7-Acetoxy-2-methylisoflavone



Compound IDCDAMM02919
Common name7-Acetoxy-2-methylisoflavone
IUPAC name(2-methyl-4-oxo-3-phenylchromen-7-yl) acetate
Molecular formulaC18H14O4

Experimental data

Retention time3.5
Adduct[M+H]+
Actual mz295.094
Theoretical mz295.096
Error6.7
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.5558

Identifiers and class information

Inchi keyDPIAJERHFDBLPT-UHFFFAOYSA-N
SmilesO=C(OC1=CC=C2C(OC(=C(C2=O)C=3C=CC=CC3)C)=C1)C
SuperclassPhenylpropanoids and polyketides
ClassIsoflavonoids

Plant source

  • Clitoria ternatea L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)2
    Number of reactive functional groups (#rtvFG)1
    Predicted central nervous system activity (CNS)0
    Molecular weight (mol_MW)294.306
    Computed dipole moment(dipole)4.284
    Total solvent accessible surface area (SASA)564.268
    Hydrophobic component of SASA (FOSA)173.627
    Hydrophilic component of SASA (FISA)86.076
    Pie component of the SASA (PISA)304.565
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)957.386
    Number of hydrogen bond donors (donorHB)0
    Number of hydrogen bond acceptors (accptHB)5
    Free energy of solvation of dipole (dip^2/V)0.0191707
    Index of cohesive interaction in solids (ACxDN^.5/SA)0
    Globularity descriptor (glob)0.832538
    Predicted polarizability in cubic angstroms (QPpolrz)33.785
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.789
    Predicted octanol/gas partition coefficient (QPlogPoct)13.897
    Predicted water/gas partition coefficient (QPlogPw)8.218
    Predicted octanol/water partition coefficient (QPlogPo/w)2.867
    Predicted aqueous solubility (QPlogS)-4.008
    Conformation-independent predicted aqueous solubility (CIQPlogS)-3.963
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.694
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)1512.3
    Predicted brain/blood partition coefficient (QPlogBB)-0.385
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)773.6
    Predicted skin permeability, log Kp (QPlogKp)-1.841
    PM3 calculated ionization potential (IP(ev))9.125
    PM3 calculated electron affinity (EA(eV))0.755
    Number of likely metabolic reactions (#metab)1
    Prediction of binding to human serum albumin (QPlogKhsa)-0.025
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)70.703
    Number of nitrogen and oxygen atoms (#NandO)4
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P22303ACHEAcetylcholinesteraseT30082SEA
    Q12809KCNH2HERGT20251SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    O43570CA12Carbonic anhydrase XIIT16987SwissTargetPrediction and SEA
    P04818TYMSThymidylate synthase (by homology)T98397SwissTargetPrediction
    Q99720SIGMAR1Sigma opioid receptorT46360SEA
    P34903GABRA3GABA A receptor alpha-3/beta-2/gamma-2T62292SwissTargetPrediction
    P47869GABRA2GABA A receptor alpha-2/beta-2/gamma-2T51452SwissTargetPrediction
    P41594GRM5Metabotropic glutamate receptor 5T99347SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction and SEA
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P42338PIK3CBPI3-kinase p110-beta subunitT05031SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    Q8IXJ6SIRT2NAD-dependent deacetylase sirtuin 2T83904SwissTargetPrediction
    O43451MGAMMaltase-glucoamylaseT92777SwissTargetPrediction
    Q96RI1NR1H4Bile acid receptor FXRT51426SwissTargetPrediction
    P34913EPHX2Epoxide hydrataseT35734SwissTargetPrediction
    Q02083NAAAN-acylsphingosine-amidohydrolase (by homology)T78326SwissTargetPrediction
    Q12879GRIN2AGlutamate NMDA receptor; GRIN1/GRIN2AT22285SwissTargetPrediction
    P43166CA7Carbonic anhydrase VIIT37541SwissTargetPrediction
    P22748CA4Carbonic anhydrase IVT53378SwissTargetPrediction
