Compound details

N\'-Demethylalfileramine

Compound ID	CDAMM02189
Common name	N\'-Demethylalfileramine
IUPAC name	4-[2-(dimethylamino)ethyl]-2-[6,6,9-trimethyl-2-[2-(methylamino)ethyl]-6a,7,10,10a-tetrahydrobenzo[c]chromen-7-yl]phenol
Molecular formula	C₂₉H₄₀N₂O₂

Experimental data

Retention time	7.63
Adduct	[M+Na]+
Actual mz	471.298
Theoretical mz	471.298
Error	1.1
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	5.1101

Identifiers and class information

Inchi key	XFRSANVUXWMXEL-AZDPRDSUNA-N
Smiles	OC1=CC=C(C=C1C2C=C(C)CC3C4=CC(=CC=C4OC(C)(C)C23)CCNC)CCN(C)C
Superclass	Organoheterocyclic compounds
Class	Benzopyrans

Plant source

Asparagus racemosus Willd.

External sources

HMDB ID
KNApSAcK ID	C00028655
FooDB ID
DrugBank ID
ChEBI ID
Pubchem Compound ID	14635638
PlantCyc ID
UNPD ID	UNPD118925
Coconut ID	CNP0153056
LipidMAPS ID
NANPDB ID

Pharmacokinetic properties

Number of descriptor values(#stars)	1
Number of non-conjugated amine groups (#amine)	2
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	0
Number of non-conjugated amide groups (#amide)	0
Number of rotatable bonds (#rotor)	7
Number of reactive functional groups (#rtvFG)	0
Predicted central nervous system activity (CNS)	1
Molecular weight (mol_MW)	448.647
Computed dipole moment(dipole)	3.396
Total solvent accessible surface area (SASA)	838.129
Hydrophobic component of SASA (FOSA)	589.267
Hydrophilic component of SASA (FISA)	67.64
Pie component of the SASA (PISA)	181.222
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	1552.38
Number of hydrogen bond donors (donorHB)	2
Number of hydrogen bond acceptors (accptHB)	5
Free energy of solvation of dipole (dip^2/V)	0.007427
Index of cohesive interaction in solids (ACxDN^.5/SA)	0.0084367
Globularity descriptor (glob)	0.773604
Predicted polarizability in cubic angstroms (QPpolrz)	53.208
Predicted hexadecane/gas partition coefficient (QPlogPC16)	15.018
Predicted octanol/gas partition coefficient (QPlogPoct)	22.91
Predicted water/gas partition coefficient (QPlogPw)	9.739
Predicted octanol/water partition coefficient (QPlogPo/w)	5.452
Predicted aqueous solubility (QPlogS)	-5.943
Conformation-independent predicted aqueous solubility (CIQPlogS)	-5.035
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	-7.512
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	140.692
Predicted brain/blood partition coefficient (QPlogBB)	0.185
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	72.692
Predicted skin permeability, log Kp (QPlogKp)	-5.581
PM3 calculated ionization potential (IP(ev))	8.803
PM3 calculated electron affinity (EA(eV))	-0.175
Number of likely metabolic reactions (#metab)	11
Prediction of binding to human serum albumin (QPlogKhsa)	1.486
Predicted qualitative human oral absorption (HumanOralAbsorption)	1
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	84.361
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	0
Van der Waals surface area (PSA)	48.385
Number of nitrogen and oxygen atoms (#NandO)	4
Number of violations of Lipinski’s rule of five (RuleOfFive)	1
Number of violations of Jorgensen’s rule of three (RuleOfThree)	2

