Ningpeisine



Compound IDCDAMM01887
Common nameNingpeisine
IUPAC name9-[1-(1,5-dimethylpiperidin-2-yl)ethyl]-3-hydroxy-10,11b-dimethyl-2,3,4,4a,6,6a,6b,7,8,9,10,10a,11,11a-tetradecahydro-1H-benzo[a]fluoren-5-one
Molecular formulaC28H47NO2

Experimental data

Retention time16.46
Adduct[M+H]+
Actual mz430.366
Theoretical mz430.368
Error6.45
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.6138

Identifiers and class information

Inchi keyUBMXONPUBFQLKA-QVXVUMDZNA-N
SmilesO=C1CC2C3CCC(C(C)C4N(C)CC(C)CC4)C(C)C3CC2C5(C)CCC(O)CC15
SuperclassOrganoheterocyclic compounds
ClassPiperidines

Plant source

  • Curcuma longa L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)3
    Number of reactive functional groups (#rtvFG)1
    Predicted central nervous system activity (CNS)1
    Molecular weight (mol_MW)429.685
    Computed dipole moment(dipole)4.32
    Total solvent accessible surface area (SASA)691.158
    Hydrophobic component of SASA (FOSA)624.717
    Hydrophilic component of SASA (FISA)66.441
    Pie component of the SASA (PISA)0
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1395.03
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)5.7
    Free energy of solvation of dipole (dip^2/V)0.0133804
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.008247
    Globularity descriptor (glob)0.873596
    Predicted polarizability in cubic angstroms (QPpolrz)47.749
    Predicted hexadecane/gas partition coefficient (QPlogPC16)11.778
    Predicted octanol/gas partition coefficient (QPlogPoct)20.228
    Predicted water/gas partition coefficient (QPlogPw)8.252
    Predicted octanol/water partition coefficient (QPlogPo/w)4.699
    Predicted aqueous solubility (QPlogS)-5.045
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.644
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.304
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)579.082
    Predicted brain/blood partition coefficient (QPlogBB)0.201
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)303.235
    Predicted skin permeability, log Kp (QPlogKp)-4.519
    PM3 calculated ionization potential (IP(ev))9.096
    PM3 calculated electron affinity (EA(eV))-0.774
    Number of likely metabolic reactions (#metab)4
    Prediction of binding to human serum albumin (QPlogKhsa)1.189
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)47.749
    Number of nitrogen and oxygen atoms (#NandO)3
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P43681CHRNA4Neuronal acetylcholine receptor; alpha4/beta2T70967SwissTargetPrediction
    P11229CHRM1Muscarinic acetylcholine receptor M1T28893SwissTargetPrediction
    Q99720SIGMAR1Sigma opioid receptorT46360SwissTargetPrediction
    P00797RENReninT61622SwissTargetPrediction
    P21917DRD4Dopamine D4 receptorT24983SwissTargetPrediction
    P05067APPBeta amyloid A4 proteinT87024SwissTargetPrediction
    P11940PABPC1Polyadenylate-binding protein 1T58679SwissTargetPrediction
    Q15125EBPAnti-estrogen binding site (AEBS)T25317SwissTargetPrediction
    P14555PLA2G2APhospholipase A2 group IIAT19160SwissTargetPrediction
    P04054PLA2G1BPhospholipase A2 group 1BT31479SwissTargetPrediction
    P08514ITGA2BIntegrin alpha-IIb/beta-3T50688SwissTargetPrediction
    P27487DPP4Dipeptidyl peptidase IVT31391SwissTargetPrediction
    P08473MMENeprilysinT05409SwissTargetPrediction
    P17612PRKACAcAMP-dependent protein kinase alpha-catalytic subunitT12808SwissTargetPrediction
    P31213SRD5A2Steroid 5-alpha-reductase 2T71390SwissTargetPrediction
    P21554CNR1Cannabinoid receptor 1 (by homology)T76685SwissTargetPrediction
    P34913EPHX2Epoxide hydrataseT35734SwissTargetPrediction
    Q02083NAAAN-acylsphingosine-amidohydrolase (by homology)T78326SwissTargetPrediction
