Leachianone B



Compound IDCDAMM02953
Common nameLeachianone B
IUPAC name5-hydroxy-2-(4-hydroxy-2-methoxyphenyl)-8,8-dimethyl-9-(3-methylbut-2-enyl)-2,3,9,10-tetrahydropyrano[2,3-h]chromen-4-one
Molecular formulaC26H30O6

Experimental data

Retention time27.82
Adduct[M+H]+
Actual mz439.211
Theoretical mz439.211
Error1.08
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score9.7679

Identifiers and class information

Inchi keyQBFPWKGRQPYWRQ-UHFFFAOYNA-N
SmilesO=C1C2=C(O)C=C3OC(C)(C)C(CC=C(C)C)CC3=C2OC(C4=CC=C(O)C=C4OC)C1
SuperclassPhenylpropanoids and polyketides
ClassFlavonoids

Plant source

  • Clitoria ternatea L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)2
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)5
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)438.519
    Computed dipole moment(dipole)4.674
    Total solvent accessible surface area (SASA)719.102
    Hydrophobic component of SASA (FOSA)428.353
    Hydrophilic component of SASA (FISA)143.877
    Pie component of the SASA (PISA)146.872
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1359.61
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)4.75
    Free energy of solvation of dipole (dip^2/V)0.0160687
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0066055
    Globularity descriptor (glob)0.825375
    Predicted polarizability in cubic angstroms (QPpolrz)46.45
    Predicted hexadecane/gas partition coefficient (QPlogPC16)13.101
    Predicted octanol/gas partition coefficient (QPlogPoct)19.638
    Predicted water/gas partition coefficient (QPlogPw)8.468
    Predicted octanol/water partition coefficient (QPlogPo/w)5.021
    Predicted aqueous solubility (QPlogS)-6.802
    Conformation-independent predicted aqueous solubility (CIQPlogS)-7.117
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.058
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)428.069
    Predicted brain/blood partition coefficient (QPlogBB)-1.146
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)197.724
    Predicted skin permeability, log Kp (QPlogKp)-3.174
    PM3 calculated ionization potential (IP(ev))8.984
    PM3 calculated electron affinity (EA(eV))0.213
    Number of likely metabolic reactions (#metab)9
    Prediction of binding to human serum albumin (QPlogKhsa)1.184
    Predicted qualitative human oral absorption (HumanOralAbsorption)1
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)90.487
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)90.211
    Number of nitrogen and oxygen atoms (#NandO)6
    Number of violations of Lipinski’s rule of five (RuleOfFive)1
    Number of violations of Jorgensen’s rule of three (RuleOfThree)2