    P27338MAOBMonoamine oxidase BT83011SwissTargetPrediction and SEA
    P28223HTR2ASerotonin 2a (5-HT2a) receptorT32060SwissTargetPrediction
    P28335HTR2CSerotonin 2c (5-HT2c) receptorT83813SwissTargetPrediction
    P42262GRIA2Glutamate receptor ionotropic, AMPA 2T42392SwissTargetPrediction
    P29275ADORA2BAdenosine A2b receptorT86679SwissTargetPrediction
    Q9H3R0KDM4CLysine-specific demethylase 4CT73863SwissTargetPrediction
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    O75164KDM4ALysine-specific demethylase 4AT18904SwissTargetPrediction
    Q6B0I6KDM4DLysine-specific demethylase 4DT17036SwissTargetPrediction
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction and SEA
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    O75762TRPA1Transient receptor potential cation channel subfamily A member 1T84040SwissTargetPrediction
    P08235NR3C2Mineralocorticoid receptorT72168SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P06401PGRProgesterone receptorT22939SwissTargetPrediction
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction and SEA
    O14684PTGESProstaglandin E synthaseT02562SwissTargetPrediction
    P18031PTPN1Protein-tyrosine phosphatase 1BT16347SEA
    P49137MAPKAPK2MAP kinase-activated protein kinase 2T21307SwissTargetPrediction
    Q7Z2W7TRPM8Transient receptor potential cation channel subfamily M member 8T41955SwissTargetPrediction
    P03372ESR1Estrogen receptor alphaT02506SwissTargetPrediction and SEA
    Q15465SHHSonic hedgehog protein (by homology)T12075SwissTargetPrediction
    Q13547HDAC1Histone deacetylase 1T68547SwissTargetPrediction
    P23975SLC6A2Norepinephrine transporterT21945SwissTargetPrediction
    P08183ABCB1P-glycoprotein 1T25258SwissTargetPrediction and SEA
    O95718ESRRBEstrogen-related receptor betaT42025SwissTargetPrediction
    O95271TNKSTankyrase-1T83059SEA
    P06276BCHEButyrylcholinesteraseT99799SEA
    O60674JAK2Tyrosine-protein kinase JAK2T08391SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    Q16769QPCTGlutaminyl-peptide cyclotransferaseT46245SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    O00767SCDAcyl-CoA desaturaseT10897SwissTargetPrediction
    P05093CYP17A1Cytochrome P450 17A1T89041SwissTargetPrediction
    Q92831KAT2BHistone acetyltransferase PCAFT16902SwissTargetPrediction
    Q5S007LRRK2Leucine-rich repeat serine/threonine-protein kinase 2T08123SwissTargetPrediction
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    Q02750MAP2K1Dual specificity mitogen-activated protein kinase kinase 1T99057SEA
    P41229KDM5CLysine-specific demethylase 5CT85540SwissTargetPrediction
    P36897TGFBR1TGF-beta receptor type IT53389SwissTargetPrediction
    O00329PIK3CDPI3-kinase p110-delta subunitT67849SwissTargetPrediction
    P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction
    P17948FLT1Vascular endothelial growth factor receptor 1T63966SwissTargetPrediction
    Q13627DYRK1ADual-specificity tyrosine-phosphorylation regulated kinase 1AT92803SwissTargetPrediction
    P24385CCND1Cyclin-dependent kinase 4/cyclin D1T12355SwissTargetPrediction
    Q9UNA0ADAMTS5ADAMTS5T98896SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P35408PTGER4Prostanoid EP4 receptorT18876SEA
    O00311CDC7CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)T81358SwissTargetPrediction
    Q9NWZ3IRAK4Interleukin-1 receptor-associated kinase 4T55398SwissTargetPrediction
    P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SwissTargetPrediction
    P07333CSF1RMacrophage colony stimulating factor receptorT20333SwissTargetPrediction
    P04629NTRK1Nerve growth factor receptor Trk-AT07173SwissTargetPrediction
    P50750CDK9Cyclin-dependent kinase 9T44458SwissTargetPrediction