    P28223HTR2ASerotonin 2a (5-HT2a) receptorT32060SwissTargetPrediction
    P32297CHRNA3Neuronal acetylcholine receptor; alpha3/beta4T74166SwissTargetPrediction
    Q01959SLC6A3Dopamine transporterT55959SwissTargetPrediction
    Q99705MCHR1Melanin-concentrating hormone receptor 1T09572SwissTargetPrediction
    P10275ARAndrogen ReceptorT11211SwissTargetPrediction
    Q96IY4CPB2Carboxypeptidase B2 isoform AT98022SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P08185SERPINA6Corticosteroid binding globulinT88452SEA
    P18405SRD5A1Steroid 5-alpha-reductase 1T70309SwissTargetPrediction
    P51681CCR5C-C chemokine receptor type 5T09960SwissTargetPrediction
    P28845HSD11B111-beta-hydroxysteroid dehydrogenase 1T65200SwissTargetPrediction
    Q6QHF9PAOXPolyamine oxidaseT88699SwissTargetPrediction
    Q8TDU6GPBAR1G-protein coupled bile acid receptor 1T86273SEA
    P08069IGF1RInsulin-like growth factor I receptorT48069SwissTargetPrediction
    Q9UM73ALKALK tyrosine kinase receptorT56418SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SwissTargetPrediction
    P25100ADRA1DAlpha-1d adrenergic receptorT53381SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    P06213INSRInsulin receptorT85435SwissTargetPrediction
    P08172CHRM2Muscarinic acetylcholine receptor M2T46185SwissTargetPrediction
    P35270SPRSubstance-P receptorT47094SwissTargetPrediction
    P32245MC4RMelanocortin receptor 4T72458SwissTargetPrediction
    P41968MC3RMelanocortin receptor 3T76846SwissTargetPrediction
    P62942FKBP1AFK506-binding protein 1AT76059SwissTargetPrediction
    Q13489BIRC3Baculoviral IAP repeat-containing protein 3T35173SwissTargetPrediction
    P51449RORCNuclear receptor ROR-gammaT25307SwissTargetPrediction
    P43116PTGER2Prostanoid EP2 receptorT38529SwissTargetPrediction
    P11413G6PDGlucose-6-phosphate 1-dehydrogenaseT63484SEA
    P13500CCL2C-C motif chemokine 2T89988SwissTargetPrediction
    P35348ADRA1AAlpha-1a adrenergic receptorT92609SwissTargetPrediction
    P31749AKT1Serine/threonine-protein kinase AKTT67619SwissTargetPrediction
    P07900HSP90AA1Heat shock protein HSP 90-alphaT18477SwissTargetPrediction
    P32246CCR1C-C chemokine receptor type 1T16016SwissTargetPrediction
    P33981TTKDual specificity protein kinase TTKT74977SwissTargetPrediction
    Q05655PRKCDProtein kinase C deltaT44861SwissTargetPrediction
    P35408PTGER4Prostanoid EP4 receptorT18876SwissTargetPrediction
    P43115PTGER3Prostanoid EP3 receptorT85467SwissTargetPrediction
    Q99558MAP3K14Mitogen-activated protein kinase kinase kinase 14T95736SwissTargetPrediction
    P41146OPRL1Nociceptin receptorT52921SwissTargetPrediction
    Q99835SMOSmoothened homologT66505SwissTargetPrediction
    Q00987MDM2p53-binding protein Mdm-2T00176SwissTargetPrediction
    P31751AKT2Serine/threonine-protein kinase AKT2T94621SwissTargetPrediction
    Q9Y243AKT3Serine/threonine-protein kinase AKTT71266SwissTargetPrediction
    Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SwissTargetPrediction and SEA
    Q04759PRKCQProtein kinase C thetaT23995SwissTargetPrediction
    P21452TACR2Neurokinin 2 receptorT52790SwissTargetPrediction
    Q9GZN0GPR88Probable G-protein coupled receptor 88T37505SwissTargetPrediction
    P22460KCNA5Voltage-gated potassium channel subunit Kv1.5T17569SwissTargetPrediction
    Q9UKP6UTS2RUrotensin II receptorT49072SwissTargetPrediction
    P29371TACR3Neurokinin 3 receptorT29683SwissTargetPrediction
    P49682CXCR3C-X-C chemokine receptor type 3T25315SwissTargetPrediction
    P33032MC5RMelanocortin receptor 5T95302SwissTargetPrediction
    P15169CPN1Carboxypeptidase N, catalytic subunitT34471SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T70967DI0029Aneurysm/dissection[ICD-11: BD50]P43681CHRNA4
