N5-(4-Methoxybenzyl)glutamine



Compound IDCDAMM01937
Common nameN5-(4-Methoxybenzyl)glutamine
IUPAC name2-amino-5-[(4-methoxyphenyl)methylamino]-5-oxopentanoic acid
Molecular formulaC13H18N2O4

Experimental data

Retention time18.75
Adduct[M+H]+
Actual mz267.136
Theoretical mz267.134
Error7.58
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.5688

Identifiers and class information

Inchi keyMLNAECTVQFEWFD-UHFFFAOYNA-N
SmilesO=C(O)C(N)CCC(=O)NCC1=CC=C(OC)C=C1
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives

Plant source

  • Curcuma longa L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)1
    Number of non-conjugated amide groups (#amide)1
    Number of rotatable bonds (#rotor)8
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)-1
    Molecular weight (mol_MW)266.296
    Computed dipole moment(dipole)5.722
    Total solvent accessible surface area (SASA)499.525
    Hydrophobic component of SASA (FOSA)221.393
    Hydrophilic component of SASA (FISA)165.083
    Pie component of the SASA (PISA)113.049
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)870.36
    Number of hydrogen bond donors (donorHB)4
    Number of hydrogen bond acceptors (accptHB)6.25
    Free energy of solvation of dipole (dip^2/V)0.0376238
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0250238
    Globularity descriptor (glob)0.882552
    Predicted polarizability in cubic angstroms (QPpolrz)24.621
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.263
    Predicted octanol/gas partition coefficient (QPlogPoct)17.447
    Predicted water/gas partition coefficient (QPlogPw)14.883
    Predicted octanol/water partition coefficient (QPlogPo/w)-1.681
    Predicted aqueous solubility (QPlogS)-0.635
    Conformation-independent predicted aqueous solubility (CIQPlogS)-0.827
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-1.516
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)10.844
    Predicted brain/blood partition coefficient (QPlogBB)-0.933
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)8.521
    Predicted skin permeability, log Kp (QPlogKp)-5.458
    PM3 calculated ionization potential (IP(ev))9.335
    PM3 calculated electron affinity (EA(eV))0.08
    Number of likely metabolic reactions (#metab)6
    Prediction of binding to human serum albumin (QPlogKhsa)-1.004
    Predicted qualitative human oral absorption (HumanOralAbsorption)2
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)35.63
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)24.589
    Van der Waals surface area (PSA)117.938
    Number of nitrogen and oxygen atoms (#NandO)6
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    Q9Y5N1HRH3Histamine H3 receptorT64765SwissTargetPrediction
    P22303ACHEAcetylcholinesteraseT30082SwissTargetPrediction
    O43570CA12Carbonic anhydrase XIIT16987SEA
    Q16790CA9Carbonic anhydrase IXT64567SEA
    P29475NOS1Nitric-oxide synthase, brainT16117SEA
    P35228NOS2Nitric oxide synthase, inducibleT02703SEA
    P29474NOS3Nitric-oxide synthase, endothelialT06046SEA
    Q16853AOC3Amine oxidase, copper containingT69619SEA
    Q99720SIGMAR1Sigma opioid receptorT46360SwissTargetPrediction
    Q8TDS4HCAR2Hydroxycarboxylic acid receptor 2T88185SwissTargetPrediction
    Q96KS0EIT6HIF-prolyl hydroxylase 1T53904SEA
    P15144ANPEPAminopeptidase NT67272SEA
    P00734F2ThrombinT94033SEA
    P09960LTA4HLeukotriene A4 hydrolaseT03691SEA
    P48066SLC6A11GABA transporter 3T38200SEA
    O15379HDAC3Histone deacetylase 3T05090SEA
    P54289CACNA2D1Voltage-gated calcium channel alpha2/delta subunit 1 (by homology)T84316SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SEA
    Q14833GRM4Metabotropic glutamate receptor 4T99402SEA
    O00222GRM8Metabotropic glutamate receptor 8T77548SEA
    P00915CA1Carbonic anhydrase IT13201SEA
    P00918CA2Carbonic anhydrase IIT20401SEA
    P06239LCKTyrosine-protein kinase LCKT12499SEA
    P16083NQO2Quinone reductase 2T75498SEA
    P14416DRD2Dopamine D2 receptorT67162SwissTargetPrediction
    Q8IXJ6SIRT2NAD-dependent deacetylase sirtuin 2T83904SwissTargetPrediction
    Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