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
P06241	FYN	Tyrosine-protein kinase FYN	T17980	SwissTargetPrediction
P00533	EGFR	Epidermal growth factor receptor erbB1	T59328	SwissTargetPrediction
P29475	NOS1	Nitric-oxide synthase, brain	T16117	SwissTargetPrediction
P35228	NOS2	Nitric oxide synthase, inducible	T02703	SwissTargetPrediction
P00734	F2	Thrombin	T94033	SwissTargetPrediction
P48066	SLC6A11	GABA transporter 3	T38200	SwissTargetPrediction
P06239	LCK	Tyrosine-protein kinase LCK	T12499	SwissTargetPrediction
P43405	SYK	Tyrosine-protein kinase SYK	T62431	SwissTargetPrediction
P98170	XIAP	Inhibitor of apoptosis protein 3	T16769	SwissTargetPrediction
P21554	CNR1	Cannabinoid receptor 1 (by homology)	T76685	SwissTargetPrediction and SEA
P42785	PRCP	Lysosomal Pro-X carboxypeptidase	T20371	SwissTargetPrediction
P07949	RET	Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET	T60631	SwissTargetPrediction
P00747	PLG	Plasminogen	T89034	SwissTargetPrediction
P35968	KDR	Vascular endothelial growth factor receptor 2	T80975	SwissTargetPrediction
P08254	MMP3	Matrix metalloproteinase 3	T86702	SwissTargetPrediction
P08069	IGF1R	Insulin-like growth factor I receptor	T48069	SwissTargetPrediction
Q9UM73	ALK	ALK tyrosine kinase receptor	T56418	SwissTargetPrediction
P52732	KIF11	Kinesin-like protein 1	T28484	SwissTargetPrediction
P00519	ABL1	Tyrosine-protein kinase ABL	T63505	SwissTargetPrediction
P53667	LIMK1	LIM domain kinase 1	T70840	SwissTargetPrediction
Q16539	MAPK14	MAP kinase p38 alpha	T65864	SwissTargetPrediction
O60674	JAK2	Tyrosine-protein kinase JAK2	T08391	SwissTargetPrediction
P06213	INSR	Insulin receptor	T85435	SwissTargetPrediction
P36888	FLT3	Tyrosine-protein kinase receptor FLT3	T74312	SwissTargetPrediction
P09237	MMP7	Matrix metalloproteinase 7	T73475	SwissTargetPrediction
P32245	MC4R	Melanocortin receptor 4	T72458	SwissTargetPrediction
P41968	MC3R	Melanocortin receptor 3	T76846	SwissTargetPrediction
Q9HAN5	TRP1	Cationic trypsinogen	T27602	SwissTargetPrediction
P49356	FNTB	Farnesyl protein transferase	T13127	SwissTargetPrediction
O75116	ROCK2	Rho-associated protein kinase 2	T06093	SwissTargetPrediction
P23458	JAK1	Tyrosine-protein kinase JAK1	T62460	SwissTargetPrediction
Q05397	PTK2	Focal adhesion kinase 1	T15068	SwissTargetPrediction
P08581	MET	Hepatocyte growth factor receptor	T40474	SwissTargetPrediction
P17948	FLT1	Vascular endothelial growth factor receptor 1	T63966	SwissTargetPrediction
P10721	KIT	Stem cell growth factor receptor	T57700	SwissTargetPrediction
P12931	SRC	Tyrosine-protein kinase SRC	T85943	SwissTargetPrediction
P24385	CCND1	Cyclin-dependent kinase 4/cyclin D1	T12355	SwissTargetPrediction
O00444	PLK4	Serine/threonine-protein kinase PLK4	T71374	SwissTargetPrediction
P52333	JAK3	Tyrosine-protein kinase JAK3	T23172	SwissTargetPrediction
P29597	TYK2	Tyrosine-protein kinase TYK2	T78932	SwissTargetPrediction
P34972	CNR2	Cannabinoid receptor 2	T37693	SwissTargetPrediction
Q9NWZ3	IRAK4	Interleukin-1 receptor-associated kinase 4	T55398	SwissTargetPrediction
