Jerantinine A



Compound IDCDAMM01949
Common nameJerantinine A
IUPAC namemethyl 12-ethyl-4-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,9,13-pentaene-10-carboxylate
Molecular formulaC22H26N2O4

Experimental data

Retention time22.37
Adduct[M+Na]+
Actual mz405.174
Theoretical mz405.178
Error10.41
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.2698

Identifiers and class information

Inchi keyQRYQVCQRVMGDEO-GSJMQOCFNA-N
SmilesO=C(OC)C1=C2NC3=CC(OC)=C(O)C=C3C24CCN5CC=CC(C1)(CC)C54
SuperclassAlkaloids and derivatives
ClassPlumeran-type alkaloids

Plant source

  • Curcuma longa L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)4
    Number of reactive functional groups (#rtvFG)1
    Predicted central nervous system activity (CNS)1
    Molecular weight (mol_MW)382.458
    Computed dipole moment(dipole)3.569
    Total solvent accessible surface area (SASA)642.131
    Hydrophobic component of SASA (FOSA)424.474
    Hydrophilic component of SASA (FISA)111.086
    Pie component of the SASA (PISA)106.572
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1172.44
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)4.5
    Free energy of solvation of dipole (dip^2/V)0.010863
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0070079
    Globularity descriptor (glob)0.837401
    Predicted polarizability in cubic angstroms (QPpolrz)39.216
    Predicted hexadecane/gas partition coefficient (QPlogPC16)10.872
    Predicted octanol/gas partition coefficient (QPlogPoct)16.683
    Predicted water/gas partition coefficient (QPlogPw)7.76
    Predicted octanol/water partition coefficient (QPlogPo/w)3.593
    Predicted aqueous solubility (QPlogS)-4.458
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.828
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.397
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)218.462
    Predicted brain/blood partition coefficient (QPlogBB)-0.335
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)105.724
    Predicted skin permeability, log Kp (QPlogKp)-4.87
    PM3 calculated ionization potential (IP(ev))8.01
    PM3 calculated electron affinity (EA(eV))0.36
    Number of likely metabolic reactions (#metab)4
    Prediction of binding to human serum albumin (QPlogKhsa)0.767
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)89.851
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)82.172
    Number of nitrogen and oxygen atoms (#NandO)6
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P43681CHRNA4Neuronal acetylcholine receptor; alpha4/beta2T70967SwissTargetPrediction
    Q9Y5N1HRH3Histamine H3 receptorT64765SwissTargetPrediction
    P08173CHRM4Muscarinic acetylcholine receptor M4T20709SwissTargetPrediction
    P08912CHRM5Muscarinic acetylcholine receptor M5T79961SwissTargetPrediction
    P11229CHRM1Muscarinic acetylcholine receptor M1T28893SwissTargetPrediction
    Q12809KCNH2HERGT20251SwissTargetPrediction
    P20309CHRM3Muscarinic acetylcholine receptor M3T67684SwissTargetPrediction
    P29475NOS1Nitric-oxide synthase, brainT16117SwissTargetPrediction
    P35228NOS2Nitric oxide synthase, inducibleT02703SwissTargetPrediction
    P29474NOS3Nitric-oxide synthase, endothelialT06046SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    Q99720SIGMAR1Sigma opioid receptorT46360SwissTargetPrediction