    P14555PLA2G2APhospholipase A2 group IIAT19160SEA
    P08514ITGA2BIntegrin alpha-IIb/beta-3T50688SEA
    P43004SLC1A2Excitatory amino acid transporter 2T95438SwissTargetPrediction
    Q96RI1NR1H4Bile acid receptor FXRT51426SEA
    P27487DPP4Dipeptidyl peptidase IVT31391SwissTargetPrediction and SEA
    P13866SLC5A1Sodium/glucose cotransporter 1T54771SwissTargetPrediction
    P55210CASP7Caspase-7T72252SwissTargetPrediction
    P08473MMENeprilysinT05409SwissTargetPrediction and SEA
    P21554CNR1Cannabinoid receptor 1 (by homology)T76685SwissTargetPrediction and SEA
    P34913EPHX2Epoxide hydrataseT35734SEA
    P43166CA7Carbonic anhydrase VIIT37541SEA
    Q9ULX7CA14Carbonic anhydrase XIVT31992SEA
    P22748CA4Carbonic anhydrase IVT53378SEA
    P28223HTR2ASerotonin 2a (5-HT2a) receptorT32060SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SEA
    P34969HTR7Serotonin 7 (5-HT7) receptorT79062SEA
    P43005SLC1A1Excitatory amino acid transporter 3T31721SwissTargetPrediction and SEA
    P39086GRIK1Glutamate receptor ionotropic kainate 1T73495SEA
    Q13002GRIK2Glutamate receptor ionotropic kainate 2T58178SEA
    O15303GRM6Metabotropic glutamate receptor 6T55956SEA
    Q14416GRM2Metabotropic glutamate receptor 2T62820SEA
    Q13003GRIK3Glutamate receptor ionotropic kainate 3T68876SEA
    Q9UQL6HDAC5Histone deacetylase 5T07930SEA
    Q8WUI4HDAC7Histone deacetylase 7T98698SEA
    P56524HDAC4Histone deacetylase 4T63816SEA
    Q9UKV0HDAC9Histone deacetylase 9T03687SEA
    P43235CTSKCathepsin KT11388SEA
    Q92769HDAC2Histone deacetylase 2T51191SEA
    Q99705MCHR1Melanin-concentrating hormone receptor 1T09572SEA
    P42330AKR1C3Aldo-keto-reductase family 1 member C3T60857SEA
    Q9H4A4RNPEPAminopeptidase BT57818SwissTargetPrediction and SEA
    Q6B0I6KDM4DLysine-specific demethylase 4DT17036SwissTargetPrediction
    Q96IY4CPB2Carboxypeptidase B2 isoform AT98022SwissTargetPrediction
    P07101THTyrosine 3-hydroxylaseT62390SEA
    P53779MAPK10c-Jun N-terminal kinase 3T85421SEA
    O00519FAAHAnandamide amidohydrolaseT11754SEA
    Q8NER1TRPV1Vanilloid receptorT83193SwissTargetPrediction and SEA
    P07339CTSDCathepsin DT67102SEA
    Q01650SLC7A5L-type amino acid transporter 1 (by homology)T48330SEA
    Q07869PPARAPeroxisome proliferator-activated receptor alphaT86591SEA
    Q03181PPARDPeroxisome proliferator-activated receptor deltaT36557SEA
    O14842FFAR1Free fatty acid receptor 1T25608SEA
    P49137MAPKAPK2MAP kinase-activated protein kinase 2T21307SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction and SEA
    P22894MMP8Matrix metalloproteinase 8T08856SEA
    P08254MMP3Matrix metalloproteinase 3T86702SEA
    P14780MMP9Matrix metalloproteinase 9T54156SEA
    P03956MMP1Matrix metalloproteinase 1T52450SEA
    P17655CAPN2Calpain 2T86837SEA
    P05121SERPINE1Plasminogen activator inhibitor-1T15556SEA
    P07550ADRB2Adrenergic receptor betaT52522SEA
    P13945ADRB3Beta-3 adrenergic receptorT51408SEA
    Q8N5Z0AADATKynurenine/alpha-aminoadipate aminotransferase, mitochondrialT82668SEA
    P10827THRAThyroid hormone receptor alphaT79591SEA
    P10828THRBThyroid hormone receptor beta-1T98933SEA
    P15086CPB1Carboxypeptidase BT36725SwissTargetPrediction
    P52732KIF11Kinesin-like protein 1T28484SEA
    P62993GRB2Growth factor receptor-bound protein 2T30926SEA
    P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction and SEA
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    Q9P1W9PIM2Serine/threonine-protein kinase PIM2T07279SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SEA
    P45452MMP13Matrix metalloproteinase 13T34296SEA
    P78536ADAM17ADAM17T82393SEA
    P09237MMP7Matrix metalloproteinase 7T73475SEA
    P13497BMP1Bone morphogenetic protein 1T53350SEA
    P25105PTAFRPlatelet activating factor receptorT87023SEA
    P07711CTSLCathepsin LT98691SEA
    Q92847GHSRGhrelin receptorT59604SEA
    Q01726MC1RMelanocortin receptor 1T35842SEA
    P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SEA
    Q9UHL4DPP7Dipeptidyl peptidase IIT50773SwissTargetPrediction and SEA
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SEA