    P34998CRHR1Corticotropin releasing factor receptor 1 (by homology)T45262SwissTargetPrediction
    P24557TBXAS1Thromboxane-A synthaseT78356SwissTargetPrediction
    Q02127DHODHDihydroorotate dehydrogenaseT61400SwissTargetPrediction
    Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SwissTargetPrediction
    Q04759PRKCQProtein kinase C thetaT23995SwissTargetPrediction
    P60568IL2Interleukin-2T61698SwissTargetPrediction and SEA
    P30837ALDH1B1Acetaldehyde dehydrogenaseT99641SwissTargetPrediction and SEA
    Q9NUW8TDP1Tyrosyl-DNA phosphodiesterase 1T33492SEA
    Q16875PFKFB36-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3T23787SwissTargetPrediction
    Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SwissTargetPrediction and SEA
    P24530EDNRBEndothelin receptor ET-BT92828SEA
    O14649KCNK3Potassium channel subfamily K member 3T15795SwissTargetPrediction
    Q9NPC2KCNK9Potassium channel subfamily K member 9T57613SwissTargetPrediction
    P35557GCKHexokinase type IVT87166SwissTargetPrediction
    P16234PDGFRAPlatelet-derived growth factor receptorT53524SwissTargetPrediction
    P00374DHFRDihydrofolate reductaseT17345SwissTargetPrediction
    P22460KCNA5Voltage-gated potassium channel subunit Kv1.5T17569SEA
    P22001KCNA3Voltage-gated potassium channel subunit Kv1.3T76914SEA
    Q16678CYP1B1Cytochrome P450 1B1T92521SEA
    Q9UNI1CELA1Elastase 1T22839SEA
    Q92952KCNN1Small conductance calcium-activated potassium channel protein 1T11911SEA
    P16152CBR1Carbonyl reductase [NADPH] 1T70518SwissTargetPrediction and SEA
    Q13332PTPRSReceptor-type tyrosine-protein phosphatase ST10147SEA
    P01137TGFB1Transforming growth factor beta-1T97257SwissTargetPrediction
    P18507GABRG2GABA-A receptor; alpha-6/beta-3/gamma-2T08910SwissTargetPrediction
    O15120AGPAT21-acylglycerol-3-phosphate O-acyltransferase betaT32821SwissTargetPrediction
    Q8TCW9PROKR1Prokineticin receptor 1T85115SwissTargetPrediction
    Q9H2S1KCNN2Small conductance calcium-activated potassium channel protein 2T86271SEA
    P30837ALDH1B1Acetaldehyde dehydrogenaseT99641SEA
    P45974USP5Ubiquitin carboxyl-terminal hydrolase 5T17067SEA
    P49862KLK7Kallikrein-7T79155SEA
    O15427SLC16A3Monocarboxylate transporter 4T31788SEA
    P16220CREB1Cyclic AMP-responsive element-binding proteinT92098SEA
    P30837ALDH1B1Acetaldehyde dehydrogenaseT99641SEA
    Q96HK3CALMCalmodulinT39610SEA
    Q09470KCNA1Voltage-gated potassium channel Kv1.1T85272SEA
    Q96RP8KCNA7Voltage-gated potassium channel Kv1.7T84737SEA
    P22459KCNA4Voltage-gated A-type potassium channelT15665SEA
    P16389KCNA2Voltage-gated potassium channel Kv1.2T19492SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T20251DI0175Heart failure[ICD-11: BD10-BD1Z]Q12809KCNH2
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
    T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
    T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
    T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T62292DI0216Intentional self-harm[ICD-11: PC91]P34903GABRA3
    T51452DI0216Intentional self-harm[ICD-11: PC91]P47869GABRA2
    T99347DI0152Fragile X chromosome[ICD-11: LD55]P41594GRM5
    T99347DI0331Parkinsonism[ICD-11: 8A00]P41594GRM5
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T05031DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42338PIK3CB
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T83904DI0365Retinopathy[ICD-11: 9B71]Q8IXJ6SIRT2
    T92777DI0009Acute diabete complication[ICD-11: 5A2Y]O43451MGAM
    T92777DI0201Inborn carbohydrate metabolism error[ICD-11: 5C51]O43451MGAM
    T51426DI0043Autoimmune liver disease[ICD-11: DB96]Q96RI1NR1H4
    T51426DI0077Cholelithiasis[ICD-11: DC11]Q96RI1NR1H4