    P41594GRM5Metabotropic glutamate receptor 5T99347SwissTargetPrediction
    P21917DRD4Dopamine D4 receptorT24983SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P14416DRD2Dopamine D2 receptorT67162SwissTargetPrediction
    P27487DPP4Dipeptidyl peptidase IVT31391SwissTargetPrediction
    P98170XIAPInhibitor of apoptosis protein 3T16769SwissTargetPrediction
    P17612PRKACAcAMP-dependent protein kinase alpha-catalytic subunitT12808SwissTargetPrediction
    P28223HTR2ASerotonin 2a (5-HT2a) receptorT32060SwissTargetPrediction
    P28335HTR2CSerotonin 2c (5-HT2c) receptorT83813SwissTargetPrediction
    Q05940SLC18A2Synaptic vesicular amine transporter (by homology)T48873SwissTargetPrediction
    P41595HTR2BSerotonin 2b (5-HT2b) receptorT31204SwissTargetPrediction
    P32297CHRNA3Neuronal acetylcholine receptor; alpha3/beta4T74166SwissTargetPrediction
    P28222HTR1BSerotonin 1b (5-HT1b) receptorT07806SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SwissTargetPrediction
    P50406HTR6Serotonin 6 (5-HT6) receptorT16691SwissTargetPrediction
    Q9UBN7HDAC6Histone deacetylase 6T22274SwissTargetPrediction
    Q99705MCHR1Melanin-concentrating hormone receptor 1T09572SwissTargetPrediction
    P07101THTyrosine 3-hydroxylaseT62390SwissTargetPrediction
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P25021HRH2Histamine H2 receptorT30985SwissTargetPrediction
    P35367HRH1Histamine H1 receptorT77913SwissTargetPrediction
    Q13547HDAC1Histone deacetylase 1T68547SwissTargetPrediction
    Q9BY41HDAC8Histone deacetylase 8T28887SwissTargetPrediction
    P35462DRD3Dopamine D3 receptorT02551SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SwissTargetPrediction
    P21918DRD5Dopamine D5 receptorT46828SwissTargetPrediction
    P23975SLC6A2Norepinephrine transporterT21945SwissTargetPrediction
    P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    O60674JAK2Tyrosine-protein kinase JAK2T08391SwissTargetPrediction
    Q9P1W9PIM2Serine/threonine-protein kinase PIM2T07279SwissTargetPrediction
    Q86V86PIM3Serine/threonine-protein kinase PIM3T16596SwissTargetPrediction
    P56817BACE1Beta-secretase 1T79031SwissTargetPrediction
    P35270SPRSubstance-P receptorT47094SwissTargetPrediction
    P00742F10Thrombin and coagulation factor XT84631SwissTargetPrediction
    Q13490BIRC2Baculoviral IAP repeat-containing protein 2T84780SwissTargetPrediction
    P48147PREPProlyl endopeptidaseT86161SwissTargetPrediction
    P49356FNTBFarnesyl protein transferaseT13127SwissTargetPrediction
    P24723PRKCHProtein kinase C etaT40149SwissTargetPrediction
    Q9UHL4DPP7Dipeptidyl peptidase IIT50773SwissTargetPrediction
    O75116ROCK2Rho-associated protein kinase 2T06093SwissTargetPrediction
    P23458JAK1Tyrosine-protein kinase JAK1T62460SwissTargetPrediction
    P31749AKT1Serine/threonine-protein kinase AKTT67619SwissTargetPrediction
    P05771PRKCBProtein kinase C betaT40276SwissTargetPrediction
    Q02156PRKCEProtein kinase C epsilonT00895SwissTargetPrediction
    O15111CHUKInhibitor of NF-kappa-B kinase (IKK)T78429SwissTargetPrediction
    Q15858SCN9ASodium channel protein type IX alpha subunitT12119SwissTargetPrediction