    P16581SELESelectin ET72835SEA
    P53779MAPK10c-Jun N-terminal kinase 3T85421SEA
    P05186ALPLAlkaline phosphatase, tissue-nonspecific isozymeT09538SEA
    Q9HBH9MKNK2MAP kinase signal-integrating kinase 2T99160SwissTargetPrediction
    P25774CTSSCathepsin ST68290SEA
    P09211GSTP1Glutathione S-transferase PiT21669SEA
    P08263GSTA1Glutathione S-transferase A1T17221SEA
    Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SwissTargetPrediction and SEA
    P06870KLK1Kallikrein 1T40000SEA
    P48039MTNR1AMelatonin receptor 1AT97613SEA
    P49286MTNR1BMelatonin receptor 1BT48268SEA
    P34972CNR2Cannabinoid receptor 2T37693SwissTargetPrediction
    P25090FPR2Lipoxin A4 receptor (by homology)T97917SEA
    Q9ULA0DNPEPAspartyl aminopeptidaseT45287SEA
    Q9BYF1ACE2Angiotensin-converting enzyme 2T27889SEA
    P23443RPS6KB1Ribosomal protein S6 kinase 1T94479SEA
    P39900MMP12Matrix metalloproteinase 12T03500SwissTargetPrediction and SEA
    O00763ACACBAcetyl-CoA carboxylase 2T08922SEA
    P25929NPY1RNeuropeptide Y receptor type 1T89213SwissTargetPrediction
    P15085CPA1Carboxypeptidase A1T33966SEA
    P50281MMP14Matrix metalloproteinase 14T65019SEA
    P35398RORANuclear receptor ROR-alphaT43206SEA
    P68400CSNK2A1Casein kinase II alphaT51565SwissTargetPrediction
    Q9H228S1PR5Sphingosine 1-phosphate receptor Edg-8T50089SwissTargetPrediction
    P00749PLAUUrokinase-type plasminogen activatorT17758SEA
    P03952KLKB1Plasma kallikreinT82739SEA
    P08709F7Coagulation factor VIIT43332SEA
    P28074PSMB5Proteasome Macropain subunit MB1T49031SEA
    P43003SLC1A3Excitatory amino acid transporter 1T86582SwissTargetPrediction and SEA
    P51685CCR8C-C chemokine receptor type 8T20575SwissTargetPrediction
    P46059SLC15A1Oligopeptide transporter small intestine isoformT91180SwissTargetPrediction
    Q07973CYP24A1Cytochrome P450 24A1T92458SEA
    Q9GZN0GPR88Probable G-protein coupled receptor 88T37505SEA
    Q9UKP6UTS2RUrotensin II receptorT49072SEA
    Q16549PCSK7Subtilisin/kexin type 7T33211SEA
    P29371TACR3Neurokinin 3 receptorT29683SEA
    Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SEA
    Q08752PPIDPeptidyl-prolyl cis-trans isomerase DT52447SEA
    Q04760GLO1Glyoxalase IT88285SEA
    P98073TMPRSS15EnteropeptidaseT75772SEA
    P28065PSMB9Proteasome subunit beta type-9T06792SEA
    P28062PSMB8Proteasome subunit beta type-8T77350SEA
    P43403ZAP70Tyrosine-protein kinase ZAP-70T64553SEA
    Q15661TPSAB1Tryptase beta-1T14558SEA
    O43497CACNA1GVoltage-gated T-type calcium channel alpha-1G subunitT64795SEA
    O95180CACNA1HVoltage-gated T-type calcium channel alpha-1H subunitT54644SEA
    O75173ADAMTS4ADAMTS4T79570SEA
    P51512MMP16Matrix metalloproteinase 16T35824SEA
    Q13822ENPP2AutotaxinT63512SEA
    Q96DB2HDAC11Histone deacetylase 11T97903SEA
    Q9H1C0LPAR5Lysophosphatidic acid receptor 5T18616SEA
    P06734FCER2Immunoglobulin epsilon Fc receptorT67207SEA
    Q969S8HDAC10Histone deacetylase 10T94324SEA
    P12004PCNAProliferating cell nuclear antigenT21782SEA
    Q9Y271CYSLTR1Cysteinyl leukotriene receptor 1T71192SEA
    Q9UJ67APAF1Caterpiller protein 1.1T08499SEA
    Q00975CACNA1BVoltage-gated N-type calcium channel alpha-1B subunitT38338SEA
    O00398P2RY10Putative P2Y purinoceptor 10T00488SEA
    Q9BXC1GPR174Probable G-protein coupled receptor 174T87661SEA
    Q92633LPAR1Lysophosphatidic acid receptor Edg-2T92640SEA
    Q6DWJ6GPR139Probable G-protein coupled receptor 139T84439SEA
    Q9UBC3DNMT3BDNA (cytosine-5)-methyltransferase 3BT65501SEA
    Q8TCW9PROKR1Prokineticin receptor 1T85115SEA
    P23284PPIBCyclophilin BT25847SEA
    P40306PSMB1026S proteosomeT09022SEA
    Q9P0X4CACNA1IVoltage-gated T-type calcium channel alpha-1I subunitT79694SEA
    Q9P0U3SENP1Sentrin-specific protease 1T96435SEA
    Q14145KEAP1Kelch-like ECH-associated protein 1T83198SEA
    Q8IWU9TPH2Tryptophan hydroxylaseT51593SEA
    P04156PRNPPrion proteinT08722SEA
    P09210GSTA2Glutathione S-transferase A2T53510SEA
    Q04609FOLH1Glutamate carboxypeptidase IIT97071SEA
    P09958FURHUMAN dibasic-processing enzymeT98945SEA
