N-Benzoylaspartic acid



Compound IDCDAMM02530
Common nameN-Benzoylaspartic acid
IUPAC name2-benzamidobutanedioic acid
Molecular formulaC11H11NO5

Experimental data

Retention time9.72
Adduct[M+H]+
Actual mz238.07
Theoretical mz238.071
Error4.94
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.1756

Identifiers and class information

Inchi keyDJLTZJGULPLVOA-UHFFFAOYNA-N
SmilesO=C(O)CC(NC(=O)C=1C=CC=CC1)C(=O)O
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives

Pharmacokinetic properties

Number of descriptor values(#stars)1
Number of non-conjugated amine groups (#amine)0
Number of amidine and guanidine groups (#amidine)0
Number of carboxylic acid groups (#acid)2
Number of non-conjugated amide groups (#amide)0
Number of rotatable bonds (#rotor)5
Number of reactive functional groups (#rtvFG)0
Predicted central nervous system activity (CNS)-2
Molecular weight (mol_MW)237.212
Computed dipole moment(dipole)13.055
Total solvent accessible surface area (SASA)464.057
Hydrophobic component of SASA (FOSA)46.228
Hydrophilic component of SASA (FISA)227.219
Pie component of the SASA (PISA)190.609
Weakly polar component of the SASA (WPSA)0
Total solvent accesible volume (volume)765.352
Number of hydrogen bond donors (donorHB)2
Number of hydrogen bond acceptors (accptHB)5.5
Free energy of solvation of dipole (dip^2/V)0.222671
Index of cohesive interaction in solids (ACxDN^.5/SA)0.0167613
Globularity descriptor (glob)0.87197
Predicted polarizability in cubic angstroms (QPpolrz)23.085
Predicted hexadecane/gas partition coefficient (QPlogPC16)8.681
Predicted octanol/gas partition coefficient (QPlogPoct)16.617
Predicted water/gas partition coefficient (QPlogPw)10.922
Predicted octanol/water partition coefficient (QPlogPo/w)1.436
Predicted aqueous solubility (QPlogS)-2.19
Conformation-independent predicted aqueous solubility (CIQPlogS)-2.312
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-0.898
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)4.45
Predicted brain/blood partition coefficient (QPlogBB)-1.73
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)2.298
Predicted skin permeability, log Kp (QPlogKp)-4.556
PM3 calculated ionization potential (IP(ev))10.39
PM3 calculated electron affinity (EA(eV))0.821
Number of likely metabolic reactions (#metab)2
Prediction of binding to human serum albumin (QPlogKhsa)-0.808
Predicted qualitative human oral absorption (HumanOralAbsorption)2
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)46.955
Solvent-accessible surface area of fluorine atoms (SAFluorine)0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
Van der Waals surface area (PSA)133.046
Number of nitrogen and oxygen atoms (#NandO)6
Number of violations of Lipinski’s rule of five (RuleOfFive)0
Number of violations of Jorgensen’s rule of three (RuleOfThree)1