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P06241FYNTyrosine-protein kinase FYNT17980SwissTargetPrediction
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P22303ACHEAcetylcholinesteraseT30082SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    O43570CA12Carbonic anhydrase XIIT16987SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    P15144ANPEPAminopeptidase NT67272SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P41594GRM5Metabotropic glutamate receptor 5T99347SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P43166CA7Carbonic anhydrase VIIT37541SwissTargetPrediction
    P22748CA4Carbonic anhydrase IVT53378SwissTargetPrediction
    P27338MAOBMonoamine oxidase BT83011SwissTargetPrediction
    P15121AKR1B1Aldose reductaseT26623SwissTargetPrediction
    P43235CTSKCathepsin KT11388SwissTargetPrediction
    P23141CES1Acyl coenzyme A:cholesterol acyltransferaseT76369SwissTargetPrediction
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    P11926ODC1Ornithine decarboxylaseT60366SEA
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction
    O60885BRD4Bromodomain-containing protein 4T00407SwissTargetPrediction
    Q8NER1TRPV1Vanilloid receptorT83193SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction and SEA
    P18031PTPN1Protein-tyrosine phosphatase 1BT16347SwissTargetPrediction
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P03372ESR1Estrogen receptor alphaT02506SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    P05121SERPINE1Plasminogen activator inhibitor-1T15556SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SwissTargetPrediction
    P33527ABCC1Multidrug resistance-associated protein 1T11288SwissTargetPrediction
    P04626ERBB2Receptor protein-tyrosine kinase erbB-2T14597SwissTargetPrediction
    Q15118PDK1Pyruvate dehydrogenase kinase isoform 1T20891SwissTargetPrediction
    P14061HSD17B1Estradiol 17-beta-dehydrogenase 1T44011SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    P30291WEE1Serine/threonine-protein kinase WEE1T69991SwissTargetPrediction
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    P11802CDK4Cyclin-dependent kinase 4T85799SwissTargetPrediction
    P56817BACE1Beta-secretase 1T79031SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P78536ADAM17ADAM17T82393SwissTargetPrediction
    P13497BMP1Bone morphogenetic protein 1T53350SwissTargetPrediction
    P07711CTSLCathepsin LT98691SwissTargetPrediction
    P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SwissTargetPrediction
    P11137MAP2Microtubule-associated protein 2T23276SwissTargetPrediction
    Q09472EP300Histone acetyltransferase p300T25956SEA
    P08238HSP90AB1Heat shock protein HSP 90-betaT96623SwissTargetPrediction
    P07900HSP90AA1Heat shock protein HSP 90-alphaT18477SwissTargetPrediction
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    P34947GRK5G protein-coupled receptor kinase 5T69612SwissTargetPrediction
    P20151KLK2Kallikrein 2T01908SwissTargetPrediction and SEA
    Q9HBH1PDFPeptide deformylase mitochondrialT89515SwissTargetPrediction
    P23443RPS6KB1Ribosomal protein S6 kinase 1T94479SwissTargetPrediction
    P39900MMP12Matrix metalloproteinase 12T03500SwissTargetPrediction
    P31639SLC5A2Sodium/glucose cotransporter 2T30085SwissTargetPrediction
    P25929NPY1RNeuropeptide Y receptor type 1T89213SwissTargetPrediction
    P49336CDK8Cell division protein kinase 8T10822SwissTargetPrediction
    P32239CCKBRCholecystokinin B receptor (by homology)T05849SwissTargetPrediction
    P19793RXRARetinoid X receptor alpha (by homology)T13726SwissTargetPrediction
    P04049RAF1Serine/threonine-protein kinase RAFT51883SwissTargetPrediction
    Q16602CALCRLCalcitonin gene-related peptide type 1 receptorT02226SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    Q06187BTKTyrosine-protein kinase BTKT97719SwissTargetPrediction
    Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SwissTargetPrediction and SEA
    P14679TYRTyrosinaseT97035SEA
    P29317EPHA2Ephrin type-A receptor 2T57278SwissTargetPrediction
    P00746CFDComplement factor DT66383SwissTargetPrediction
    P51451BLKTyrosine-protein kinase BLKT74307SwissTargetPrediction
    P41240CSKTyrosine-protein kinase CSKT08741SwissTargetPrediction
    P29323EPHB2Ephrin type-B receptor 2T73756SwissTargetPrediction
    P51813BMXTyrosine-protein kinase BMXT99990SwissTargetPrediction
    P07948LYNTyrosine-protein kinase LynT68163SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    Q16678CYP1B1Cytochrome P450 1B1T92521SwissTargetPrediction and SEA
