Helipyrone



Compound IDCDAMM02962
Common nameHelipyrone
IUPAC name6-ethyl-3-[(6-ethyl-4-hydroxy-5-methyl-2-oxopyran-3-yl)methyl]-4-hydroxy-5-methylpyran-2-one
Molecular formulaC17H20O6

Experimental data

Retention time4.33
Adduct[M+K]+
Actual mz359.089
Theoretical mz359.089
Error0.12
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score5.1093

Identifiers and class information

Inchi keyBYRZLWJKTOLLBX-UHFFFAOYSA-N
SmilesO=C1OC(=C(C(O)=C1CC=2C(=O)OC(=C(C2O)C)CC)C)CC
SuperclassOrganoheterocyclic compounds
ClassPyrans

Plant source

  • Clitoria ternatea L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)1
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)6
    Number of reactive functional groups (#rtvFG)2
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)320.341
    Computed dipole moment(dipole)0.577
    Total solvent accessible surface area (SASA)597.553
    Hydrophobic component of SASA (FOSA)425.197
    Hydrophilic component of SASA (FISA)144.457
    Pie component of the SASA (PISA)27.9
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1039.54
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)6.5
    Free energy of solvation of dipole (dip^2/V)0.0003207
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0153834
    Globularity descriptor (glob)0.830518
    Predicted polarizability in cubic angstroms (QPpolrz)31.862
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.509
    Predicted octanol/gas partition coefficient (QPlogPoct)16.403
    Predicted water/gas partition coefficient (QPlogPw)10.338
    Predicted octanol/water partition coefficient (QPlogPo/w)2.027
    Predicted aqueous solubility (QPlogS)-3.895
    Conformation-independent predicted aqueous solubility (CIQPlogS)-3.872
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.407
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)422.685
    Predicted brain/blood partition coefficient (QPlogBB)-1.194
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)195.038
    Predicted skin permeability, log Kp (QPlogKp)-3.507
    PM3 calculated ionization potential (IP(ev))8.834
    PM3 calculated electron affinity (EA(eV))0.22
    Number of likely metabolic reactions (#metab)7
    Prediction of binding to human serum albumin (QPlogKhsa)-0.06
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)85.815
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)110.893
    Number of nitrogen and oxygen atoms (#NandO)6
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P15144ANPEPAminopeptidase NT67272SwissTargetPrediction
    O15379HDAC3Histone deacetylase 3T05090SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P41594GRM5Metabotropic glutamate receptor 5T99347SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    P08473MMENeprilysinT05409SwissTargetPrediction
    P08913ADRA2AAlpha-2a adrenergic receptorT11448SwissTargetPrediction
    Q9UQL6HDAC5Histone deacetylase 5T07930SwissTargetPrediction
    Q8WUI4HDAC7Histone deacetylase 7T98698SwissTargetPrediction
    P56524HDAC4Histone deacetylase 4T63816SwissTargetPrediction
    Q9UKV0HDAC9Histone deacetylase 9T03687SwissTargetPrediction
    Q9UBN7HDAC6Histone deacetylase 6T22274SwissTargetPrediction
    P07384CAPN1Calpain 1T92517SwissTargetPrediction
    P05164MPOMyeloperoxidaseT23471SwissTargetPrediction
    Q92769HDAC2Histone deacetylase 2T51191SwissTargetPrediction
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    P35354PTGS2Cyclooxygenase-2T66665SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    O14684PTGESProstaglandin E synthaseT02562SwissTargetPrediction
    P14902IDO1Indoleamine 2,3-dioxygenaseT89697SwissTargetPrediction
    P28845HSD11B111-beta-hydroxysteroid dehydrogenase 1T65200SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    Q13547HDAC1Histone deacetylase 1T68547SwissTargetPrediction
    P09917ALOX5Arachidonate 5-lipoxygenaseT00140SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    Q9BY41HDAC8Histone deacetylase 8T28887SwissTargetPrediction
    P18825ADRA2CAdrenergic receptor alpha-2T01777SwissTargetPrediction
    P14061HSD17B1Estradiol 17-beta-dehydrogenase 1T44011SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    P36888FLT3Tyrosine-protein kinase receptor FLT3T74312SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P78536ADAM17ADAM17T82393SwissTargetPrediction
    P09237MMP7Matrix metalloproteinase 7T73475SwissTargetPrediction
    P13497BMP1Bone morphogenetic protein 1T53350SwissTargetPrediction
    P07711CTSLCathepsin LT98691SwissTargetPrediction
    P07858CTSBCathepsin (B and K)T61746SwissTargetPrediction
    P00742F10Thrombin and coagulation factor XT84631SwissTargetPrediction
    Q13490BIRC2Baculoviral IAP repeat-containing protein 2T84780SwissTargetPrediction
    P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SwissTargetPrediction
    Q08499PDE4DPhosphodiesterase 4DT02001SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P08238HSP90AB1Heat shock protein HSP 90-betaT96623SwissTargetPrediction
    P07900HSP90AA1Heat shock protein HSP 90-alphaT18477SwissTargetPrediction
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    P05186ALPLAlkaline phosphatase, tissue-nonspecific isozymeT09538SwissTargetPrediction