    Q9BWQ3ASCT2Alanine/serine/cysteine transporter 2T59493SEA
    P29120PCSK1Neuroendocrine convertase 1T36445SEA
    Q92824PCSK5Proprotein convertase subtilisin/kexin type 5T38581SEA
    Q9GZQ6NPFFR1Neuropeptide FF receptor 1T79780SEA
    Q9BY41HDAC8Histone deacetylase 8T28887SEA
    P37088SCNN1AAmiloride-sensitive sodium channelT52173SEA
    Q9Y4G9PCSK6Proprotein convertase subtilisin/kexin type 6T86503SEA
    Q7RTX1TAS1R1Taste receptorT41263SEA
    P05106ITGB3Integrin beta-3T26457SEA
    P00480OTCOrnithine transcarbamylaseT52098SEA
    Q6ZQN7SLCO4C1Organic anion transporter M1T36053SEA
    Q9HAN5TRP1Cationic trypsinogenT27602SEA
    P14672GLUT4Glucose transporter type 4T67658SEA
    Q96HK3CALMCalmodulinT39610SEA
    Q9UK17KCND3Voltage-gated potassium channel Kv4.3T74500SEA
    Q09470KCNA1Voltage-gated potassium channel Kv1.1T85272SEA
    Q9H4A3WNK1Serine/threonine-protein kinase WNK1T52638SEA
    P16519PCSK2Neuroendocrine convertase 2T97749SEA
    Q86VZ5SGMS1Sphingomyelin synthaseT68967SEA
    Q9BXA5SUCNR1Succinate receptorT70633SEA
    Q8NFJ6PROKR2Prokineticin receptor 2T04497SEA
    Q96KS0EIT6HIF-prolyl hydroxylase 1T53904SEA
    Q9GZT9EGLN1Egl nine homolog 1T32880SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T64765DI0392Somnolence[ICD-11: MG42]Q9Y5N1HRH3
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
    T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T16117DI0173Headache[ICD-11: 8A80-8A84]P29475NOS1
    T16117DI0264Migraine[ICD-11: 8A80]P29475NOS1
    T02703DI0083Chronic kidney disease[ICD-11: GB61]P35228NOS2
    T02703DI0320Osteoarthritis[ICD-11: FA00-FA05]P35228NOS2
    T02703DI0375Sepsis[ICD-11: 1G40-1G41]P35228NOS2
    T02703DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35228NOS2
    T06046DI0287Myocardial infarction[ICD-11: BA41-BA43]P29474NOS3
    T69619DI0190Hypertension[ICD-11: BA00-BA04]Q16853AOC3
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T88185DI0203Inborn lipid metabolism error[ICD-11: 5C52]Q8TDS4HCAR2
    T53904DI0010Acute disease anaemia[ICD-11: 3A90]Q96KS0EIT6
    T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
    T94033DI0052Bleeding disorder[ICD-11: GA20-GA21]P00734F2
    T94033DI0091Coagulation defect[ICD-11: 3B10]P00734F2
    T94033DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P00734F2
    T94033DI0275Multiple sclerosis[ICD-11: 8A40]P00734F2
    T94033DI0287Myocardial infarction[ICD-11: BA41-BA43]P00734F2
    T94033DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00734F2
    T94033DI0403Thrombocytopenia[ICD-11: 3B64]P00734F2
    T94033DI0405Thrombosis[ICD-11: DB61-GB90]P00734F2
    T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
    T38200DI0207Indeterminate colitis[ICD-11: DD72]P48066SLC6A11
    T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
    T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
    T84316DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P54289CACNA2D1
    T84316DI0190Hypertension[ICD-11: BA00-BA04]P54289CACNA2D1
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T99402DI0331Parkinsonism[ICD-11: 8A00]Q14833GRM4
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
    T75498DI0214Insomnia[ICD-11: 7A00-7A0Z]P16083NQO2
    T67162DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P14416DRD2
    T67162DI0025Alzheimer disease[ICD-11: 8A20]P14416DRD2
    T67162DI0037Asthma[ICD-11: CA23]P14416DRD2
    T67162DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P14416DRD2
    T67162DI0051Bipolar disorder[ICD-11: 6A60]P14416DRD2
    T67162DI0063Breathing abnormality[ICD-11: MD11]P14416DRD2
    T67162DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P14416DRD2
    T67162DI0073Cerebral ischaemia[ICD-11: 8B1Z]P14416DRD2
    T67162DI0117Depression[ICD-11: 6A70-6A7Z]P14416DRD2
    T67162DI0124Digestive system disease[ICD-11: DE2Z]P14416DRD2
    T67162DI0137Essential hypertension[ICD-11: BA00]P14416DRD2
    T67162DI0142Faecal incontinence[ICD-11: ME07]P14416DRD2
    T67162DI0156Gangrene[ICD-11: MC85]P14416DRD2
    T67162DI0166Glaucoma[ICD-11: 9C61]P14416DRD2
    T67162DI0175Heart failure[ICD-11: BD10-BD1Z]P14416DRD2