    T70967DI0191Hypertensive crisis[ICD-11: BA03]P43681CHRNA4
    T70967DI0196Hypotension[ICD-11: BA20-BA21]P43681CHRNA4
    T28893DI0001Abdominal pelvic pain[ICD-11: MD81]P11229CHRM1
    T28893DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P11229CHRM1
    T28893DI0101Corneal disease[ICD-11: 9A76-9A78]P11229CHRM1
    T28893DI0129Dystonic disorder[ICD-11: 8A02]P11229CHRM1
    T28893DI0154Functional bladder disorder[ICD-11: GC50]P11229CHRM1
    T28893DI0157Gastric ulcer[ICD-11: DA60]P11229CHRM1
    T28893DI0166Glaucoma[ICD-11: 9C61]P11229CHRM1
    T28893DI0186Hyperhidrosis[ICD-11: EE00]P11229CHRM1
    T28893DI0218Irritable bowel syndrome[ICD-11: DD91]P11229CHRM1
    T28893DI0331Parkinsonism[ICD-11: 8A00]P11229CHRM1
    T28893DI0333Peptic ulcer[ICD-11: DA61]P11229CHRM1
    T28893DI0371Sebaceous gland disorder[ICD-11: ED91]P11229CHRM1
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T61622DI0190Hypertension[ICD-11: BA00-BA04]P00797REN
    T24983DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21917DRD4
    T24983DI0370Schizophrenia[ICD-11: 6A20]P21917DRD4
    T87024DI0025Alzheimer disease[ICD-11: 8A20]P05067APP
    T87024DI0122Diagnostic imaging[ICD-11: N.A.]P05067APP
    T58679DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11940PABPC1
    T25317DI0366Rheumatoid arthritis[ICD-11: FA20]Q15125EBP
    T19160DI0062Breast cancer[ICD-11: 2C60-2C6Y]P14555PLA2G2A
    T31479DI0230Leishmaniasis[ICD-11: 1F54]P04054PLA2G1B
    T31479DI0335Peroxisomal disease[ICD-11: 5C57]P04054PLA2G1B
    T31479DI0367Rosacea[ICD-11: ED90]P04054PLA2G1B
    T31479DI0398Synthesis disorder[ICD-11: 5C52-5C59]P04054PLA2G1B
    T50688DI0007Acquired hypermelanosis[ICD-11: ED60]P08514ITGA2B
    T50688DI0030Angina pectoris[ICD-11: BA40]P08514ITGA2B
    T50688DI0287Myocardial infarction[ICD-11: BA41-BA43]P08514ITGA2B
    T31391DI0009Acute diabete complication[ICD-11: 5A2Y]P27487DPP4
    T31391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P27487DPP4
    T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
    T12808DI0279Muscular atrophy[ICD-11: 8B61]P17612PRKACA
    T71390DI0348Prostate hyperplasia[ICD-11: GA90]P31213SRD5A2
    T76685DI0031Anorexia nervosa[ICD-11: 6B80]P21554CNR1
    T76685DI0214Insomnia[ICD-11: 7A00-7A0Z]P21554CNR1
    T76685DI0308Obesity[ICD-11: 5B80-5B81]P21554CNR1
    T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
    T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
    T32060DI0009Acute diabete complication[ICD-11: 5A2Y]P28223HTR2A
    T32060DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P28223HTR2A
    T32060DI0073Cerebral ischaemia[ICD-11: 8B1Z]P28223HTR2A
    T32060DI0270Mood disorder[ICD-11: 6A60-6E23]P28223HTR2A
    T32060DI0331Parkinsonism[ICD-11: 8A00]P28223HTR2A
    T32060DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28223HTR2A
    T32060DI0370Schizophrenia[ICD-11: 6A20]P28223HTR2A
    T74166DI0105Cough[ICD-11: MD12]P32297CHRNA3
    T55959DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q01959SLC6A3
    T55959DI0051Bipolar disorder[ICD-11: 6A60]Q01959SLC6A3
    T55959DI0101Corneal disease[ICD-11: 9A76-9A78]Q01959SLC6A3
    T55959DI0290Narcolepsy[ICD-11: 7A20]Q01959SLC6A3
    T55959DI0308Obesity[ICD-11: 5B80-5B81]Q01959SLC6A3
    T55959DI0331Parkinsonism[ICD-11: 8A00]Q01959SLC6A3
    T09572DI0308Obesity[ICD-11: 5B80-5B81]Q99705MCHR1
    T11211DI0005Acne vulgaris[ICD-11: ED80]P10275AR
    T11211DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10275AR
    T11211DI0021Alcoholic liver disease[ICD-11: DB94]P10275AR
    T11211DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10275AR
    T11211DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P10275AR