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID Gene name Target name TTD_ID Prediction source
O43570CA12Carbonic anhydrase XIIT16987SEA
Q16790CA9Carbonic anhydrase IXT64567SEA
P04818TYMSThymidylate synthase (by homology)T98397SEA
P15144ANPEPAminopeptidase NT67272SEA
O75899GABBR2GABA-B receptorT42446SEA
P00734F2ThrombinT94033SEA
P09960LTA4HLeukotriene A4 hydrolaseT03691SEA
O75899GABBR2GABA-B receptorT42446SEA
O15379HDAC3Histone deacetylase 3T05090SEA
P0DMS8ADORA3Adenosine A3 receptorT36059SEA
P00915CA1Carbonic anhydrase IT13201SEA
P00918CA2Carbonic anhydrase IIT20401SEA
Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
P08514ITGA2BIntegrin alpha-IIb/beta-3T50688SEA
P78352DLG4Disks large homolog 4T04507SEA
P08473MMENeprilysinT05409SEA
P34913EPHX2Epoxide hydrataseT35734SEA
P43005SLC1A1Excitatory amino acid transporter 3T31721SEA
P56524HDAC4Histone deacetylase 4T63816SEA
P43235CTSKCathepsin KT11388SEA
Q92769HDAC2Histone deacetylase 2T51191SEA
P23141CES1Acyl coenzyme A:cholesterol acyltransferaseT76369SEA
P10145CXCL8Interleukin-8T22658SEA
P42330AKR1C3Aldo-keto-reductase family 1 member C3T60857SEA
Q6B0I6KDM4DLysine-specific demethylase 4DT17036SEA
Q96IY4CPB2Carboxypeptidase B2 isoform AT98022SEA
Q16719KYNUKynureninaseT99912SEA
P18031PTPN1Protein-tyrosine phosphatase 1BT16347SEA
Q07075ENPEPAminopeptidase AT31956SEA
Q01650SLC7A5L-type amino acid transporter 1 (by homology)T48330SEA
P08575PTPRCLeukocyte common antigenT43115SEA
P08253MMP2Matrix metalloproteinase 2T68251SEA
P22894MMP8Matrix metalloproteinase 8T08856SEA
P08254MMP3Matrix metalloproteinase 3T86702SEA
P14780MMP9Matrix metalloproteinase 9T54156SEA
P03956MMP1Matrix metalloproteinase 1T52450SEA
P17655CAPN2Calpain 2T86837SEA
P15086CPB1Carboxypeptidase BT36725SEA
P52732KIF11Kinesin-like protein 1T28484SEA
P07711CTSLCathepsin LT98691SEA
P07858CTSBCathepsin (B and K)T61746SEA
P23946CMA1ChymaseT05114SEA
P00742F10Thrombin and coagulation factor XT84631SEA
P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SEA
P49356FNTBFarnesyl protein transferaseT13127SEA
P29466CASP1Caspase-1T98269SEA
P25774CTSSCathepsin ST68290SEA
P08263GSTA1Glutathione S-transferase A1T17221SEA
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SEA
P06870KLK1Kallikrein 1T40000SEA
P06756ITGAVVitronectin receptor alphaT67103SEA
Q9BYF1ACE2Angiotensin-converting enzyme 2T27889SEA
P17301ITGA2Integrin alpha-2T55293SEA
P42892ECE1Endothelin-converting enzyme 1T50970SEA
P05556ITGB1Integrin alpha2/beta1T01851SEA
Q9ULW8PADI3Protein-arginine deiminase type-3T36612SEA
Q9UM07PADI4Protein-arginine deiminase type-4T50429SEA
P39900MMP12Matrix metalloproteinase 12T03500SEA
P06737PYGLLiver glycogen phosphorylaseT19184SEA
P42574CASP3Caspase-3T57943SEA
P15085CPA1Carboxypeptidase A1T33966SEA
P10619CTSALysosomal protective proteinT37154SEA
O43174CYP26A1Cytochrome P450 26A1T84634SEA
P32239CCKBRCholecystokinin B receptor (by homology)T05849SEA
P50281MMP14Matrix metalloproteinase 14T65019SEA
Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SEA
Q9H244P2RY12Purinergic receptor P2Y12 (by homology)T46937SEA
P48067SLC6A9Glycine transporter 1T69685SEA
P00390GSRGlutathione reductaseT30803SEA
P32238CCKARCholecystokinin A receptorT28330SEA
