35462DRD3
    T02551DI0331Parkinsonism[ICD-11: 8A00]P35462DRD3
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T69991DI0321Ovarian cancer[ICD-11: 2C73]P30291WEE1
    T69991DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P30291WEE1
    T69991DI0429Uterine ligament/parametrium/uterine adnexa neoplasm[ICD-11: 2C72]P30291WEE1
    T12646DI0012Acute myeloid leukaemia[ICD-11: 2A60]P55072VCP
    T12646DI0274Multiple myeloma[ICD-11: 2A83]P55072VCP
    T12646DI0284Myelodysplastic syndrome[ICD-11: 2A37]P55072VCP
    T12646DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P55072VCP
    T85799DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11802CDK4
    T85799DI0238Lung cancer[ICD-11: 2C25]P11802CDK4
    T85799DI0351Psoriasis[ICD-11: EA90]P11802CDK4
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T82393DI0062Breast cancer[ICD-11: 2C60-2C6Y]P78536ADAM17
    T82393DI0366Rheumatoid arthritis[ICD-11: FA20]P78536ADAM17
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T25307DI0042Autoimmune disease[ICD-11: 4A40-4A45]P51449RORC
    T25307DI0107Crohn disease[ICD-11: DD70]P51449RORC
    T25307DI0238Lung cancer[ICD-11: 2C25]P51449RORC
    T25307DI0275Multiple sclerosis[ICD-11: 8A40]P51449RORC
    T25307DI0351Psoriasis[ICD-11: EA90]P51449RORC
    T25307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P51449RORC
    T01003DI0062Breast cancer[ICD-11: 2C60-2C6Y]O75460ERN1
    T18477DI0015Acute upper respiratory infection[ICD-11: CA07]P07900HSP90AA1
    T18477DI0037Asthma[ICD-11: CA23]P07900HSP90AA1
    T67849DI0151Follicular lymphoma[ICD-11: 2A80]O00329PIK3CD
    T67849DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00329PIK3CD
    T67849DI0249Mature B-cell leukaemia[ICD-11: 2A82]O00329PIK3CD
    T67849DI0250Mature B-cell lymphoma[ICD-11: 2A85]O00329PIK3CD
    T67849DI0395Stomach cancer[ICD-11: 2B72]O00329PIK3CD
    T09538DI0164Genetic prion disease[ICD-11: 8E02]P05186ALPL
    T09538DI0330Parasitic infection[ICD-11: 1D0Y-1G2Z]P05186ALPL
    T21669DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P09211GSTP1
    T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
    T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
    T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
    T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
    T81735DI0360Rectum cancer[ICD-11: 2B92]P78527PRKDC
    T81735DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P78527PRKDC
    T17758DI0211Inherited coagulation factor deficiency[ICD-11: 3B14]P00749PLAU
    T17758DI0287Myocardial infarction[ICD-11: BA41-BA43]P00749PLAU
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T92687DI0161Gastro-oesophageal reflux disease[ICD-11: DA22]P51164ATP4B
    T92687DI0176Helicobacter infection[ICD-11: DA42-DA63]P51164ATP4B
    T92687DI0312Oesophageal ulcer[ICD-11: DA25]P51164ATP4B
    T92687DI0333Peptic ulcer[ICD-11: DA61]P51164ATP4B
    T96413DI0242Lysosomal disease[ICD-11: 5C56]P08236GUSB
    T40954DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]P47989XDH
    T40954DI0266Mineral deficiency[ICD-11: 5B5K]P47989XDH
    T76914DI0198Idiopathic inflammatory myopathy[ICD-11: 4A41]P22001KCNA3
    T76914DI0351Psoriasis[ICD-11: EA90]P22001KCNA3
    T76914DI0352Psoriatic arthritis[ICD-11: FA21]P22001KCNA3
    T31406DI0207Indeterminate colitis[ICD-11: DD72]P08631HCK
    T12541DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]Q9UBF8PI4KB
    T12541DI0440Zoonotic viral diseaseICD-11: 1D6YQ9UBF8PI4KB
    T45593DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10636MAPT
    T45593DI0025Alzheimer disease[ICD-11: 8A20]P10636MAPT
    T45593DI0265Mild neurocognitive disorder[ICD-11: 6D71]P10636MAPT
    T06955DI0283Mycosis fungoides[ICD-11: 2B01]P51679CCR4
    T06955DI0379Sezary syndrome[ICD-11: 2B02]P51679CCR4
    T47081DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P62937PPIA
    T97592DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]Q9UQB9AURKC
    T97592DI0346Prostate cancer[ICD-11: 2C82]Q9UQB9AURKC
    T97592DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UQB9AURKC
    T82028DI0030Angina pectoris[ICD-11: BA40]P19634SLC9A1
    T98091DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q9NQS5GPR84
    T98091DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q9NQS5GPR84
    T74483DI0324Pain[ICD-11: MG30-MG3Z]O43526KCNQ2
    T41263DI0078Cholera[ICD-11: 1A00]Q7RTX1TAS1R1

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