    T67162DI0185Hyperaemia[ICD-11: 9A61-9B7Y]P14416DRD2
    T67162DI0190Hypertension[ICD-11: BA00-BA04]P14416DRD2
    T67162DI0196Hypotension[ICD-11: BA20-BA21]P14416DRD2
    T67162DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]P14416DRD2
    T67162DI0214Insomnia[ICD-11: 7A00-7A0Z]P14416DRD2
    T67162DI0222Itching[ICD-11: 1F28-1G07]P14416DRD2
    T67162DI0264Migraine[ICD-11: 8A80]P14416DRD2
    T67162DI0293Nausea/vomiting[ICD-11: MD90]P14416DRD2
    T67162DI0324Pain[ICD-11: MG30-MG3Z]P14416DRD2
    T67162DI0331Parkinsonism[ICD-11: 8A00]P14416DRD2
    T67162DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P14416DRD2
    T67162DI0340Postpartum haemorrhage[ICD-11: JA43]P14416DRD2
    T67162DI0354Psychotic disorder[ICD-11: 6A20-6A25]P14416DRD2
    T67162DI0356Pulmonary hypertension[ICD-11: BB01]P14416DRD2
    T67162DI0370Schizophrenia[ICD-11: 6A20]P14416DRD2
    T67162DI0396Substance abuse[ICD-11: 6C40]P14416DRD2
    T67162DI0408Thyrotoxicosis[ICD-11: 5A02]P14416DRD2
    T67162DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14416DRD2
    T83904DI0365Retinopathy[ICD-11: 9B71]Q8IXJ6SIRT2
    T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
    T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
    T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
    T19160DI0062Breast cancer[ICD-11: 2C60-2C6Y]P14555PLA2G2A
    T50688DI0007Acquired hypermelanosis[ICD-11: ED60]P08514ITGA2B
    T50688DI0030Angina pectoris[ICD-11: BA40]P08514ITGA2B
    T50688DI0287Myocardial infarction[ICD-11: BA41-BA43]P08514ITGA2B
    T51426DI0043Autoimmune liver disease[ICD-11: DB96]Q96RI1NR1H4
    T51426DI0077Cholelithiasis[ICD-11: DC11]Q96RI1NR1H4
    T51426DI0320Osteoarthritis[ICD-11: FA00-FA05]Q96RI1NR1H4
    T31391DI0009Acute diabete complication[ICD-11: 5A2Y]P27487DPP4
    T31391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P27487DPP4
    T54771DI0120Diabetes mellitus[ICD-11: 5A10]P13866SLC5A1
    T54771DI0175Heart failure[ICD-11: BD10-BD1Z]P13866SLC5A1
    T54771DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P13866SLC5A1
    T72252DI0110Cystic fibrosis[ICD-11: CA25]P55210CASP7
    T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
    T76685DI0031Anorexia nervosa[ICD-11: 6B80]P21554CNR1
    T76685DI0214Insomnia[ICD-11: 7A00-7A0Z]P21554CNR1
    T76685DI0308Obesity[ICD-11: 5B80-5B81]P21554CNR1
    T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
    T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
    T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
    T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
    T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
    T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
    T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
    T32060DI0009Acute diabete complication[ICD-11: 5A2Y]P28223HTR2A
    T32060DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P28223HTR2A
    T32060DI0073Cerebral ischaemia[ICD-11: 8B1Z]P28223HTR2A
    T32060DI0270Mood disorder[ICD-11: 6A60-6E23]P28223HTR2A
    T32060DI0331Parkinsonism[ICD-11: 8A00]P28223HTR2A
    T32060DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28223HTR2A
    T32060DI0370Schizophrenia[ICD-11: 6A20]P28223HTR2A
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T79062DI0025Alzheimer disease[ICD-11: 8A20]P34969HTR7
    T79062DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34969HTR7
    T79062DI0051Bipolar disorder[ICD-11: 6A60]P34969HTR7
    T79062DI0117Depression[ICD-11: 6A70-6A7Z]P34969HTR7
    T79062DI0265Mild neurocognitive disorder[ICD-11: 6D71]P34969HTR7
    T79062DI0331Parkinsonism[ICD-11: 8A00]P34969HTR7
    T79062DI0370Schizophrenia[ICD-11: 6A20]P34969HTR7
    T73495DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P39086GRIK1
    T73495DI0396Substance abuse[ICD-11: 6C40]P39086GRIK1
    T62820DI0025Alzheimer disease[ICD-11: 8A20]Q14416GRM2
    T62820DI0051Bipolar disorder[ICD-11: 6A60]Q14416GRM2
    T62820DI0116Dengue fever[ICD-11: 1D2Z]Q14416GRM2
    T62820DI0117Depression[ICD-11: 6A70-6A7Z]Q14416GRM2
    T62820DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]Q14416GRM2