    Q9UNA0ADAMTS5ADAMTS5T98896SwissTargetPrediction
    P18089ADRA2BAlpha-2b adrenergic receptorT41580SwissTargetPrediction
    Q13443ADAM9ADAM9T03672SwissTargetPrediction
    P42892ECE1Endothelin-converting enzyme 1T50970SwissTargetPrediction
    P28482MAPK1MAP kinase ERK2T58970SwissTargetPrediction
    Q99808SLC29A1Equilibrative nucleoside transporter 1T13491SwissTargetPrediction
    P39900MMP12Matrix metalloproteinase 12T03500SwissTargetPrediction
    P50281MMP14Matrix metalloproteinase 14T65019SwissTargetPrediction
    O76074PDE5APhosphodiesterase 5AT07663SwissTargetPrediction
    Q13093PLA2G7LDL-associated phospholipase A2T69912SwissTargetPrediction
    P12268IMPDH2Inosine-5'-monophosphate dehydrogenase 2T89360SwissTargetPrediction
    P27815PDE4APhosphodiesterase 4AT61744SwissTargetPrediction
    Q12791KCNMA1Calcium-activated potassium channel subunit alpha-1T66538SwissTargetPrediction
    P08236GUSBBeta-glucuronidaseT96413SwissTargetPrediction
    P09238MMP10Matrix metalloproteinase 10T40488SwissTargetPrediction
    Q16549PCSK7Subtilisin/kexin type 7T33211SEA
    Q07343PDE4BPhosphodiesterase 4B (by homology)T10265SwissTargetPrediction
    P19525EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinaseT04831SwissTargetPrediction
    Q16678CYP1B1Cytochrome P450 1B1T92521SwissTargetPrediction
    P15559NQO1Quinone reductase 1T52389SwissTargetPrediction
    O75173ADAMTS4ADAMTS4T79570SwissTargetPrediction
    P51512MMP16Matrix metalloproteinase 16T35824SwissTargetPrediction
    Q08493PDE4CPhosphodiesterase 4CT12081SwissTargetPrediction
    P06734FCER2Immunoglobulin epsilon Fc receptorT67207SwissTargetPrediction
    Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SEA
    P30837ALDH1B1Acetaldehyde dehydrogenaseT99641SEA
    P30837ALDH1B1Acetaldehyde dehydrogenaseT99641SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
    T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
    T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T99347DI0152Fragile X chromosome[ICD-11: LD55]P41594GRM5
    T99347DI0331Parkinsonism[ICD-11: 8A00]P41594GRM5
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
    T11448DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P08913ADRA2A
    T11448DI0317Opioid use disorder[ICD-11: 6C43]P08913ADRA2A
    T11448DI0396Substance abuse[ICD-11: 6C40]P08913ADRA2A
    T63816DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P56524HDAC4
    T22274DI0274Multiple myeloma[ICD-11: 2A83]Q9UBN7HDAC6
    T22274DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UBN7HDAC6
    T23471DI0229Left ventricular failure[ICD-11: BD11]P05164MPO
    T23471DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P05164MPO
    T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
    T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T66665DI0087Chronic pain[ICD-11: MG30]P35354PTGS2
    T66665DI0145Female pelvic pain[ICD-11: GA34]P35354PTGS2
    T66665DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P35354PTGS2
    T66665DI0207Indeterminate colitis[ICD-11: DD72]P35354PTGS2
    T66665DI0227Knee osteoarthritis[ICD-11: FA01]P35354PTGS2
    T66665DI0320Osteoarthritis[ICD-11: FA00-FA05]P35354PTGS2
    T66665DI0324Pain[ICD-11: MG30-MG3Z]P35354PTGS2
    T66665DI0366Rheumatoid arthritis[ICD-11: FA20]P35354PTGS2
    T66665DI0416Tuberculosis[ICD-11: 1B10-1B12]P35354PTGS2
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T02562DI0025Alzheimer disease[ICD-11: 8A20]O14684PTGES
    T89697DI0117Depression[ICD-11: 6A70-6A7Z]P14902IDO1
    T65200DI0210Influenza[ICD-11: 1E30-1E32]P28845HSD11B1
    T65200DI0239Lupus erythematosus[ICD-11: 4A40]P28845HSD11B1
    T65200DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P28845HSD11B1
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T68547DI0274Multiple myeloma[ICD-11: 2A83]Q13547HDAC1
    T68547DI0283Mycosis fungoides[ICD-11: 2B01]Q13547HDAC1
    T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
    T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
    T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
    T01777DI0166Glaucoma[ICD-11: 9C61]P18825ADRA2C
    T01777DI0190Hypertension[ICD-11: BA00-BA04]P18825ADRA2C
    T01777DI0196Hypotension[ICD-11: BA20-BA21]P18825ADRA2C
    T01777DI0308Obesity[ICD-11: 5B80-5B81]P18825ADRA2C
    T01777DI0310Ocular disease[ICD-11: N.A.]P18825ADRA2C
    T01777DI0396Substance abuse[ICD-11: 6C40]P18825ADRA2C
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T74312DI0012Acute myeloid leukaemia[ICD-11: 2A60]P36888FLT3
    T74312DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P36888FLT3
    T74312DI0095Colorectal cancer[ICD-11: 2B91]P36888FLT3
    T74312DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P36888FLT3
    T74312DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P36888FLT3
    T74312DI0248Mastocytosis[ICD-11: 2A21]P36888FLT3
    T74312DI0250Mature B-cell lymphoma[ICD-11: 2A85]P36888FLT3
    T74312DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P36888FLT3
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T82393DI0062Breast cancer[ICD-11: 2C60-2C6Y]P78536ADAM17
    T82393DI0366Rheumatoid arthritis[ICD-11: FA20]P78536ADAM17