    T11211DI0145Female pelvic pain[ICD-11: GA34]P10275AR
    T11211DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P10275AR
    T11211DI0237Low bone mass disorder[ICD-11: FB83]P10275AR
    T11211DI0247Mammary tumour[ICD-11: 2C60-2C6Z]P10275AR
    T11211DI0346Prostate cancer[ICD-11: 2C82]P10275AR
    T11211DI0401Testicular dysfunction[ICD-11: 5A81]P10275AR
    T98022DI0073Cerebral ischaemia[ICD-11: 8B1Z]Q96IY4CPB2
    T98022DI0074Cerebral ischaemic stroke[ICD-11: 8B11]Q96IY4CPB2
    T98022DI0405Thrombosis[ICD-11: DB61-GB90]Q96IY4CPB2
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T88452DI0037Asthma[ICD-11: CA23]P08185SERPINA6
    T88452DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P08185SERPINA6
    T88452DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08185SERPINA6
    T70309DI0347Prostate disease[ICD-11: GA91]P18405SRD5A1
    T09960DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P51681CCR5
    T65200DI0210Influenza[ICD-11: 1E30-1E32]P28845HSD11B1
    T65200DI0239Lupus erythematosus[ICD-11: 4A40]P28845HSD11B1
    T65200DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P28845HSD11B1
    T86273DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q8TDU6GPBAR1
    T48069DI0276Multiple structural anomalies syndrome[ICD-11: LD2F]P08069IGF1R
    T48069DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P08069IGF1R
    T48069DI0408Thyrotoxicosis[ICD-11: 5A02]P08069IGF1R
    T56418DI0238Lung cancer[ICD-11: 2C25]Q9UM73ALK
    T56418DI0251Mature T-cell lymphoma[ICD-11: 2A90]Q9UM73ALK
    T56418DI0303Non-small-cell lung cancer[ICD-11: 2C25]Q9UM73ALK
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T53381DI0166Glaucoma[ICD-11: 9C61]P25100ADRA1D
    T53381DI0175Heart failure[ICD-11: BD10-BD1Z]P25100ADRA1D
    T53381DI0190Hypertension[ICD-11: BA00-BA04]P25100ADRA1D
    T53381DI0348Prostate hyperplasia[ICD-11: GA90]P25100ADRA1D
    T53381DI0378Sexual dysfunction[ICD-11: HA00-HA01]P25100ADRA1D
    T53381DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P25100ADRA1D
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T85435DI0009Acute diabete complication[ICD-11: 5A2Y]P06213INSR
    T85435DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P06213INSR
    T46185DI0037Asthma[ICD-11: CA23]P08172CHRM2
    T46185DI0166Glaucoma[ICD-11: 9C61]P08172CHRM2
    T46185DI0278Muscle disorder[ICD-11: FB32-FB3Z]P08172CHRM2
    T46185DI0333Peptic ulcer[ICD-11: DA61]P08172CHRM2
    T46185DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08172CHRM2
    T46185DI0371Sebaceous gland disorder[ICD-11: ED91]P08172CHRM2
    T47094DI0117Depression[ICD-11: 6A70-6A7Z]P35270SPR
    T47094DI0293Nausea/vomiting[ICD-11: MD90]P35270SPR
    T72458DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]P32245MC4R
    T72458DI0228Large intestine motility disorder[ICD-11: DB32]P32245MC4R
    T72458DI0308Obesity[ICD-11: 5B80-5B81]P32245MC4R
    T76846DI0308Obesity[ICD-11: 5B80-5B81]P41968MC3R
    T76846DI0378Sexual dysfunction[ICD-11: HA00-HA01]P41968MC3R
    T76846DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P41968MC3R
    T76059DI0331Parkinsonism[ICD-11: 8A00]P62942FKBP1A
    T76059DI0349Pruritus[ICD-11: EC90]P62942FKBP1A
    T76059DI0413Transplant rejection[ICD-11: NE84]P62942FKBP1A
    T35173DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]Q13489BIRC3
    T25307DI0042Autoimmune disease[ICD-11: 4A40-4A45]P51449RORC
    T25307DI0107Crohn disease[ICD-11: DD70]P51449RORC
    T25307DI0238Lung cancer[ICD-11: 2C25]P51449RORC
    T25307DI0275Multiple sclerosis[ICD-11: 8A40]P51449RORC
    T25307DI0351Psoriasis[ICD-11: EA90]P51449RORC
    T25307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P51449RORC
    T38529DI0003Abortion[ICD-11: JA00]P43116PTGER2
