Apo-12\'-violaxanthal



Compound IDCDAMM01929
Common nameApo-12\'-violaxanthal
IUPAC name13-(4-hydroxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl)-2,7,11-trimethyltrideca-2,4,6,8,10,12-hexaenal
Molecular formulaC25H34O3

Experimental data

Retention time24.65
Adduct[M+H]+
Actual mz383.253
Theoretical mz383.258
Error12.98
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.2103

Identifiers and class information

Inchi keyCAXVJDRXJFKYQP-RXCALXPUNA-N
SmilesO=CC(=CC=CC=C(C=CC=C(C=CC12OC2(C)CC(O)CC1(C)C)C)C)C
SuperclassLipids and lipid-like molecules
ClassPrenol lipids

Plant source

  • Curcuma longa L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)13
    Number of reactive functional groups (#rtvFG)2
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)382.542
    Computed dipole moment(dipole)3.607
    Total solvent accessible surface area (SASA)787.75
    Hydrophobic component of SASA (FOSA)576.749
    Hydrophilic component of SASA (FISA)118.85
    Pie component of the SASA (PISA)92.151
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1410.03
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)5.7
    Free energy of solvation of dipole (dip^2/V)0.009227
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0072358
    Globularity descriptor (glob)0.77196
    Predicted polarizability in cubic angstroms (QPpolrz)42.808
    Predicted hexadecane/gas partition coefficient (QPlogPC16)13.211
    Predicted octanol/gas partition coefficient (QPlogPoct)18.069
    Predicted water/gas partition coefficient (QPlogPw)7.262
    Predicted octanol/water partition coefficient (QPlogPo/w)5.025
    Predicted aqueous solubility (QPlogS)-6.366
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.564
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.661
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)739.336
    Predicted brain/blood partition coefficient (QPlogBB)-1.55
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)356.93
    Predicted skin permeability, log Kp (QPlogKp)-2.137
    PM3 calculated ionization potential (IP(ev))8.489
    PM3 calculated electron affinity (EA(eV))1.11
    Number of likely metabolic reactions (#metab)4
    Prediction of binding to human serum albumin (QPlogKhsa)0.764
    Predicted qualitative human oral absorption (HumanOralAbsorption)1
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)94.754
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)69.141
    Number of nitrogen and oxygen atoms (#NandO)3
    Number of violations of Lipinski’s rule of five (RuleOfFive)1
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P11229CHRM1Muscarinic acetylcholine receptor M1T28893SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P34903GABRA3GABA A receptor alpha-3/beta-2/gamma-2T62292SwissTargetPrediction
    P47869GABRA2GABA A receptor alpha-2/beta-2/gamma-2T51452SwissTargetPrediction
    P05067APPBeta amyloid A4 proteinT87024SwissTargetPrediction
    P42338PIK3CBPI3-kinase p110-beta subunitT05031SwissTargetPrediction
    P11712CYP2C9Cytochrome P450 2C9T19244SwissTargetPrediction
    P06239LCKTyrosine-protein kinase LCKT12499SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P17612PRKACAcAMP-dependent protein kinase alpha-catalytic subunitT12808SwissTargetPrediction
    P21554CNR1Cannabinoid receptor 1 (by homology)T76685SwissTargetPrediction
    P34913EPHX2Epoxide hydrataseT35734SwissTargetPrediction
    P24864CCNE1Cyclin-dependent kinase 2/cyclin E1T10052SwissTargetPrediction
    P29275ADORA2BAdenosine A2b receptorT86679SwissTargetPrediction
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    P53985SLC16A1Monocarboxylate transporter 1 (by homology)T95842SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction
    O60885BRD4Bromodomain-containing protein 4T00407SwissTargetPrediction
    P25440BRD2Bromodomain-containing protein 2T86597SwissTargetPrediction
    Q15059BRD3Bromodomain-containing protein 3T42048SwissTargetPrediction
    Q8NER1TRPV1Vanilloid receptorT83193SwissTargetPrediction
    P51681CCR5C-C chemokine receptor type 5T09960SwissTargetPrediction