Q16581C3AR1C3a anaphylatoxin chemotactic receptorT30219SEA
P03952KLKB1Plasma kallikreinT82739SEA
P28074PSMB5Proteasome Macropain subunit MB1T49031SEA
O14649KCNK3Potassium channel subfamily K member 3T15795SEA
Q9NPC2KCNK9Potassium channel subfamily K member 9T57613SEA
O60760HPGDSHematopoietic prostaglandin D synthaseT19433SEA
P43490NAMPTNicotinamide phosphoribosyltransferaseT54582SEA
P14679TYRTyrosinaseT97035SEA
P43003SLC1A3Excitatory amino acid transporter 1T86582SEA
Q9Y3Q0NAALAD2NAALADase IIT70036SEA
Q92820GGHGamma-glutamyl hydrolaseT71646SEA
P00374DHFRDihydrofolate reductaseT17345SEA
P53609PGGT1BGeranylgeranyl transferase type IT76396SEA
O15151MDM4Protein Mdm4T36741SEA
P26010ITGB7Integrin alpha-4/beta-7T07403SEA
P09238MMP10Matrix metalloproteinase 10T40488SEA
O75582RPS6KA5Ribosomal protein S6 kinase alpha 5T50224SEA
Q9UKP6UTS2RUrotensin II receptorT49072SEA
Q13526PIN1Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1T16308SEA
P29371TACR3Neurokinin 3 receptorT29683SEA
Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SEA
Q13237PRKG2cGMP-dependent protein kinase 2T23606SEA
P22102GARTGAR transformylaseT72042SEA
P15328FOLR1Folate receptor alphaT83386SEA
P14207FOLR2Folate receptor betaT82297SEA
Q96NT5SLC46A1Proton-coupled folate transporterT19229SEA
P98073TMPRSS15EnteropeptidaseT75772SEA
O75173ADAMTS4ADAMTS4T79570SEA
O60911CTSVCathepsin (V and K)T93653SEA
P06734FCER2Immunoglobulin epsilon Fc receptorT67207SEA
P13612ITGA4Integrin alpha-4T97587SEA
Q9H2K8TAOK3Serine/threonine-protein kinase TAO3T63682SEA
Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SEA
Q7L7X3TAOK1Serine/threonine-protein kinase TAO1T97016SEA
Q9Y345SLC6A5Glycine transporter 2T58937SEA
P21462FPR1Formyl peptide receptor 1T87831SEA
Q03405PLAURUrokinase plasminogen activator surface receptorT74363SEA
P51684CCR6C-C chemokine receptor type 6T63165SEA
Q6DWJ6GPR139Probable G-protein coupled receptor 139T84439SEA
P40306PSMB1026S proteosomeT09022SEA
P08311CTSGCathepsin GT86385SEA
Q9UJM8HAO1Hydroxyacid oxidase 1T63170SEA
Q9P0U3SENP1Sentrin-specific protease 1T96435SEA
O95822MLYCDMalonyl-CoA decarboxylaseT98078SEA
O60235TMPRSS11DTransmembrane protease serine 11DT00302SEA
O95551TDP2Tyrosyl-DNA phosphodiesterase 2T04696SEA
Q8IWU9TPH2Tryptophan hydroxylaseT51593SEA
Q04609FOLH1Glutamate carboxypeptidase IIT97071SEA
Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
Q9GZQ6NPFFR1Neuropeptide FF receptor 1T79780SEA
Q9Y5X5NPFFR2Neuropeptide FF receptor 2T90818SEA
Q9BY41HDAC8Histone deacetylase 8T28887SEA
Q06609RAD51DNA repair protein RAD51 homolog 1T63083SEA
P04632CAPNS1HUMAN calpain-1 or calpain small subunit 1 heterodimerT00099SEA
Q7RTX1TAS1R1Taste receptorT41263SEA
P05106ITGB3Integrin beta-3T26457SEA
Q16348PEPT2Solute carrier family 15 member 2T52067SEA
P49356FNTBFarnesyl protein transferaseT13127SEA
Q9NXA8SIRT5NAD-dependent deacetylase sirtuin-5T91940SEA
Q9HAN5TRP1Cationic trypsinogenT27602SEA
Q96BR1SGK3Serum-and glucocorticoid-inducible kinase SGKT64102SEA
P25786PSMA1Core proteasome 20S complexT61997SEA
P28072PSMB6Proteasome beta-1T54973SEA
Q99436PSMB7Proteasome beta-2T55986SEA
P55211CASP9Caspase-9T93903SEA
Q9UQ81MCH5Caspase-8T15700SEA