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
    T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
    T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
    T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
    T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
    T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
    T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
    T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
    T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
    T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
    T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
    T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
    T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
    T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
    T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
    T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
    T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
    T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
    T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
    T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
    T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
    T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
    T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
    T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
    T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
    T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
    T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
    T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
    T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
    T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
    T84780DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]Q13490BIRC2
    T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
    T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
    T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
    T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T96623DI0062Breast cancer[ICD-11: 2C60-2C6Y]P08238HSP90AB1
    T96623DI0238Lung cancer[ICD-11: 2C25]P08238HSP90AB1
    T96623DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P08238HSP90AB1
    T96623DI0249Mature B-cell leukaemia[ICD-11: 2A82]P08238HSP90AB1
    T96623DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P08238HSP90AB1
    T96623DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P08238HSP90AB1
    T96623DI0395Stomach cancer[ICD-11: 2B72]P08238HSP90AB1
    T18477DI0015Acute upper respiratory infection[ICD-11: CA07]P07900HSP90AA1
    T18477DI0037Asthma[ICD-11: CA23]P07900HSP90AA1
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T09538DI0164Genetic prion disease[ICD-11: 8E02]P05186ALPL
    T09538DI0330Parasitic infection[ICD-11: 1D0Y-1G2Z]P05186ALPL
    T98896DI0320Osteoarthritis[ICD-11: FA00-FA05]Q9UNA0ADAMTS5
    T41580DI0396Substance abuse[ICD-11: 6C40]P18089ADRA2B
    T03672DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q13443ADAM9
    T58970DI0036Arteries/arterioles disorder[ICD-11: BD52]P28482MAPK1
    T58970DI0252Melanoma[ICD-11: 2C30]P28482MAPK1
    T58970DI0326Pancreatic cancer[ICD-11: 2C10]P28482MAPK1
    T58970DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28482MAPK1
    T13491DI0030Angina pectoris[ICD-11: BA40]Q99808SLC29A1
    T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
    T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
    T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
    T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
    T07663DI0190Hypertension[ICD-11: BA00-BA04]O76074PDE5A
    T07663DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]O76074PDE5A
    T07663DI0378Sexual dysfunction[ICD-11: HA00-HA01]O76074PDE5A
    T07663DI0411Tonus and reflex abnormality[ICD-11: MB47]O76074PDE5A
    T69912DI0025Alzheimer disease[ICD-11: 8A20]Q13093PLA2G7
    T69912DI0035Arterial occlusive disease[ICD-11: BD40]Q13093PLA2G7
    T69912DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]Q13093PLA2G7
    T89360DI0413Transplant rejection[ICD-11: NE84]P12268IMPDH2
    T61744DI0037Asthma[ICD-11: CA23]P27815PDE4A
    T66538DI0037Asthma[ICD-11: CA23]Q12791KCNMA1
    T66538DI0154Functional bladder disorder[ICD-11: GC50]Q12791KCNMA1
    T96413DI0242Lysosomal disease[ICD-11: 5C56]P08236GUSB
    T10265DI0037Asthma[ICD-11: CA23]Q07343PDE4B
    T10265DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q07343PDE4B
    T10265DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q07343PDE4B
    T52389DI0079Choreiform disorder[ICD-11: 8A01]P15559NQO1
    T52389DI0090CNS anomalies syndrome[ICD-11: LD20]P15559NQO1
    T52389DI0202Inborn energy metabolism error[ICD-11: 5C53]P15559NQO1
    T52389DI0215Intellectual development disorder[ICD-11: LD90]P15559NQO1
    T52389DI0326Pancreatic cancer[ICD-11: 2C10]P15559NQO1
    T52389DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P15559NQO1
    T67207DI0231Leukaemia[ICD-11: 2A60-2B33]P06734FCER2
    T99641DI0396Substance abuse[ICD-11: 6C40]P30837ALDH1B1
    T99641DI0396Substance abuse[ICD-11: 6C40]P30837ALDH1B1

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