    T51426DI0320Osteoarthritis[ICD-11: FA00-FA05]Q96RI1NR1H4
    T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
    T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
    T22285DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q12879GRIN2A
    T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
    T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
    T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
    T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
    T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
    T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
    T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
    T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
    T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
    T32060DI0009Acute diabete complication[ICD-11: 5A2Y]P28223HTR2A
    T32060DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P28223HTR2A
    T32060DI0073Cerebral ischaemia[ICD-11: 8B1Z]P28223HTR2A
    T32060DI0270Mood disorder[ICD-11: 6A60-6E23]P28223HTR2A
    T32060DI0331Parkinsonism[ICD-11: 8A00]P28223HTR2A
    T32060DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28223HTR2A
    T32060DI0370Schizophrenia[ICD-11: 6A20]P28223HTR2A
    T83813DI0117Depression[ICD-11: 6A70-6A7Z]P28335HTR2C
    T83813DI0264Migraine[ICD-11: 8A80]P28335HTR2C
    T83813DI0308Obesity[ICD-11: 5B80-5B81]P28335HTR2C
    T83813DI0324Pain[ICD-11: MG30-MG3Z]P28335HTR2C
    T83813DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28335HTR2C
    T42392DI0298Neuropathy[ICD-11: 8C0Z]P42262GRIA2
    T86679DI0180Herpes simplex infection[ICD-11: 1F00]P29275ADORA2B
    T86679DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P29275ADORA2B
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T84040DI0422Upper respiratory tract disorder[ICD-11: CA0Z]O75762TRPA1
    T72168DI0018Adrenocortical insufficiency[ICD-11: 5A74]P08235NR3C2
    T72168DI0083Chronic kidney disease[ICD-11: GB61]P08235NR3C2
    T72168DI0100Contraceptive management[ICD-11: QA21]P08235NR3C2
    T72168DI0175Heart failure[ICD-11: BD10-BD1Z]P08235NR3C2
    T72168DI0190Hypertension[ICD-11: BA00-BA04]P08235NR3C2
    T72168DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P08235NR3C2
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T22939DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06401PGR
    T22939DI0100Contraceptive management[ICD-11: QA21]P06401PGR
    T22939DI0255Menstrual cycle bleeding disorder[ICD-11: GA20]P06401PGR
    T22939DI0344Preterm labour/delivery[ICD-11: JB00]P06401PGR
    T22939DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06401PGR
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T02562DI0025Alzheimer disease[ICD-11: 8A20]O14684PTGES
    T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
    T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
    T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
    T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
    T21307DI0011Acute laryngitis/tracheitis[ICD-11: CA05]P49137MAPKAPK2
    T21307DI0181Hidradenitis suppurativa[ICD-11: ED92]P49137MAPKAPK2
    T21307DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P49137MAPKAPK2
    T21307DI0334Peritoneal cancer[ICD-11: 2C51]P49137MAPKAPK2
    T21307DI0352Psoriatic arthritis[ICD-11: FA21]P49137MAPKAPK2
    T21307DI0366Rheumatoid arthritis[ICD-11: FA20]P49137MAPKAPK2
    T21307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49137MAPKAPK2
    T41955DI0422Upper respiratory tract disorder[ICD-11: CA0Z]Q7Z2W7TRPM8
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T68547DI0274Multiple myeloma[ICD-11: 2A83]Q13547HDAC1
    T68547DI0283Mycosis fungoides[ICD-11: 2B01]Q13547HDAC1
    T21945DI0013Acute pain[ICD-11: MG31]P23975SLC6A2