    T62820DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]Q14416GRM2
    T62820DI0308Obesity[ICD-11: 5B80-5B81]Q14416GRM2
    T62820DI0354Psychotic disorder[ICD-11: 6A20-6A25]Q14416GRM2
    T62820DI0370Schizophrenia[ICD-11: 6A20]Q14416GRM2
    T63816DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P56524HDAC4
    T11388DI0237Low bone mass disorder[ICD-11: FB83]P43235CTSK
    T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
    T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
    T09572DI0308Obesity[ICD-11: 5B80-5B81]Q99705MCHR1
    T60857DI0145Female pelvic pain[ICD-11: GA34]P42330AKR1C3
    T98022DI0073Cerebral ischaemia[ICD-11: 8B1Z]Q96IY4CPB2
    T98022DI0074Cerebral ischaemic stroke[ICD-11: 8B11]Q96IY4CPB2
    T98022DI0405Thrombosis[ICD-11: DB61-GB90]Q96IY4CPB2
    T62390DI0019Adrenomedullary hyperfunction[ICD-11: 5A75]P07101TH
    T62390DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P07101TH
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T67102DI0275Multiple sclerosis[ICD-11: 8A40]P07339CTSD
    T86591DI0187Hyperlipidemia[ICD-11: 5C80]Q07869PPARA
    T86591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q07869PPARA
    T86591DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q07869PPARA
    T36557DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]Q03181PPARD
    T36557DI0308Obesity[ICD-11: 5B80-5B81]Q03181PPARD
    T25608DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O14842FFAR1
    T21307DI0011Acute laryngitis/tracheitis[ICD-11: CA05]P49137MAPKAPK2
    T21307DI0181Hidradenitis suppurativa[ICD-11: ED92]P49137MAPKAPK2
    T21307DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P49137MAPKAPK2
    T21307DI0334Peritoneal cancer[ICD-11: 2C51]P49137MAPKAPK2
    T21307DI0352Psoriatic arthritis[ICD-11: FA21]P49137MAPKAPK2
    T21307DI0366Rheumatoid arthritis[ICD-11: FA20]P49137MAPKAPK2
    T21307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49137MAPKAPK2
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T86837DI0106COVID-19[ICD-11: 1D6Y]P17655CAPN2
    T15556DI0037Asthma[ICD-11: CA23]P05121SERPINE1
    T15556DI0405Thrombosis[ICD-11: DB61-GB90]P05121SERPINE1
    T52522DI0037Asthma[ICD-11: CA23]P07550ADRB2
    T52522DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07550ADRB2
    T52522DI0097Conduction disorder[ICD-11: BC63]P07550ADRB2
    T52522DI0344Preterm labour/delivery[ICD-11: JB00]P07550ADRB2
    T52522DI0387Sleep-related breathing disorder[ICD-11: 7A4Z]P07550ADRB2
    T51408DI0030Angina pectoris[ICD-11: BA40]P13945ADRB3
    T51408DI0037Asthma[ICD-11: CA23]P13945ADRB3
    T51408DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P13945ADRB3
    T51408DI0129Dystonic disorder[ICD-11: 8A02]P13945ADRB3
    T51408DI0154Functional bladder disorder[ICD-11: GC50]P13945ADRB3
    T51408DI0190Hypertension[ICD-11: BA00-BA04]P13945ADRB3
    T51408DI0331Parkinsonism[ICD-11: 8A00]P13945ADRB3
    T82668DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q8N5Z0AADAT
    T82668DI0370Schizophrenia[ICD-11: 6A20]Q8N5Z0AADAT
    T79591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10827THRA
    T79591DI0197Hypo-thyroidism[ICD-11: 5A00]P10827THRA
    T98933DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10828THRB
    T28484DI0012Acute myeloid leukaemia[ICD-11: 2A60]P52732KIF11
    T28484DI0172Head and neck cancer[ICD-11: 2D42]P52732KIF11
    T28484DI0241Lymphoma[ICD-11: 2A80-2A86]P52732KIF11
    T28484DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P52732KIF11
    T28484DI0274Multiple myeloma[ICD-11: 2A83]P52732KIF11
    T28484DI0321Ovarian cancer[ICD-11: 2C73]P52732KIF11
    T28484DI0361Renal cell carcinoma[ICD-11: 2C90]P52732KIF11
    T28484DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P52732KIF11
    T30926DI0012Acute myeloid leukaemia[ICD-11: 2A60]P62993GRB2
    T30926DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P62993GRB2
    T30926DI0250Mature B-cell lymphoma[ICD-11: 2A85]P62993GRB2
    T30926DI0284Myelodysplastic syndrome[ICD-11: 2A37]P62993GRB2
    T30926DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P62993GRB2
    T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