Target associated diseases

TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
T42446DI0117Depression[ICD-11: 6A70-6A7Z]O75899GABBR2
T42446DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]O75899GABBR2
T42446DI0275Multiple sclerosis[ICD-11: 8A40]O75899GABBR2
T42446DI0290Narcolepsy[ICD-11: 7A20]O75899GABBR2
T94033DI0052Bleeding disorder[ICD-11: GA20-GA21]P00734F2
T94033DI0091Coagulation defect[ICD-11: 3B10]P00734F2
T94033DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P00734F2
T94033DI0275Multiple sclerosis[ICD-11: 8A40]P00734F2
T94033DI0287Myocardial infarction[ICD-11: BA41-BA43]P00734F2
T94033DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00734F2
T94033DI0403Thrombocytopenia[ICD-11: 3B64]P00734F2
T94033DI0405Thrombosis[ICD-11: DB61-GB90]P00734F2
T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
T42446DI0117Depression[ICD-11: 6A70-6A7Z]O75899GABBR2
T42446DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]O75899GABBR2
T42446DI0275Multiple sclerosis[ICD-11: 8A40]O75899GABBR2
T42446DI0290Narcolepsy[ICD-11: 7A20]O75899GABBR2
T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
T50688DI0007Acquired hypermelanosis[ICD-11: ED60]P08514ITGA2B
T50688DI0030Angina pectoris[ICD-11: BA40]P08514ITGA2B
T50688DI0287Myocardial infarction[ICD-11: BA41-BA43]P08514ITGA2B
T04507DI0073Cerebral ischaemia[ICD-11: 8B1Z]P78352DLG4
T04507DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P78352DLG4
T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
T63816DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P56524HDAC4
T11388DI0237Low bone mass disorder[ICD-11: FB83]P43235CTSK
T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
T76369DI0335Peroxisomal disease[ICD-11: 5C57]P23141CES1
T76369DI0398Synthesis disorder[ICD-11: 5C52-5C59]P23141CES1
T22658DI0324Pain[ICD-11: MG30-MG3Z]P10145CXCL8
T60857DI0145Female pelvic pain[ICD-11: GA34]P42330AKR1C3
T98022DI0073Cerebral ischaemia[ICD-11: 8B1Z]Q96IY4CPB2
T98022DI0074Cerebral ischaemic stroke[ICD-11: 8B11]Q96IY4CPB2
T98022DI0405Thrombosis[ICD-11: DB61-GB90]Q96IY4CPB2
T99912DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q16719KYNU
T99912DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q16719KYNU
T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
T31956DI0190Hypertension[ICD-11: BA00-BA04]Q07075ENPEP
T43115DI0012Acute myeloid leukaemia[ICD-11: 2A60]P08575PTPRC
T43115DI0414Transplanted organ/tissue[ICD-11: QB63]P08575PTPRC
T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
T86837DI0106COVID-19[ICD-11: 1D6Y]P17655CAPN2
T28484DI0012Acute myeloid leukaemia[ICD-11: 2A60]P52732KIF11
T28484DI0172Head and neck cancer[ICD-11: 2D42]P52732KIF11
T28484DI0241Lymphoma[ICD-11: 2A80-2A86]P52732KIF11
T28484DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P52732KIF11
T28484DI0274Multiple myeloma[ICD-11: 2A83]P52732KIF11
T28484DI0321Ovarian cancer[ICD-11: 2C73]P52732KIF11
T28484DI0361Renal cell carcinoma[ICD-11: 2C90]P52732KIF11
T28484DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P52732KIF11
T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
T05114DI0039Atopic eczema[ICD-11: EA80]P23946CMA1
T05114DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P23946CMA1
T05114DI0169Gram-positive bacterial infection[ICD-11: 1B74-1F40]P23946CMA1
T05114DI0175Heart failure[ICD-11: BD10-BD1Z]P23946CMA1
T05114DI0229Left ventricular failure[ICD-11: BD11]P23946CMA1
T05114DI0287Myocardial infarction[ICD-11: BA41-BA43]P23946CMA1
T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
T98269DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P29466CASP1
T98269DI0146Fibrosis[ICD-11: GA14-GC01]P29466CASP1
T98269DI0366Rheumatoid arthritis[ICD-11: FA20]P29466CASP1
T98269DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P29466CASP1
T68290DI0042Autoimmune disease[ICD-11: 4A40-4A45]P25774CTSS
T68290DI0092Coeliac disease[ICD-11: DA95]P25774CTSS
T68290DI0107Crohn disease[ICD-11: DD70]P25774CTSS
T68290DI0120Diabetes mellitus[ICD-11: 5A10]P25774CTSS
T68290DI0163General pain disorder[ICD-11: 8E43]P25774CTSS
T68290DI0324Pain[ICD-11: MG30-MG3Z]P25774CTSS
T68290DI0382Sjogren syndrome[ICD-11: 4A43]P25774CTSS
T67103DI0095Colorectal cancer[ICD-11: 2B91]P06756ITGAV
T67103DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06756ITGAV
T27889DI0009Acute diabete complication[ICD-11: 5A2Y]Q9BYF1ACE2