    P09769FGRTyrosine-protein kinase FGRT49925SwissTargetPrediction
    P29320EPHA3Ephrin type-A receptor 3T28413SwissTargetPrediction
    Q06418TYRO3Tyrosine-protein kinase receptor TYRO3T94880SwissTargetPrediction
    P42681TXKTyrosine-protein kinase TXKT32590SwissTargetPrediction
    P14625HSP90B1EndoplasminT81311SwissTargetPrediction
    P16152CBR1Carbonyl reductase [NADPH] 1T70518SwissTargetPrediction and SEA
    P33316DUTdUTP pyrophosphataseT39054SwissTargetPrediction
    P06734FCER2Immunoglobulin epsilon Fc receptorT67207SwissTargetPrediction
    P30550GRPRGastrin releasing peptide receptorT99816SwissTargetPrediction
    P54756EPHA5Ephrin type-A receptor 5T18474SwissTargetPrediction
    P54764EPHA4Ephrin type-A receptor 4T70234SwissTargetPrediction
    Q9UF33EPHA6Ephrin type-A receptor 6T08647SwissTargetPrediction
    Q13882PTK6Tyrosine-protein kinase BRKT73694SwissTargetPrediction
    P54753EPHB3Ephrin type-B receptor 3T56121SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T17980DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06241FYN
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
    T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T99347DI0152Fragile X chromosome[ICD-11: LD55]P41594GRM5
    T99347DI0331Parkinsonism[ICD-11: 8A00]P41594GRM5
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
    T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
    T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
    T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
    T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
    T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
    T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
    T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
    T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
    T26623DI0298Neuropathy[ICD-11: 8C0Z]P15121AKR1B1
    T26623DI0366Rheumatoid arthritis[ICD-11: FA20]P15121AKR1B1
    T11388DI0237Low bone mass disorder[ICD-11: FB83]P43235CTSK
    T76369DI0335Peroxisomal disease[ICD-11: 5C57]P23141CES1
    T76369DI0398Synthesis disorder[ICD-11: 5C52-5C59]P23141CES1
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T60366DI0020African trypanosomiasis[ICD-11: 1F51]P11926ODC1
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
    T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
    T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
    T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T15556DI0037Asthma[ICD-11: CA23]P05121SERPINE1
    T15556DI0405Thrombosis[ICD-11: DB61-GB90]P05121SERPINE1
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T11288DI0167Gout[ICD-11: FA25]P33527ABCC1
    T14597DI0062Breast cancer[ICD-11: 2C60-2C6Y]P04626ERBB2
    T14597DI0238Lung cancer[ICD-11: 2C25]P04626ERBB2
    T14597DI0346Prostate cancer[ICD-11: 2C82]P04626ERBB2
    T20891DI0241Lymphoma[ICD-11: 2A80-2A86]Q15118PDK1
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T69991DI0321Ovarian cancer[ICD-11: 2C73]P30291WEE1
    T69991DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P30291WEE1
    T69991DI0429Uterine ligament/parametrium/uterine adnexa neoplasm[ICD-11: 2C72]P30291WEE1
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T85799DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11802CDK4
    T85799DI0238Lung cancer[ICD-11: 2C25]P11802CDK4
    T85799DI0351Psoriasis[ICD-11: EA90]P11802CDK4
    T79031DI0025Alzheimer disease[ICD-11: 8A20]P56817BACE1
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T82393DI0062Breast cancer[ICD-11: 2C60-2C6Y]P78536ADAM17
    T82393DI0366Rheumatoid arthritis[ICD-11: FA20]P78536ADAM17
    T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
    T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
    T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
    T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
    T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
    T23276DI0036Arteries/arterioles disorder[ICD-11: BD52]P11137MAP2
    T23276DI0252Melanoma[ICD-11: 2C30]P11137MAP2
    T23276DI0326Pancreatic cancer[ICD-11: 2C10]P11137MAP2
    T23276DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11137MAP2
    T25956DI0346Prostate cancer[ICD-11: 2C82]Q09472EP300
    T25956DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q09472EP300
    T96623DI0062Breast cancer[ICD-11: 2C60-2C6Y]P08238HSP90AB1
    T96623DI0238Lung cancer[ICD-11: 2C25]P08238HSP90AB1
    T96623DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P08238HSP90AB1