    T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T07279DI0274Multiple myeloma[ICD-11: 2A83]Q9P1W9PIM2
    T07279DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9P1W9PIM2
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T82393DI0062Breast cancer[ICD-11: 2C60-2C6Y]P78536ADAM17
    T82393DI0366Rheumatoid arthritis[ICD-11: FA20]P78536ADAM17
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T87023DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P25105PTAFR
    T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
    T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
    T59604DI0087Chronic pain[ICD-11: MG30]Q92847GHSR
    T59604DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]Q92847GHSR
    T35842DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]Q01726MC1R
    T35842DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]Q01726MC1R
    T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
    T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
    T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T72835DI0012Acute myeloid leukaemia[ICD-11: 2A60]P16581SELE
    T72835DI0037Asthma[ICD-11: CA23]P16581SELE
    T72835DI0039Atopic eczema[ICD-11: EA80]P16581SELE
    T72835DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P16581SELE
    T72835DI0088Circulatory system disease[ICD-11: BE2Z]P16581SELE
    T72835DI0190Hypertension[ICD-11: BA00-BA04]P16581SELE
    T72835DI0351Psoriasis[ICD-11: EA90]P16581SELE
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T09538DI0164Genetic prion disease[ICD-11: 8E02]P05186ALPL
    T09538DI0330Parasitic infection[ICD-11: 1D0Y-1G2Z]P05186ALPL
    T99160DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9HBH9MKNK2
    T99160DI0095Colorectal cancer[ICD-11: 2B91]Q9HBH9MKNK2
    T99160DI0235Liver cancer[ICD-11: 2C12]Q9HBH9MKNK2
    T99160DI0241Lymphoma[ICD-11: 2A80-2A86]Q9HBH9MKNK2
    T99160DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9HBH9MKNK2
    T68290DI0042Autoimmune disease[ICD-11: 4A40-4A45]P25774CTSS
    T68290DI0092Coeliac disease[ICD-11: DA95]P25774CTSS
    T68290DI0107Crohn disease[ICD-11: DD70]P25774CTSS
    T68290DI0120Diabetes mellitus[ICD-11: 5A10]P25774CTSS
    T68290DI0163General pain disorder[ICD-11: 8E43]P25774CTSS
    T68290DI0324Pain[ICD-11: MG30-MG3Z]P25774CTSS
    T68290DI0382Sjogren syndrome[ICD-11: 4A43]P25774CTSS
    T21669DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P09211GSTP1
    T97613DI0214Insomnia[ICD-11: 7A00-7A0Z]P48039MTNR1A
    T48268DI0214Insomnia[ICD-11: 7A00-7A0Z]P49286MTNR1B
    T37693DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34972CNR2
    T37693DI0214Insomnia[ICD-11: 7A00-7A0Z]P34972CNR2
    T97917DI0025Alzheimer disease[ICD-11: 8A20]P25090FPR2
    T45287DI0190Hypertension[ICD-11: BA00-BA04]Q9ULA0DNPEP
    T27889DI0009Acute diabete complication[ICD-11: 5A2Y]Q9BYF1ACE2
    T27889DI0217Intrathoracic organs injury[ICD-11: NB32]Q9BYF1ACE2
    T27889DI0356Pulmonary hypertension[ICD-11: BB01]Q9BYF1ACE2
    T94479DI0025Alzheimer disease[ICD-11: 8A20]P23443RPS6KB1
    T94479DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P23443RPS6KB1
    T94479DI0419Ulcerative colitis[ICD-11: DD71]P23443RPS6KB1
    T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
    T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
    T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
    T08922DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O00763ACACB
    T89213DI0050Binge eating disorder[ICD-11: 6B82]P25929NPY1R
    T89213DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25929NPY1R
    T89213DI0174Heart disease[ICD-11: BA41-BA42]P25929NPY1R
    T89213DI0190Hypertension[ICD-11: BA00-BA04]P25929NPY1R
    T89213DI0308Obesity[ICD-11: 5B80-5B81]P25929NPY1R
    T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
    T43206DI0235Liver cancer[ICD-11: 2C12]P35398RORA
    T43206DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P35398RORA
    T51565DI0104Coronavirus infection[ICD-11: 1D92]P68400CSNK2A1
    T51565DI0235Liver cancer[ICD-11: 2C12]P68400CSNK2A1
    T51565DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P68400CSNK2A1