    P09917ALOX5Arachidonate 5-lipoxygenaseT00140SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    P08069IGF1RInsulin-like growth factor I receptorT48069SwissTargetPrediction
    P25100ADRA1DAlpha-1d adrenergic receptorT53381SwissTargetPrediction
    P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
    P11474ESRRAEstrogen-related receptor alphaT72841SwissTargetPrediction
    O95718ESRRBEstrogen-related receptor betaT42025SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    P00519ABL1Tyrosine-protein kinase ABLT63505SwissTargetPrediction
    O60674JAK2Tyrosine-protein kinase JAK2T08391SwissTargetPrediction
    P06213INSRInsulin receptorT85435SwissTargetPrediction
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    Q9P1W9PIM2Serine/threonine-protein kinase PIM2T07279SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    P37288AVPR1AVasopressin V1a receptor (by homology)T79232SwissTargetPrediction
    Q92847GHSRGhrelin receptorT59604SwissTargetPrediction
    P04035HMGCRHMG-CoA reductaseT53585SwissTargetPrediction
    Q16850CYP51A1Cytochrome P450 51 (by homology)T32972SwissTargetPrediction
    P20701ITGALIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2T35640SwissTargetPrediction
    O75116ROCK2Rho-associated protein kinase 2T06093SwissTargetPrediction
    P32246CCR1C-C chemokine receptor type 1T16016SwissTargetPrediction
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    Q02750MAP2K1Dual specificity mitogen-activated protein kinase kinase 1T99057SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    Q14432PDE3APhosphodiesterase 3T88975SwissTargetPrediction
    P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction
    Q99572P2RX7P2X purinoceptor 7T63414SwissTargetPrediction
    Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SwissTargetPrediction
    Q13627DYRK1ADual-specificity tyrosine-phosphorylation regulated kinase 1AT92803SwissTargetPrediction
    P24385CCND1Cyclin-dependent kinase 4/cyclin D1T12355SwissTargetPrediction
    Q12884FAPFibroblast activation protein alpha (by homology)T53764SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P29597TYK2Tyrosine-protein kinase TYK2T78932SwissTargetPrediction
    Q9NWZ3IRAK4Interleukin-1 receptor-associated kinase 4T55398SwissTargetPrediction
    P34995PTGER1Prostanoid EP1 receptorT15497SwissTargetPrediction
    P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SwissTargetPrediction
    P31644GABRA5GABA receptor alpha-5 subunitT26368SwissTargetPrediction
    P07333CSF1RMacrophage colony stimulating factor receptorT20333SwissTargetPrediction
    P04629NTRK1Nerve growth factor receptor Trk-AT07173SwissTargetPrediction
    P50750CDK9Cyclin-dependent kinase 9T44458SwissTargetPrediction
    P06737PYGLLiver glycogen phosphorylaseT19184SwissTargetPrediction
    Q92793CREBBPCREB-binding protein/p53T03634SwissTargetPrediction
    P21730C5AR1C5a anaphylatoxin chemotactic receptorT15439SwissTargetPrediction
    Q99835SMOSmoothened homologT66505SwissTargetPrediction
    Q00987MDM2p53-binding protein Mdm-2T00176SwissTargetPrediction
    P56373P2RX3P2X purinoceptor 3T17140SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    O14649KCNK3Potassium channel subfamily K member 3T15795SwissTargetPrediction
    P35557GCKHexokinase type IVT87166SwissTargetPrediction
    P43490NAMPTNicotinamide phosphoribosyltransferaseT54582SwissTargetPrediction
    P16234PDGFRAPlatelet-derived growth factor receptorT53524SwissTargetPrediction
    P25116F2RProteinase-activated receptor 1T36483SwissTargetPrediction
    P22460KCNA5Voltage-gated potassium channel subunit Kv1.5T17569SwissTargetPrediction
    Q13370PDE3BPhosphodiesterase 3BT21357SwissTargetPrediction
    P00746CFDComplement factor DT66383SwissTargetPrediction
    O00408PDE2APhosphodiesterase 2AT77400SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    Q15910EZH2EZH2/SUZ12/EED/RBBP7/RBBP4T25265SwissTargetPrediction
    Q12866MERTKProto-oncogene tyrosine-protein kinase MERT55781SwissTargetPrediction
    Q06418TYRO3Tyrosine-protein kinase receptor TYRO3T94880SwissTargetPrediction
    Q05513PRKCZProtein kinase C (PKC)T59190SwissTargetPrediction