    Q5S007LRRK2Leucine-rich repeat serine/threonine-protein kinase 2T08123SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    Q9UGN5PARP2Poly [ADP-ribose] polymerase 2T40812SwissTargetPrediction
    Q12884FAPFibroblast activation protein alpha (by homology)T53764SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P29597TYK2Tyrosine-protein kinase TYK2T78932SwissTargetPrediction
    P47898HTR5ASerotonin 5a (5-HT5a) receptorT15571SwissTargetPrediction
    P49286MTNR1BMelatonin receptor 1BT48268SwissTargetPrediction
    Q05655PRKCDProtein kinase C deltaT44861SwissTargetPrediction
    Q9NWZ3IRAK4Interleukin-1 receptor-associated kinase 4T55398SwissTargetPrediction
    P41146OPRL1Nociceptin receptorT52921SwissTargetPrediction
    P35346SSTR5Somatostatin receptor 5T64830SwissTargetPrediction
    P25929NPY1RNeuropeptide Y receptor type 1T89213SwissTargetPrediction
    Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SwissTargetPrediction
    Q04759PRKCQProtein kinase C thetaT23995SwissTargetPrediction
    Q6V1X1DPP8Dipeptidyl peptidase VIIIT15855SwissTargetPrediction
    Q86TI2DPP9Dipeptidyl peptidase IXT66252SwissTargetPrediction
    P41180CASRCalcium sensing receptorT92076SwissTargetPrediction
    Q9UQM7CAMK2ACaM kinase II alphaT18299SwissTargetPrediction
    P30536TSPOTranslocator protein (by homology)T75440SwissTargetPrediction
    O43614HCRTR2Orexin receptor 2T69485SwissTargetPrediction
    O43613HCRTR1Orexin receptor 1T73482SwissTargetPrediction
    O15111CHUKInhibitor of NF-kappa-B kinase (IKK)T78429SwissTargetPrediction
    Q14680MELKMaternal embryonic leucine zipper kinaseT96892SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    Q96KB5PBKPDZ-binding kinaseT98642SwissTargetPrediction
    P30939HTR1FSerotonin 1f (5-HT1f) receptorT78656SwissTargetPrediction
    Q06418TYRO3Tyrosine-protein kinase receptor TYRO3T94880SwissTargetPrediction
    P61073CXCR4C-X-C chemokine receptor type 4T96079SwissTargetPrediction
    Q13393PLD1Phospholipase D1T38996SwissTargetPrediction
    O14939PLD2Phospholipase D2T10383SwissTargetPrediction
    P53634CTSCDipeptidyl peptidase IT70490SwissTargetPrediction
    P51843NR0B1Orphan nuclear receptor DAX-1T23191SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T70967DI0029Aneurysm/dissection[ICD-11: BD50]P43681CHRNA4
    T70967DI0191Hypertensive crisis[ICD-11: BA03]P43681CHRNA4
    T70967DI0196Hypotension[ICD-11: BA20-BA21]P43681CHRNA4
    T64765DI0392Somnolence[ICD-11: MG42]Q9Y5N1HRH3
    T20709DI0037Asthma[ICD-11: CA23]P08173CHRM4
    T20709DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]P08173CHRM4
    T20709DI0166Glaucoma[ICD-11: 9C61]P08173CHRM4
    T20709DI0293Nausea/vomiting[ICD-11: MD90]P08173CHRM4
    T20709DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08173CHRM4
    T79961DI0002Abnormal micturition[ICD-11: MF50]P08912CHRM5
    T79961DI0032Anterior uveitis[ICD-11: 9A96]P08912CHRM5
    T79961DI0034Appearance/behaviour symptom[ICD-11: MB23]P08912CHRM5
    T79961DI0037Asthma[ICD-11: CA23]P08912CHRM5
    T79961DI0061Brain disease[ICD-11: 8C70-8E61]P08912CHRM5
    T79961DI0071Central and peripheral nervous disease[ICD-11: 8A04-8E7Z]P08912CHRM5
    T79961DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P08912CHRM5
    T79961DI0093Cognition symptoms/signs/clinical symptom[ICD-11: MB21]P08912CHRM5
    T79961DI0105Cough[ICD-11: MD12]P08912CHRM5