    T21945DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P23975SLC6A2
    T21945DI0087Chronic pain[ICD-11: MG30]P23975SLC6A2
    T21945DI0101Corneal disease[ICD-11: 9A76-9A78]P23975SLC6A2
    T21945DI0117Depression[ICD-11: 6A70-6A7Z]P23975SLC6A2
    T21945DI0166Glaucoma[ICD-11: 9C61]P23975SLC6A2
    T21945DI0264Migraine[ICD-11: 8A80]P23975SLC6A2
    T21945DI0301Nicotine use disorder[ICD-11: 6C4A]P23975SLC6A2
    T21945DI0308Obesity[ICD-11: 5B80-5B81]P23975SLC6A2
    T21945DI0324Pain[ICD-11: MG30-MG3Z]P23975SLC6A2
    T21945DI0395Stomach cancer[ICD-11: 2B72]P23975SLC6A2
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T83059DI0060Brain cancer[ICD-11: 2A00]O95271TNKS
    T83059DI0062Breast cancer[ICD-11: 2C60-2C6Y]O95271TNKS
    T83059DI0321Ovarian cancer[ICD-11: 2C73]O95271TNKS
    T83059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O95271TNKS
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T08391DI0039Atopic eczema[ICD-11: EA80]O60674JAK2
    T08391DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60674JAK2
    T08391DI0366Rheumatoid arthritis[ICD-11: FA20]O60674JAK2
    T08391DI0404Thrombocytosis[ICD-11: 3B63]O60674JAK2
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T46245DI0115Dementia[ICD-11: 6D80-6D8Z]Q16769QPCT
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T10897DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O00767SCD
    T89041DI0346Prostate cancer[ICD-11: 2C82]P05093CYP17A1
    T08123DI0331Parkinsonism[ICD-11: 8A00]Q5S007LRRK2
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T99057DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q02750MAP2K1
    T99057DI0336Phakomatoses/hamartoneoplastic syndrome[ICD-11: LD2D]Q02750MAP2K1
    T53389DI0035Arterial occlusive disease[ICD-11: BD40]P36897TGFBR1
    T53389DI0238Lung cancer[ICD-11: 2C25]P36897TGFBR1
    T67849DI0151Follicular lymphoma[ICD-11: 2A80]O00329PIK3CD
    T67849DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00329PIK3CD
    T67849DI0249Mature B-cell leukaemia[ICD-11: 2A82]O00329PIK3CD
    T67849DI0250Mature B-cell lymphoma[ICD-11: 2A85]O00329PIK3CD
    T67849DI0395Stomach cancer[ICD-11: 2B72]O00329PIK3CD
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T63966DI0361Renal cell carcinoma[ICD-11: 2C90]P17948FLT1
    T92803DI0113Cytomegaloviral disease[ICD-11: 1D82]Q13627DYRK1A
    T12355DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P24385CCND1
    T98896DI0320Osteoarthritis[ICD-11: FA00-FA05]Q9UNA0ADAMTS5
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T18876DI0037Asthma[ICD-11: CA23]P35408PTGER4
    T18876DI0175Heart failure[ICD-11: BD10-BD1Z]P35408PTGER4
    T18876DI0264Migraine[ICD-11: 8A80]P35408PTGER4
    T18876DI0303Non-small-cell lung cancer[ICD-11: 2C25]P35408PTGER4
    T18876DI0324Pain[ICD-11: MG30-MG3Z]P35408PTGER4
    T18876DI0360Rectum cancer[ICD-11: 2B92]P35408PTGER4
    T18876DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35408PTGER4
    T18876DI0414Transplanted organ/tissue[ICD-11: QB63]P35408PTGER4
    T81358DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00311CDC7
    T81358DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O00311CDC7
    T55398DI0039Atopic eczema[ICD-11: EA80]Q9NWZ3IRAK4
    T55398DI0109Cutaneous lupus erythematosus[ICD-11: EB50-EB5Z]Q9NWZ3IRAK4
    T55398DI0241Lymphoma[ICD-11: 2A80-2A86]Q9NWZ3IRAK4
    T55398DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q9NWZ3IRAK4
    T55398DI0351Psoriasis[ICD-11: EA90]Q9NWZ3IRAK4
    T55398DI0366Rheumatoid arthritis[ICD-11: FA20]Q9NWZ3IRAK4
    T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
    T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
    T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
    T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