    Q15759MAPK11MAP kinase p38 betaT55729SwissTargetPrediction
    P30530AXLTyrosine-protein kinase receptor UFOT82383SwissTargetPrediction
    P49682CXCR3C-X-C chemokine receptor type 3T25315SwissTargetPrediction
    Q5VT25CDC42BPASerine or threonine-protein kinase MRCK-AT00075SwissTargetPrediction
    Q9NS86LANCL2LanC-like protein 2T63207SEA
    Q9NRG4SMYD2N-lysine methyltransferase SMYD2T15797SwissTargetPrediction
    P14618PKMPyruvate kinase isozymes M1/M2T65889SwissTargetPrediction
    O95136S1PR2Sphingosine 1-phosphate receptor Edg-5T47888SwissTargetPrediction
    P21802FGFR2Fibroblast growth factor receptor 2T58454SwissTargetPrediction
    P18507GABRG2GABA-A receptor; alpha-6/beta-3/gamma-2T08910SwissTargetPrediction
    Q02224CENPECentromere-associated protein ET14945SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T28893DI0001Abdominal pelvic pain[ICD-11: MD81]P11229CHRM1
    T28893DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P11229CHRM1
    T28893DI0101Corneal disease[ICD-11: 9A76-9A78]P11229CHRM1
    T28893DI0129Dystonic disorder[ICD-11: 8A02]P11229CHRM1
    T28893DI0154Functional bladder disorder[ICD-11: GC50]P11229CHRM1
    T28893DI0157Gastric ulcer[ICD-11: DA60]P11229CHRM1
    T28893DI0166Glaucoma[ICD-11: 9C61]P11229CHRM1
    T28893DI0186Hyperhidrosis[ICD-11: EE00]P11229CHRM1
    T28893DI0218Irritable bowel syndrome[ICD-11: DD91]P11229CHRM1
    T28893DI0331Parkinsonism[ICD-11: 8A00]P11229CHRM1
    T28893DI0333Peptic ulcer[ICD-11: DA61]P11229CHRM1
    T28893DI0371Sebaceous gland disorder[ICD-11: ED91]P11229CHRM1
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T62292DI0216Intentional self-harm[ICD-11: PC91]P34903GABRA3
    T51452DI0216Intentional self-harm[ICD-11: PC91]P47869GABRA2
    T87024DI0025Alzheimer disease[ICD-11: 8A20]P05067APP
    T87024DI0122Diagnostic imaging[ICD-11: N.A.]P05067APP
    T05031DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42338PIK3CB
    T19244DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P11712CYP2C9
    T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T12808DI0279Muscular atrophy[ICD-11: 8B61]P17612PRKACA
    T76685DI0031Anorexia nervosa[ICD-11: 6B80]P21554CNR1
    T76685DI0214Insomnia[ICD-11: 7A00-7A0Z]P21554CNR1
    T76685DI0308Obesity[ICD-11: 5B80-5B81]P21554CNR1
    T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
    T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
    T86679DI0180Herpes simplex infection[ICD-11: 1F00]P29275ADORA2B
    T86679DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P29275ADORA2B
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T86597DI0106COVID-19[ICD-11: 1D6Y]P25440BRD2
    T42048DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q15059BRD3
    T42048DI0346Prostate cancer[ICD-11: 2C82]Q15059BRD3
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T09960DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P51681CCR5
    T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
    T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
    T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T48069DI0276Multiple structural anomalies syndrome[ICD-11: LD2F]P08069IGF1R
    T48069DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P08069IGF1R
    T48069DI0408Thyrotoxicosis[ICD-11: 5A02]P08069IGF1R
    T53381DI0166Glaucoma[ICD-11: 9C61]P25100ADRA1D
    T53381DI0175Heart failure[ICD-11: BD10-BD1Z]P25100ADRA1D
    T53381DI0190Hypertension[ICD-11: BA00-BA04]P25100ADRA1D
    T53381DI0348Prostate hyperplasia[ICD-11: GA90]P25100ADRA1D
    T53381DI0378Sexual dysfunction[ICD-11: HA00-HA01]P25100ADRA1D
    T53381DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P25100ADRA1D
    T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
    T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
    T72841DI0366Rheumatoid arthritis[ICD-11: FA20]P11474ESRRA
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T63505DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00519ABL1
    T63505DI0220Ischemia[ICD-11: 8B10-8B11]P00519ABL1
    T63505DI0250Mature B-cell lymphoma[ICD-11: 2A85]P00519ABL1
    T63505DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00519ABL1