    T79961DI0124Digestive system disease[ICD-11: DE2Z]P08912CHRM5
    T79961DI0145Female pelvic pain[ICD-11: GA34]P08912CHRM5
    T79961DI0154Functional bladder disorder[ICD-11: GC50]P08912CHRM5
    T79961DI0158Gastritis[ICD-11: DA42]P08912CHRM5
    T79961DI0162General examination[ICD-11: QA00]P08912CHRM5
    T79961DI0166Glaucoma[ICD-11: 9C61]P08912CHRM5
    T79961DI0190Hypertension[ICD-11: BA00-BA04]P08912CHRM5
    T79961DI0208Infectious gastroenteritis/colitis[ICD-11: 1A40]P08912CHRM5
    T79961DI0218Irritable bowel syndrome[ICD-11: DD91]P08912CHRM5
    T79961DI0307Nystagmus[ICD-11: 9C84]P08912CHRM5
    T79961DI0315Oesophagus motility disorder[ICD-11: DA21]P08912CHRM5
    T79961DI0324Pain[ICD-11: MG30-MG3Z]P08912CHRM5
    T79961DI0329Pancreatitis[ICD-11: DC31-DC34]P08912CHRM5
    T79961DI0331Parkinsonism[ICD-11: 8A00]P08912CHRM5
    T79961DI0333Peptic ulcer[ICD-11: DA61]P08912CHRM5
    T79961DI0338Polyuria[ICD-11: MF55]P08912CHRM5
    T79961DI0411Tonus and reflex abnormality[ICD-11: MB47]P08912CHRM5
    T79961DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P08912CHRM5
    T79961DI0424Urgency[ICD-11: N.A.]P08912CHRM5
    T28893DI0001Abdominal pelvic pain[ICD-11: MD81]P11229CHRM1
    T28893DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P11229CHRM1
    T28893DI0101Corneal disease[ICD-11: 9A76-9A78]P11229CHRM1
    T28893DI0129Dystonic disorder[ICD-11: 8A02]P11229CHRM1
    T28893DI0154Functional bladder disorder[ICD-11: GC50]P11229CHRM1
    T28893DI0157Gastric ulcer[ICD-11: DA60]P11229CHRM1
    T28893DI0166Glaucoma[ICD-11: 9C61]P11229CHRM1
    T28893DI0186Hyperhidrosis[ICD-11: EE00]P11229CHRM1
    T28893DI0218Irritable bowel syndrome[ICD-11: DD91]P11229CHRM1
    T28893DI0331Parkinsonism[ICD-11: 8A00]P11229CHRM1
    T28893DI0333Peptic ulcer[ICD-11: DA61]P11229CHRM1
    T28893DI0371Sebaceous gland disorder[ICD-11: ED91]P11229CHRM1
    T20251DI0175Heart failure[ICD-11: BD10-BD1Z]Q12809KCNH2
    T67684DI0037Asthma[ICD-11: CA23]P20309CHRM3
    T67684DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P20309CHRM3
    T67684DI0154Functional bladder disorder[ICD-11: GC50]P20309CHRM3
    T67684DI0166Glaucoma[ICD-11: 9C61]P20309CHRM3
    T67684DI0293Nausea/vomiting[ICD-11: MD90]P20309CHRM3
    T67684DI0333Peptic ulcer[ICD-11: DA61]P20309CHRM3
    T67684DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P20309CHRM3
    T67684DI0371Sebaceous gland disorder[ICD-11: ED91]P20309CHRM3
    T67684DI0382Sjogren syndrome[ICD-11: 4A43]P20309CHRM3
    T67684DI0411Tonus and reflex abnormality[ICD-11: MB47]P20309CHRM3
    T16117DI0173Headache[ICD-11: 8A80-8A84]P29475NOS1
    T16117DI0264Migraine[ICD-11: 8A80]P29475NOS1
    T02703DI0083Chronic kidney disease[ICD-11: GB61]P35228NOS2
    T02703DI0320Osteoarthritis[ICD-11: FA00-FA05]P35228NOS2
    T02703DI0375Sepsis[ICD-11: 1G40-1G41]P35228NOS2
    T02703DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35228NOS2
    T06046DI0287Myocardial infarction[ICD-11: BA41-BA43]P29474NOS3
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T99347DI0152Fragile X chromosome[ICD-11: LD55]P41594GRM5
    T99347DI0331Parkinsonism[ICD-11: 8A00]P41594GRM5
    T24983DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21917DRD4
    T24983DI0370Schizophrenia[ICD-11: 6A20]P21917DRD4