    T96623DI0249Mature B-cell leukaemia[ICD-11: 2A82]P08238HSP90AB1
    T96623DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P08238HSP90AB1
    T96623DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P08238HSP90AB1
    T96623DI0395Stomach cancer[ICD-11: 2B72]P08238HSP90AB1
    T18477DI0015Acute upper respiratory infection[ICD-11: CA07]P07900HSP90AA1
    T18477DI0037Asthma[ICD-11: CA23]P07900HSP90AA1
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T01908DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P20151KLK2
    T89515DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]Q9HBH1PDF
    T89515DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9HBH1PDF
    T89515DI0243Malaria[ICD-11: 1F40-1F45]Q9HBH1PDF
    T89515DI0251Mature T-cell lymphoma[ICD-11: 2A90]Q9HBH1PDF
    T89515DI0351Psoriasis[ICD-11: EA90]Q9HBH1PDF
    T89515DI0412Toxoplasmosis[ICD-11: 1F57]Q9HBH1PDF
    T94479DI0025Alzheimer disease[ICD-11: 8A20]P23443RPS6KB1
    T94479DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P23443RPS6KB1
    T94479DI0419Ulcerative colitis[ICD-11: DD71]P23443RPS6KB1
    T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
    T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
    T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
    T30085DI0120Diabetes mellitus[ICD-11: 5A10]P31639SLC5A2
    T30085DI0175Heart failure[ICD-11: BD10-BD1Z]P31639SLC5A2
    T30085DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P31639SLC5A2
    T89213DI0050Binge eating disorder[ICD-11: 6B82]P25929NPY1R
    T89213DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25929NPY1R
    T89213DI0174Heart disease[ICD-11: BA41-BA42]P25929NPY1R
    T89213DI0190Hypertension[ICD-11: BA00-BA04]P25929NPY1R
    T89213DI0308Obesity[ICD-11: 5B80-5B81]P25929NPY1R
    T10822DI0012Acute myeloid leukaemia[ICD-11: 2A60]P49336CDK8
    T10822DI0284Myelodysplastic syndrome[ICD-11: 2A37]P49336CDK8
    T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
    T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
    T13726DI0225Kaposi sarcoma[ICD-11: 2B57]P19793RXRA
    T13726DI0283Mycosis fungoides[ICD-11: 2B01]P19793RXRA
    T51883DI0252Melanoma[ICD-11: 2C30]P04049RAF1
    T51883DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04049RAF1
    T51883DI0321Ovarian cancer[ICD-11: 2C73]P04049RAF1
    T51883DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04049RAF1
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T97719DI0231Leukaemia[ICD-11: 2A60-2B33]Q06187BTK
    T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
    T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
    T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
    T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
    T57278DI0060Brain cancer[ICD-11: 2A00]P29317EPHA2
    T57278DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29317EPHA2
    T66383DI0170Haemolytic anemia[ICD-11: 3A20-3A2Z]P00746CFD
    T66383DI0365Retinopathy[ICD-11: 9B71]P00746CFD
    T73756DI0225Kaposi sarcoma[ICD-11: 2B57]P29323EPHB2
    T73756DI0252Melanoma[ICD-11: 2C30]P29323EPHB2
    T73756DI0326Pancreatic cancer[ICD-11: 2C10]P29323EPHB2
    T73756DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29323EPHB2
    T68163DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]P07948LYN
    T68163DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P07948LYN
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T28413DI0012Acute myeloid leukaemia[ICD-11: 2A60]P29320EPHA3
    T28413DI0060Brain cancer[ICD-11: 2A00]P29320EPHA3
    T28413DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P29320EPHA3
    T28413DI0284Myelodysplastic syndrome[ICD-11: 2A37]P29320EPHA3
    T94880DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06418TYRO3
    T81311DI0238Lung cancer[ICD-11: 2C25]P14625HSP90B1
    T70518DI0037Asthma[ICD-11: CA23]P16152CBR1
    T39054DI0238Lung cancer[ICD-11: 2C25]P33316DUT
    T39054DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P33316DUT
    T67207DI0231Leukaemia[ICD-11: 2A60-2B33]P06734FCER2
    T99816DI0062Breast cancer[ICD-11: 2C60-2C6Y]P30550GRPR
    T99816DI0218Irritable bowel syndrome[ICD-11: DD91]P30550GRPR
    T99816DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P30550GRPR
    T70234DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P54764EPHA4
    T73694DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]Q13882PTK6
    T73694DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q13882PTK6

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