    T50089DI0275Multiple sclerosis[ICD-11: 8A40]Q9H228S1PR5
    T17758DI0211Inherited coagulation factor deficiency[ICD-11: 3B14]P00749PLAU
    T17758DI0287Myocardial infarction[ICD-11: BA41-BA43]P00749PLAU
    T82739DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P03952KLKB1
    T82739DI0364Retinal vascular occlusion[ICD-11: 9B74]P03952KLKB1
    T43332DI0091Coagulation defect[ICD-11: 3B10]P08709F7
    T20575DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P51685CCR8
    T92458DI0351Psoriasis[ICD-11: EA90]Q07973CYP24A1
    T49072DI0037Asthma[ICD-11: CA23]Q9UKP6UTS2R
    T29683DI0254Menopausal disorder[ICD-11: GA30]P29371TACR3
    T88285DI0210Influenza[ICD-11: 1E30-1E32]Q04760GLO1
    T77350DI0274Multiple myeloma[ICD-11: 2A83]P28062PSMB8
    T14558DI0155Fungal infection[ICD-11: 1F29-1F2F]Q15661TPSAB1
    T14558DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q15661TPSAB1
    T64795DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]O43497CACNA1G
    T64795DI0190Hypertension[ICD-11: BA00-BA04]O43497CACNA1G
    T64795DI0276Multiple structural anomalies syndrome[ICD-11: LD2F]O43497CACNA1G
    T64795DI0326Pancreatic cancer[ICD-11: 2C10]O43497CACNA1G
    T64795DI0370Schizophrenia[ICD-11: 6A20]O43497CACNA1G
    T54644DI0004Acidosis[ICD-11: 5C73]O95180CACNA1H
    T54644DI0264Migraine[ICD-11: 8A80]O95180CACNA1H
    T63512DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q13822ENPP2
    T67207DI0231Leukaemia[ICD-11: 2A60-2B33]P06734FCER2
    T94324DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q969S8HDAC10
    T21782DI0308Obesity[ICD-11: 5B80-5B81]P12004PCNA
    T71192DI0037Asthma[ICD-11: CA23]Q9Y271CYSLTR1
    T08499DI0087Chronic pain[ICD-11: MG30]Q9UJ67APAF1
    T08499DI0167Gout[ICD-11: FA25]Q9UJ67APAF1
    T08499DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q9UJ67APAF1
    T08499DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UJ67APAF1
    T38338DI0264Migraine[ICD-11: 8A80]Q00975CACNA1B
    T38338DI0305Non-thrombocytopenic purpura[ICD-11: 3B60]Q00975CACNA1B
    T38338DI0324Pain[ICD-11: MG30-MG3Z]Q00975CACNA1B
    T92640DI0146Fibrosis[ICD-11: GA14-GC01]Q92633LPAR1
    T92640DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q92633LPAR1
    T92640DI0351Psoriasis[ICD-11: EA90]Q92633LPAR1
    T92640DI0399Systemic sclerosis[ICD-11: 4A42]Q92633LPAR1
    T84439DI0377Sex development malformative disorder[ICD-11: LD2A]Q6DWJ6GPR139
    T65501DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UBC3DNMT3B
    T25847DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P23284PPIB
    T83198DI0356Pulmonary hypertension[ICD-11: BB01]Q14145KEAP1
    T83198DI0425Urinary system clinical symptom[ICD-11: MF8Y]Q14145KEAP1
    T51593DI0066Carcinoid syndrome[ICD-11: 5B10]Q8IWU9TPH2
    T51593DI0389Small intestine developmental anomaly[ICD-11: DA90]Q8IWU9TPH2
    T97071DI0122Diagnostic imaging[ICD-11: N.A.]Q04609FOLH1
    T97071DI0346Prostate cancer[ICD-11: 2C82]Q04609FOLH1
    T98945DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P09958FUR
    T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
    T52173DI0175Heart failure[ICD-11: BD10-BD1Z]P37088SCNN1A
    T52173DI0190Hypertension[ICD-11: BA00-BA04]P37088SCNN1A
    T52173DI0311Oedema[ICD-11: MG29]P37088SCNN1A
    T41263DI0078Cholera[ICD-11: 1A00]Q7RTX1TAS1R1
    T52098DI0258Metabolism inborn error[ICD-11: 5C50]P00480OTC
    T36053DI0068Cardiac arrhythmia[ICD-11: BC9Z]Q6ZQN7SLCO4C1
    T36053DI0175Heart failure[ICD-11: BD10-BD1Z]Q6ZQN7SLCO4C1
    T27602DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q9HAN5TRP1
    T27602DI0274Multiple myeloma[ICD-11: 2A83]Q9HAN5TRP1
    T67658DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14672GLUT4
    T39610DI0068Cardiac arrhythmia[ICD-11: BC9Z]Q96HK3CALM
    T39610DI0243Malaria[ICD-11: 1F40-1F45]Q96HK3CALM
    T39610DI0370Schizophrenia[ICD-11: 6A20]Q96HK3CALM
    T74500DI0004Acidosis[ICD-11: 5C73]Q9UK17KCND3
    T68967DI0190Hypertension[ICD-11: BA00-BA04]Q86VZ5SGMS1
    T53904DI0010Acute disease anaemia[ICD-11: 3A90]Q96KS0EIT6

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