P06493	CDK1	Cyclin-dependent kinase 1/cyclin B1	T49898	SwissTargetPrediction
P23415	GLRA1	Glycine receptor subunit alpha-1	T50269	SwissTargetPrediction
P07333	CSF1R	Macrophage colony stimulating factor receptor	T20333	SwissTargetPrediction
P04629	NTRK1	Nerve growth factor receptor Trk-A	T07173	SwissTargetPrediction
P50613	CDK7	Cyclin-dependent kinase 7	T58449	SwissTargetPrediction
P35346	SSTR5	Somatostatin receptor 5	T64830	SwissTargetPrediction
P25929	NPY1R	Neuropeptide Y receptor type 1	T89213	SwissTargetPrediction
P46098	HTR3A	Serotonin 3a (5-HT3a) receptor	T64591	SwissTargetPrediction
P31391	SSTR4	Somatostatin receptor 4	T62974	SwissTargetPrediction
P50281	MMP14	Matrix metalloproteinase 14	T65019	SwissTargetPrediction
P00749	PLAU	Urokinase-type plasminogen activator	T17758	SwissTargetPrediction
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	T77537	SwissTargetPrediction
P03952	KLKB1	Plasma kallikrein	T82739	SwissTargetPrediction
Q96GD4	AURKB	Serine/threonine-protein kinase Aurora-B	T46781	SwissTargetPrediction
P50053	KHK	Ketohexokinase	T79326	SwissTargetPrediction
P29317	EPHA2	Ephrin type-A receptor 2	T57278	SwissTargetPrediction
P21452	TACR2	Neurokinin 2 receptor	T52790	SwissTargetPrediction
P53609	PGGT1B	Geranylgeranyl transferase type I	T76396	SwissTargetPrediction
Q14680	MELK	Maternal embryonic leucine zipper kinase	T96892	SwissTargetPrediction
P51451	BLK	Tyrosine-protein kinase BLK	T74307	SwissTargetPrediction
P22607	FGFR3	Fibroblast growth factor receptor 3	T91331	SwissTargetPrediction
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	T63846	SwissTargetPrediction
Q2M2I8	AAK1	Adaptor-associated kinase	T32764	SwissTargetPrediction
P51813	BMX	Tyrosine-protein kinase BMX	T99990	SwissTargetPrediction
P07948	LYN	Tyrosine-protein kinase Lyn	T68163	SwissTargetPrediction
Q13233	MAP3K1	Mitogen-activated protein kinase kinase kinase 1	T06031	SwissTargetPrediction
Q13464	ROCK1	Rho-associated protein kinase 1	T51282	SwissTargetPrediction
P43403	ZAP70	Tyrosine-protein kinase ZAP-70	T64553	SwissTargetPrediction
P61073	CXCR4	C-X-C chemokine receptor type 4	T96079	SwissTargetPrediction
P03951	F11	Coagulation factor XI	T46040	SwissTargetPrediction
Q14703	MBTPS1	Membrane-bound transcription factor site-1 protease	T67231	SwissTargetPrediction
Q13393	PLD1	Phospholipase D1	T38996	SwissTargetPrediction
O14939	PLD2	Phospholipase D2	T10383	SwissTargetPrediction
Q9Y5Y6	ST14	Matriptase	T31543	SwissTargetPrediction
P30530	AXL	Tyrosine-protein kinase receptor UFO	T82383	SwissTargetPrediction
Q14330	GPR18	N-arachidonyl glycine receptor	T72267	SwissTargetPrediction and SEA
P33032	MC5R	Melanocortin receptor 5	T95302	SwissTargetPrediction
Q04912	MST1R	Macrophage-stimulating protein receptor	T01973	SwissTargetPrediction
Q9H7B4	SMYD3	Histone-lysine N-methyltransferase SMYD3	T35792	SwissTargetPrediction
P06748	NPM1	NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)	T45591	SwissTargetPrediction
Q15139	PRKD1	Protein kinase C mu	T47885	SwissTargetPrediction
Q9UQB9	AURKC	Serine/threonine-protein kinase Aurora-C	T97592	SwissTargetPrediction