    T38529DI0102Coronary atherosclerosis[ICD-11: BA52]P43116PTGER2
    T38529DI0121Diabetic foot ulcer[ICD-11: BD54]P43116PTGER2
    T38529DI0166Glaucoma[ICD-11: 9C61]P43116PTGER2
    T38529DI0356Pulmonary hypertension[ICD-11: BB01]P43116PTGER2
    T38529DI0378Sexual dysfunction[ICD-11: HA00-HA01]P43116PTGER2
    T38529DI0413Transplant rejection[ICD-11: NE84]P43116PTGER2
    T63484DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P11413G6PD
    T89988DI0083Chronic kidney disease[ICD-11: GB61]P13500CCL2
    T89988DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P13500CCL2
    T89988DI0087Chronic pain[ICD-11: MG30]P13500CCL2
    T89988DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P13500CCL2
    T89988DI0252Melanoma[ICD-11: 2C30]P13500CCL2
    T89988DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P13500CCL2
    T89988DI0275Multiple sclerosis[ICD-11: 8A40]P13500CCL2
    T89988DI0326Pancreatic cancer[ICD-11: 2C10]P13500CCL2
    T89988DI0366Rheumatoid arthritis[ICD-11: FA20]P13500CCL2
    T89988DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P13500CCL2
    T92609DI0190Hypertension[ICD-11: BA00-BA04]P35348ADRA1A
    T92609DI0348Prostate hyperplasia[ICD-11: GA90]P35348ADRA1A
    T67619DI0062Breast cancer[ICD-11: 2C60-2C6Y]P31749AKT1
    T18477DI0015Acute upper respiratory infection[ICD-11: CA07]P07900HSP90AA1
    T18477DI0037Asthma[ICD-11: CA23]P07900HSP90AA1
    T16016DI0120Diabetes mellitus[ICD-11: 5A10]P32246CCR1
    T16016DI0366Rheumatoid arthritis[ICD-11: FA20]P32246CCR1
    T74977DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P33981TTK
    T44861DI0287Myocardial infarction[ICD-11: BA41-BA43]Q05655PRKCD
    T18876DI0037Asthma[ICD-11: CA23]P35408PTGER4
    T18876DI0175Heart failure[ICD-11: BD10-BD1Z]P35408PTGER4
    T18876DI0264Migraine[ICD-11: 8A80]P35408PTGER4
    T18876DI0303Non-small-cell lung cancer[ICD-11: 2C25]P35408PTGER4
    T18876DI0324Pain[ICD-11: MG30-MG3Z]P35408PTGER4
    T18876DI0360Rectum cancer[ICD-11: 2B92]P35408PTGER4
    T18876DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35408PTGER4
    T18876DI0414Transplanted organ/tissue[ICD-11: QB63]P35408PTGER4
    T85467DI0166Glaucoma[ICD-11: 9C61]P43115PTGER3
    T85467DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43115PTGER3
    T85467DI0414Transplanted organ/tissue[ICD-11: QB63]P43115PTGER3
    T52921DI0039Atopic eczema[ICD-11: EA80]P41146OPRL1
    T52921DI0117Depression[ICD-11: 6A70-6A7Z]P41146OPRL1
    T52921DI0173Headache[ICD-11: 8A80-8A84]P41146OPRL1
    T52921DI0175Heart failure[ICD-11: BD10-BD1Z]P41146OPRL1
    T66505DI0047Basal cell carcinoma[ICD-11: 2C32]Q99835SMO
    T66505DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]Q99835SMO
    T66505DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q99835SMO
    T00176DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q00987MDM2
    T00176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q00987MDM2
    T71266DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9Y243AKT3
    T23995DI0413Transplant rejection[ICD-11: NE84]Q04759PRKCQ
    T52790DI0218Irritable bowel syndrome[ICD-11: DD91]P21452TACR2
    T17569DI0030Angina pectoris[ICD-11: BA40]P22460KCNA5
    T49072DI0037Asthma[ICD-11: CA23]Q9UKP6UTS2R
    T29683DI0254Menopausal disorder[ICD-11: GA30]P29371TACR3
    T25315DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P49682CXCR3
    T25315DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P49682CXCR3
    T25315DI0351Psoriasis[ICD-11: EA90]P49682CXCR3
    T25315DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49682CXCR3
    T95302DI0005Acne vulgaris[ICD-11: ED80]P33032MC5R
    T95302DI0371Sebaceous gland disorder[ICD-11: ED91]P33032MC5R

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