    T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
    T20333DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P07333CSF1R
    T07173DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04629NTRK1
    T07173DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04629NTRK1
    T44458DI0012Acute myeloid leukaemia[ICD-11: 2A60]P50750CDK9
    T44458DI0241Lymphoma[ICD-11: 2A80-2A86]P50750CDK9
    T44458DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P50750CDK9
    T44458DI0249Mature B-cell leukaemia[ICD-11: 2A82]P50750CDK9
    T44458DI0250Mature B-cell lymphoma[ICD-11: 2A85]P50750CDK9
    T44458DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]P50750CDK9
    T44458DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50750CDK9
    T45262DI0394Staphylococcal/streptococcal disease[ICD-11: 1B5Y]P34998CRHR1
    T78356DI0030Angina pectoris[ICD-11: BA40]P24557TBXAS1
    T61400DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q02127DHODH
    T61400DI0275Multiple sclerosis[ICD-11: 8A40]Q02127DHODH
    T23995DI0413Transplant rejection[ICD-11: NE84]Q04759PRKCQ
    T61698DI0275Multiple sclerosis[ICD-11: 8A40]P60568IL2
    T61698DI0361Renal cell carcinoma[ICD-11: 2C90]P60568IL2
    T99641DI0396Substance abuse[ICD-11: 6C40]P30837ALDH1B1
    T23787DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16875PFKFB3
    T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
    T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
    T92828DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P24530EDNRB
    T92828DI0356Pulmonary hypertension[ICD-11: BB01]P24530EDNRB
    T15795DI0309Obstructive sleep apnoea[ICD-11: 7A41]O14649KCNK3
    T87166DI0009Acute diabete complication[ICD-11: 5A2Y]P35557GCK
    T87166DI0120Diabetes mellitus[ICD-11: 5A10]P35557GCK
    T87166DI0308Obesity[ICD-11: 5B80-5B81]P35557GCK
    T87166DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P35557GCK
    T53524DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P16234PDGFRA
    T53524DI0225Kaposi sarcoma[ICD-11: 2B57]P16234PDGFRA
    T53524DI0403Thrombocytopenia[ICD-11: 3B64]P16234PDGFRA
    T17345DI0207Indeterminate colitis[ICD-11: DD72]P00374DHFR
    T17345DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00374DHFR
    T17345DI0416Tuberculosis[ICD-11: 1B10-1B12]P00374DHFR
    T17345DI0427Urinary tract infection[ICD-11: GC08]P00374DHFR
    T17569DI0030Angina pectoris[ICD-11: BA40]P22460KCNA5
    T76914DI0198Idiopathic inflammatory myopathy[ICD-11: 4A41]P22001KCNA3
    T76914DI0351Psoriasis[ICD-11: EA90]P22001KCNA3
    T76914DI0352Psoriatic arthritis[ICD-11: FA21]P22001KCNA3
    T22839DI0024Alpha-1-antitrypsin deficiency[ICD-11: 5C5A]Q9UNI1CELA1
    T22839DI0065Bronchitis[ICD-11: CA20]Q9UNI1CELA1
    T11911DI0285Myelopathy[ICD-11: 8B42]Q92952KCNN1
    T70518DI0037Asthma[ICD-11: CA23]P16152CBR1
    T10147DI0057Bone paget disease[ICD-11: FB85]Q13332PTPRS
    T97257DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P01137TGFB1
    T08910DI0117Depression[ICD-11: 6A70-6A7Z]P18507GABRG2
    T08910DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P18507GABRG2
    T08910DI0411Tonus and reflex abnormality[ICD-11: MB47]P18507GABRG2
    T86271DI0285Myelopathy[ICD-11: 8B42]Q9H2S1KCNN2
    T99641DI0396Substance abuse[ICD-11: 6C40]P30837ALDH1B1
    T17067DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P45974USP5
    T17067DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45974USP5
    T99641DI0396Substance abuse[ICD-11: 6C40]P30837ALDH1B1
    T39610DI0068Cardiac arrhythmia[ICD-11: BC9Z]Q96HK3CALM
    T39610DI0243Malaria[ICD-11: 1F40-1F45]Q96HK3CALM
    T39610DI0370Schizophrenia[ICD-11: 6A20]Q96HK3CALM

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