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T67162DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P14416DRD2
    T67162DI0025Alzheimer disease[ICD-11: 8A20]P14416DRD2
    T67162DI0037Asthma[ICD-11: CA23]P14416DRD2
    T67162DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P14416DRD2
    T67162DI0051Bipolar disorder[ICD-11: 6A60]P14416DRD2
    T67162DI0063Breathing abnormality[ICD-11: MD11]P14416DRD2
    T67162DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P14416DRD2
    T67162DI0073Cerebral ischaemia[ICD-11: 8B1Z]P14416DRD2
    T67162DI0117Depression[ICD-11: 6A70-6A7Z]P14416DRD2
    T67162DI0124Digestive system disease[ICD-11: DE2Z]P14416DRD2
    T67162DI0137Essential hypertension[ICD-11: BA00]P14416DRD2
    T67162DI0142Faecal incontinence[ICD-11: ME07]P14416DRD2
    T67162DI0156Gangrene[ICD-11: MC85]P14416DRD2
    T67162DI0166Glaucoma[ICD-11: 9C61]P14416DRD2
    T67162DI0175Heart failure[ICD-11: BD10-BD1Z]P14416DRD2
    T67162DI0185Hyperaemia[ICD-11: 9A61-9B7Y]P14416DRD2
    T67162DI0190Hypertension[ICD-11: BA00-BA04]P14416DRD2
    T67162DI0196Hypotension[ICD-11: BA20-BA21]P14416DRD2
    T67162DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]P14416DRD2
    T67162DI0214Insomnia[ICD-11: 7A00-7A0Z]P14416DRD2
    T67162DI0222Itching[ICD-11: 1F28-1G07]P14416DRD2
    T67162DI0264Migraine[ICD-11: 8A80]P14416DRD2
    T67162DI0293Nausea/vomiting[ICD-11: MD90]P14416DRD2
    T67162DI0324Pain[ICD-11: MG30-MG3Z]P14416DRD2
    T67162DI0331Parkinsonism[ICD-11: 8A00]P14416DRD2
    T67162DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P14416DRD2
    T67162DI0340Postpartum haemorrhage[ICD-11: JA43]P14416DRD2
    T67162DI0354Psychotic disorder[ICD-11: 6A20-6A25]P14416DRD2
    T67162DI0356Pulmonary hypertension[ICD-11: BB01]P14416DRD2
    T67162DI0370Schizophrenia[ICD-11: 6A20]P14416DRD2
    T67162DI0396Substance abuse[ICD-11: 6C40]P14416DRD2
    T67162DI0408Thyrotoxicosis[ICD-11: 5A02]P14416DRD2
    T67162DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14416DRD2
    T31391DI0009Acute diabete complication[ICD-11: 5A2Y]P27487DPP4
    T31391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P27487DPP4
    T16769DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]P98170XIAP
    T12808DI0279Muscular atrophy[ICD-11: 8B61]P17612PRKACA
    T32060DI0009Acute diabete complication[ICD-11: 5A2Y]P28223HTR2A
    T32060DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P28223HTR2A
    T32060DI0073Cerebral ischaemia[ICD-11: 8B1Z]P28223HTR2A
    T32060DI0270Mood disorder[ICD-11: 6A60-6E23]P28223HTR2A
    T32060DI0331Parkinsonism[ICD-11: 8A00]P28223HTR2A
    T32060DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28223HTR2A
    T32060DI0370Schizophrenia[ICD-11: 6A20]P28223HTR2A
    T83813DI0117Depression[ICD-11: 6A70-6A7Z]P28335HTR2C
    T83813DI0264Migraine[ICD-11: 8A80]P28335HTR2C
    T83813DI0308Obesity[ICD-11: 5B80-5B81]P28335HTR2C
    T83813DI0324Pain[ICD-11: MG30-MG3Z]P28335HTR2C
    T83813DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28335HTR2C
    T48873DI0079Choreiform disorder[ICD-11: 8A01]Q05940SLC18A2
    T48873DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]Q05940SLC18A2
    T48873DI0129Dystonic disorder[ICD-11: 8A02]Q05940SLC18A2
    T48873DI0137Essential hypertension[ICD-11: BA00]Q05940SLC18A2