T27889DI0217Intrathoracic organs injury[ICD-11: NB32]Q9BYF1ACE2
T27889DI0356Pulmonary hypertension[ICD-11: BB01]Q9BYF1ACE2
T55293DI0095Colorectal cancer[ICD-11: 2B91]P17301ITGA2
T55293DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P17301ITGA2
T01851DI0060Brain cancer[ICD-11: 2A00]P05556ITGB1
T01851DI0238Lung cancer[ICD-11: 2C25]P05556ITGB1
T01851DI0365Retinopathy[ICD-11: 9B71]P05556ITGB1
T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
T57943DI0060Brain cancer[ICD-11: 2A00]P42574CASP3
T37154DI0009Acute diabete complication[ICD-11: 5A2Y]P10619CTSA
T84634DI0314Oesophagitis[ICD-11: DA24]O43174CYP26A1
T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
T46937DI0287Myocardial infarction[ICD-11: BA41-BA43]Q9H244P2RY12
T46937DI0405Thrombosis[ICD-11: DB61-GB90]Q9H244P2RY12
T69685DI0370Schizophrenia[ICD-11: 6A20]P48067SLC6A9
T30803DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00390GSR
T28330DI0210Influenza[ICD-11: 1E30-1E32]P32238CCKAR
T28330DI0328Pancreatic malfunction[ICD-11: DC30-DC3Z]P32238CCKAR
T82739DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P03952KLKB1
T82739DI0364Retinal vascular occlusion[ICD-11: 9B74]P03952KLKB1
T15795DI0309Obstructive sleep apnoea[ICD-11: 7A41]O14649KCNK3
T19433DI0148Flatworm infection[ICD-11: 1F70-1F86]O60760HPGDS
T54582DI0231Leukaemia[ICD-11: 2A60-2B33]P43490NAMPT
T54582DI0241Lymphoma[ICD-11: 2A80-2A86]P43490NAMPT
T54582DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43490NAMPT
T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
T17345DI0207Indeterminate colitis[ICD-11: DD72]P00374DHFR
T17345DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00374DHFR
T17345DI0416Tuberculosis[ICD-11: 1B10-1B12]P00374DHFR
T17345DI0427Urinary tract infection[ICD-11: GC08]P00374DHFR
T76396DI0241Lymphoma[ICD-11: 2A80-2A86]P53609PGGT1B
T36741DI0012Acute myeloid leukaemia[ICD-11: 2A60]O15151MDM4
T36741DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O15151MDM4
T36741DI0284Myelodysplastic syndrome[ICD-11: 2A37]O15151MDM4
T36741DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15151MDM4
T07403DI0107Crohn disease[ICD-11: DD70]P26010ITGB7
T49072DI0037Asthma[ICD-11: CA23]Q9UKP6UTS2R
T16308DI0238Lung cancer[ICD-11: 2C25]Q13526PIN1
T29683DI0254Menopausal disorder[ICD-11: GA30]P29371TACR3
T72042DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P22102GART
T83386DI0243Malaria[ICD-11: 1F40-1F45]P15328FOLR1
T83386DI0321Ovarian cancer[ICD-11: 2C73]P15328FOLR1
T19229DI0150Folate deficiency anaemia[ICD-11: 3A02]Q96NT5SLC46A1
T19229DI0231Leukaemia[ICD-11: 2A60-2B33]Q96NT5SLC46A1
T19229DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q96NT5SLC46A1
T93653DI0055Bone cancer[ICD-11: 2B5Z]O60911CTSV
T93653DI0087Chronic pain[ICD-11: MG30]O60911CTSV
T67207DI0231Leukaemia[ICD-11: 2A60-2B33]P06734FCER2
T97587DI0107Crohn disease[ICD-11: DD70]P13612ITGA4
T97587DI0275Multiple sclerosis[ICD-11: 8A40]P13612ITGA4
T97587DI0419Ulcerative colitis[ICD-11: DD71]P13612ITGA4
T87831DI0333Peptic ulcer[ICD-11: DA61]P21462FPR1
T74363DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q03405PLAUR
T74363DI0404Thrombocytosis[ICD-11: 3B63]Q03405PLAUR
T63165DI0207Indeterminate colitis[ICD-11: DD72]P51684CCR6
T84439DI0377Sex development malformative disorder[ICD-11: LD2A]Q6DWJ6GPR139
T86385DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P08311CTSG
T63170DI0201Inborn carbohydrate metabolism error[ICD-11: 5C51]Q9UJM8HAO1
T51593DI0066Carcinoid syndrome[ICD-11: 5B10]Q8IWU9TPH2
T51593DI0389Small intestine developmental anomaly[ICD-11: DA90]Q8IWU9TPH2
T97071DI0122Diagnostic imaging[ICD-11: N.A.]Q04609FOLH1
T97071DI0346Prostate cancer[ICD-11: 2C82]Q04609FOLH1
T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
T63083DI0048B-cell lymphoma[ICD-11: 2A86]Q06609RAD51
T63083DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06609RAD51
T00099DI0106COVID-19[ICD-11: 1D6Y]P04632CAPNS1
T41263DI0078Cholera[ICD-11: 1A00]Q7RTX1TAS1R1
T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
T27602DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q9HAN5TRP1
T27602DI0274Multiple myeloma[ICD-11: 2A83]Q9HAN5TRP1
T93903DI0110Cystic fibrosis[ICD-11: CA25]P55211CASP9
T15700DI0120Diabetes mellitus[ICD-11: 5A10]Q9UQ81MCH5
T15700DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UQ81MCH5

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