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T17980	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P06241	FYN
T59328	DI0030	Angina pectoris	[ICD-11: BA40]	P00533	EGFR
T59328	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00533	EGFR
T59328	DI0095	Colorectal cancer	[ICD-11: 2B91]	P00533	EGFR
T59328	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P00533	EGFR
T59328	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P00533	EGFR
T59328	DI0238	Lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P00533	EGFR
T59328	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P00533	EGFR
T59328	DI0420	Unspecific body region injury	[ICD-11: ND56]	P00533	EGFR
T16117	DI0173	Headache	[ICD-11: 8A80-8A84]	P29475	NOS1
T16117	DI0264	Migraine	[ICD-11: 8A80]	P29475	NOS1
T02703	DI0083	Chronic kidney disease	[ICD-11: GB61]	P35228	NOS2
T02703	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P35228	NOS2
T02703	DI0375	Sepsis	[ICD-11: 1G40-1G41]	P35228	NOS2
T02703	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P35228	NOS2
T94033	DI0052	Bleeding disorder	[ICD-11: GA20-GA21]	P00734	F2
T94033	DI0091	Coagulation defect	[ICD-11: 3B10]	P00734	F2
T94033	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P00734	F2
T94033	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P00734	F2
T94033	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00734	F2
T94033	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P00734	F2
T94033	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P00734	F2
T94033	DI0405	Thrombosis	[ICD-11: DB61-GB90]	P00734	F2
T38200	DI0207	Indeterminate colitis	[ICD-11: DD72]	P48066	SLC6A11
T12499	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P06239	LCK
T62431	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P43405	SYK
T16769	DI0259	Metastatic lymph node neoplasm	[ICD-11: 2D60]	P98170	XIAP
T76685	DI0031	Anorexia nervosa	[ICD-11: 6B80]	P21554	CNR1
T76685	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P21554	CNR1
T76685	DI0308	Obesity	[ICD-11: 5B80-5B81]	P21554	CNR1
T60631	DI0095	Colorectal cancer	[ICD-11: 2B91]	P07949	RET
T60631	DI0238	Lung cancer	[ICD-11: 2C25]	P07949	RET
T60631	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P07949	RET
T60631	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P07949	RET
T60631	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P07949	RET
T60631	DI0407	Thyroid cancer	[ICD-11: 2D10]	P07949	RET
T89034	DI0030	Angina pectoris	[ICD-11: BA40]	P00747	PLG
T89034	DI0052	Bleeding disorder	[ICD-11: GA20-GA21]	P00747	PLG
T89034	DI0254	Menopausal disorder	[ICD-11: GA30]	P00747	PLG
T89034	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00747	PLG
T89034	DI0345	Procedure injury	[ICD-11: NE81]	P00747	PLG
T89034	DI0357	Pulmonary thromboembolism	[ICD-11: BB00]	P00747	PLG
T80975	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P35968	KDR
T80975	DI0095	Colorectal cancer	[ICD-11: 2B91]	P35968	KDR
T80975	DI0160	Gastrointestinal stromal tumour	[ICD-11: 2B5B]	P35968	KDR
T80975	DI0244	Malignant digestive organ neoplasm	[ICD-11: 2C11]	P35968	KDR
T80975	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P35968	KDR
T80975	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P35968	KDR
T80975	DI0395	Stomach cancer	[ICD-11: 2B72]	P35968	KDR
T80975	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P35968	KDR
T80975	DI0407	Thyroid cancer	[ICD-11: 2D10]	P35968	KDR
T86702	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P08254	MMP3
T86702	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P08254	MMP3
T86702	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P08254	MMP3
T86702	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P08254	MMP3
T86702	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08254	MMP3
T86702	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P08254	MMP3
T86702	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P08254	MMP3
T48069	DI0276	Multiple structural anomalies syndrome	[ICD-11: LD2F]	P08069	IGF1R
T48069	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P08069	IGF1R
T48069	DI0408	Thyrotoxicosis	[ICD-11: 5A02]	P08069	IGF1R
T56418	DI0238	Lung cancer	[ICD-11: 2C25]	Q9UM73	ALK
T56418	DI0251	Mature T-cell lymphoma	[ICD-11: 2A90]	Q9UM73	ALK
T56418	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	Q9UM73	ALK
T28484	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P52732	KIF11
T28484	DI0172	Head and neck cancer	[ICD-11: 2D42]	P52732	KIF11
T28484	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P52732	KIF11
T28484	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P52732	KIF11
T28484	DI0274	Multiple myeloma	[ICD-11: 2A83]	P52732	KIF11
T28484	DI0321	Ovarian cancer	[ICD-11: 2C73]	P52732	KIF11
T28484	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P52732	KIF11