    T48873DI0190Hypertension[ICD-11: BA00-BA04]Q05940SLC18A2
    T31204DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P41595HTR2B
    T31204DI0117Depression[ICD-11: 6A70-6A7Z]P41595HTR2B
    T31204DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P41595HTR2B
    T31204DI0354Psychotic disorder[ICD-11: 6A20-6A25]P41595HTR2B
    T74166DI0105Cough[ICD-11: MD12]P32297CHRNA3
    T07806DI0264Migraine[ICD-11: 8A80]P28222HTR1B
    T07806DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28222HTR1B
    T07806DI0354Psychotic disorder[ICD-11: 6A20-6A25]P28222HTR1B
    T07806DI0370Schizophrenia[ICD-11: 6A20]P28222HTR1B
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T16691DI0025Alzheimer disease[ICD-11: 8A20]P50406HTR6
    T16691DI0370Schizophrenia[ICD-11: 6A20]P50406HTR6
    T22274DI0274Multiple myeloma[ICD-11: 2A83]Q9UBN7HDAC6
    T22274DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UBN7HDAC6
    T09572DI0308Obesity[ICD-11: 5B80-5B81]Q99705MCHR1
    T62390DI0019Adrenomedullary hyperfunction[ICD-11: 5A75]P07101TH
    T62390DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P07101TH
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T30985DI0161Gastro-oesophageal reflux disease[ICD-11: DA22]P25021HRH2
    T30985DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P25021HRH2
    T30985DI0333Peptic ulcer[ICD-11: DA61]P25021HRH2
    T77913DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P35367HRH1
    T77913DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P35367HRH1
    T77913DI0063Breathing abnormality[ICD-11: MD11]P35367HRH1
    T77913DI0099Conjunctiva disorder[ICD-11: 9A60]P35367HRH1
    T77913DI0105Cough[ICD-11: MD12]P35367HRH1
    T77913DI0117Depression[ICD-11: 6A70-6A7Z]P35367HRH1
    T77913DI0136Episodic vestibular syndrome[ICD-11: AB31]P35367HRH1
    T77913DI0173Headache[ICD-11: 8A80-8A84]P35367HRH1
    T77913DI0214Insomnia[ICD-11: 7A00-7A0Z]P35367HRH1
    T77913DI0272Morning sickness disorder[ICD-11: SC00]P35367HRH1
    T77913DI0292Nasopharyngitis[ICD-11: CA00]P35367HRH1
    T77913DI0293Nausea/vomiting[ICD-11: MD90]P35367HRH1
    T77913DI0331Parkinsonism[ICD-11: 8A00]P35367HRH1
    T77913DI0349Pruritus[ICD-11: EC90]P35367HRH1
    T77913DI0366Rheumatoid arthritis[ICD-11: FA20]P35367HRH1
    T77913DI0388Sleep-wake disorder[ICD-11: 7A00-7B2Z]P35367HRH1
    T77913DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P35367HRH1
    T68547DI0274Multiple myeloma[ICD-11: 2A83]Q13547HDAC1
    T68547DI0283Mycosis fungoides[ICD-11: 2B01]Q13547HDAC1
    T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
    T02551DI0051Bipolar disorder[ICD-11: 6A60]P35462DRD3
    T02551DI0331Parkinsonism[ICD-11: 8A00]P35462DRD3
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T46828DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21918DRD5
    T21945DI0013Acute pain[ICD-11: MG31]P23975SLC6A2
    T21945DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P23975SLC6A2
    T21945DI0087Chronic pain[ICD-11: MG30]P23975SLC6A2
    T21945DI0101Corneal disease[ICD-11: 9A76-9A78]P23975SLC6A2
    T21945DI0117Depression[ICD-11: 6A70-6A7Z]P23975SLC6A2
    T21945DI0166Glaucoma[ICD-11: 9C61]P23975SLC6A2
    T21945DI0264Migraine[ICD-11: 8A80]P23975SLC6A2
    T21945DI0301Nicotine use disorder[ICD-11: 6C4A]P23975SLC6A2