    T08391DI0039Atopic eczema[ICD-11: EA80]O60674JAK2
    T08391DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60674JAK2
    T08391DI0366Rheumatoid arthritis[ICD-11: FA20]O60674JAK2
    T08391DI0404Thrombocytosis[ICD-11: 3B63]O60674JAK2
    T85435DI0009Acute diabete complication[ICD-11: 5A2Y]P06213INSR
    T85435DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P06213INSR
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T07279DI0274Multiple myeloma[ICD-11: 2A83]Q9P1W9PIM2
    T07279DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9P1W9PIM2
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T79232DI0009Acute diabete complication[ICD-11: 5A2Y]P37288AVPR1A
    T79232DI0041Autism spectrum disorder[ICD-11: 6A02]P37288AVPR1A
    T79232DI0190Hypertension[ICD-11: BA00-BA04]P37288AVPR1A
    T79232DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P37288AVPR1A
    T79232DI0236Localisation[ICD-11: N.A.]P37288AVPR1A
    T59604DI0087Chronic pain[ICD-11: MG30]Q92847GHSR
    T59604DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]Q92847GHSR
    T53585DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P04035HMGCR
    T53585DI0102Coronary atherosclerosis[ICD-11: BA52]P04035HMGCR
    T53585DI0128Dyslipidemia[ICD-11: 5C80-5C81]P04035HMGCR
    T53585DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P04035HMGCR
    T53585DI0275Multiple sclerosis[ICD-11: 8A40]P04035HMGCR
    T53585DI0287Myocardial infarction[ICD-11: BA41-BA43]P04035HMGCR
    T53585DI0324Pain[ICD-11: MG30-MG3Z]P04035HMGCR
    T32972DI0209Infectious meningitis[ICD-11: 1D01]Q16850CYP51A1
    T32972DI0289Nail/perionychium infection[ICD-11: EE12]Q16850CYP51A1
    T32972DI0316Onchocerciasis[ICD-11: 1F6A]Q16850CYP51A1
    T35640DI0351Psoriasis[ICD-11: EA90]P20701ITGAL
    T35640DI0436Visual system disease[ICD-11: 9E1Z]P20701ITGAL
    T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
    T16016DI0120Diabetes mellitus[ICD-11: 5A10]P32246CCR1
    T16016DI0366Rheumatoid arthritis[ICD-11: FA20]P32246CCR1
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T99057DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q02750MAP2K1
    T99057DI0336Phakomatoses/hamartoneoplastic syndrome[ICD-11: LD2D]Q02750MAP2K1
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T88975DI0035Arterial occlusive disease[ICD-11: BD40]Q14432PDE3A
    T88975DI0037Asthma[ICD-11: CA23]Q14432PDE3A
    T88975DI0175Heart failure[ICD-11: BD10-BD1Z]Q14432PDE3A
    T88975DI0404Thrombocytosis[ICD-11: 3B63]Q14432PDE3A
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T63414DI0224Joint pain[ICD-11: ME82]Q99572P2RX7
    T92803DI0113Cytomegaloviral disease[ICD-11: 1D82]Q13627DYRK1A
    T12355DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P24385CCND1
    T53764DI0300Neutropenia[ICD-11: 4B00]Q12884FAP
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T78932DI0351Psoriasis[ICD-11: EA90]P29597TYK2
    T55398DI0039Atopic eczema[ICD-11: EA80]Q9NWZ3IRAK4
    T55398DI0109Cutaneous lupus erythematosus[ICD-11: EB50-EB5Z]Q9NWZ3IRAK4
    T55398DI0241Lymphoma[ICD-11: 2A80-2A86]Q9NWZ3IRAK4
    T55398DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q9NWZ3IRAK4
    T55398DI0351Psoriasis[ICD-11: EA90]Q9NWZ3IRAK4
    T55398DI0366Rheumatoid arthritis[ICD-11: FA20]Q9NWZ3IRAK4
    T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
    T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
    T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
    T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
    T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
    T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
    T26368DI0216Intentional self-harm[ICD-11: PC91]P31644GABRA5
    T20333DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P07333CSF1R
    T07173DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04629NTRK1
    T07173DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04629NTRK1
    T44458DI0012Acute myeloid leukaemia[ICD-11: 2A60]P50750CDK9
    T44458DI0241Lymphoma[ICD-11: 2A80-2A86]P50750CDK9
    T44458DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P50750CDK9