T28484	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P52732	KIF11
T63505	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00519	ABL1
T63505	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P00519	ABL1
T63505	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P00519	ABL1
T63505	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P00519	ABL1
T65864	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	Q16539	MAPK14
T65864	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	Q16539	MAPK14
T65864	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q16539	MAPK14
T65864	DI0437	Vitamin deficiency	[ICD-11: 5B55-5B5F]	Q16539	MAPK14
T08391	DI0039	Atopic eczema	[ICD-11: EA80]	O60674	JAK2
T08391	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	O60674	JAK2
T08391	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	O60674	JAK2
T08391	DI0404	Thrombocytosis	[ICD-11: 3B63]	O60674	JAK2
T85435	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P06213	INSR
T85435	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P06213	INSR
T74312	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P36888	FLT3
T74312	DI0058	Bone/articular cartilage neoplasm	[ICD-11: 2F7B]	P36888	FLT3
T74312	DI0095	Colorectal cancer	[ICD-11: 2B91]	P36888	FLT3
T74312	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	P36888	FLT3
T74312	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P36888	FLT3
T74312	DI0248	Mastocytosis	[ICD-11: 2A21]	P36888	FLT3
T74312	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P36888	FLT3
T74312	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P36888	FLT3
T73475	DI0238	Lung cancer	[ICD-11: 2C25]	P09237	MMP7
T72458	DI0192	Hypoactive sexual desire dysfunction	[ICD-11: HA00]	P32245	MC4R
T72458	DI0228	Large intestine motility disorder	[ICD-11: DB32]	P32245	MC4R
T72458	DI0308	Obesity	[ICD-11: 5B80-5B81]	P32245	MC4R
T76846	DI0308	Obesity	[ICD-11: 5B80-5B81]	P41968	MC3R
T76846	DI0378	Sexual dysfunction	[ICD-11: HA00-HA01]	P41968	MC3R
T76846	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P41968	MC3R
T27602	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q9HAN5	TRP1
T27602	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q9HAN5	TRP1
T13127	DI0342	Premature ageing appearance	[ICD-11: LD2B]	P49356	FNTB
T06093	DI0168	Graft-versus-host disease	[ICD-11: 4B24]	O75116	ROCK2
T62460	DI0039	Atopic eczema	[ICD-11: EA80]	P23458	JAK1
T62460	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P23458	JAK1
T62460	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P23458	JAK1
T62460	DI0404	Thrombocytosis	[ICD-11: 3B63]	P23458	JAK1
T15068	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	Q05397	PTK2
T15068	DI0321	Ovarian cancer	[ICD-11: 2C73]	Q05397	PTK2
T15068	DI0326	Pancreatic cancer	[ICD-11: 2C10]	Q05397	PTK2
T15068	DI0334	Peritoneal cancer	[ICD-11: 2C51]	Q05397	PTK2
T15068	DI0356	Pulmonary hypertension	[ICD-11: BB01]	Q05397	PTK2
T15068	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q05397	PTK2
T40474	DI0238	Lung cancer	[ICD-11: 2C25]	P08581	MET
T40474	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P08581	MET
T40474	DI0407	Thyroid cancer	[ICD-11: 2D10]	P08581	MET
T63966	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P17948	FLT1
T57700	DI0058	Bone/articular cartilage neoplasm	[ICD-11: 2F7B]	P10721	KIT
T57700	DI0095	Colorectal cancer	[ICD-11: 2B91]	P10721	KIT
T57700	DI0160	Gastrointestinal stromal tumour	[ICD-11: 2B5B]	P10721	KIT
T57700	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P10721	KIT
T57700	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P10721	KIT
T57700	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P10721	KIT
T57700	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P10721	KIT
T85943	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P12931	SRC
T85943	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P12931	SRC
T85943	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P12931	SRC
T85943	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P12931	SRC
T12355	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P24385	CCND1
T71374	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	O00444	PLK4
T23172	DI0023	Alopecia	[ICD-11: ED70]	P52333	JAK3
T23172	DI0039	Atopic eczema	[ICD-11: EA80]	P52333	JAK3
T23172	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P52333	JAK3
T23172	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P52333	JAK3
T78932	DI0351	Psoriasis	[ICD-11: EA90]	P29597	TYK2
T37693	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P34972	CNR2
T37693	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P34972	CNR2
T55398	DI0039	Atopic eczema	[ICD-11: EA80]	Q9NWZ3	IRAK4
T55398	DI0109	Cutaneous lupus erythematosus	[ICD-11: EB50-EB5Z]	Q9NWZ3	IRAK4
T55398	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q9NWZ3	IRAK4