    T21945DI0308Obesity[ICD-11: 5B80-5B81]P23975SLC6A2
    T21945DI0324Pain[ICD-11: MG30-MG3Z]P23975SLC6A2
    T21945DI0395Stomach cancer[ICD-11: 2B72]P23975SLC6A2
    T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
    T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T08391DI0039Atopic eczema[ICD-11: EA80]O60674JAK2
    T08391DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60674JAK2
    T08391DI0366Rheumatoid arthritis[ICD-11: FA20]O60674JAK2
    T08391DI0404Thrombocytosis[ICD-11: 3B63]O60674JAK2
    T07279DI0274Multiple myeloma[ICD-11: 2A83]Q9P1W9PIM2
    T07279DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9P1W9PIM2
    T79031DI0025Alzheimer disease[ICD-11: 8A20]P56817BACE1
    T47094DI0117Depression[ICD-11: 6A70-6A7Z]P35270SPR
    T47094DI0293Nausea/vomiting[ICD-11: MD90]P35270SPR
    T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
    T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
    T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
    T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
    T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
    T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
    T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
    T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
    T84780DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]Q13490BIRC2
    T86161DI0092Coeliac disease[ICD-11: DA95]P48147PREP
    T86161DI0210Influenza[ICD-11: 1E30-1E32]P48147PREP
    T86161DI0238Lung cancer[ICD-11: 2C25]P48147PREP
    T86161DI0265Mild neurocognitive disorder[ICD-11: 6D71]P48147PREP
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T40149DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P24723PRKCH
    T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
    T62460DI0039Atopic eczema[ICD-11: EA80]P23458JAK1
    T62460DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P23458JAK1
    T62460DI0366Rheumatoid arthritis[ICD-11: FA20]P23458JAK1
    T62460DI0404Thrombocytosis[ICD-11: 3B63]P23458JAK1
    T67619DI0062Breast cancer[ICD-11: 2C60-2C6Y]P31749AKT1
    T40276DI0123Diffuse large B-cell lymphoma[ICD-11: 2A81]P05771PRKCB
    T40276DI0241Lymphoma[ICD-11: 2A80-2A86]P05771PRKCB
    T40276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P05771PRKCB
    T00895DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]Q02156PRKCE
    T00895DI0243Malaria[ICD-11: 1F40-1F45]Q02156PRKCE
    T78429DI0250Mature B-cell lymphoma[ICD-11: 2A85]O15111CHUK
    T12119DI0051Bipolar disorder[ICD-11: 6A60]Q15858SCN9A
    T12119DI0087Chronic pain[ICD-11: MG30]Q15858SCN9A
    T12119DI0140Extremities vasodilatation[ICD-11: EG00]Q15858SCN9A
    T12119DI0163General pain disorder[ICD-11: 8E43]Q15858SCN9A
    T12119DI0320Osteoarthritis[ICD-11: FA00-FA05]Q15858SCN9A
    T12119DI0324Pain[ICD-11: MG30-MG3Z]Q15858SCN9A
    T12119DI0358Radiculopathy[ICD-11: 8B93]Q15858SCN9A
    T12119DI0415Trigeminal nerve disorder[ICD-11: 8B82]Q15858SCN9A
    T08123DI0331Parkinsonism[ICD-11: 8A00]Q5S007LRRK2
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T40812DI0321Ovarian cancer[ICD-11: 2C73]Q9UGN5PARP2
    T40812DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UGN5PARP2
    T53764DI0300Neutropenia[ICD-11: 4B00]Q12884FAP