    T44458DI0249Mature B-cell leukaemia[ICD-11: 2A82]P50750CDK9
    T44458DI0250Mature B-cell lymphoma[ICD-11: 2A85]P50750CDK9
    T44458DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]P50750CDK9
    T44458DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50750CDK9
    T03634DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q92793CREBBP
    T03634DI0346Prostate cancer[ICD-11: 2C82]Q92793CREBBP
    T03634DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92793CREBBP
    T03634DI0399Systemic sclerosis[ICD-11: 4A42]Q92793CREBBP
    T15439DI0431Vasculitis[ICD-11: 4A44]P21730C5AR1
    T66505DI0047Basal cell carcinoma[ICD-11: 2C32]Q99835SMO
    T66505DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]Q99835SMO
    T66505DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q99835SMO
    T00176DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q00987MDM2
    T00176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q00987MDM2
    T17140DI0105Cough[ICD-11: MD12]P56373P2RX3
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T15795DI0309Obstructive sleep apnoea[ICD-11: 7A41]O14649KCNK3
    T87166DI0009Acute diabete complication[ICD-11: 5A2Y]P35557GCK
    T87166DI0120Diabetes mellitus[ICD-11: 5A10]P35557GCK
    T87166DI0308Obesity[ICD-11: 5B80-5B81]P35557GCK
    T87166DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P35557GCK
    T54582DI0231Leukaemia[ICD-11: 2A60-2B33]P43490NAMPT
    T54582DI0241Lymphoma[ICD-11: 2A80-2A86]P43490NAMPT
    T54582DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43490NAMPT
    T53524DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P16234PDGFRA
    T53524DI0225Kaposi sarcoma[ICD-11: 2B57]P16234PDGFRA
    T53524DI0403Thrombocytopenia[ICD-11: 3B64]P16234PDGFRA
    T36483DI0287Myocardial infarction[ICD-11: BA41-BA43]P25116F2R
    T17569DI0030Angina pectoris[ICD-11: BA40]P22460KCNA5
    T66383DI0170Haemolytic anemia[ICD-11: 3A20-3A2Z]P00746CFD
    T66383DI0365Retinopathy[ICD-11: 9B71]P00746CFD
    T77400DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]O00408PDE2A
    T77400DI0207Indeterminate colitis[ICD-11: DD72]O00408PDE2A
    T77400DI0218Irritable bowel syndrome[ICD-11: DD91]O00408PDE2A
    T77400DI0270Mood disorder[ICD-11: 6A60-6E23]O00408PDE2A
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T25265DI0151Follicular lymphoma[ICD-11: 2A80]Q15910EZH2
    T55781DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q12866MERTK
    T55781DI0025Alzheimer disease[ICD-11: 8A20]Q12866MERTK
    T55781DI0284Myelodysplastic syndrome[ICD-11: 2A37]Q12866MERTK
    T55781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q12866MERTK
    T94880DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06418TYRO3
    T59190DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q05513PRKCZ
    T55729DI0025Alzheimer disease[ICD-11: 8A20]Q15759MAPK11
    T55729DI0366Rheumatoid arthritis[ICD-11: FA20]Q15759MAPK11
    T82383DI0012Acute myeloid leukaemia[ICD-11: 2A60]P30530AXL
    T25315DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P49682CXCR3
    T25315DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P49682CXCR3
    T25315DI0351Psoriasis[ICD-11: EA90]P49682CXCR3
    T25315DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49682CXCR3
    T63207DI0366Rheumatoid arthritis[ICD-11: FA20]Q9NS86LANCL2
    T63207DI0419Ulcerative colitis[ICD-11: DD71]Q9NS86LANCL2
    T15797DI0238Lung cancer[ICD-11: 2C25]Q9NRG4SMYD2
    T15797DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9NRG4SMYD2
    T65889DI0361Renal cell carcinoma[ICD-11: 2C90]P14618PKM
    T47888DI0419Ulcerative colitis[ICD-11: DD71]O95136S1PR2
    T58454DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P21802FGFR2
    T58454DI0235Liver cancer[ICD-11: 2C12]P21802FGFR2
    T58454DI0318Oral mucositis[ICD-11: DA01]P21802FGFR2
    T08910DI0117Depression[ICD-11: 6A70-6A7Z]P18507GABRG2
    T08910DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P18507GABRG2
    T08910DI0411Tonus and reflex abnormality[ICD-11: MB47]P18507GABRG2
    T14945DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q02224CENPE

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