T55398	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	Q9NWZ3	IRAK4
T55398	DI0351	Psoriasis	[ICD-11: EA90]	Q9NWZ3	IRAK4
T55398	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9NWZ3	IRAK4
T49898	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P06493	CDK1
T49898	DI0238	Lung cancer	[ICD-11: 2C25]	P06493	CDK1
T49898	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P06493	CDK1
T49898	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P06493	CDK1
T49898	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P06493	CDK1
T50269	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P23415	GLRA1
T20333	DI0058	Bone/articular cartilage neoplasm	[ICD-11: 2F7B]	P07333	CSF1R
T07173	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P04629	NTRK1
T07173	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P04629	NTRK1
T58449	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P50613	CDK7
T58449	DI0238	Lung cancer	[ICD-11: 2C25]	P50613	CDK7
T58449	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P50613	CDK7
T58449	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P50613	CDK7
T64830	DI0108	Cushing syndrome	[ICD-11: 5A70]	P35346	SSTR5
T89213	DI0050	Binge eating disorder	[ICD-11: 6B82]	P25929	NPY1R
T89213	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P25929	NPY1R
T89213	DI0174	Heart disease	[ICD-11: BA41-BA42]	P25929	NPY1R
T89213	DI0190	Hypertension	[ICD-11: BA00-BA04]	P25929	NPY1R
T89213	DI0308	Obesity	[ICD-11: 5B80-5B81]	P25929	NPY1R
T64591	DI0087	Chronic pain	[ICD-11: MG30]	P46098	HTR3A
T64591	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P46098	HTR3A
T64591	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P46098	HTR3A
T64591	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P46098	HTR3A
T64591	DI0293	Nausea/vomiting	[ICD-11: MD90]	P46098	HTR3A
T62974	DI0087	Chronic pain	[ICD-11: MG30]	P31391	SSTR4
T62974	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P31391	SSTR4
T65019	DI0178	Hepatic fibrosis/cirrhosis	[ICD-11: DB93]	P50281	MMP14
T17758	DI0211	Inherited coagulation factor deficiency	[ICD-11: 3B14]	P00749	PLAU
T17758	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00749	PLAU
T82739	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	P03952	KLKB1
T82739	DI0364	Retinal vascular occlusion	[ICD-11: 9B74]	P03952	KLKB1
T46781	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	Q96GD4	AURKB
T46781	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q96GD4	AURKB
T57278	DI0060	Brain cancer	[ICD-11: 2A00]	P29317	EPHA2
T57278	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P29317	EPHA2
T52790	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P21452	TACR2
T76396	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P53609	PGGT1B
T96892	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q14680	MELK
T96892	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q14680	MELK
T96892	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	Q14680	MELK
T96892	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q14680	MELK
T96892	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	Q14680	MELK
T96892	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	Q14680	MELK
T91331	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	P22607	FGFR3
T91331	DI0235	Liver cancer	[ICD-11: 2C12]	P22607	FGFR3
T91331	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P22607	FGFR3
T32764	DI0163	General pain disorder	[ICD-11: 8E43]	Q2M2I8	AAK1
T68163	DI0281	Musculoskeletal disorder	[ICD-11: FA00-FC0Z]	P07948	LYN
T68163	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P07948	LYN
T51282	DI0166	Glaucoma	[ICD-11: 9C61]	Q13464	ROCK1
T96079	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P61073	CXCR4
T96079	DI0274	Multiple myeloma	[ICD-11: 2A83]	P61073	CXCR4
T46040	DI0074	Cerebral ischaemic stroke	[ICD-11: 8B11]	P03951	F11
T46040	DI0089	Clotting disorder	[ICD-11: 3B4Z]	P03951	F11
T10383	DI0091	Coagulation defect	[ICD-11: 3B10]	O14939	PLD2
T82383	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P30530	AXL
T95302	DI0005	Acne vulgaris	[ICD-11: ED80]	P33032	MC5R
T95302	DI0371	Sebaceous gland disorder	[ICD-11: ED91]	P33032	MC5R
T01973	DI0025	Alzheimer disease	[ICD-11: 8A20]	Q04912	MST1R
T35792	DI0094	Colon cancer	[ICD-11: 2B90]	Q9H7B4	SMYD3
T35792	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9H7B4	SMYD3
T45591	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P06748	NPM1
T47885	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q15139	PRKD1
T47885	DI0426	Urinary system disease	[ICD-11: GC2Z]	Q15139	PRKD1
T97592	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	Q9UQB9	AURKC
T97592	DI0346	Prostate cancer	[ICD-11: 2C82]	Q9UQB9	AURKC
T97592	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9UQB9	AURKC