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T78932DI0351Psoriasis[ICD-11: EA90]P29597TYK2
    T15571DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P47898HTR5A
    T48268DI0214Insomnia[ICD-11: 7A00-7A0Z]P49286MTNR1B
    T44861DI0287Myocardial infarction[ICD-11: BA41-BA43]Q05655PRKCD
    T55398DI0039Atopic eczema[ICD-11: EA80]Q9NWZ3IRAK4
    T55398DI0109Cutaneous lupus erythematosus[ICD-11: EB50-EB5Z]Q9NWZ3IRAK4
    T55398DI0241Lymphoma[ICD-11: 2A80-2A86]Q9NWZ3IRAK4
    T55398DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q9NWZ3IRAK4
    T55398DI0351Psoriasis[ICD-11: EA90]Q9NWZ3IRAK4
    T55398DI0366Rheumatoid arthritis[ICD-11: FA20]Q9NWZ3IRAK4
    T52921DI0039Atopic eczema[ICD-11: EA80]P41146OPRL1
    T52921DI0117Depression[ICD-11: 6A70-6A7Z]P41146OPRL1
    T52921DI0173Headache[ICD-11: 8A80-8A84]P41146OPRL1
    T52921DI0175Heart failure[ICD-11: BD10-BD1Z]P41146OPRL1
    T64830DI0108Cushing syndrome[ICD-11: 5A70]P35346SSTR5
    T89213DI0050Binge eating disorder[ICD-11: 6B82]P25929NPY1R
    T89213DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25929NPY1R
    T89213DI0174Heart disease[ICD-11: BA41-BA42]P25929NPY1R
    T89213DI0190Hypertension[ICD-11: BA00-BA04]P25929NPY1R
    T89213DI0308Obesity[ICD-11: 5B80-5B81]P25929NPY1R
    T23995DI0413Transplant rejection[ICD-11: NE84]Q04759PRKCQ
    T15855DI0300Neutropenia[ICD-11: 4B00]Q6V1X1DPP8
    T66252DI0300Neutropenia[ICD-11: 4B00]Q86TI2DPP9
    T92076DI0189Hyper-parathyroidism[ICD-11: 5A51]P41180CASR
    T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
    T75440DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P30536TSPO
    T75440DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P30536TSPO
    T75440DI0214Insomnia[ICD-11: 7A00-7A0Z]P30536TSPO
    T75440DI0216Intentional self-harm[ICD-11: PC91]P30536TSPO
    T75440DI0271Mood/affect symptom[ICD-11: MB24]P30536TSPO
    T75440DI0411Tonus and reflex abnormality[ICD-11: MB47]P30536TSPO
    T69485DI0214Insomnia[ICD-11: 7A00-7A0Z]O43614HCRTR2
    T73482DI0117Depression[ICD-11: 6A70-6A7Z]O43613HCRTR1
    T73482DI0214Insomnia[ICD-11: 7A00-7A0Z]O43613HCRTR1
    T73482DI0317Opioid use disorder[ICD-11: 6C43]O43613HCRTR1
    T78429DI0250Mature B-cell lymphoma[ICD-11: 2A85]O15111CHUK
    T96892DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q14680MELK
    T96892DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q14680MELK
    T96892DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q14680MELK
    T96892DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q14680MELK
    T96892DI0284Myelodysplastic syndrome[ICD-11: 2A37]Q14680MELK
    T96892DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q14680MELK
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T98642DI0291Nasopharyngeal cancer[ICD-11: 2B6B]Q96KB5PBK
    T78656DI0264Migraine[ICD-11: 8A80]P30939HTR1F
    T78656DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30939HTR1F
    T94880DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06418TYRO3
    T96079DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P61073CXCR4
    T96079DI0274Multiple myeloma[ICD-11: 2A83]P61073CXCR4
    T10383DI0091Coagulation defect[ICD-11: 3B10]O14939PLD2
    T70490DI0064Bronchiectasis[ICD-11: CA24]P53634CTSC

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